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| 1 | Role of the renin angiotensin system in diabetic nephropathy显示文摘Diabetic nephropathy has been the cause of lot of mor bidity and mortality in the diabetic population.The renin angiotensin system(RAS) is considered to be involved in most of the pathological processes that result in diabetic nephropathy.This system has var ious subsystems which contribute to the disease pat ho logy.One of these involves angiotensin Ⅱ(Ang Ⅱ) which shows in c reased activity during diabetic nephropathy.This causes hypertrophy of various renal cells and has a pres sor effect on arteriolar smooth muscle resulting in increas ed vascular pressure.Ang Ⅱ also induces inflamm ation,apoptosis,cell growth,migration and differentiation.Monocyte chemoattractant protein-1 production responsible for renal f ibrosis is also regulated by RAS.Polymorphism of angiotensin converting enzym e(ACE) and Angiotensinogen has been shown to have effects on RAS.Available treatment modalities have proven effective in controlling the progression of nephropathy.Various drugs(based on antagonism of RAS) are currently in the market and others are still under trial.Amongst the approved drugs,ACE inhibitors and ang iot ensin receptor blockers(ARBs) are widely used in clinical practice.ARBs are shown to be superior to ACE inhibitors in terms of reducing proteinuria but the combined role of ARBs with ACE inhibitors in diabetic nephropathy is under debate. | Tanuj Chawla Deepika Sharma Archana Singh | 2010 | World Journal of Diabetes2010，1，5： | 34 |
| 2 | Abscisic Acid Signal off the STARTing Block显示文摘一年 2009 在我们理解行动 abscisic 酸(骆驼毛的织物) 的模式标记一个真实重组。自从在 Vicia 警卫房间的 plasmalemma 的骆驼毛的织物绑定蛋白质的第一生物化学的察觉被报导,将近 25years 过去了。这 recentand laudableachievement 主要被欠到蛋白质其交往的专业碰巧是一些在骆驼毛的织物发信号的最早的步的最生长得很好的部件的可溶的骆驼毛的织物受体的发现。与 PYRABACTIN 抵抗(PYR ) 或骆驼毛的织物受体(RCAR ) 的规章的部件的双名字,这些可溶的受体是分享一个保存开始领域的大约 150200amino 酸的 Arabidopsis 蛋白质的一个家庭。在非压力条件下面的骆驼毛的织物信号 transduction 电路被 clade 减弱 A 蛋白质磷酸酶 2C (PP2C )( 尤其是 HAB1, ABI1,和 ABI2 ) 。在骆驼毛的织物发信号的起始的步期间,到受体的荷尔蒙的绑定在允许它扣押的后者导致一个 conformational 变化 PP2Cs。这从下游地激活骆驼毛的织物的 kinases (OST1/SnRK2.6/SRK2E, SnRK2.2,和 SnRK2.3 ) 的否定规定排除他们,因此由下游地释放他们到 phosphorylate 解开小径指向那现在包括几个 b 压缩抄写因素,离子隧道(SLAC1, KAT1 ) ,并且 NADPH oxidase (AtrbohF ) 。可溶的受体和已经与骆驼毛的织物, PP2C,和合成收缩筋 pyrabactin 的不同 isoforms 从他们的建筑群的结构的研究获得的富有的卓见的这个家庭的发现向能在植物支持干旱强壮的化学开关的合理设计打了基础。 | Archana Joshi-Saha Christiane Valon Jeffrey Leung | 2011 | Molecular Plant2011，4，4： | 17 |
| 3 | Changing role of histopathology in the diagnosis and management of hepatocellular carcinoma显示文摘Hepatocellular carcinoma (HCC) is one of the most common and fatal cancer in the world. HCC frequently presents with advanced disease, has a high recurrence rate and limited treatment options, which leads to very poor prognosis. This warrants urgent improvement in the diagnosis and treatment. Liver biopsy plays very important role in the diagnosis and prognosis of HCC, but with technical advancements and progression in the field of imaging, clinical guidelines have restricted the role of biopsy to very limited situations. Biopsy also has its own problems of needle tract seeding of tumor, small risk of complications, technical and sampling errors along with interpretative errors. Despite this, tissue analysis is often required because imaging is not always specific, limited expertise and lack of advanced imaging in many centers and limitations of imaging in the diagnosis of small, mixed and other variant forms of HCC. In addition, biopsy confirmation is often required for clinical trials of new drugs and targeted therapies. Tissue biomarkers along with certain morphological features, phenotypes and immune-phenotypes that serve as important prognostic and outcome predictors and as decisive factors for therapy decisions, add to the continuing role of histopathology. Advancements in cancer biology and development of molecular classification of HCC with clinic pathological correlation, lead to discovery of HCC phenotypic surrogates of prognostic and therapeutically significant molecular signatures. Thus tissue characteristics and morphology based correlates of molecular subtypes provide invaluable information for management and prognosis. This review thus focuses on the importance of histopathology and resurgence of role of biopsy in the diagnosis, management and prognostication of HCC. | Archana Rastogi | 2018 | World Journal of Gastroenterology2018，24，35： | 17 |
