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| 1 | A randomized controlled clinical trial on the treatment of Thymosin-a1 versus interferon-α in patients with hepatitis B显示文摘INTRODUCTIONChronic hepatitis B virus (HBV) infection is a serious problem because of its world wide distribution and possible adverse sequelae ,such as cirrhosis and hepatocellular carcinoma .The World Health Organization estimates that HBV has infected mord than 350 million people worldwide ,and up to 20% of them will become chromic carricrs and will be at significant risk for cirrhosis and HCC .The ultimate goal of the therapy for chronic hepatitis B is to prevent progression to cirrhosis and to prevent development of HCC. | Jing You Lin Zhuang Bao Zhang Tang Wei Bo Yang Su Ying Ding Wu Li Rong Xue Wu Hong Li Zhang Yan Mei Zhang Shao Ming Yan Lu Zhang ~1Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China ~2Departrnent of Hepatology,Kunming Third Municipal People’s Hospital,Kunming 650041,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 48 |
| 2 | Significance of dredging on sediment denitrification in Meiliang Bay,China:A year long simulation study显示文摘An experiment for studying the effects of sediment dredging on denitrification in sediments was carried out through a one-year incubation of undredged (control) and dredged cores in laboratory. Dredging the upper 30 cm of sediment can significantly affect physico-chemical characteristics of sediments. Less degradation of organic matter in the dredged sediments was found during the experiment. Denitrification rates in the sediments were estimated by the acetylene blockage technique, and ranged from 21.6 to 102.7 nmol N2/(g dry weight (dw)·hr) for the undredged sediment and from 6.9 to 26.9 nmol N2/(g dw·hr) for dredged sediments. The denitrification rates in the undredged sediments were markedly higher (p<0.05) than those in the dredged sediments throughout the incubation, with the exception of February 2006. The importance of various environmental factors on denitrification was assessed, which indicated that denitrification was regulated by temperature. Nitrate was probably the key factor limiting denitrification in both undredged and dredged sediments. Organic carbon played some role in determining the denitrification rates in the dredged sediments, but not in the undredged sediments. Sediment dredging influenced the mineralization of organic matter and denitrification in the sediment; and therefore changed the pattern of inherent cycling of nitrogen. | Jicheng Zhong Chengxin Fan Lu Zhang Edward Hall Shiming Ding Bao Li Guofeng Liu | 2010 | Journal of Environmental Sciences2010，22，1： | 40 |
| 3 | Trace Elements and Rare Earth Elements of Sulfide Minerals in the Tianqiao Pb-Zn Ore Deposit,Guizhou Province,China显示文摘硫化物矿物质的踪迹元素和稀土元素元素(REE ) 被诱导地联合的血浆团 spectrometry 决定。结果显示那 V, Cu, Sn, Ga, Cd,在里面并且 Se 在闪锌矿被集中, Sb,同样 Ge,和 Tl 在方铅矿被集中,并且在黄铁矿的几乎所有踪迹元素是低的。在轻黄的闪锌矿的 Ga 和 Cd 内容在褐和黑闪锌矿比那高。Ge 的内容, Tl,在里面并且在棕色的闪锌矿的 Se 在轻黄的闪锌矿和黑闪锌矿比那高。它证明 REE 集中比在闪锌矿,和方铅矿在黄铁矿是更高的。在闪锌矿, REE 集中从轻黄的闪锌矿减少,棕色的闪锌矿,到黑闪锌矿。Ga/In 的比率是超过 10,并且分别地, Co/Ni 在学习闪锌矿和黄铁矿是不到 1 显示 Tianqiao PbZn 矿石沉积物的开始可能属于沉积改革的开始与热水的开始联系了。在在闪锌矿的 LnGa 和 LnIn 之间,并且在在方铅矿的 LnBi 和 LnSb 之间的关系,显示 Tianqiao PbZn 矿石存款可能属于沉积改革的开始。基于使球粒状陨石正常化的 REE 模式, Eu 是一个否定异例(0.130.88 ) ,和 Ce 不显示出明显的异例(0.881.31 ) ;所有样品有低全部的 REE 集中(< 3 ppm ) 并且大量轻稀土元素元素 / 高度稀土元素元素比率(1.1212.35 ) 。这些结果显示形成矿石的液体在减少的环境下面发生。从更低的含碳的 Datang 形成的闪锌矿,方铅矿,黄铁矿,矿石,改变的 dolostone 岩石,阶层碳酸盐,和黄铁矿的比较 REE 作文和参数证明形成矿石的液体可能来自 polycomponent 系统,也就是说不同的 chronostratigraphic 单位能做重要贡献到形成矿石的液体。与构造背景和以前的同位素的地球化学证据结合了,我们断定矿石存款开始是热水的,沉积改过,与形成矿石的液体的 multisources 特征。 | ZHOU Jiaxi HUANG Zhilong ZHOU Guofu LI Xiaobiao DING Wei BAO Guangping | 2011 | Acta Geologica Sinica(English Edition)2011，85，1： | 35 |
