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| 1 | Intestinal permeability in the pathogenesis of liver damage: From non-alcoholic fatty liver disease to liver transplantation显示文摘The intimate connection and the strict mutual cooperation between the gut and the liver realizes a functional entity called gut-liver axis.The integrity of intestinal barrier is crucial for the maintenance of liver homeostasis.In this mutual relationship,the liver acts as a second firewall towards potentially harmful substances translocated from the gut,and is,in turn,is implicated in the regulation of the barrier.Increasing evidence has highlighted the relevance of increased intestinal permeability and consequent bacterial translocation in the development of liver damage.In particular,in patients with non-alcoholic fatty liver disease recent hypotheses are considering intestinal permeability impairment,diet and gut dysbiosis as the primary pathogenic trigger.In advanced liver disease,intestinal permeability is enhanced by portal hypertension.The clinical consequence is an increased bacterial translocation that further worsens liver damage.Furthermore,this pathogenic mechanism is implicated in most of liver cirrhosis complications,such as spontaneous bacterial peritonitis,hepatorenal syndrome,portal vein thrombosis,hepatic encephalopathy,and hepatocellular carcinoma.After liver transplantation,the decrease in portal pressure should determine beneficial effects on the gut-liver axis,although are incompletely understood data on the modifications of the intestinal permeability and gut microbiota composition are still lacking.How the modulation of the intestinal permeability could prevent the initiation and progression of liver disease is still an uncovered area,which deserves further attention. | Alberto Nicoletti Francesca Romana Ponziani Marco Biolato Venanzio Valenza Giuseppe Marrone Gabriele Sganga Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，33： | 19 |
| 2 | Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease显示文摘BACKGROUND In non-alcoholic fatty liver disease(NAFLD), a high-fat or high-fructose diet increases intestinal permeability and promotes derangement of the gut-liver axis.We hypothesize that, diet could be able to modulate intestinal permeability in patients with NAFLD.AIM To detect diet-induced modification of intestinal permeability in patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.METHODS The current study was a dietary intervention for non-diabetic, patients with biopsy-verified NAFLD and increased transaminases. A crossover design was employed: participants underwent 16 weeks of Mediterranean diet, 16 wk of free wash-out, and 16 weeks of low-fat diet. Both diets were hypocaloric and no consumption of supplements was allowed. All patients were followed bimonthly by a dietitian. Evaluations of clinical and metabolic parameters were completed at baseline and at the end of each dietary period. Intestinal permeability was assessed by chromium-51 ethylene diamine tetraacetate excretion testing(51 CrEDTA).RESULTS Twenty Caucasian patients, 90% male, median age 43 years, body mass index(BMI) 30.9, with biopsy-verified NAFLD were enrolled. At the end of 16 weeks of a Mediterranean diet, a significant reduction in mean body weight(-5.3 ± 4.1 kg,P = 0.003), mean waist circumference(-7.9 ± 4.9 cm, P = 0.001), and mean transaminase levels [alanine aminotransferase(ALT)-28.3 ± 11.9 IU/L, P =0.0001; aspartate aminotransferase(AST)-6.4 ± 56.3 IU/L, P = 0.01] were observed. These benefits were maintained after 16 wk of wash-out and also after16 wk of low-fat diet, without further improvements. Fourteen of the 20 patients had intestinal permeability alteration at baseline(mean percentage retention of51 Cr-EDTA = 5.4%), but no significant changes in intestinal permeability were observed at the end of the 16 wk of the Mediterranean diet or 16 wk of the low-fat diet.CONCLUSION Mediterranean diet is an effective strategy for treating overweight, visceral obesity and serum transaminase in patients with NAFLD. If the Mediterranean diet can improve intestinal permeability in patients with NAFLD, it deserves further investigation. | Marco Biolato Fiorella Manca Giuseppe Marrone Consuelo Cefalo Simona Racco Giacinto A Miggiano Venanzio Valenza Antonio Gasbarrini Luca Miele Antonio Grieco | 2019 | World Journal of Gastroenterology2019，25，4： | 4 |