| 4 | Modern imaging of the tracheo-bronchial tree显示文摘Recent state-of-the-art computed tomography and improved three-dimensional(3-D) postprocessing techniques have revolutionized the capability of visualizing airway pathology,offering physicians an advanced view of pathology and allowing for appropriate management planning.This article is a comprehensive review of trachea and main bronchi imaging,with emphasis on the dynamic airway anatomy,and a discussion of a wide variety of diseases including,but not limited to,congenital large airway abnormalities,tracheobronchial stenoses,benign and malignant neoplasms and tracheobronchomalacia.The importance of multiplanar reconstruction,3-D reconstruction and incorporation of dynamic imaging for non-invasive evaluation of the large airways is stressed. | Archana T Laroia Brad H Thompson Sandeep T Laroia Edwin JR van Beek | 2010 | World Journal of Radiology2010，2，7： | 8 |
| 5 | An improved random forest classifier for multi-class classification显示文摘The paper presents an improved-RFC(Random Forest Classifier)approach for multi-class disease classification problem.It consists of a combination of Random Forest machine learning algorithm,an attribute evaluator method and an instance filter method.It intends to improve the performance of Random Forest algorithm.The performance results confirm that the proposed improved-RFC approach performs better than Random Forest algorithm with increase in disease classification accuracy up to 97.80%for multi-class groundnut disease dataset.The performance of improved-RFC approach is tested for its efficiency on five benchmark datasets.It shows superior performance on all these datasets. | Archana Chaudhary Savita Kolhe Raj Kamal | 2016 | Information Processing in Agriculture2016，3，4： | 8 |
| 6 | Relationship of Periodontal Status and Dental Caries Status with Oral Health Knowledge, Attitude and Behavior among Professional Students in India显示文摘Aim To find the relationship of periodontal status and dental caries status with oral health knowledge, attitude, behavior, among professional students in India. Methodology In a cross sectional study, a total of 825 students (males: 577, females: 248) from six professions were surveyed using a self administered structured questionnaire including 41 multiple choice questions and the WHO Oral Health Assessment Form (1997). The data was analyzed using the SPSS version 13.0 to perform the Student's t-test, ANOVA test, Scheffe's test and Chi-square test, linear regression analysis. Results The mean percentage scores of the students for knowledge were 53.25 ± 15.05; for attitude 74.97 ±20.48; and for behavior 59.09 ± 18.77. The percentage of students with calculus score was found to be significantly high (43.8%). The percentage of professional students with DMFT>4 was 14.1% and the percentage of students with decayed teeth was 46.2%. The regression analysis showed that the oral health behavior of the students was dependent on the attitude (P<0.001), but showed no significant linear relation with the knowledge. Also, that the mean DMFT score was dependent on the oral health behavior (P<0.05), but showed no significant relationship with the knowledge and attitude of the students. The periodontal status was independent on the knowledge, but showed a significant relationship with attitude and behavior of the students. Conclusion A positive attitude and adherence to good oral hygiene behaviors is associated with better oral health. | Archana J. Sharda Srinath Shetty | 2009 | International Journal of Oral Science2009，1，4： | 8 |