| 4 | Influence of Sediment Dredging on Chemical Forms and Release of Phosphorus显示文摘A laboratory experiment was carried out through a six-month incubation of undredged (control) and dredged cores to study the effect of sediment dredging on phosphorus (P) release from the sediment in the Taihu Lake.During the experiment,dredging the upper 30 cm layer could efficiently reduce the interstitial PO_4^(3-)-P concentration and different P forms in the sediment.The P fluxes of the undredged and dredged cores ranged from-5.1 to 3047.6 and-60.7 to 14.4μg m^(-2) d^(-1),respectively.The fluxes of the dredged cores were generally lower than those of the control.Differences in the fluxes between the dredged and undredged cores were statistically significant (P<0.05) from March to June 2006. The sediment P in the dredged cores had a lower release potential than that in the control.Dredging can be considered as a useful measure for rehabilitating the aquatic ecosystem after the external P loading in the Taihu Lake catchment was efficiently reduced. | ZHONG Ji-Cheng YOU Ben-Sheng FAN Cheng-Xin LI Bao ZHANG Lu DING Shi-Ming | 2008 | Pedosphere2008，18，1： | 27 |
| 5 | Preliminary results of Thymosin-a1 versus interferon-α treatment in patients with HBeAg negative and serum HBV DNA positive chronic hepatitis B显示文摘INTRODUCTIONIn China ,the incidence and mortality of gastric cancer rank the second among all cancers. Recent development of cancer [1-20].The aim of this study was investigat the insight of apoptosis and bcl-2, p53 and C-myc protein expression in the development of gastric cancer . | Lin Zhuang Jing You Bao Zhang Tang Su Ying Ding Kui Hua Yan Dan Peng Yan Mei Zhang Lu Zhang ~1Department of Hepatology,Kunming Third Municipal Peoples Hospital,Kunming 650041,Yunnan Province,China ~2Department of Infectious Diseases,The First Affiliated Hospital of Kunming Medical College,Kunming 650032,Yunnan Province,China | 2001 | World Journal of Gastroenterology2001，7，3： | 22 |
| 6 | A chlorinated copolymer donor demonstrates a 18.13% power conversion efficiency显示文摘The rapid development of low-bandgap(LBG)nonfullerene acceptors and wide-bandgap(WBG)copolymer donors in recent years has boosted the power conversion efficiency(PCE)of organic solar cells(OSCs)to the 18%level[1−21].The commercialization of OSCs is highly expected.However,critical issues like the cost and the stability also determine whether OSCs can enter the market or not[22]. | Jianqiang Qin Lixiu Zhang Chuantian Zuo Zuo Xiao Yongbo Yuan Shangfeng Yang Feng Hao Ming Cheng Kuan Sun Qinye Bao Zhengyang Bin Zhiwen Jin and Liming Ding | 2021 | Journal of Semiconductors2021，42，1： | 19 |
| 7 | Sulfur isotopic composition of the Tianqiao Pb-Zn ore deposit,Northwest Guizhou Province,China:Implications for the source of sulfur in the ore-forming fluids显示文摘The Tianqiao Pb-Zn ore deposit of Guizhou Province, China, is located in the mid-east of the Sichuan-Yunnan-Guizhou Pb-Zn-Ag multi-metallic mineralization area, which is representative of the Pb-Zn ore de-posits in this area. It consists of three main orebodies, whose Pb+Zn reserves are more than 0.2 million ton. This paper analyzes the sulfur isotopic composition of these orebodies. The data