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| 1 | Differential secretome analysis reveals CST6 as a suppressor of breast cancer bone metastasis显示文摘骨头转移从疾病是乳癌的经常的复杂并发症和病态和死亡的一个普通原因。在转移期间,分泌蛋白质在在癌症房间和主人基质之间的相互作用起关键作用。为了描绘分泌蛋白质,那与乳癌骨头转移被联系,我们比较四个 MDA-MB-231 (MDA231 ) 衍生物房间的 secretomes 的没有标签的 proteomic 分析与骨头转移的改变的能力衬里的 preformed。128 蛋白质的一个总数被发现是一致地在骨头回归线癌症房间的调节媒介的 up-/down-regulated。改变的蛋白质的充实的分子的函数包括了受体绑定和 peptidase 抑制。通过乳癌房间的另外的 transcriptomic 分析,我们选择了 cystatin E/M (CST6 ) ,在骨头变形的房间下面调整的一个半胱氨酸朊酶禁止者,为进一步功能的研究。我们的结果证明 CST6 压制了乳癌房间的增长,殖民地形成,迁居和侵略。对癌症房间活动性的镇压功能被癌症执行导出房间的可溶的 CST6。更重要地,在癌症房间的 CST6 的宫外的表示在动物学习救了老鼠免于公开 osteolytic 转移和死亡,当时 CST6 击倒的显著地提高的癌症房间骨头转移和弄短的动物幸存。总的来说,我们的学习提供了乳癌骨头向性的全身的 secretome 分析并且作为乳癌 osteolytic 转移的真正的 suppressor 建立了分泌 CST6。 | Lei Jin Yan Zhang Hui Li Ling Yao Da Fu Xuebiao Yao Lisa X Xu Xiaofang Hu Guohong Hu | 2012 | Cell Research2012，22，9： | 15 |
| 2 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 3 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 4 | Numerical simulation of effect of rotational tool with screw on material flow behavior of friction stir welding of Ti6Al4V alloy显示文摘The rotational tool is put forward, which is composed of the one-spiral-flute shoul-der and the rotational pin with screw. Using the turbulent model of the FLUENT software, material plastic flow behavior during the process of friction stir welding of Ti6Al4V alloy is researched by the numerical simulation method and then the effect of rotational tool geometry on material flow during the welding process is attained. The results show that the flow direction of the material near the rotational tool is mainly the same as the rotational direction of the tool while the material near tool flows more violently than the other regions. For the tapered rotational pin, the flow velocity of material inside the workpiece decreases with the increase of the distance away from the workpiece surface because of the change of pin diameter. For the rotational tool, the flute added to the shoulder and the screw added to the pin can greatly increase the flow velocity of material during the welding process while the peak value of the flow velocity of material appears on the flute or the screw. Moreover, the rotational tool with the one-spiral-flute shoulder is better than the tool with the concentric-circles-flute shoulder. Decreasing the width of pin screw and increasing the diameter of pin tip are both good for the increase of flow velocity. | Shude JI Aili ZOU Yumei YUE Guohong L UAN Yanye JIN Fu LI | 2012 | Acta Metallurgica Sinica(English Letters)2012，25，5： | 2 |
| 5 | An integrated approach to Chinese word segmentation显示文摘 | Guohong Fu Luke | 2003 | Journal of Chinese Language and Computing2003，，13： | 1 |
| 6 | Chinese word segmentation as morpheme-based lexical chunking 显示文摘 | Fu Guohong Kit Chunyu Webster J J | 2008 | Information Sciences2008，178，9： | 1 |
| 7 | Chinese word segmentation as morpheme-based lexical chunking显示文摘 | Fu Guohong Chunyu Kit Jonathan J Webster | 2008 | Information Sciences2008，178，9： | 1 |
| 8 | Mechanical and thermal properties of poly(laetic acid) composites with rice straw fiber modified by poly (butyl acrylate)显示文摘 | Qin Lijun Qiu Jianhui Liu Mingzhu Ding Shenglong Shao Liang Lv Shaoyu Zhang Guohong Zhao Yang Fu Xie | 2011 | Chemical Engineering Journal2011，166，： | 1 |
| 9 | Chinese named entity recognition using lexicalized HMMs 显示文摘 | FU GUOHONG LUKE K-K | 2005 | ACM SIGKDD Explorations Newsletter2005，7，1： | 1 |
| 10 | Chinese word segmentation as morpheme-based lexical chunking显示文摘 | Fu Guohong Kit Chunyu Webster Jonathan J | 2008 | Information Sciences2008，178，9： | 1 |
| 11 | Friction Stir Welding of Al Alloy Thin Plate by Rotational Tool without Pin显示文摘For friction stir welding (FSW), a new idea is put forward in this paper to weld the thin plate of Al alloy by using the rotational tool without pin. The experiments of FSW are carried out by using the tools with inner-concave-flute shoulder, concentric-circles-flute shoulder and three-spiral-flute shoulder, respectively. The experimental results show that the grain size in weld nugget zone attained by the tool with three-spiral-flute shoulder is nearly the same while the grain sizes decrease with the decrease of welding velocity. The displacement of material flow in the heat-mechanical affected zone by the tool with three-spiral-flute shoulder is much larger than that by the tool with inner-concave-flute shoulder or concentric-circles-flute shoulder. The above-mentioned results are verified by numerical simulation. For the tool with three-spiral-flute shoulder, the tensile strength of FSW joint increases with the decrease of welding velocity while the value of tensile strength attained by the welding velocity of 20 mm/min and the rotation speed of 1800 r/min is about 398 MPa, which is 80% more than that of parent mental tensile strength. Those verify that the tool with three-spiral-flute shoulder can be used to join the thin plate of Al alloy. | Liguo Zhang Shude Ji Guohong Luan Chunlin Dong Li Fu | 2011 | Journal of Materials Science & Technology2011，27，7： | 0 |