| 7 | Pharmacological cyclin dependent kinase inhibitors: Implications for colorectal cancer显示文摘Colorectal cancer accounts for a significant proportion of cancer deaths worldwide. The need to develop more chemotherapeutic agents to combat this disease is critical. Cyclin dependent kinases(CDKs), along with its binding partner cyclins, serve to control the growth of cells through the cell cycle. A new class of drugs, termed CDK inhibitors, has been studied in preclinical and now clinical trials. These inhibitors are believed to act as an anti-cancer drug by blocking CDKs to block the uncontrolled cellular proliferation that is hallmark of cancers like colorectal cancer. CDK article provides overview of the emerging drug class of CDK inhibitors and provides a list of ones that are currently in clinical trials. | Archana Balakrishnan Arpita Vyas Kaivalya Deshpande Dinesh Vyas | 2016 | World Journal of Gastroenterology2016，22，7： | 5 |
| 8 | Vitamins and non-alcoholic fatty liver disease: A molecular insight显示文摘The incidence of non-alcoholic fatty liver disease(NAFLD)is rising rapidly across the globe.NAFLD pathogenesis is largely driven by an imbalance in hepatic energy metabolism,and at present,there is no approved drug for its treatment.The liver plays a crucial role in micronutrient metabolism,and deregulation of this micronutrient metabolism may contribute to the pathogenesis of NAFLD.Vitamins regulate several enzymatic processes in the liver,and derangement in vitamin metabolism is believed to play a critical role in NAFLD progression.The anti-oxidant activities of vitamins C and E have been attributed to mitigate hepatocyte injury,and alterations in the serum levels of vitamin D,vitamin B12 and folate have shown a strong correlation with NAFLD severity.This review aims to highlight the role of these vitamins,which represent promising therapeutic targets for the management of NAFLD. | Sana Raza Archana Tewari Sangam Rajak Rohit A.Sinha | 2021 | Liver Research2021，5，2： | 4 |
| 9 | Protease inhibitors:recent advancement in its usage as a potential biocontrol agent for insect pest management显示文摘Plant derived protease inhibitors(PIs)are a promising defensin for crop im-provement and insect pest management.Although agronomist made significant efforts in utilizing PIs for managing insect pests.the potentials of PIs are still obscured.Insect ability to compensate nutrient starvation induced by dietary PI feeding using different strategies,that is,overexpression of PI-sensitive protease,expression of PI-insensitive proteases,degradation of PI,has made this innumerable collection of PIs worthless.A practical challenge for agronomist is to identify potent PI candidates,to limit insect compensatory responses and to elucidate insect compensatory and resistance mechanisms activated upon herbivory.This knowledge could be further efficiently utilized to identify potential targets for RNAi-mediated pest control.These vital genes of insects could be functionally anno-tated using the advanced gene-editing technique,CRISPR/Cas9.Contemporary research is exploiting different in silico and modern molecular biology techniques to utilize PIs in controlling insect pests efficiently.This review is structured to update recent advancements in this field,along with is chronological background. | Sujata Singh Archana Singh Sumit Kumar Pooja Mittal Indrakant K.Singh | 2020 | Insect Science2020，27，2： | 4 |
| 10 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 4 |
| 11 | Screening of Antioxidant Potential of Selected Barks of Indian Medicinal Plants by Multiple in vitro Assays显示文摘Objective To evaluate the antioxidant potential in herbal extract barks of five therapeutically important medicinal plants native to India, i.e. Crataeva nurvala Buch.