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| 1 | The impact of iodinated X-ray contrast agents on formation and toxicity of disinfection by-products in drinking water显示文摘The presence of iodinated X-ray contrast media(ICM) in source waters is of high concern to public health because of their potential to generate highly toxic disinfection by-products(DBPs). The objective of this study was to determine the impact of ICM in source waters and the type of disinfectant on the overall toxicity of DBP mixtures and to determine which ICM and reaction conditions give rise to toxic by-products. Source waters collected from Akron,OH were treated with five different ICMs, including iopamidol, iopromide, iohexol,diatrizoate and iomeprol, with or without chlorine or chloramine disinfection. The reaction product mixtures were concentrated with XAD resins and the mammalian cell cytotoxicity and genotoxicity of the reaction mixture concentrates was measured. Water containing iopamidol generated an enhanced level of mammalian cell cytotoxicity and genotoxicity after disinfection. While chlorine disinfection with iopamidol resulted in the highest cytotoxicity overall, the relative iopamidol-mediated increase in toxicity was greater when chloramine was used as the disinfectant compared with chlorine. Four other ICMs(iopromide, iohexol, diatrizoate, and iomeprol) expressed some cytotoxicity over the control without any disinfection, and induced higher cytotoxicity when chlorinated. Only iohexol enhanced genotoxicity compared to the chlorinated source water. | Clara H.Jeong Edward J.Machek Morteza Shakeri Stephen E.Duirk Thomas A.Ternes Susan D.Richardson Elizabeth D.Wagner Michael J.Plewa | 2017 | Journal of Environmental Sciences2017，29，8： | 11 |
| 2 | Endoscopic treatment of anastomotic biliary strictures after living donor liver transplantation: outcomes after maximal stent therapy显示文摘 | Ting-Hui Hsieh Kristin L. Mekeel Michael D. Crowell Cuong C. Nguyen Ananya Das Bashar A. Aqel Elizabeth J. Carey Thomas J. Byrne Hugo E. Vargas David D. Douglas David C. Mulligan M. Edwyn Harrison | 2013 | Gastrointestinal Endoscopy2013，，1： | 3 |
| 3 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 4 | Molecular evolution of the HSP70 multigene family显示文摘 | William R. Boorstein Thomas Ziegelhoffer Elizabeth A. Craig | 1994 | Journal of Molecular Evolution1994，，1： | 3 |
| 5 | Study to Determine Adequate Margins in Radiotherapy Planning for Esophageal Carcinoma by Detailing Patterns of Recurrence After Definitive Chemoradiotherapy显示文摘 | Michael R. Button Carys A. Morgan Elizabeth S. Croydon S. Ashley Roberts Thomas D.L. Crosby | 2009 | International Journal of Radiation Oncology, Biology, Physics2009，，3： | 2 |
| 6 | Senescent human hepatocytes express a unique secretory phenotype and promote macrophage migration显示文摘AIM:To develop a model of stress-induced senescence to study the hepatocyte senescence associated secretory phenotype(SASP).METHODS:Hydrogen peroxide treatment was used to induce senescence in the human Hep G2 hepatocyte cell line.Senescence was confirmed by cytochemical staining for a panel of markers including Ki67,p21,heterochromatin protein 1β,and senescence-associated-β-galactosidase activity.Senescent hepatocytes were characterised by gene expression arrays and quantitative polymerase chain reaction(q PCR),and conditioned media was used in proteomic analyses,a human chemokine protein array,and cell migration assays to characterise the composition and function of the hepatocyte SASP.RESULTS:Senescent hepatocytes induced classical markers of senescence(p21,heterochromatin