show that the ore minerals (galena, sphalerite, pyrite) in these orebodies are enriched in heavy sulfur, with δ34SV-CDT values varying between 8.35‰ and 14.44‰, i.e. the δ34SV-CDT values of pyrite are between 12.81‰ and 14.44‰, the mean value is 13.40‰; the δ34SV-CDT values of sphalerite are range from 10.87‰ to 14.00‰, the mean value is 12.53‰; the δ34SV-CDT values of galena are range from 8.35‰ to 9.83‰, the mean value is 8.84‰, and they have the feature of δ34Spyrite>δ34Ssphalerite>δ34Sgalena, which indicates the sulfur isotope in ore-forming fluids has attained equilibrium. The δ34S V-CDT values of the deposit are close to those of sulfates from carbonate strata of different ages in the ore-field (15‰), which suggests that the sulfur in the ore-forming fluids should be derived from the thermo-chemical sulfate reduction of sulfates from the sedimentary strata. | ZHOU Jiaxi HUANG Zhilong ZHOU Guofu LI Xiaobiao DING Wei BAO Guangping | 2010 | Chinese Journal Of Geochemistry2010，29，3： | 16 |
| 8 | In vivo theranostics with near-infraredemitting carbon dots—highly efficient photothermal therapy based on passive targeting after intravenous administration显示文摘Carbon dots that exhibit near-infrared fluorescence(NIR CDs)are considered emerging nanomaterials for advanced biomedical applications with low toxicity and superior photostability and targeting compared to currently used photoluminescence agents.Despite progress in the synthesis of NIR CDs,there remains a key obstacle to using them as an in vivo theranostic agent.This work demonstrates that the newly developed sulfur and nitrogen codoped NIR CDs are highly efficient in photothermal therapy(PTT)in mouse models(conversion efficiency of 59%)and can be readily visualized by photoluminescence and photoacoustic imaging.The real theranostic potential of NIR CDs is enhanced by their unique biodistribution and targeting.Contrary to all other nanomaterials that have been tested in biomedicine,they are excreted through the body’s renal filtration system.Moreover,after intravenous injection,NIR CDs are accumulated in tumor tissue via passive targeting,without any active species such as antibodies.Due to their accumulation in tumor tissue without the need for intratumor injection,high photothermal conversion,excellent optical and photoacoustic imaging performance,and renal excretion,the developed CDs are suitable for transfer to clinical biomedical practice. | Xin Bao Ye Yuan Jingqin Chen Bohan Zhang Di Li Ding Zhou Pengtao Jing Guiying Xu Yingli Wang Kateřina Holá Dezhen Shen Changfeng Wu Liang Song Chengbo Liu Radek Zbořil Songnan Qu | 2018 | Light(Science & Applications)2018，7，1： | 13 |
| 9 | Orthogonal Test Design for Optimization of the Extraction of Flavonid from the Fructus Gardeniae显示文摘Objective It is imperative to provide some consistent experimental results for the extraction of flavonid from Fructus Gardeniae.Methods The key extraction parameters that influenced the yield of flavonid from Fructus Gardeniae were optimized by employing an orthogonal experiment [L9(3)4],including the ratio of buffer solution (Na2B4O7·10H2O) to raw material,concentration of Fructus Gardeniae in extracting solution,extraction time and pH of buffer solution.An UV/Vis detector was used to perform the qualitative and quantitative analyses of the extracted flavonid with the using of the standard sample.Results The maximum extraction yield of the crude extract was 5.0533 (mg/g) after 20 min when the mass ratio