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| 1 | Prevalence of Autism Spectrum Disorder in China:A Nationwide Multi-center Population-based Study Among Children Aged 6 to 12 Years显示文摘This study aimed to obtain the first national estimate of the prevalence of autism spectrum disorder(ASD) in Chinese children.We targeted the population of 6 to 12-year-old children for this prevalence study by multistage convenient cluster sampling.The Modified Chinese Autism Spectrum Rating Scale was used for the screening process.Of the target population of 142,086 children,88.5%(n=125,806) participated in the study.A total of 363 children were confirmed as having ASD.The observed ASD prevalence rate was 0.29%(95% CI:0.26%-0.32%) for the overall population.After adjustment for response rates,the estimated number of ASD cases was867 in the target population sample,thereby achieving an estimated prevalence of 0.70%(95% CI:0.64%-0.74%).The prevalence was significantly higher in boys than in girls(0.95%;95% CI:0.87%-1.02% versus 0.30%;95%CI:0.26%-0.34%;P <0.001).Of the 363 confirmed ASD cases,43.3% were newly diagnosed,and most of those(90.4%) were attending regular schools,and 68.8% of the children with ASD had at least one neuropsychiatric comorbidity.Our findings provide reliable data on the estimated ASD prevalence and comorbidities in Chinese children. | Hao Zhou Xiu Xu Weili Yan Xiaobing Zou Lijie Wu Xuerong Luo Tingyu Li Yi Huang Hongyan Guan Xiang Chen Meng Mao Kun Xia Lan Zhang Erzhen Li Xiaoling Ge Lili Zhang Chunpei Li Xudong Zhang Yuanfeng Zhou Ding Ding Andy Shih Eric Fombonne Yi Zheng Jisheng Han Zhongsheng Sun Yong-hui Jiang Yi Wang LATENT-NHC Study Team | 2020 | Neuroscience Bulletin2020，36，9： | 158 |
| 2 | Towards 6G wireless communication networks:vision,enabling technologies,and new paradigm shifts显示文摘The fifth generation(5G)wireless communication networks are being deployed worldwide from 2020 and more capabilities are in the process of being standardized,such as mass connectivity,ultra-reliability,and guaranteed low latency.However,5G will not meet all requirements of the future in 2030 and beyond,and sixth generation(6G)wireless communication networks are expected to provide global coverage,enhanced spectral/energy/cost efficiency,better intelligence level and security,etc.To meet these requirements,6G networks will rely on new enabling technologies,i.e.,air interface and transmission technologies and novel network architecture,such as waveform design,multiple access,channel coding schemes,multi-antenna technologies,network slicing,cell-free architecture,and cloud/fog/edge computing.Our vision on 6G is that it will have four new paradigm shifts.First,to satisfy the requirement of global coverage,6G will not be limited to terrestrial communication networks,which will need to be complemented with non-terrestrial networks such as satellite and unmanned aerial vehicle(UAV)communication networks,thus achieving a space-airground-sea integrated communication network.Second,all spectra will be fully explored to further increase data rates and connection density,including the sub-6GHz,millimeter wave(mmWave),terahertz(THz),and optical frequency bands.Third,facing the big datasets generated by the use of extremely heterogeneous networks,diverse communication scenarios,large numbers of antennas,wide bandwidths,and new service requirements,6G networks will enable a new range of smart applications with the aid of artificial intelligence(AI)and big data technologies.Fourth,network security will have to be strengthened when developing 6G networks.This article provides a comprehensive survey of recent advances and future trends in these four aspects.Clearly,6G with additional technical requirements beyond those of 5G will enable faster and further communications to the extent that the boundary between physical and cyber worlds disappears. | Xiaohu