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| 1 | Altitude dependency of trends of daily climate extremes in southwestern China, 1961-2008显示文摘A total of 12 indices of temperature extremes and 11 indices of precipitation ex-tremes at 111 stations in southwestern China at altitudes of 285-4700 m were examined for the period 1961-2008. Significant correlations of temperature extremes and elevation in-cluded the trends of diurnal temperature range, frost days, ice days, cold night frequency and cold day frequency. Regional trends of growing season length, warm night frequency, coldest night and warmest night displayed a statistically significant positive correlation with altitude. These characteristics indicated the obvious warming with altitude. For precipitation extreme indices, only the trends of consecutive dry days, consecutive wet days, wet day precipitation and the number of heavy precipitation days had significant correlations with increasing alti-tude owing to the complex influence of atmospheric circulation. It also indicated the increased precipitation mainly at higher altitude areas, whereas the increase of extreme precipitation events mainly at lowers altitude. In addition, the clearly local influences are also crucial on climate extremes. The analysis revealed an enhanced sensitivity of climate extremes to ele-vation in southwestern China in the context of recent warming. | Li Zongxing He Yuanqing Theakstone, Wilfred H. Wang Xufeng Zhang Wei Cao Weihong Du Jiankuo Xin Huijuan Chang Li | 2012 | Journal of Geographical Sciences2012，22，3： | 36 |
| 2 | Biochar and its importance on nutrient dynamics in soil and plant显示文摘Biochar,an environmentally friendly soil conditioner,is produced using several thermochemical processes.It has unique characteristics like high surface area,porosity,and surface charges.This paper reviews the fertilizer value of biochar,and its effects on soil properties,and nutrient use efficiency of crops.Biochar serves as an important source of plant nutrients,especially nitrogen in biochar produced from manures and wastes at low temperature(≤400℃).The phosphorus,potassium,and other nutrient contents are higher in manure/waste biochars than those in crop residues and woody biochars.The nutrient contents and pH of biochar are positively correlated with pyrolysis temperature,except for nitrogen content.Biochar improves the nutrient retention capacity of soil,which depends on porosity and surface charge of biochar.Biochar increases nitrogen retention in soil by reducing leaching and gaseous loss,and also increases phosphorus availability by decreasing the leaching process in soil.However,for potassium and other nutrients,biochar shows inconsistent(positive and negative)impacts on soil.After addition of biochar,porosity,aggregate stability,and amount of water held in soil increase and bulk density decreases.Mostly,biochar increases soil pH and,thus,influences nutrient availability for plants.Biochar also alters soil biological properties by increasing microbial populations,enzyme activity,soil respiration,and microbial biomass.Finally,nutrient use efficiency and nutrient uptake improve with the application of biochar to soil.Thus,biochar can be a potential nutrient reservoir for plants and a good amendment to improve soil properties. | Md Zahangir Hossain Md Mezbaul Bahar Binoy Sarkar Scott Wilfred Donne Young Sik Ok Kumuduni Niroshika Palansooriya Mary Beth Kirkham Saikat Chowdhury Nanthi Bolan | 2020 | Biochar2020，2，4： | 15 |