of Na2B4O7·10H2O to raw material was 0.4%,the concentration of Fructus Gardeniae in the extraction solution was 1/12 (g/mL),and pH of buffer solution was 4.5.The positive reactions to the Molish and HCl‐Mg tests suggested that the extracted compound was flavonoid,and FTIR measurements also identified the presence of flavonoid in the extracts.Conclusion This work is expected to provide a basis for further research,development,and utilization of Fructus gardenia in flavonid extraction. | CAI Ding Jian SHU Qing XU Bao Quan PENG Li Mei HE Yan | 2011 | Biomedical and Environmental Sciences2011，24，6： | 12 |
| 10 | Optimization of flow control devices in a single-strand slab continuous casting tundish显示文摘The optimization of flow control devices in a single-slab continuous casting tundish was carried out by physical modeling, and the optimized scheme was presented. With the optimal tundish configuration, the minimum residence time of liquid steel was increased by 1.4 times, the peak concentration time was increased by 97%, and the dead volume fraction was decreased by 72%. A mathematical model for molten steel in the tundish was established by using the fluid dynamics package Fluent. The velocity field, concentration field, and the resi-dence time distribution (RTD) curves of molten steel flow before and after optimization were obtained. Experimental results showed that the reasonable configuration with flow control devices can improve the fluid flow characteristics in the tundish. The results of industrial applica-tion show that the nonmetallic inclusion area ratio in casting slabs is decreased by 32% with the optimal tundish configuration. | Ning Ding Yan-ping Bao Qi-song Sun Li-feng Wang | 2011 | International Journal of Minerals,Metallurgy and Materials2011，18，3： | 10 |
| 11 | Strengths, weaknesses, opportunities and threats (SWOT) analysis of reinitiation into methamphetamine abusers: qualitative findings from an exploration of methamphetamine abusers in Shanghai, China显示文摘Background Despite high relapse rate among methamphetamine (MA) abusers, there still have been little empirical data to date detecting the risk factors related to craving and relapse from the perspective of MA abusers. Therefore, the aim of this study was to use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors that could facilitate or impede individuals' abstinence in a real-life context from the perspectives of MA abusers. Aim To use qualitative research methods exploring the strengths, weaknesses, opportunities and threat factors relating to individuals' abstinence in a real-life context. Method Semistructured interviews were conducted with 32 MA abusers recruited in Shanghai guided by open-ended questions on narrating the real-life catalysts and inhibitors related to craving, initiation, relapse and abstinence. All data were transcribed verbatim and analysed using a strengths, weaknesses, opportunities and threats (SWOT) analysis. Results The results of the SWOT analysis revealed that contextual factors including peer influence, prevalence and availability of MA, familiar venue of MA use, discrimination, sexual behaviours, alcohol, emotional states and their attitudes towards smoking MA were important factors that contribute to reinitiation and relapse. Surveillance systems, antidrug social workers, vocational skills trainings, moving to another city and family responsibility might serve as counter measures targeti叩 those mentioned weaknesses and threats above. Conclusion This SWOT analysis highlights the complex nature of relapse. Comprehensive interventions strengtheni叩 coping skills such as virtual reality techniques are desperately needed to facilitate individuals1 sustained abstinence. | Youwei Zhu Na Zhong Hang Su Xiaolu Ruan Jiayi Bao Lei Zhang Jiang Du Ding Xu Rongjie Ding Ke Xiao Min Zhao | 2019 | General Psychiatry2019，32，3： | 9 |