YOU Cheng-Xiang WANG Jie HUANG Xiqi GAO Zaichen ZHANG Mao WANG Yongming HUANG Chuan ZHANG Yanxiang JIANG Jiaheng WANG Min ZHU Bin SHENG Dongming WANG Zhiwen PAN Pengcheng ZHU Yang YANG Zening LIU Ping ZHANG Xiaofeng TAO Shaoqian LI Zhi CHEN Xinying MA Chih-Lin I Shuangfeng HAN Ke LI Chengkang PAN Zhimin ZHENG Lajos HANZO Xuemin(Sherman)SHEN Yingjie Jay GUO Zhiguo DING Harald HAAS Wen TONG Peiying ZHU Ganghua YANG Jun WANG Erik GLARSSON Hien Quoc NGO Wei HONG Haiming WANG Debin HOU Jixin CHEN Zhe CHEN Zhangcheng HAO Geoffrey Ye LI Rahim TAFAZOLLI Yue GAO HVincent POOR Gerhard P.FETTWEIS Ying-Chang LIANG | 2021 | Science China(Information Sciences)2021，64，1： | 122 |
| 3 | Optimization of phenol degradation by Candida tropicalis Z-04 using Plackett-Burman design and response surface methodology显示文摘Statistical experimental designs were used to optimize the process of phenol degradation by Candida tropicalis Z-04,isolated from phenol-degrading aerobic granules.The most important factors influencing phenol degradation (p<0.05),as identified by a two-level Plackett-Burman design with 11 variables,were yeast extract,phenol,inoculum size,and temperature.Steepest ascent method was undertaken to determine the optimal regions of these four significant factors.Central composite design (CCD) and response surface analysis were adopted to further investigate the mutual interactions between these variables and to identify their optimal values that would generate maximum phenol degradation.The analysis results indicated that interactions between yeast extract and temperature,phenol and temperature,inoculum size and temperature affected the response variable (phenol degradation) significantly.The predicted results showed that the maximum removal efficiency of phenol (99.10%) could be obtained under the optimum conditions of yeast extract 0.41 g/L,phenol 1.03 g/L,inoculum size 1.43% (V/V) and temperature 30.04°C.These predicted values were further verified by validation experiments.The excellent correlation between predicted and experimental values confirmed the validity and practicability of this statistical optimum strategy.This study indicated the excellent ability of C.tropicalis Z-04 in degrading high-strength phenol.Optimal conditions obtained in this experiment laid a solid foundation for further use of this microorganism in the treatment of highstrength phenol effluents. | Jiangya Zhou Xiaojuan Yu Cong Ding Zhiping Wang Qianqian Zhou Hao Pao Weimin Ca | 2011 | Journal of Environmental Sciences2011，23，1： | 48 |
| 4 | 3RISPR-P 2.0: An Improved CRISPR-Cas9 Too For Genome Editing in Plants显示文摘 | Hao Liu Yuduan Ding Yanqing Zhou Wenqi Jin Kabin Xie Ling-Ling Chen | 2017 | Molecular Plant2017，10，3： | 32 |
| 5 | Progress of Air Pollution Control in China and Its Challenges and Opportunities in the Ecological Civilization Era显示文摘China’s past economic growth has substantially relied on fossil fuels,causing serious air pollution issues.Decoupling economic growth and pollution has become the focus in developing ecological civilization in China.We have analyzed the three-decade progress of air pollution controls in China,highlighting a strategic transformation from emission control toward air quality management.Emission control of sulfur dioxide(SO2)resolved the deteriorating acid rain issue in China in 2007.Since 2013,control actions on multiple precursors and sectors have targeted the reduction of the concentration of fine particulate matter(PM2.5),marking a transition to an air-quality-oriented strategy.Increasing ozone(O3)pollution further requires O3 and PM2.5 integrated control strategies with an emphasis on their complex photochemical interactions.Fundamental improvement of air quality in China,as a key indicator for the success of ecological civilization construction,demands the deep de-carbonization of China’s energy system as well as more synergistic pathways to address air pollution and global climate change simultaneously. | Xi Lu Shaojun Zhang Jia Xing Yunjie Wang Wenhui Chen Dian Ding Ye Wu Shuxiao Wang Lei Duan Jiming Hao | 2020 | Engineering2020，6，12： | 24 |