| 3 | 陶瓷表面Mo-Ni-Si金属化及其与Ag的润湿性研究(英文)显示文摘采用真空熔烧工艺在SiC陶瓷表面制备了3种化学成分的Mo-Ni-Si金属化涂层,研究了涂层的相组成和涂层/SiC陶瓷界面的微结构。通过座滴法实验考察了纯Ag在SiC 陶瓷涂层上的润湿与铺展特性,分析和讨论了Ag/金属化SiC陶瓷体系的界面行为。结果表明,该金属化涂层主要由Mo_5Si_3、MoSi_2、Ni_2Si、NiSi_2和MoNiSi组成,同时随着涂层中Mo金属由20%增加至40% (摩尔分数),位于涂层表面的具有四方结构的MoSi_2晶粒逐渐消失。Ag对Mo20-Ni32-Si48、Mo30-Ni28-Si42、Mo40-Ni24-Si36金属化SiC陶瓷在1000℃保温30min后对应的最终接触角分别为45°,79°和85°,该结果与Ag滴和3种Mo-Ni-Si涂层之间的相互作用密切相关。同时,在润湿试验前后,在Mo-Ni-Si涂层/SiC衬底界面没有发现明显的反应层。 | 赵三团 张相召 刘桂武 Valenza Fabrizio Muolo Maria Luigia 乔冠军 Passerone Alberto | 2018 | 稀有金属材料与工程2018，47，3： | 3 |
| 4 | Ni-56Si合金对SiC陶瓷的润湿和铺展显示文摘采用座滴法考察了不同温度和气氛下Ni-56Si合金对SiC陶瓷的润湿和铺展行为。分析了固化后的液滴/SiC衬底界面和液滴表面的微结构和相组成。结果表明:该润湿体系于1350℃下在真空、1个大气压的静态或流动的Ar+5%(体积分数)H2的混合气3种气氛中均可获得优良的润湿性。在真空条件下,其铺展最快达到平衡,1350℃时的润湿性明显优于1100℃和1200℃,且在1100℃时的铺展过程与1350℃和1200℃有显著不同,即存在2种不同的铺展机制,这与SiC表面的润湿壁垒(SiO2层)的消除动力学有关。界面微结构分析进一步证实该系统的非反应润湿特性。 | 刘桂武 乔冠军 卢天健 VALENZA Fabrizio MUOLO Maria Luigia PASSERONE Alberto | 2010 | 硅酸盐学报2010，38，8： | 2 |
| 5 | Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease显示文摘 | Luca Miele Venanzio Valenza Giuseppe La Torre Massimo Montalto Giovanni Cammarota Riccardo Ricci Roberta Mascianà Alessandra Forgione Maria L. Gabrieli Germano Perotti Fabio M. Vecchio Gianlodovico Rapaccini Giovanni Gasbarrini Chris P. Day Antonio Grieco | 2009 | Hepatology2009，，6： | 2 |
| 6 | The effect of a liquid CTBN rubber modifier on the thermo-kinetic parameters of an epoxy resin during a pultrusion process显示文摘 | L Calabrese A Valenza | 2003 | Composites Science and Technology2003，63，6： | 1 |
| 7 | Glass-basah/epoxy hybrid composites for marine applications显示文摘 | Fiore V Di Bella G Valenza A | 2011 | Materials & Design2011，32，4： | 1 |
| 8 | Explicit and implicit perception of illusory contours in unilateral spatial neglect: behavioural and anatomical correlates of preattentive grouping mechanisms 显示文摘 | Vuilleumier P Valenza N Landis T | 2001 | Neuropsychologia2001，39，6： | 1 |
| 9 | Injuriousventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model显示文摘 | Tremblay L Valenza F Ribeiro SP | 1997 | JClin Invest1997，99，5： | 1 |
| 10 | Increased intestinal permeabilityand tight junction alterations in nonalcoholic fattyliver disease显示文摘 | Miele L Valenza V La Torre | 2009 | Hepatology2009，49，： | 1 |
| 11 | A novel EDA glove based on textile-integrated electrodes for affective computing显示文摘 | Antonio Lanata Gaetano Valenza | 2012 | Med Biol Eng Comput2012，50，： | 1 |
| 12 | The applicationof esophageal pressure measurement in patients with respiratoryfailure显示文摘 | Akoumianaki E Maggiore SM Valenza F | 2014 | Am J Respir Crit Care Med2014，189，5： | 1 |
| 13 | Injurious ventilatory strategies increase cytokines and c-fos m-RNA expression in an isolated rat lung model显示文摘 | Tremblay L Valenza F Ribeiro SP | 1997 | J Clin Invest1997，99，5： | 1 |
| 14 | Postoperative dysphagia versus neurogenic dysphagia: scintigraphic assessment 显示文摘 | Galli J Valenza V D'AlatriL | 2003 | Ann Otol Rhinol Laryngol ( S0003 4894)2003，112，1： | 1 |
| 15 | Mechanism for salt scaling显示文摘 | VALENZA J J SCHERER G W | 2006 | Journal of the American Ceramic Society2006，89，4： | 1 |
| 16 | Pharyngocutaneous fistula onset after total laryngectomy: scintigraphic analysis 显示文摘 | Galli J Valenza V Parrilla C | 2009 | Acta Otorhino- laryngol Ital2009，29，5： | 1 |
| 17 | Quantitative PCR and RT-PCR in virology 显示文摘 | Menzo S Bagnarelli P Manzin A Valenza A Varaldo PE | 1993 | PCR Methods Appl1993，2，3： | 1 |
| 18 | Transcatheter arterial ehemoembolisation for hepatocellular carcinoma in cirrhosis: sur- vival rate and prognostic faetors 显示文摘 | Olivo M Valenza F Buccellato A | 2010 | Dig Liver Dis2010，42，7： | 1 |
| 19 | First survey of metallo lactamases in clinical isolates of Pseudomonas aeruginosa in a german university hospital显示文摘 | Valenza G Joseph B Elias J | 2010 | Antimicrob Agents Chemoth- er2010，54，8： | 1 |
| 20 | Increased intestinal permeability and tight junction alterations in nonalcoholic fatty liver disease显示文摘 | Miele L Valenza V Ira Torte | 2009 | Hepatology2009，49，： | 1 |
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