-Ham., Buchanania lanzan Spreng., Aegle marmelos Corr., Dalbergia sissoo Roxb. ex DC., and Cedrela toona Roxb. Methods Standardized aqueous alcoholic extracts from the selected barks having different target radicals, such as superoxide radical, nitric oxide, ABTS radical, and peroxidative decomposition of phospholipids, were prepared and screened by multiple in vitro assays. These extracts were also tested for total phenolic and tannin content and correlated with antioxidant capacity. Results Total phenolic and tannin contents were found to be the highest in C. nurvala (195 GAE mg/g and 218.3 mg/g CE). SOD mimetic activity was found to be the highest in Crataeva nurvula, although all barks showed activity more than 100 units/mg extract. Lipid peroxidation inhibitory potential was found to be the highest in Crataeva nurvala (83.4% inhibition of MDA formation/10 μg extract), and also showed a comparatively high NO quenching capacity (45.5% per 10 μg extract). The highest NO quenching potential was found in Aegle marmelos (47.3% per 10 μg extract). Cedrela toona showed the lowest LPO inhibitory potential and NO quenching capacity (50.5% and 30.5%, respectively). Buchanania lanzan, a medicinal plant extensively used for inflammatory disorders and Dalbergia sissoo also showed 72.5% and 69.1% LPO inhibitory potential/10 μg extract. Trolox equivalent antioxidant capacity ranged from 0.24 to 0.39 mmol/L TEAC/mg extract, indicating that all the barks tested had ABTS+· radical quenching capacity. Conclusion Bark of Crataeva nurvula has the highest antioxidant capacity and a positive correlation between antioxidant activity and their plendic content was found. | ARCHANA KUMARI POONAM KAKKAR | 2008 | Biomedical and Environmental Sciences2008，21，1： | 4 |
| 12 | Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia显示文摘Background and Objective: Leukemic microenvironment has a major role in the progression of leukemia. Leukemic cells can induce reversible changes in microenvironmental components, especially the stromal function which results in improved growth conditions for maintaining the malignant leukemic cells. This study aimed to investigate the survival advantage of leukemic cells over normal hematopoietic cells in stromal microenvironment in long term. Methods: The mice were injected intraperitoneally with N-N’ ethylnitrosourea (ENU) to induce leukemia; the mice received injection of normal saline were used as control. At 180 days after ENU induction, the mice were killed and the bone marrows were cultured for 19 days. Colony-forming assays were used to analyze the formation of various cell colonies. The expression of Sca-1, CD146, VEGFR2, CD95, pStat3, pStat5, and Bcl-xL in marrow cells were detected by flow cytometry. Results: Long-term leukemic bone marrow culture showed abnormal elongated stromal fibroblasts with almost absence of normal hematopoietic cells. Adherent cell colonies were increased, but CFU-F and other hematopoietic cell colonies were significantly decreased in leukemia group (P< 0.001). Primitive progenitor-specific Sca-1 receptor expression was decreased with subsequent increased expression of CD146 and VEGFR-2 in leukemic bone marrow cells. Decreased Fas antigen expression with increased intracellular pStat3, pStat5 and Bcl-xL proteins were observed in leukemic bone marrow cells. Conclusions: Stromal microenvironment shows altered morphology and decreased maturation in leukemia. Effective progenitor cells are decreased in leukemia with increased leukemia-specific cell population. Leukemic microenvironment plays a role in promoting and maintaining the leukemic cell proliferation and survivability in long term. | Pratima Basak Sumanta Chatterjee Prosun Das Madhurima Das Jacintha Archana Pereira Ranjan Kumar Dutta Malay Chaklader Samaresh Chaudhuri Sujata Law | 2010 | Chinese Journal of Cancer2010，29，12： | 3 |
| 13 | 葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有显示文摘哺乳动物睾丸中的精子经过“附睾成熟”期,由静止状态转变成为运动状态。该过程中精子从附睾头部向附睾尾部移动,同时精子发生了一系列的形态、生理和生化改变,如蛋白组成和蛋白修饰的改变可能会影响精子获能的潜能。本实验使用基质辅助激光解吸/电离串联质谱(MALDI-MS/MS)法分析仓鼠睾丸头部和尾部精子的蛋白组学,成功发现了113个蛋白质点。对113个蛋白质点进一步对照比较发现30个蛋白质点(对应20个蛋白)的密度发生了显著改变,其中附睾尾部精子5个蛋白的密度增加,11个蛋白密度减少;此外,葡萄糖调节蛋白前体GRP78和肿瘤排斥抗原GP96为仓鼠附睾头部精子特有,而纤维蛋白原样蛋白1为附睾尾部精子所特有。几个蛋白密度增加可能与附睾成熟过程中精子代谢和ATP产生相关。一些蛋白如ERp57,GRP78,GP96,Hsp60,Hsp70和二氢硫辛酰胺S-乙酰转移酶的密度改变通过免疫印迹法得到验证。本研究首次报道了仓鼠精子的蛋白质组学研究,全面展示了仓鼠精子附睾成熟过程中的蛋白结构改变。 | Duvvuri Butchi Kameshwari Satish Bhande Curam Sreenivasacharlu Sundaram Venkatesh Kota Archana B. Siva Sisinthy Shivaji | 2010 | Asian Journal of Andrology2010，12，3： | 3 |
| 14 | Antioxidant activity and total phenolic content of ethanolic extract of Caesalpinia bonducella seeds显示文摘 | Shruti Shukla Archana Mehta Jinu John Siddharth Singh Pradeep Mehta Suresh Prasad Vyas | 2009 | Food and Chemical Toxicology2009，，8： | 3 |