| 6 | Tri-Co Robot: a Chinese robotic research initiative for enhanced robot interaction capabilities显示文摘Since the invention of the first industrial robot in 1959, the missions of robots have evolved from basic mechanical transfer or assistance to a diverse range of tasks through close interactions with environment, their human counterparts and robot peers. Through adaptation to uncertain and dynamic environments. | Han Ding Xuejun Yang Nanning Zheng Ming Li Yinan Lai Hao Wu | 2018 | National Science Review2018，5，6： | 24 |
| 7 | Gastrointestinal symptoms: A comparison between patients undergoing peritoneal dialysis and hemodialysis显示文摘AIM: To compare the prevalence and diversity of gastrointestinal(GI) symptoms in patients undergoing peritoneal dialysis(PD) and hemodialysis(HD).METHODS: Two hundred and ninety-four end-stage renal disease patients participated in the study, including 182 HD and 112 PD patients. Dimension scores were calculated from a modified gastrointestinal symptom rating scale(GSRS) 18-item questionnaire, including items concerning eating dysfunction, and were used for measuring GI symptoms. Information on patient age, condition contributing to end-stage renal disease and the most recent dialysis adequacy assessment(serum Kt/V urea value) was obtained from the follow-up database and by interviewing patients and/or reviewing the medical records. Differences between the HD and PD groups were evaluated using Student's t, Pearson's χ2 or Fisher's exact tests.RESULTS: The overall prevalence of GI symptoms,defined by a GSRS > 1, in end-stage renal disease patients was 70.7%(208/294), which differed between HD and PD patients(76.4% vs 61.6%, P < 0.01). HD patients had a higher prevalence of constipation, abdominal pain and diarrhea compared to PD patients(36.3% vs 17.9%, 32.4% vs 5.4%, 17.6% vs 4.5%, respectively, P < 0.05). PD patients had a higher prevalence of reflux compared to HD patients(32.1% vs 24.2%, P < 0.05). Additionally, reflux and eating dysfunction were more severe in PD patients(GSRS: 1.71 ± 1.15 vs 1.30 ± 0.67, 1.57 ± 0.84 vs 1.39 ± 0.61, respectively, P < 0.05), whereas HD patients had greater abdominal pain, diarrhea and constipation(GSRS: 1.22 ± 0.39 vs 1.04 ± 0.19, 1.19 ± 0.53 vs 1.07 ± 0.35, 1.51 ± 0.83 vs 1.23 ± 0.58, respectively, P < 0.05). Finally, 14.8%(27/182) of HD patients presented with more than three GI symptoms, compared to 7.2%(8/112) of PD patients(P < 0.01).CONCLUSION: HD and PD patients differ in prevalence, severity and diversity of GI symptoms. | Rui Dong Zhi-Yong Guo Jia-Rong Ding Yang-Yang Zhou Hao Wu | 2014 | World Journal of Gastroenterology2014，20，32： | 20 |
| 8 | Shanghai Synchrotron Radiation Facility显示文摘The Shanghai Synchrotron Radiation Facility (SSRF) is an intermediate energy, third generation light source located in Zhangjiang High-Tech Park, Shanghai. In December 2007, an electron beam was first stored and accumulated in the SSRF storage ring. Since then the accelerator commissioning and beam line installation had steadily progressed toward routine user operation in May 2009. This article presents an overview of the SSRF design, construction, commissioning and current status of its user operation. | JIANG MianHeng YANG Xiong XU HongJie ZHAO ZhenTang DING Hao | 2009 | Chinese Science Bulletin2009，54，22： | 19 |