| 12 | Improved approach to atrial septum puncture: experience in 539 cases显示文摘 | YAO Yan GUO Jun DING Li-gang BAO Jing-ru HUANG Wen SHI Rui WU Ling-min ZHANG Shu | 2012 | Chinese Medical Journal2012，，6： | 9 |
| 13 | Novel SNP of EPAS1 gene associated with higher hemoglobin concentration revealed the hypoxia adaptation of yak(Bos grunniens)显示文摘Endothelial PAS domain protein 1 gene(EPAS1) is a key transcription factor that activates the expression of oxygen-regulated genes. In this study, in order to better understand the effects of EPAS1 gene on hematologic parameters in yak, we firstly quantified the tissue expression patterns for EPAS1 m RNA of yak, identified polymorphism in this gene and evaluated its association with hematologic parameters. Expression of EPAS1 m RNA was detected in all eight tissues(heart, liver, lung, spleen, pancreas, kidney, muscles and ovary). The expressions of EPAS1 in lung and pancreas were extremely higher than other tissues examined. Three novel single nucleotide polymorphisms(SNPs)(g.83052 C>T, g.83065 G>A and g.83067 C>A) within the EPAS1 were identified and genotyped in Pali(PL), Gannan(GN) and Tianzhu White(TZW) yak breeds. Significant higher frequencies of the AA and GA genotypes and A allele of the g.83065 G>A were observed in the PL and GN breeds than that in the TZW breed(P<0.01). Association analysis of the PL breed indicated that the g.83065 G>A polymorphism was significantly associated with hemoglobin(HGB) concentration in yaks(P<0.05). Individuals with genotype AA had significantly higher HGB concentration(P<0.05) than those with genotype GA and GG. All these results will help our further understanding of biological functional of yak EPAS1 gene in responding to hypoxia and also indicate EPAS1 might contribute to the hypoxia adaptation of the yak. | WU Xiao-yun DING Xue-zhi CHU Min GUO Xian BAO Peng-jia LIANG Chun-nian YAN Ping | 2015 | Journal of Integrative Agriculture2015，14，4： | 8 |
| 14 | Micro/nano-structured TiO2 surface with dual-functional antibacterial effects for biomedical applications显示文摘Implant-associated infections are generally difficult to cure owing to the bacterial antibiotic resistance which is attributed to the widespread usage of antibiotics.Given the global threat and increasing influence of antibiotic resistance,there is an urgent demand to explore novel antibacterial strategies other than using antibiotics.Recently,using a certain surface topography to provide a more persistent antibacterial solution attracts more and more attention.However,the clinical application of biomimetic nano-pillar array is not satisfactory,mainly because its antibacterial ability against Gram-positive strain is not good enough.Thus,the pillar array should be equipped with other antibacterial agents to fulfill the bacteriostatic and bactericidal requirements of clinical application.Here,we designed a novel model substrate which was a combination of periodic micro/nano-pillar array and TiO2 for basically understanding the topographical bacteriostatic effects of periodic micro/nano-pillar array and the photocatalytic