|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Human cytomegalovirus and Epstein-Barr virus infection in inflammatory bowel disease:Need for mucosal viral load measurement显示文摘AIM:To evaluate the best diagnostic technique and risk factors of the human Cytomegalovirus(HCMV)and Epstein-Barr virus(EBV)infection in inflammatory bowel disease(IBD).METHODS:A cohort of 40 IBD patients(17 refractory)and 40 controls underwent peripheral blood and endoscopic colonic mucosal sample harvest.Viral infection was assessed by quantitative real-time polymerase chain reaction and immunohistochemistry,and correlations with clinical and endoscopic indexes of activity,and risk factors were investigated.RESULTS:All refractory patients carried detectable levels of HCMV and/or EBV mucosal load as comparedto 13/23(56.5%)non-refractory and 13/40(32.5%)controls.The median DNA value was significantly higher in refractory(HCMV 286 and EBV 5.440 copies/105cells)than in non-refractory(HCMV 0 and EBV 6copies/105 cells;P<0.05 and<0.001)IBD patients and controls(HCMV and EBV 0 copies/105 cells;P<0.001 for both).Refractory patients showed DNA peak values≥103 copies/105 cells in diseased mucosa in comparison to non-diseased mucosa(P<0.0121 for HCMV and<0.0004 for EBV),while non-refractory patients and controls invariably displayed levels below this threshold,thus allowing us to differentiate viral colitis from mucosal infection.Moreover,the mucosal load positively correlated with the values found in the peripheral blood,whilst no correlation with the number of positive cells at immunohistochemistry was found.Steroid use was identified as a significant risk factor for both HCMV(P=0.018)and EBV(P=0.002)colitis.Finally,a course of specific antiviral therapy with ganciclovir was successful in all refractory patients with HCMV colitis,whilst refractory patients with EBV colitis did not show any improvement despite steroid tapering and discontinuation of the other medications.CONCLUSION:Viral colitis appeared to contribute to mucosal lesions in refractory IBD,and its correct diagnosis and management require quantitative real-time polymerase chain reaction assay of mucosal specimens. | Rachele Ciccocioppo Francesca Racca Stefania Paolucci Giulia Campanini Lodovica Pozzi Elena Betti Roberta Riboni Alessandro Vanoli Fausto Baldanti Gino Roberto Corazza | 2015 | World Journal of Gastroenterology2015，21，6： | 12 |
| 2 | Evidence-based medicine: An update on treatments for peritoneal dialysis-related peritonitis显示文摘Peritonitis continues to be a major complication of peritoneal dialysis(PD), and adequate treatment is crucial for a favorable outcome. There is no consensus regarding the optimal therapeutic regimen, and few prospective controlled studies have been published. The objective of this manuscript is to review the results of PD peritonitis treatment reported in narrative reviews, systematic reviews, and proportional meta-analyses. Two narrative reviews, the only existing systematic review and its update published between 1991 and 2014 were included. In addition, we reported the results of a proportional metaanalysis published by our group. Results from systematic reviews of randomized control trials(RCT) and quasiRCT were not able to identify any optimal antimicrobial treatment, but glycopeptide regimens were more likely to achieve a complete cure than a first generation cephalosporin. Compared to urokinase, simultaneous catheter removal and replacement resulted in better outcomes. Continuous and intermittent IP antibiotic use had similar outcomes. Intraperitoneal antibiotics were superior to intravenous antibiotics in reducing treatment failure. In the proportional meta-analysis of RCTs and the case series, the resolution rate(86%) of ceftazidime plus glycopeptide