| 3 | 玉龙山温冰川浅冰芯内气候环境信息的初步剖析显示文摘稳定同位素和离子分析结果表明 ,我国青藏高原东缘玉龙山温冰川的一支浅冰芯内的大部分气候环境信息有良好的对应关系 ,可揭示近期若干年冰川净积累时期内的气候变化趋势和冰川的净积累量 ,且与当地实测气候资料相对应 .该浅冰芯的研究也揭示出冬夏季风和融水渗浸作用对冰芯气候记录的影响过程 ,表明温冰川气候环境信息的时间序列有限 .温性冰川浅冰芯现代过程的分析为研究西南季风环流的动态变化提供了一个新的重要途径 . | 何元庆 姚檀栋 程国栋 陈拓 杨梅学 Wilfred H. Theakstone | 2001 | 兰州大学学报(自然科学版)2001，37，4： | 12 |
| 4 | 锕系计算化学进展显示文摘本文简要总结了过去十年中应用量子力学方法研究锕系化学的若干结果。我们将其大致归为几何与电子结构和化学反应两类。对于前者,简要总结了锕系元素化合物中的An—O键和金属—金属键;而后者则涉及水合反应和配体交换反应,歧化反应,氧化反应,铀酰离子的还原,氢胺化反应以及铀的叠氮化合物的光解反应等。 | 王东琪 Wilfred F. van Gunsteren | 2011 | 化学进展2011，23，7： | 11 |
| 5 | Survey of Genomics Approaches to Improve Bioenergy Traits in Maize,Sorghum and Sugarcane显示文摘Bioenergy crops currently provide the only source of alternative energy with the potential to reduce the use of fossil transportation fuels in a way that is compatible with existing engine technology,including in developing countries.Even though bioenergy research is currently receiving considerable attention,many of the concepts are not new,but rather build on intense research efforts from 30 years ago.A major difference with that era is the availability of genomics tools that have the potential to accelerate crop improvement significantly.This review is focused on maize,sorghum and sugarcane as representatives of bioenergy grasses that produce sugar and/or lignocellulosic biomass.Examples of how genetic mapping,forward and reverse genetics,highthroughput expression profiling and comparative genomics can be used to unravel and improve bioenergy traits will be presented. | Wilfred Vermerris | 2011 | Journal of Integrative Plant Biology2011，53，2： | 9 |
| 6 | 肯尼亚内罗毕地区HIV携带者和艾滋病患者饮用中药Restore Plus颗粒冲剂提高免疫功能降低病毒载量的初步研究显示文摘目的:评价肯尼亚内罗毕地区HIV携带者和艾滋病(AIDS)患者饮用Restore Plus颗粒冲剂22个月后受试者免疫功能的改善情况。方法:将29~49岁的受试者71人随机分为2组:安慰剂组(n=30)和Restore Plus颗粒冲剂组(n=41)。其中61人(80%以上)为低收入、低教育背景的单身、已婚或离异女性。结果:与安慰剂组相比,服用Restore Plus的患者在服用期间和后续时间内,食欲、体重、身体机能、低体温方面均有所改善,特别是HIV和AIDS体征性状改善更佳,主要表现在:患者中有腹泻症状者的比例从10.5%降至0%;上呼吸道感染者从10.5%降至0%;头疼患者从15.8%降至4.0%;皮疹者从21.1%降至4.2%;感觉乏力者从15.8%降至0%。85.7%的患者在服用第12个月可见改善。而且,服用Restore Plus患者的CD 3+和CD 4+淋巴细胞计数增高,HIV病毒载量明显降低,甚至低于检测限。对服用者的肝功能检测表明其与对照组之间较为一致,未显示对肝脏的不良反应。结论:服用Restore Plus的患者没有出现毒性作用,用其对抗HIV感染和AIDS,患者免疫功能恢复,病毒载量可低于检测下限。服用Restore Plus将是HIV携带者和AIDS患者的可选辅助治疗方案。 | 鲁自云 Charles F.L.Mbakaya Yeri Kombe Wilfred Kisingu James Kariuki Erastus Muniu Lucy Kanyara 方静 毛建平 | 2011 | 中国新药杂志2011，20，22： | 9 |
| 7 | Chemical Composition of Aerosol and Fresh Snow and Tourism Influences at Baishui Glacier No.1 from Mt. Yulong,Southeastern Tibetan Plateau显示文摘Aerosol and snow samples were collected at ablation zone of Baishui(白水) Glacier No.1,Mt.Yulong(玉龙),from May to June,2006.The concentrations of Cl-,NO3-,SO42-,Na+,K+,Mg2+,and Ca2+ were determined by ion chromatograph both in aerosol and snow samples.The average totalaerosol loading is 25.45 neq·scm-1,NO3-and Na+ are the dominant soluble ions in the aerosol,accounting for 39% and 21% of average total aerosol loading,respectively.Monsoon circulation reduces the concentration of most ions,indicating that wet scavenging is effective for aerosol particles.In snow samples,SO42-and Ca2+ are the dominant anion and cation,respectively.A lower Na+/Cl-ratio was found in fresh snow samples compared to the higher ratio that was found in aerosol samples.Analyzing the difference in SO42-and NO3-in air and fresh snow indicated that the aerosol was influenced by local circulation,but the components in fresh snow samples were from long-distance transport.Enrichment of NO3-in aerosol samples is attributed to motor exhaust emissions from tourism by calculating the SO42-/NO3-ratio in aerosol and fresh snow samples.The temporal variation and correlation coefficients between soluble species in aerosol samples suggest that Cl-,Na+ and K+ come from sea-salt aerosol,and SO42-,Mg2+ and Ca2+ are from continental crust sources. | 张宁宁 何元庆 Wilfred H Theakstone 庞洪喜 | 2010 | Journal of Earth Science2010，21，2： | 7 |