bactericidal activity of TiO2.Such innovation may potentially exert the synergistic effects by integrating the persistent topographical antibacterial activity and the non-invasive X-ray induced photocatalytic antibacterial property of TiO2 to combat against antibiotic-resistant implant-associated infections.First,to separately verify the topographical antibacterial activity of TiO2 periodic micro/nano-pillar array,we systematically investigated its effects on bacterial adhesion,growth,proliferation,and viability in the dark without involving the photocatalysis of TiO2.The pillar array with sub-micron motif size can significantly inhibit the adhesion,growth,and proliferation of Staphylococcus aureus(S.aureus)and Escherichia coli(E.coli).Such antibacterial ability is mainly attributed to a spatial confinement size-effect and limited contact area availability generated by the special topography of pillar array.Moreover,the pillar array is not lethal to S.aureus and E.coli in 24 h.Then,the X-ray induced photocatalytic antibacterial property of TiO2 periodic micro/nano-pillar array in vitro and in vivo will be systematically studied in a future work.This study could shed light on the direction of surface topography design for future medical implants to combat against antibiotic-resistant implant-associated infections without using antibiotics. | Xiang Ge Chengzu Ren Yonghui Ding Guang Chen Xiong Lu Kefeng Wang Fuzeng Ren Meng Yang Zhuochen Wang Junlan Li Xinxin An Bao Qian Yang Leng | 2019 | Bioactive Materials2019，4，1： | 8 |
| 15 | Preliminary optimization of a Chinese herbal medicine formula based on the neuroprotective effects in a rat model of rotenone-induced Parkinson's disease显示文摘Objective: The main objective of this study was to preliminarily determine the optimum formulation of a Chinese herbal formula that may have neuroprotective effects against rotenone-induced Parkinson's disease(PD).Methods: Seven recipes were made from Dihuang(DH, Rehmannia glutinosa Libosch), Roucongrong(RCR,Cistanche deserticola Y.C.Ma), Niuxi(NX, Achyranthes bidentata Bl.) and Shanzhuyu(SZY, Cornus officinalis Sieb. et Zucc) in different proportions, according to the principles of uniform design(4 factors 7 levels).Tyrosine hydroxylase(TH)-positive neurons in substantia nigra pars compacta(SNpc) were detected by immunohistochemistry and rotenone-exposure days necessary to induce PD symptoms were recorded.To probe one likely mechanism of the formulas, echinacoside(ECH) concentrations of all seven recipes were determined by high-performance liquid chromatography and related to number of TH-positive neurons.Results: The data showed that recipe 4(DH:RCR:SZY:NX = 1:1:1:1) and recipe 7(DH:RCR:SZY:NX = 7:5:3:1) partially reversed rotenone-induced death of TH-positive neurons in the SNpc and significantly increased rotenone-exposed days compared with model group. Pharmacologically, there was not a strong correlation between ECH concentration and TH-positive neurons.Conclusion: The investigated formulations of Chinese herbs had neuroprotective effects against PD models, and the neuroprotective effects were weakly related to the proportion of key herbs. However the neuroprotective effects of the formula may not result from a single active constituent. | Xu-xia Bao Hui-han Ma Hao Ding Wen-wei Li Min Zhu | 2018 | Journal of Integrative Medicine2018，16，4： | 7 |