as initial treatment was significantly higher than first generation cephalosporin plus aminoglycosides(66%) and glycopeptides plus aminoglycosides(75%). Other comparisons of regimens used for either initial treatment or treatment of gram-positive rods or gramnegative rods did not show statistically significant differences. The superiority of a combination of a glycopeptide and a third generation cephalosporin was also reported by a narrative review study published in 1991, which reported an 88% resolution rate. | Pasqual Barretti Joo Vitor Pereira Doles Douglas Gonalves Pinotti Regina Paolucci El Dib | 2015 | World Journal of Nephrology2015，4，2： | 9 |
| 3 | Adequate extent in radical re-resection of incidental gallbladder carcinoma: analysis of the German Registry显示文摘 | Thorsten Oliver Goetze Vittorio Paolucci | 2010 | Surgical Endoscopy2010，，9： | 2 |
| 4 | Quantification of the risk of post stroke depression: the Italian multicenter observational study DESTRO 显示文摘 | Paolucci S Gandolfo C Provinciali L | 2005 | Acta Psychiatr Scand2005，112，4： | 1 |
| 5 | Automated Discovery, Interaction and Composition of Semantic Web Services显示文摘 | Sycara K Paolucci M Ankolekar A | 2003 | Journal of Web Semantics2003，1，1： | 1 |
| 6 | On the reliability of long-period response spectral ordinates from digital accelerograms 显示文摘 | Paolucci R Rovelli A | 2008 | Earthquake Engineering and Structural Dynamics2008，37，： | 1 |
| 7 | Experiences with percutaneous endoscopic gastrostomy显示文摘 | Gutt CN Held S Paolucci V | 1996 | Word J Surg1996，20，8： | 1 |
| 8 | Epidemiology and treatment of post-stroke depression显示文摘 | Paolucci S | 2008 | Neuropsychiatr Dis Treat2008，4，1： | 1 |
| 9 | Towards virtual engineer in machine tools design显示文摘 | BIANCHI G PAOLUCCI F | 1996 | CIRP Annals-Manufacturing Technology1996，45，1： | 1 |
| 10 | A multi- level wavelet collocation method for solving partial differential equations in a finite, domain显示文摘 | VASILYEV O V PAOLUCCI S SEN M | 1995 | J Comput Phys1995，120，： | 1 |
| 11 | Post-stroke depression:researchmethodology of a large multicentre observational study(DESTRO) 显示文摘 | V Toso C Gandolfo S Paolucci L et ai | 2004 | Neu-rol Sci2004，25，3： | 1 |
| 12 | Reduced-intensity modified constraint-induced movement therapy versus conventional therapy for upper extremity rehabilitation after stroke : a muhicenter trial 显示文摘 | Smania N Gandolfi M Paolucci S | 2012 | Neurorehabil Neural Repair2012，26，9： | 1 |
| 13 | Epidemiology and treatment of post-stroke depression显示文摘 | Paolucci S | 2008 | Neuropsychiatr Dis Treat2008，4，1： | 1 |
| 14 | Towards Virtual Engineering in Machine Tools Design 显示文摘 | G Bianchi F Paolucci P Vanden Braembussche | 1996 | C IRP Annals-manufacturing Technology1996，45，1： | 1 |
| 15 | Epidemiology and treatement of poststroke depression显示文摘 | Paolucci S | 2008 | Neuropsychiatr Dis Treat2008，4，1： | 1 |
| 16 | Reliability of the Thoracolumbar Injury Classification and Severity Score and Comparison With the Denis Classification for Injury to the Thoracic and Lumbar Spine显示文摘 | Peter Lewkonia Elizabeth Oddone Paolucci Ken Thomas | 2012 | Spine2012，，26： | 1 |
| 17 | Port site recurrences after laparoscopic surgery显示文摘 | Schaeff B Paolucci V Thomopoulos J | 1998 | Dig Surg1998，15，： | 1 |
| 18 | Port site recurrences after lapamscopic cholecystecto- my显示文摘 | Paolucci V | 2001 | J Hepatobiliary Pancreat Surg2001，，8： | 1 |
| 19 | Development of neuropsychiatric symptoms in poststroke patients: a cross-sectional study 显示文摘 | Angelelli P Paolucci S Bivona U | 2004 | Acta Psychiatr Scand2004，110，1： | 1 |
| 20 | Gasification process of Cuban bagasse in a two-stage reactor显示文摘 | Paolo De Filippis Carlo Borgianni Martino Paolucci | 2004 | Biomass and Bioenergy2004，27，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员