| 9 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 10 | A chlorinated copolymer donor demonstrates a 18.13% power conversion efficiency显示文摘The rapid development of low-bandgap(LBG)nonfullerene acceptors and wide-bandgap(WBG)copolymer donors in recent years has boosted the power conversion efficiency(PCE)of organic solar cells(OSCs)to the 18%level[1−21].The commercialization of OSCs is highly expected.However,critical issues like the cost and the stability also determine whether OSCs can enter the market or not[22]. | Jianqiang Qin Lixiu Zhang Chuantian Zuo Zuo Xiao Yongbo Yuan Shangfeng Yang Feng Hao Ming Cheng Kuan Sun Qinye Bao Zhengyang Bin Zhiwen Jin and Liming Ding | 2021 | Journal of Semiconductors2021，42，1： | 19 |
| 11 | Value of gamma-glutamyltranspeptidase-to-platelet ratio in diagnosis of hepatic fibrosis in patients with chronic hepatitis B显示文摘AIM To investigate the value of the gamma-glutamyltraspeptidase(GGT)-to-platelet(PLT) ratio(GPR) in the diagnosis of hepatic fibrosis in patients with chronic hepatitis B(CHB). METHODS We included 390 untreated CHB patients in this study. The GPR, aspartate aminotransferase(AST)-to-PLT ratio index(APRI), and fibrosis-4(FIB-4) of all patients were analysed to determine if these parameter were correlated with age, gender, medical history, liver function [total bilirubin(TBil), alanine aminotransferase(ALT), and AST], GGT, PLT count, or hepatic fibrosis stage. The GPR, APRI, and FIB-4, as well as the combination of the GPR and APRI or the GPR and FIB-4 were assessed in different cirrhosis stages using receiver operating characteristic(ROC) curve analysis to evaluate their value in diagnosing hepatic fibrosis in CHB patients. RESULTS The GPR, APRI, and FIB-4 were not correlated withCHB patients' age, gender, or disease duration(P > 0.05), but all of these parameters were positively correlated with serum ALT, AST, GGT, and PLT count(P < 0.01). Additionally, the GPR, APRI, and FIB-4 were positively correlated with hepatic fibrosis(P < 0.01); the areas under the ROC curve for the GPR in F1, F2, F3, and F4 stages were 0.723, 0.741, 0.826, and 0.833, respectively, which were significantly higher than the respective values for the FIB-4 and APRI(F1: 0.581, 0.612; F2: 0.706, 0.711; F3: 0.73, 0.751; and F4: 0.799, 0.778). The respective diagnostic cut-off points for each stage were 0.402, 0.448, 0.548, and 0.833, respectively. The diagnostic sensitivity and specificity were, respectively, 88.8% and 87.5% in F1, 72.7% and 89.7% in F2, 81.3% and 98.6% in F3, and 80% and 97.4% in F4 when the GPR and APRI were connected in parallel; 86.6% and 90.2%, 78.4% and 96%, 78.6% and 97.4%, and 73.2% and 97.9%, respectively, when the GPR and APRI were connected in series; 80.2% and 89%, 65% and 89%, 70.3% and 98.5%, and 78.8% and 96.8%, respectively, when the GPR and FIB-4 were connected in parallel; and 83.6% and 87.9%, 76.8% and 96.6%, 72.7% and 98%, and 74.4% and 97.7%, respectively, when the GPR and FIB-4 were connected in series.CONCLUSION The GPR, as a serum diagnostic index of liver fibrosis, is more accurate, sensitive, and easy to use than the FIB-4 and APRI, and the GPR can significantly improve the sensitivity and specificity of hepatic fibrosis diagnosis in CHB when combined with the FIB-4 or APRI. | Yan-Chao Hu Hao Liu Xiao-Yan Liu Li-Na Ma Yu-Hua Guan Xia Luo Xiang-Chun Ding | 2017 | World Journal of Gastroenterology2017，23，41： | 19 |
| 12 | Methylmercury and sulfate-reducing bacteria in mangrove sediments from Jiulong River Estuary,China显示文摘Estuaries are important sites for mercury (Hg) methylation,with sulfate-reducing bacteria (SRB) thought to be the main Hg methylators.Distributions of total mercury (THg) and methylmercury (MeHg) in mangrove sediment and sediment core from Jiulong River Estuary Provincial Mangrove Reserve,China were determined and the possible mechanisms of Hg methylation and their controlling factors in mangrove sediments were investigated.Microbiological and geochemical parameters were also determined.Results showed that SRB constitute a small fraction of total bacteria (TB) in both surface sediments and the profile of sediments.The content of THg,MeHg,TB,and SRB were (350±150)ng/g,(0.47±0.11)ng/g,(1.4×10 11±4.1×109)cfu/g dry