| 16 | The flavonoid TL-2-8 induces cell death and immature mitophagy in breast cancer cells via abrogating the function of the AHA1/Hsp90 complex显示文摘flavonoid 橡黄素与很少副作用展出重要 anticancer 活动。在当前的学习,我们描绘了 TL-2-8,橡黄素衍生物,在 vitro 并且在 vivo 的一个新奇 anticancer 代理人。房间增长和生存能力用分别地数 Kit-8 和 CellTiter 蓝的试金的房间被估计。房间死亡用 PI 染色或 TUNEL 试金被检验。Mitophagy 被测量 autophagic 流动并且由共焦的成像决定。蛋白质表示被西方的弄污检验。我们发现 TL-2-8 有选择地禁止了增长并且减少各种各样的癌症房间的生存能力(在在 72 h 的 MDA-MB-231 , MDA-MB-468 和 MCF-7 乳癌房间的反增长 IC50 价值是 8.28 , 8.56 ,和 9.58 mol/L ,分别地),并且它对正常 MCF-10A 和 HEK-293 房间显示了仅仅细微的 cytotoxicity 。在 MDA-MB-231 和 MDA-MB-468 乳癌房间,没有导致 Hsp70, TL-2-8 治疗导致了多重 Hsp90 顾客蛋白质的降级。TL-2-8 (3, 6, 12 mol/L ) dose-dependently 禁止了 AHA1, Hsp90 ATPase 的使活跃之物,和减少的 Hsp90-AHA1 复杂形成的表达式,导致减少的 Hsp90 女伴函数和减少的像马球的 kinase 1 (PLK1 ) 发信号。因而,损害了 mitophagy 经由联系 lysosomal 的膜蛋白质 2 的 downregulation (LAMP2 ) 被导致。在里面 TL-2-8 的 vivo anticancer 效果在一个 MDA-MB-231 乳癌异种皮移植模型被评估,它与 TL-2-8 被对待(25, 50, 100 | Hui-juan LIU Xiao-xiao JIANG Yi-zhen GUO Fang-hui SUN Xin-hui KOU Yong BAO Zhu-qing ZHANG Zhao-hu LIN Ting-bo DING Lan JIANG Xin-sheng LEI Yong-hua YANG | 2017 | Acta Pharmacologica Sinica2017，38，10： | 7 |
| 17 | Dosage effect of multiple genes accounts for multisystem disorder of myotonic dystrophy type 1显示文摘Multisystem manifestations in myotonic dystrophy type 1(DM1)may be due to dosage reduction in multiple genes induced by aberrant expansion of CTG repeats in DMPK,including DMPK,its neighboring genes(SIX5 or DMWD)and downstream MBNLh However,direct evidence is lacking.Here,we develop a new strategy to generate mice carrying multigene heterozygous mutations to mimic dosage reduction in one step by injection of haploid embryonic stem cells with mutant Dmpk,Six5 and Mbnll into oocytes.The triple heterozygous mutant mice exhibit adult-onset DM1 phenotypes.With the additional mutation in Dmwd,the quadruple heterozygous mutant mice recapitulate many major manifestations in congenital DM1.Moreover,muscle stem cells in both models display reduced sternness,providing a unique model for screening small molecules for treatment of DM1.Our results suggest that the complex symptoms of DM1 result from the reduced dosage of multiple genes. | Qi Yin Hongye Wang Na Li Yifu Ding Zhenfei Xie Lifang Jin Yan Li Qiong Wang Xinyi Liu Liuqing Xu Qing Li Yongjian Ma Yanbo Cheng Kai Wang Cuiqing Zhong Qian Yu Wei Tang Wanjin Chen Wenjun Yang Fan Zhang Chen Ding Lan Bao Bin Zhou Ping Hu Jinsong Li | 2020 | Cell Research2020，30，2： | 7 |
| 18 | The Lyman-alpha Solar Telescope(LST) for the ASO-S mission——Ⅱ. design of LST显示文摘As one of the three payloads for the Advanced Space-based Solar Observatory(ASO-S)mission,the Lyman-alpha(Lyα)Solar Telescope(LST)is composed of three instruments:a Solar Corona Imager(SCI),a LyαSolar Disk Imager(SDI)and a full-disk White-light Solar Telescope(WST).When working in-orbit,LST will simultaneously perform high-resolution imaging observations of all regions from the solar disk to the inner corona up to 2.5 R⊙(R⊙stands for the mean solar radius)with a spatial resolution of 4.8′′and 1.2′′for coronal and disk observations,respectively,and a temporal resolution of 30–120 s and 1–120 s for coronal and disk observations,respectively.The maximum exposure time can be up to20 s due to precise pointing and image stabilization function.Among the three telescopes of LST,SCI is a dual-waveband coronagraph simultaneously and independently observing the inner corona in the HI Lyα(121.6±10 nm)line and white light(WL)(700±40 nm)wavebands by using a narrowband Lyαbeam splitter and has a field of view(FOV)from 1.1 to 2.5 R⊙.The stray-light