protein1β,and senescence-associated-β-galactosidase activity);and downregulated the proliferation marker,Ki67.Hepatocyte senescence induced a 4.6-fold increase in total secreted protein(P=0.06)without major alterations in the protein profile.Senescence-induced genes were identified by microarray(Benjamini Hochbergcorrected P<0.05);and,consistent with the increase in secreted protein,gene ontology analysis revealed a significant enrichment of secreted proteins among inducible genes.The hepatocyte SASP included characteristic factors such as interleukin(IL)-8 and IL-6,as well as novel components such as SAA4,IL-32and Fibrinogen,which were validated by q PCR and/or chemokine protein array.Senescent hepatocyteconditioned medium elicited migration of inflammatory(granulocyte-macrophage colony stimulating factor,GM-CSF-derived),but not non-inflammatory(CSF-1-derived)human macrophages(P=0.022),which could contribute to a pro-inflammatory microenvironment in vivo,or facilitate the clearance of senescent cells.CONCLUSION:Our novel model of hepatocyte senescence provides insights into mechanisms by which senescent hepatocytes may promote chronic liver disease pathogenesis. | Katharine M Irvine Richard Skoien Nilesh J Bokil Michelle Melino Gethin P Thomas Dorothy Loo Brian Gabrielli Michelle M Hill Matthew J Sweet Andrew D Clouston Elizabeth E Powell | 2014 | World Journal of Gastroenterology2014，20，47： | 2 |
| 7 | Crystal structure of a TAF1-TAF7 complex in human transcription factor liD reveals a promoter binding module显示文摘 | Hui Wang Elizabeth C Curran Thomas R Hinds Edith H Wang Ning Zheng | 2014 | Cell Research2014，24，12： | 2 |
| 8 | Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A‐RIPK1‐dependent necroptosis显示文摘 | Sahar A. Saddoughi Salih Gencer Yuri K. Peterson Katherine E. Ward Archana Mukhopadhyay Joshua Oaks Jacek Bielawski Zdzislaw M. Szulc Raquela J. Thomas Shanmugam P. Selvam Can E. Senkal Elizabeth Garrett‐Mayer Ryan M. De Palma Dzmitry Fedarovich Angen Liu | 2012 | EMBO Mol Med2012，，1： | 2 |
| 9 | Impact of experience with a retrograde-viewing device on adenoma detection rates and withdrawal times during colonoscopy: the Third Eye Retroscope study group显示文摘 | Daniel C. DeMarco Elizabeth Odstrcil Luis F. Lara David Bass Chase Herdman Timothy Kinney Kapil Gupta Leon Wolf Thomas Dewar Thomas M. Deas Manoj K. Mehta M. Badar Anwer Randall Pellish J. Kent Hamilton Daniel Polter K. Gautham Reddy Ira Hanan | 2010 | Gastrointestinal Endoscopy2010，，3： | 2 |
| 10 | 国际卒中遗传学联盟的推荐意见(第2部分):生物样本的采集和储存显示文摘在2003年人类基因组测序以及全基因组基因分型技术发展的共同促进下,人类遗传学的进步已使我们识别出2000多个与性状相关的基因突变。由于这些突变大多数对疾病风险仅有微小的独立影响,因此成功的遗传学研究需要很大的样本量(包含数以千计、万计或者十万计的病例和对照)才能达到足够的研究效能。如此大的样本量积累需要依赖在人类遗传学研究乃至在临床研究中史无前例的大规模国际协作。现在已有许多常见疾病的专病联盟将大量独立机构和合作者联合起来。每个联盟均面临至少2个基本问题:如何整合具有足够数量、同质性和表型质量高的研究样本以及如何储存和分析来自入组受试者的生物样本,有时可能需要在数年间反复进行。 | Thomas W.K.Battey Valerie Valant Sylvia Baedorf Kassis Christina Kourkoulis Chaeyoung Lee Christopher D. Anderson Guido J. Falcone Jordi Jimenez-Conde Israel Fernandez-Cadenas Guillaume Pare Tatjana Rundek Michael L. James Robin Lemmens Tsong-Hai Lee Turgut Tatlisumak Steven J. Kittner Arne Lindgren Farrah J. Mateen Aaron L. Berkowitz Elizabeth G. Holliday Jennifer Majersik 李海峰 姜平 岳耀先 | 2015 | 国际脑血管病杂志2015，23，9： | 2 |
| 11 | Curcumin-loaded polymeric nanoparticles for neuro-protection in neonatal rats with hypoxic-ischemic encephalopathy显示文摘 | Andrea Joseph Thomas Wood Chih-Chung Chen Kylie Corry Jessica M. Snyder Sandra E. Juul Pratik Parikh Elizabeth Nance | 2018 | Nano Research2018，11，10： | 2 |