| 8 | Antibacterial activity of selected ethnomedicinal plants from South India显示文摘Objective:To screen the antimicrobial potential of three ethnomedicinal plants Chassalia curviflora Thw.(C.curviflora),Cyclea peltata Hook.F.& Thomson(C.peltata) and Euphorbia hirta L(E.hirta) used in folk medicines in Aarukani hills Kani tribe,Tamil Nadu,India against human bacterial pathogens.Methods:Antibacterial efficacy was performed by disc diffusion method against the pathogens viz.,Escherichia coli(E.coli)(ATCC 35218),Staphylococcus aureus (S.aureus)(ATCC 6538),Salmonella typhi(S.typhi)(MTCC 733),Proteus vulgaris(P.vulgaris), Proteus mirabilis(P.mirabilis) and Streptococcus pyogenes(S.pyogenes) and incubated for 24 h at 37°C.Results:The maximum degree of antibacterial activity was observed in C.peltata followed by C.curviflora.While E.hirta showed comparatively low degree of antibacterial activity.The methanolic extract of C.peltata showed the antibacterial activity against three pathogens viz.,S.pyogenes,P.vulgaris and E.coli with the inhibition zones 12 mm,10 mm and 9 mm,respectively,hexane extracts of C.peltata also showed the antibacterial activity against two selected pathogens viz.,P.vulgaris and P.mirabilis with 15 mm and 12 mm of inhibition zones.All the three different concentrations(025,0.50 & 0.75 mg/mL) of methanolic extract of C. peltata show the inhibitory effect on the three susceptible bacteria S.pyogenes,P.vulgaris and E. coli with the maximum inhibition in the highest concentration(0.75 mg/mL).The methanolic and hexane extracts of C.curviflora exhibited the antibacterial activity against only one bacterium each i.e.P.vulgaris and S.typhi with the maximum zone of inhibition 13 and 11 mm respectively. The methanolic and hexane extracts of E.hirta exhibited the antibacterial activity against only one bacterium Le.S.pyogenes with the maximum zone of inhibition 13 and 11 mm respectively. Conclusions:The present investigation revealed that the C.curviflora,C.peltata and E.hirta are potentially good source of antibacterial agents and demonstrates the importance of such plants in traditional medicines. | Rajendran Darling Anpin Raja Solomon Jeeva Juststella Wilfred Prakash Johnson Marimuthu Antonisamy Varaprasadham Irudayaraj | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，5： | 6 |
| 9 | Role of Positive Selection Pressure on the Evolution of H5N1 Hemagglutinin显示文摘The surface glycoprotein hemagglutinin (HA) helps the influenza A virus to evade the host immune system by antigenic variation and is a major driving force for viral evolution. In this study, the selection pressure on HA of H5N1 influenza A virus was analyzed using bioinformatics algorithms. Most of the identified positive selection (PS) sites were found to be within or adjacent to epitope sites. Some of the identified PS sites are consistent with previous experimental studies, providing further support to the biological significance of our findings. The highest