| 15 | Ion Conduction in Superionic Glassy Electrolytes:An Overview显示文摘The various theoretical and experimental models for ion conduction mechanism of fast ion conducting(FIC) glass electrolytes have been reported in the present review paper.Some characterization techniques of FIC glasses are presented.The experimental methods for determination of some ion transport parameters viz ionic conductivity [σ),ionic mobility(μ),mobile ion concentration(n),ionic drift velocity(v_d),ionic transference number(t_(ion)) and activation energies of FIC glasses are explained.The solid state battery fabrication by using some FIC glasses is also reported. | Angesh Chandra Alok Bhatt Archana Chandra | 2013 | Journal of Materials Science & Technology2013，29，3： | 3 |
| 16 | A simple and efficient method for solvent-free iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid by grinding method显示文摘Green,mild and efficient iodination of hydroxylated aromatic aldehydes and ketones using iodine and iodic acid in the solidstate by grinding under solvent-free conditions at room temperature.This method provides several advantages such as environmentally friendly,short reaction times,high yields,non-hazardous and simple work-up procedure. | Archana Vibhute Shyam Mokle Khushal Karamunge Vasant Gurav Yeshwant Vibhute | 2010 | Chinese Chemical Letters2010，21，8： | 3 |
| 17 | SYNTHESIS, CHARACTERIZATION AND ION TRANSPORT PROPERTIES OF HOT-PRESSED SOLID POLYMER ELECTROLYTES (1-x) PEO:x KI显示文摘Synthesis and ion transport properties of hot-pressed solid polymer electrolytes (SPEs), (1-x) PEO: x KI, where x is the content of KI in wt%, are reported. A hot-press technique has been used for the formation of the polymeric membranes in place of the usual solution cast method. The composition (80PEO:20KI) was identified as the highest conducting polymer electrolyte on the basis of compositional dependent conductivity studies of PEO:KI films. A conductivity enhancement of more than two orders of magnitude from that of the pure PEO was achieved. Materials characterization and ion transport mechanism were explained by using various experimental techniques. | Angesh Chandra Archana Chandra K. Thakur | 2013 | Chinese Journal of Polymer Science2013，31，2： | 3 |
| 18 | Transport of chemical signals in systemic acquired resistance显示文摘Systemic acquired resistance(SAR) is a form of broad-spectrum resistance induced in response to local infections that protects uninfected parts against subsequent secondary infections by related or unrelated pathogens. SAR signaling requires two parallel branches,one regulated by salicylic acid(SA),and the other by azelaic acid(AzA) and glycerol-3-phosphate(G3P). Az A and G3P function downstream of the free radicals nitric oxide(NO) and reactive oxygen species(ROS). During SAR,SA,Az A and G3P accumulate in the infected leaves,but only a small portion of these is transported to distal uninfected leaves. SA is preferentially transported via the apoplast,whereas phloem loading of Az A and G3P occurs via the symplast. The symplastic transport of Az A and G3P is regulated by gating of the plasmodesmata(PD). The PD localizing proteins,PDLP1 and PDLP5,regulate SAR by regulating PD gating as well as the subcellular partitioning of a SAR-associated protein. | Archana Singh Gah-Hyun Lim Pradeep Kachroo | 2017 | Journal of Integrative Plant Biology2017，59，5： | 2 |
| 19 | Secondary cardiovascular prevention in older adults: an evidence based review显示文摘 | Abdulla A Damluji Archana Ramlreddy Lynda Otalvaro Daniel E Forman | 2015 | Journal of Geriatric Cardiology2015，12，5： | 2 |
| 20 | Acute-on-chronic liver failure: consensus recommendations of the Asian Pacific Association for the study of the liver (APASL)显示文摘 | Shiv Kumar Sarin Ashish Kumar John A. Almeida Yogesh Kumar Chawla Sheung Tat Fan Hitendra Garg H. Janaka Silva Saeed Sadiq Hamid Rajiv Jalan Piyawat Komolmit George K. Lau Qing Liu Kaushal Madan Rosmawati Mohamed Qin Ning Salimur Rahman Archana Rastogi St | 2009 | Hepatology International2009，，1： | 2 |
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