suppression level can attain<10^-6 B⊙(B⊙is the mean brightness of the solar disk)at 1.1 R⊙and≤5×10^-8 B⊙at 2.5 R⊙.SDI and WST are solar disk imagers working in the Lyαline and 360.0 nm wavebands,respectively,which adopt an off-axis two-mirror reflective structure with an FOV up to 1.2 R⊙,covering the inner coronal edge area and relating to coronal imaging.We present the up-to-date design for the LST payload. | Bo Chen Hui Li Ke-Fei Song Quan-Feng Guo Pei-Jie Zhang Ling-Ping He Shuang Dai Xiao-Dong Wang Hai-Feng Wang Chun-Long Liu Hong-Ji Zhang Guang Zhang Yunqi Wang Shi-Jie Liu Hong-Xin Zhang Lei Liu Shi-Lei Mao Yang Liu Jia-Hao Peng Peng Wang Liang Sun Yang Liu Zhen-Wei Han Yan-Long Wang Kun Wu Guang-Xing Ding Peng Zhou Xin Zheng Ming-Yi Xia Qing-Wen Wu Jin-Jiang Xie Ya Chen Shu-Mei Song Hong Wang Bo Zhu Chang-Bo Chu Wen-Gang Yang Li Feng Yu Huang Wei-Qun Gan Ying Li Jing-Wei Li Lei Lu Jian-Chao Xue Bei-Li Ying Ming-Zhe Sun Cheng Zhu Wei-Min Bao Lei Deng Zeng-Shan Yin | 2019 | Research in Astronomy and Astrophysics2019，19，11： | 6 |
| 19 | An NT-3-releasing bioscaffold supports the formation of TrkC-modified neural stem cell-derived neural network tissue with efficacy in repairing spinal cord injury显示文摘The mechanism underlying neurogenesis during embryonic spinal cord development involves a specific ligand/receptor interaction,which may be help guide neuroengineering to boost stem cell-based neural regeneration for the structural and functional repair of spinal cord injury.Herein,we hypothesized that supplying spinal cord defects with an exogenous neural network in the NT-3/fibroin-coated gelatin sponge(NF-GS)scaffold might improve tissue repair efficacy.To test this,we engineered tropomyosin receptor kinase C(TrkC)-modified neural stem cell(NSC)-derived neural network tissue with robust viability within an NF-GS scaffold.When NSCs were genetically modified to overexpress TrkC,the NT-3 receptor,a functional neuronal population dominated the neural network tissue.The pro-regenerative niche allowed the long-term survival and phenotypic maintenance of the donor neural network tissue for up to 8 weeks in the injured spinal cord.Additionally,host nerve fibers regenerated into the graft,making synaptic connections with the donor neurons.Accordingly,motor function recovery was significantly improved in rats with spinal cord injury(SCI)that received TrkC-modified NSC-derived neural network tissue transplantation.Together,the results suggested that transplantation of the neural network tissue formed in the 3D bioactive scaffold may represent a valuable approach to study and develop therapies for SCI. | Ge Li Bao Zhang Jia-hui Sun Li-yang Shi Meng-yao Huang Li-jun Huang Zi-jing Lin Qiong-yu Lin Bi-qin Lai Yuan-huan Ma Bin Jiang Ying Ding Hong-bo Zhang Miao-xin Li Ping Zhu Ya-qiong Wang Xiang Zeng Yuan-shan Zeng | 2021 | Bioactive Materials2021，6，11： | 6 |
| 20 | Direct imaging and determination of the crystal structure of six-layered graphdiyne显示文摘自从它的发现,因为它在由一根电子横梁的照耀下面是太精细的,很少层 graphdiyne 的水晶结构的直接成像和决心证明了困难。在这个工作,六分层的 graphdiyne nanosheet 的水晶结构被低电压的传播电子显微镜学(TEM ) 直接用低当前的密度观察。高分辨率的 TEM (HRTEM ) 模拟,电子精力损失光谱学,和电子衍射的联合使用表明同样综合的 nanosheet 是有 2.19 nm 的厚度的水晶的 graphdiyne (相应于六层的厚度) 并且叠的显示出的 ABC。因此,这个工作为存在和很少层 graphdiyne 的水晶结构提供直接证据,它是对 graphene 补足的二维的碳材料的一种新类型。 | Chao Li Xiuli Lu Yingying Han Shangfeng Tang Yi Ding Ruirui Liu Haihong Bao Yuliang Li Jun Luo Tongbu Lu | 2018 | Nano Research2018，11，3： | 5 |
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