| 12 | Preservation of immune function in cervical cancer patients during chemoradiation using a novel integrative approach显示文摘 | Susan K. Lutgendorf Elizabeth Mullen-Houser Daniel Russell Koen DeGeest Geraldine Jacobson Laura Hart David Bender Barrie Anderson Thomas E. Buekers Michael J. Goodheart Michael H. Antoni Anil K. Sood David M. Lubaroff | 2010 | Brain Behavior and Immunity2010，，8： | 2 |
| 13 | Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells显示文摘AIM: To present an approach for selectively killing retrovirus-infected cells that combines the toxicity of Pseudomonas exotoxin (PE) and the presence of reverse transcriptase (RT) in infected cells. METHODS: PE antisense toxin RNA has palindromic stem loops at its 5' and 3' ends enabling self-primed generation of cDNA in the presence of RT. The RT activity expressed in retrovirus-infected cells converts 'antisense-toxin-RNA' into a lethal toxin gene exclusively in these cells. RESULTS: Using cotransfection studies with PE-expressing RNAs and β-gal expressing reporter plasmids, we show that, in HepG2 and HepG2.2.15 hepatoma cells as well as in duck hepatitis B virus (DHBV) infected cells, HBV or DHBV-polymerase reverse transcribe a lethal cDNA copy of an antisense toxin RNA, which is composed of sequences complementary to a PE gene and eukaryotic transcription and translation signals. CONCLUSION: This finding may have important implications as a novel therapeutic strategy aimed at the elimination of HBV infection. | Peter Hafkemeyer Ulrich Brinkmann Elizabeth Brinkmann Ira Pastan Hubert E Blum Thomas F Baumert | 2008 | World Journal of Gastroenterology2008，14，18： | 2 |
| 14 | Does Nonalcoholic Fatty Liver Disease Predispose Patients to Hepatocellular Carcinoma in the Absence of Cirrhosis?显示文摘 | Guzman Grace Brunt Elizabeth M Petrovic Lydia M Chejfec Gregorio Layden Thomas J Cotler Scott J | 2008 | Archives of Pathology & Laboratory Medicine2008，，11： | 2 |
| 15 | Using an information problem- solving model as a meta cognitive scaffold for multimedia - squpportedinformation - based problems显示文摘 | Sara Elizabeth Wolf Thomas Brush John Save | 2003 | Journal of Research on Technology in Education2003，，35： | 1 |
| 16 | Extreme Values of Ma- ternal Serum Analytes in Second Trimester Screening: Looking Be- yond Trisomy and NTD's显示文摘 | Elizabeth McPherson Ginger D Thomas | 2011 | J Genet Counsel2011，20，： | 1 |
| 17 | The role of the natural environment in the emergence of antibiotic resistance in Gram-negative bacteria显示文摘 | Elizabeth MH Wellington Alistair BA Boxall Paul Cross Edward J Feil William H Gaze Peter M Hawkey Ashley S Johnson-Rollings Davey L Jones Nicholas M Lee Wilfred Otten Christopher M Thomas A Prysor Williams | 2013 | The Lancet Infectious Diseases2013，，2： | 1 |
| 18 | Reliability of the Thoracolumbar Injury Classification and Severity Score and Comparison With the Denis Classification for Injury to the Thoracic and Lumbar Spine显示文摘 | Peter Lewkonia Elizabeth Oddone Paolucci Ken Thomas | 2012 | Spine2012，，26： | 1 |
| 19 | EUS-guided trucut biopsy in establishing autoimmune pancreatitis as the cause of obstructive jaundice显示文摘 | Michael J. Levy Raghuram P. Reddy Maurits J. Wiersema Thomas C. Smyrk Jonathan E. Clain Gavin C. Harewood Randall K. Pearson Elizabeth Rajan Mark D. Topazian Tony E. Yusuf Suresh T. Chari Bret T. Petersen | 2005 | Gastrointestinal Endoscopy2005，，3： | 1 |
| 20 | Work and Family Environments and the Adoption of Computer-Supported Supplemental Work-at-Home显示文摘 | Linda Elizabeth Duxbury Christopher Alan Higgins D.Roland Thomas | 1996 | Journal of Vocational Behavior1996，，1： | 1 |
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