frequency of PS sites was observed in recent strains isolated during 2005–2007. Phylogenetic analysis was also conducted on HA sequences from various hosts. Viral drift is almost similar in both avian and human species with a progressive trend over the years. Our study reports new mutations in functional regions of HA that might provide markers for vaccine design or can be used to predict isolates of pandemic potential. | Venkata R.S.K. Duvvuri Bhargavi Duvvuri Wilfred R. Cuff Gillian E. Wu Jianhong Wu | 2009 | Genomics, Proteomics & Bioinformatics2009，7，1： | 6 |
| 10 | Non-alcoholic fatty liver disease: The mist gradually clears显示文摘 | Nimantha Mark Wilfred de Alwis Christopher Paul Day | 2008 | Journal of Hepatology2008，，： | 5 |
| 11 | Altitude Effects of Climatic Variation on Tibetan Plateau and Its Vicinities显示文摘High topographies,such as the Tibetan plateau(TP) in China,have been considered as the sensitive areas in response to global climate change.By analyzing the relationship between warming structure and altitude(1000-5000m) in the TP and its vicinities using the 46-year January mean observed temperature data,we found that there was a significant altitude effect of temperature warming onset time(mutation time) on the plateau and the neighboring regions:the higher the altitude,the later the climate warming happens,and vice versa.There also seems a slight altitude effect on warming magnitude:the higher the altitude,the less the warming magnitude.Therefore,the temperature warming in the high altitude area of the TP(below 5000 m) responds to global warming less sensitively than the low-altitude neighboring areas both in onset time and magnitude,which may be mainly caused by high albedo and large thermal capacity of the ice/snow cover on the higher part of the plateau and possible heat island effect in the lower part of the plateau. | 卢爱刚 康世昌 李宗省 Wilfred H Theakstone | 2010 | Journal of Earth Science2010，21，2： | 5 |
| 12 | 儿童系统性红斑狼疮神经精神症状的研究(一)显示文摘目的通过分析儿童系统性红斑狼疮(SLE)神经精神症状的发病情况、临床及实验室表现、治疗等,探讨中国儿童神经精神性狼疮(NPSLE)的发病特点。方法回顾性研究1990-2006年诊断为SLE的62例中国儿童SLE患者。收集神经精神症状发病时的性别、年龄、病程、临床表现、实验室检查、影像学检查、治疗等资料,并与其他研究结果相对比。结果19例(31%)患者被诊断为NPSLE,共发生症状21次;最常见的神经精神症状是认知障碍(48%)、癫痫(43%)和头痛(29%)。单光子发射计算机断层成像(SPECT)的表现异常率达80%。86%的患者接受了甲泼尼龙治疗;大部分(74%)患者无神经精神系统后遗症。结论中国儿童SLE的神经精神症状是常见的,其发病特点与其他种族的报道有所不同;SPECT与MR是诊断NPSLE较敏感的辅助检查;儿童NPSLE的预后良好。 | 董静 王吉波 Yu Lung Lau Tsz Leung Lee Pamela Pui Wah Lee Wilfred Hing Sang Wong | 2008 | 中华风湿病学杂志2008，12，12： | 5 |
| 13 | Climate Change and Its Effect on Annual Runoff in Lijiang Basin-Mt. Yulong Region,China显示文摘Based on the meteorological and hydrologic data in the Lijang(丽江) basin from 1979 to 2006,variational trend and characteristics of climate change and its effect on runoff in Yanggong(漾弓) River were examined in the study.The results show that the temperature have significantly increased in the drainage basin during the past 28 years.The average temperature increased markedly from 1979 to 2006,and the increase of temperature in winter was higher than those in other seasons.The annual precipitation varied with a slightly upward trend in the same period,suggesting that the increase mainly occurred in spring and summer while the decrease occurred in autumn and winter.The streamflow at Yanggong River showed a significant increasing trend.During the four seasons,spring experienced the most significant increase,and autumn experienced the smallest.On the basis of the above study,we found that the increasing trend in runoff was more significant than the increase in precipitation in the study area.That was the synactic results of variation of groundwater,ice-snow meltwater and precipitation caused by global climate change. | 何元庆 蒲焘 李宗省 朱国锋 王世金 张宁宁 王淑新 辛惠娟 Wilfred H Theakstone 杜建括 | 2010 | Journal of Earth Science2010，21，2： | 4 |