weight (dw),and (5.0×106±2.7×106)cfu/g dw in surficial sediments,respectively,and (240±24)ng/g,(0.30±0.15)ng/g,(1.9×1011± 4.2×1010)cfu/g dw,and (1.3×106± 2.0×106) cfu/g dw in sediment core,respectively.Results showed that THg,MeHg,TB,MeHg/THg,salinity and total sulfur (TS) increased with depth,but total organic matter (TOM),SRB,and pH decreased with depth.Concentrations of MeHg in sediments showed significant positive correlation with THg,salinity,TS,and MeHg/THg,and significant negative correlation with SRB,TOM,and pH.It was concluded that other microbes,rather than SRB,may also act as main Hg methylators in mangrove sediments. | Hao Wu Zhenhua Ding Yang Liu Jinling Liu Haiyu Yan Jiayong Pan Liuqiang Li Huina Lin Guanghui Lin Haoliang Lu | 2011 | Journal of Environmental Sciences2011，23，1： | 17 |
| 13 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 14 | Paeoniflorin inhibits human gastric carcinoma cell proliferation through up-regulation of microRNA-124 and suppression of PI3K/Akt and STAT3 signaling显示文摘AIM: To examine the potential anti-tumor activity of paeoniflorin in the human gastric carcinoma cell line MGC-803.METHODS: Cell viability and cytotoxic effects in MGC-803 cells were analyzed using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and lactate dehydrogenase assay, respectively. Cell apoptosis of MGC-803 cells was measured using flow cytometry,DAPI staining assay and caspase-3 activity assay.Quantitative reverse transcription-polymerase chain reaction(RT-PCR) was used to measure the expression of microRNA-124(miR-124) in response to paeoniflorin.The expression of phosphatidylinositol 3-kinase(PI3K),protein kinase B(Akt), phospho-Akt(p-Akt) and phospho-signal transducer and activator of transcription3(p-STAT3) were also measured by quantitative RTPCR and Western blot analysis in normal, miR-124 and anti-miR-124 over-expressing MGC-803 cells, treated with paeoniflorin.RESULTS: Paeoniflorin was found to inhibit MGC-803 cell viability in a dose-dependent manner. Paeoniflorin treatment was associated with the induction of apoptosis and caspase-3 activity in MGC-803 cells. Paeoniflorin treatment significantly increased miR-124 levels and inhibited the expression of PI3 K, Akt, p-Akt and p-STAT3 in MGC-803 cells. Interestingly, the over-expression of miR-124 inhibits PI3K/Akt and phospho-STAT3 expressions in MGC-803 cells. PI3 K agonist(IGF-1, 1μg/10 μL) or over-expression of STAT3 reversed the effect of paeoniflorin on the proliferation of MGC-803 cells. Over-expression of anti-miR-124 in MGC-803 cells reversed paeoniflorin-induced up-regulation.CONCLUSION: In summary, the in vitro data suggest that paeoniflorin is a potential novel therapeutic agent against gastric carcinoma, which inhibits cell viability and induces apoptosis through the up-regulation of miR-124 and suppression of PI3K/Akt and STAT3 signaling. | Yong-Bin Zheng Gao-Chun Xiao Shi-Lun Tong Yu Ding Qiu-Shuang Wang Sheng-Bo Li Zhi-Nan Hao | 2015 | World Journal of Gastroenterology2015，21，23： | 15 |
| 15 | Fault Detection of Networked Control Systems Subject to Access Constraints and Random Packet Dropout显示文摘 | WANG Yong-Qiang YE Hao DING Steven WANG Gui-Zeng | 2009 | 自动化学报2009，35，9： | 15 |
| 16 | Adipose-derived mesenchymal stem cells protect against CMS-induced depression-like behaviors in mice via regulating the Nrf2/HO-1 and TLR4/NF-κB signaling pathways显示文摘Increasing studies show that inflammatory processes may be involved in depressive disorders.Nuclear factor erythroid-2 related factor 2(Nrf2)modulates tissue microglial M1 phenotypic changes to the M2 phenotype,which is implicated in protection against inflammatory diseases.We have reported that the adipose-derived mesenchymal stem cells(ADSCs)display anti-inflammatory activity.In this study we explored whether the mechanism of anti-inflammatory activity of ADSCs was related to Nrf2.ADSCs were isolated