| 12 | Expanding Corpora for Chinese Polarity Classification via Opinion Paraphrase Generation显示文摘Although much progress has been made to date on sentiment classification, lacking annotated corpora remains a problem. In this paper we propose to expand corpora for Chinese polarity classification via opinion paraphrase generation. To this end, we first exploit three strategies for opinion paraphrase generation, namely sentences re-ordering, opinion element substitution and explicit attribution implying. To improve the quality of the generated opinion paraphrases, we define four criteria for opinion paraphrase evaluation and thus present a filtering algorithm to discard improper opinion paraphrase candidates. To assess the proposed method, we further apply the expanded corpus to a SVM classifier for polarity classification. The experimental results show that the generated opinion paraphrases are beneficial to polarity classification. | Da Pan Jiaying Song Guohong Fu | 2016 | 国际计算机前沿大会会议论文集2016，，1： | 0 |
| 13 | Chinese Explanatory Segment Recognition as Sequence Labeling显示文摘How to mine the underlying reasons for opinions is a key issue on opinion mining. In this paper, we propose a CRF-based labeling approach to explanatory segment recognition in Chinese product reviews. To this end, we first reformulate explanatory segments recognition as a labeling task on a sequence of words, and then explore various features from three linguistic levels, namely character, word and semantic under the framework of conditional random fields. Experimental results over product reviews from mobilephone and car domains show that the proposed approach significantly outperforms existing state-of-the-art methods for explanatory segment extraction. | Yu He Da Pan Guohong Fu | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 14 | Normalization of Homophonic Words in Chinese Microblogs显示文摘Homophonic words are very popular in Chinese microblog, posing a new challenge for Chinese microblog text analysis. However, to date, there has been very little research conducted on Chinese homophonic words normalization. In this paper, we take Chinese homophonic word normalization as a process of language decoding and propose an n-gram based approach. To this end, we first employ homophonic–original word or character mapping tables to generate normalization candidates for a given sentence with homophonic words, and thus exploit n-gram language models to decode the best normalization from the candidate set. Our experimental results show that using the homophonic-original character mapping table and n-grams trained from the microblog corpus help improve performance in homophonic word recognition and restoration. | Xin Zhang Jiaying Song Yu He Guohong Fu | 2015 | 国际计算机前沿大会会议论文集2015，，1： | 0 |
| 15 | Extracting Chinese Explanatory Expressions with Discrete and Neural CRFs显示文摘Recent work on opinion mining typically focuses on subtasks such as aspect mining or polarity classification, ignoring the detailed explanatory evidences that account for one certain user opinion. In this paper, we study the extraction of explanatory expressions, by modeling the problem based on conditional random field (CRF). We compare the effectiveness of both discrete and neural features, and further integrate them.We evaluate the models on two datasets from two different domains which have been annotated with ground-truth explanatory expression.Results show that the neural CRF model performs better than the discrete CRF. After a combination of the discrete and neural features, our final CRF mode achieves the top-performing results. | Da Pan Mengqi Wang Meishan Zhang Guohong Fu | 2017 | 国际计算机前沿大会会议论文集2017，，2： | 0 |
| 16 | Ultrafast photocarrier and coherent phonon dynamics in type-II Dirac semimetal PtTe2 thin films probed by optical spectroscopy显示文摘We report the ultrafast photocarrier dynamics and coherent phonon excitation in type-II Dirac semimetal platinum ditelluride(PtTe2)thin films via femtosecond(fs)pump-probe spectroscopy at room temperature.Quantitative analysis revealed that the incoherent electronic relaxation consists of two components:a subpicosecond fast relaxation process and a slow component with a time constant of hundreds of picoseconds(ps).Furthermore,the launch of a coherent acoustic phonon(CAP)in the 20 nm film but absence in the 6.8 nm film uncovers the dominant role of temperature gradient in producing a strain wave.The sound velocity and Young’s modulus in the thick PtTe_(2) are determined to be 1.736 km/s and 29.5 GPa,respectively.In addition,the coherent optical phonon(COP)with a frequency of 4.7 THz corresponding to Te atoms out-of-plane A1g vibration has been well resolved in all films,which is ascribed to displacive excitation of coherent phonon(DECP).The observation of a strong probe-wavelength dependent COP amplitude reveals the resonant feature of the optical excitation-induced atomic displacement in PtTe2.Our findings provide deep insight into the excitation and dynamics of CAP and COP as well as the photocarriers’recovery pathway and lifetimes in PtTe_(2).Our study also demonstrates that the COP spectroscopy is a powerful tool to reveal the modulation of frequency-dependent optical constants induced by atomic vibrations,which may find applications in the fields of optoelectronics and ultrafast photonics. | Peng Suo Shengnan Yan Ruihua Pu Wenjie Zhang Di Li Jiaming Chen Jibo Fu Xian Lin Feng Miao Shi-Jun Liang Weimin Liu Guohong Ma | 2022 | Photonics Research2022，10，3： | 0 |
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