| 14 | 基于离子液的超声辅助萃取小蓼叶中的精油及真实溶剂似导体屏蔽模型研究显示文摘Ionic liquids ( ILs) based ultrasonic-assisted extract has been applied for the extraction of essential oil from Persicaria minor leaves. The effects of temperature,sonication time,and particle size of the plant material on the yield of essential oil were investigated. Among the different ILs employed,1-ethyl-3-methyli midazolium acetate was the most effective,providing a 9. 55% yield of the essential oil under optimum conditions( 70 ℃,25 min,IL ∶hexane ratio of 7 ∶10 ( v /v) ,particle size 60-80 mesh) . The performance of 1-ethyl-3-methylimidazolium acetate in the extraction was attributed to its lowviscosity and ability to disintegrate the structural matrix of the plant material. The ability of 1-ethyl-3-methylimidazolium acetate was also confirmed using the conductor like-screening model for realistic solvents. This research proves that ILs can be used to extract essential oils from lignocellulosic biomass. | Habib ULLAH Cecilia D WILFRED Maizatul S SHAHARUN | 2017 | 色谱2017，35，6： | 3 |
| 15 | Characterization of novel Brown midrib 6 mutations affecting lignin biosynthesis in sorghum显示文摘The presence of lignin reduces the quality of lignocellulosic biomass for forage materials and feedstock for biofuels. In C4 grasses,the brown midrib phenotype has been linked to mutations to genes in the monolignol biosynthesis pathway. For example,the Bmr6 gene in sorghum(Sorghum bicolor) has been previously shown to encode cinnamyl alcohol dehydrogenase(CAD),which catalyzes the final step of the monolignol biosynthesis pathway. Mutations in this gene have been shown to reduce the abundance of lignin,enhance digestibility,and improve saccharification efficiencies and ethanol yields. Nine sorghum lines harboring five different bmr6 alleles were identified in an EMS-mutagenized TILLING population. DNA sequencing of Bmr6 revealed that the majority of the mutations impacted evolutionarily conserved amino acids while three-dimensional structural modeling predicted that all of these alleles interfered with the enzyme's ability to bind with its NADPH cofactor. All of the new alleles reduced in vitro CAD activity levels and enhanced glucose yields following saccharification. Further,many of these lines were associated with higher reductions in acid detergent lignin compared to lines harboring the previously characterized bmr6-ref allele. These bmr6 lines represent new breeding tools for manipulating biomass composition to enhance forage and feedstock quality. | Erin D. Scully Tammy Gries Deanna L. Funnell-Harris Zhanguo Xin Frank A. Kovacs Wilfred Vermerris Scott E. Sattler | 2016 | Journal of Integrative Plant Biology2016，58，2： | 3 |
| 16 | Energizing miRNA research: A review of the role of miRNAs in lipid metabolism, with a prediction that miR-103/107 regulates human metabolic pathways显示文摘 | Bernard R. Wilfred Wang-Xia Wang Peter T. Nelson | 2007 | Molecular Genetics and Metabolism2007，，3： | 3 |