from mouse fat pads and intravenously administered to chronic mild stress(CMS)-exposed C57BL/6 mice at the dose of 1×106 once a week for 3 weeks.We showed that ADSC administration significantly remedied CMS-induced depressive-like behaviors in sucrose preference test,tail suspension test,and forced swim test accompanied by suppressing microglial activation and the expression of inflammatory factors including MCP-1,TNF-α,IL-1β,and IL-6.Furthermore,ADSC administration promoted both the expression of BDNF and TrkB,and promoted Nrf2/HO-1 signaling but suppressed TLR4/NF-κB signaling in brain tissue.In order to elucidate the role of Nrf2/HO-1 signaling in ADSC-caused neuroprotection,Nrf2-modified ADSCs were cocultured with BV2 microglial cells,then exposed to lipopolysaccharide(LPS).Downregulation of Nrf2 in ADSCs decreased the protective effects of ADSCs against LPS-induced microglial activation and M1 polarization.Nrf2 overexpression in ADSCs markedly suppressed LPS-induced TLR4 and NF-κB expression in microglial cells.These results suggest a possible antidepressive mechanism correlated with microglial polarization for anti-inflammatory agents,which may provide a new microglia-targeted strategy for depression therapy. | Xiao Huang Guo-qiang Fei Wen-juan Liu Jing Ding Yuan Wang Hao Wang Jian-lin Ji Xin Wang | 2020 | Acta Pharmacologica Sinica2020，41，5： | 15 |
| 17 | Progress of the key materials for organic solar cells显示文摘Organic solar cells have attracted academic and industrial interests due to the advantages like lightweight,flexibility and roll-to-roll fabrication.Nowadays,18%power conversion efficiency has been achieved in the state-of-the-art organic solar cells.The recent rapid progress in organic solar cells relies on the continuously emerging new materials and device fabrication technologies,and the deep understanding on film morphology,molecular packing and device physics.Donor and acceptor materials are the key materials for organic solar cells since they determine the device performance.The past 25 years have witnessed an odyssey in developing high-performance donors and acceptors.In this review,we focus on those star materials and milestone work,and introduce the molecular structure evolution of key materials.These key materials include homopolymer donors,D-A copolymer donors,A-D-A small molecular donors,fullerene acceptors and nonfullerene acceptors.At last,we outlook the challenges and very important directions in key materials development. | Yang Tong Zuo Xiao Xiaoyan Du Chuantian Zuo Yuelong Li Menglan Lv Yongbo Yuan Chenyi Yi Feng Hao Yong Hua Ting Lei Qianqian Lin Kuan Sun Dewei Zhao Chunhui Duan Xiangfeng Shao Wei Li Hin-Lap Yip Zhengguo Xiaol Bin Zhang Qingzhen Bian Yuanhang Cheng Shengjian Liu Ming Cheng Zhiwen Jin Shangfeng Yang Liming Ding | 2020 | Science China Chemistry2020，63，6： | 15 |
| 18 | miR-132 inhibits colorectal cancer invasion and metastasis via directly targeting ZEB2显示文摘AIM:To investigate the biological role and underlying mechanism of miR-132 in colorectal cancer(CRC)progression and invasion.METHODS:Quantitative RT-PCR analysis was used to examine the expression levels of miR-132 in five CRC cell lines(SW480,SW620,HCT116,HT29 and LoVo)and a normal colonic cell line NCM460,as well as in tumor tissues with or without metastases.The KaplanMeier method was used to analyze the prognostic significance of miR-132 in CRC patients.The biological effects of miR-132 were assessed in CRC cell lines using the transwell assay.Quantitative RT-PCR and western blot analyses were employed to evaluate the expression of miR-132 targets.The regulation of ZEB2 by miR-132was confirmed using the luciferase activity assay.RESULTS:miR-132 was significantly down-regulated in the CRC cell lines compared with the normal colonic cell line(P<0.05),as well as in the CRC tissues withdistant metastases compared with the tissues without metastases(10.52±4.69 vs 23.11±7.84)(P<0.001).Down-regulation of miR-132 was associated with tumor size(P=0.016),distant metastasis(P=0.002),and TNM stage(P=0.020)in CRC patients.Kaplan-Meier survival curve analysis indicated that patients with low expression of miR-132 tended to have worse diseasefree survival than patients with high expression of miR-132(P<0.001).Moreover,ectopic expression of miR-132 markedly inhibited cell invasion(P<0.05)and the epithelial-mesenchymal transition(EMT)in CRC cell lines.Further investigation revealed ZEB2,an EMT regulator,was a downstream target of miR-132.CONCLUSION:Our study indicated that miR-132 plays an important role in the invasion and metastasis of CRC. | Yong-Bin Zheng Hai-Ping Luo Qiang Shi Zhi-Nan Hao Yu Ding Qiu-Shuang Wang Sheng-Bo Li Gao-Chun Xiao Shi-Lun Tong | 2014 | World Journal of Gastroenterology2014，20，21： | 14 |
| 19 | PGC-1α induces apoptosis in human epithelial ovarian cancer cells through a PPARy-dependent pathway显示文摘Peroxisome 激活 proliferator 的受体鲸鱼群妈(PPAR γ) coactivator-1 高山哈(PGC-1 α) coactivates 多重抄写因素并且调整几个代谢过程。Thecurrent 学习在人的上皮的卵巢的癌症房间在 apoptosis 的正式就职调查了 PGC-1 α的角色。在人的卵巢和人的卵巢的上皮的肿瘤之间的 PGC-1 α信使 rna 水平被量的 RT-PCR 检验。更少的 PGC-1 α表示与正常卵巢相比在恶意的肿瘤的表面上皮被发现。在人的上皮的卵巢的癌症房间线 Ho-8910 的 PGC-1 α的 Overexpression 通过 Bcl-2 和 Bax 表示的协调规定导致了房间 apoptosis。Microarray 分析证实 PGC-1 α戏剧性地在 Ho-8910 房间影响了 apoptosis 相关的基因。 Mitochondrial 功能的试金证明 apoptosis 的正式就职通过由细胞色素 c.Furthermore 的版本的终端阶段,导致的 apoptosis 部分是,然而并非完全,由 PPAR γa ntagonist ( GW9662 )堵住了的 PGC-1 α-,并且由 siRNA 的 PPAR γ 表示的抑制也在 Ho-8910 房间禁止了 PGC-1 α- inducedapoptosis 。这些数据建议 PGC-1 α通过 aPPAR γ - 依赖者小径施加了它的效果。我们的调查结果显示 PGC-1 α涉及 apoptotic signaltransduction 小径, PGC-1 α的 down 规定可以是在支持上皮的卵巢的癌症生长和前进的一个关键点。 | Yan Zhang Yi Ba Chang Liu Guoxun Sun Li Ding Songyuan Gao Jihui Hao Zhentao Yu Junfeng Zhang Ke Zen Zhongsheng Tong Yang Xiang Chen-Yu Zhang | 2007 | Cell Research2007，17，4： | 14 |
| 20 | Analysis and assessment of bridge health monitoring mass data——progress in research/development of “Structural Health Monitoring”显示文摘The 'Structural Health Monitoring' is a project supported by National Natural Science Foundation for Distinguished Young Scholars of China(Grant No.50725828).To meet the urgent requirements of analysis and assessment of mass monitoring data of bridge environmental actions and structural responses,the monitoring of environmental actions and action effect modeling methods,dynamic performance monitoring and early warning methods,condition assessment and operation maintenance methods of key members are systematically studied in close combination with structural characteristics of long-span cable-stayed bridges and suspension bridges.The paper reports the progress of the project as follows.(1) The environmental action modeling methods of long-span bridges are established based on monitoring data of temperature,sustained wind and typhoon.The action effect modeling methods are further developed in combination with the multi-scale baseline finite element modeling method for long-span bridges.(2) The identification methods of global dynamic characteristics and internal forces of cables and hangers for long-span cable-stayed bridges and suspension bridges are proposed using the vibration monitoring data,on the basis of which the condition monitoring and early warning methods of bridges are developed using the environmental-condition-normalization technique.(3) The analysis methods for fatigue loading effect of welded details of steel box girder,temperature and traffic loading effect of expansion joint are presented based on long-term monitoring data of strain and beam-end displacement,on the basis of which the service performance assessment and remaining life prediction methods are developed. | LI AiQun DING YouLiang WANG Hao GUO Tong | 2012 | Science China(Technological Sciences)2012，55，8： | 14 |
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