| 17 | Utilization of autoclaved and fermented sesame(Sesamum indicum L.) seed meal in diets for Til-aqua natural male tilapia显示文摘Current research emphasis has been on the reduction of feed cost by incorporating processed sesame seed meal in the diet of tilapia. Raw sesame(Sesamum indicum) seed was soaked and subjected to either autoclaving or fermentation, after which their oil contents were mechanically extracted. Graded levels of autoclaved(71.2,165,5 and 296.3 g/kg designated as diets 1, 2 and 3, respectively) and fermented(71.0,164.3 and 292,2 g/kg designated as diets 4, 5 and 6, respectively) sesame seed meal were included into fishmeal based diets for Til-aqua natural male tilapia(NMT) fry(initial weight,1.69 ± 0.02 g), A diet without sesame seed meal served as the control. Diets were approximately iso-nitrogenous(35% crude protein). Fish were fed 5 times their maintenance requirement, which was 3.2 x 5 x [fish weight(g)/1,000]^(0.8) daily for 56 days. Processing improved the nutritional profile of raw sesame seed meal in terms of its crude protein and antinutrient compositions. Growth performance of fish was similar(P> 0.05) in the control and dietary treatments. The group fed diet 3 exhibited significantly poorer feed conversion ratio(1.14), protein efficiency ratio(2.77) and economic conversion ratio(US$1.38/kg) relative to the group that received diet 5. Apparent digestibility coefficients for protein, lipid and energy in diet 3 were similar(P > 0.05) to those in diet 6 but significantly lower(P < 0.05) than those of the control and other dietary groups. The sesame seed meals processed with different methods did not significantly affect crude protein, crude lipid and gross energy compositions in the fish carcass. The study demonstrated that71.2 g/kg of autoclaved and 164.3 g/kg of fermented sesame seed meal could be incorporated in the diet of Til-aqua NMT with cost benefit. | Oluwagbenga Olude Francisca George Wilfred Alegbeleye | 2016 | Animal Nutrition2016，，4： | 2 |
| 18 | 利用曲线面变形提取产品形态体特征的方法研究显示文摘在变形设计理论的基础上,提出了将产品主体形态分解为子形态。研究了基于超椭圆方程和三次带参均匀B样条曲线构造技术提取影响产品艺术风格子形态横截面造型特征的方法,并结合曲面构造变形技术实现产品形态体特征的提取。以电动手工具为例研究了产品形态体特征提取与形态优化设计效果,得出超椭圆方程提取算法参数少,可较好地提取对称图形、非倒角图形的造型特征;基于三次带参均匀B样条曲线构造技术的算法参数较多,可较好地提取多种图形。 | 王毅 王家民 Richard Wilfred Yelle 胡钢 | 2015 | 机械科学与技术2015，34，1： | 2 |
| 19 | Effect of dynamic light at the coronary care unit on the length of hospital stay and development of delirium: a retrospective cohort study显示文摘BackgroundDisturbed 生理节奏的节奏是谵妄的一个潜在的原因并且被连接到生理节奏的 rhythmicity 的 disorganisation。动态光(DL ) 能由 suprachiasmatic 原子核的激活重设生理节奏的节奏阻止谵妄。关于轻治疗的效果的证据主要集中于精神病学的混乱和生理节奏的节奏睡觉混乱。在这研究,我们在停留(LOS ) 的全部的医院长度上调查了 DL 的效果,在病人的谵妄的出现承认 .MethodsThis 是回顾的队研究到联合起来的冠的照顾(CCU ) 。比 18 年老的病人,在 CCU 比 12 h 长被就医并且为至少 24 h 有全部的医院 LOS,被包括。病人们与 DL 被分到一个房间(n = 369 ) 或常规点亮条件(n = 379 ) 。DL 被与在 2700 和 6500 度凯尔文之间的颜色温度交付光的二块装天花板的轻面板在 CCU 管理。报导结果数据是:全部的医院 LOS,谵妄发生,一个老人病学者的会诊和 prescripted antipsychotics.ResultsBetween 2015 年 5 月和 2016 年 5 月的数量,从 748 个病人的数据被收集。包括挑起谵妄的风险因素,基线特征在两个组是相等的。在 DL 组的中部的全部的医院 LOS 是 100.5 (70.8-186.0 ) 并且 101.0 (73.0-176.4 ) 在控制组的 h (P = 0.935 ) 。在 DL 和控制组的谵妄的发生是 5.4%(20/369 ) 并且 5.0%(19/379 ) ,分别地(P = 0.802 ) 。DL 和控制组之间的重要差别都没在第二等的端点被观察。亚群分析也基于年龄和 CCU LOS 证明当一条早单个的途径不导致全部的医院 LOS 的减小或减少谵妄的发生,没有 differences.ConclusionOur 学习建议暴露到 DL。当谵妄被诊断时,它与差的医院结果被联系。 | Tobias Pustjens Antonius MC Schoutens Loes Janssen Wilfred F Heesen | 2018 | Journal of Geriatric Cardiology2018，15，9： | 2 |
| 20 | 1961-2008年中国西南地区极端气候变化幅度的海拔效应(英文)显示文摘 | 李宗省 何元庆 Wilfred H.THEAKSTONE 王旭峰 张薇 曹伟宏 杜建扩 辛惠娟 常丽 | 2012 | Journal of Geographical Sciences2012，，03： | 2 |
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