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| 1 | Environmental connections of novel avian-origin H7N9 influenza virus infection and virus adaptation to the human显示文摘A novel H7N9 influenza A virus has been discovered as the causative identity of the emerging acute respiratory infection cases in Shanghai,China.This virus has also been identified in cases of infection in the neighboring area Hangzhou City in Zhejiang Province.In this study,epidemiologic,clinical,and virological data from three patients in Hangzhou who were confirmed to be infected by the novel H7N9 influenza A virus were collected and analyzed.Human respiratory specimens and chicken feces from a contacted free market were tested for influenza virus by real-time reverse transcription PCR(RT-PCR) and sequencing.The clinical features of the three cases were similar featured with high fever and severe respiratory symptoms;however,only one of the patients died.A certain degree of diversity was observed among the three Hangzhou viruses sequenced from human samples compared with other reported H7N9 influenza A viruses.The sequences of the novel avian-origin H7N9 influenza viruses from Hangzhou City contained important amino acid substitutions related to human adaptation.One of the Hangzhou viruses had gained a novel amino acid substitution(Q226I) in the receptor binding region of hemagglutinin.More importantly,the virus sequenced from the chicken feces had a 627E substitution in the PB2 protein instead of the mammalian-adapted 627K substitution that was found in the PB2 proteins from the Hangzhou viruses from the three patients.Therefore,the newly-emerging H7N9 virus might be under adaptation pressure that will help it 'jump' from avian to human hosts.The significance of these substitutions needs further exploration,with both laboratory experiments and extensive field surveillance. | LI Jun YU XinFen PU XiaoYing XIE Li SUN YongXiang XIAO HaiXia WANG FenJuan DIN Hua WU Ying LIU Di ZHAO GuoQiu LIU Jun PAN JingCao | 2013 | Science China(Life Sciences)2013，56，6： | 32 |
| 2 | Epigenetic silencing of microRNA-149 in cancer-associated fibroblasts mediates prostaglandin E2/interleukin-6 signaling in the tumor microenvironment显示文摘 | Pu Li Jing-Xuan Shan Xue-Hua Chen Di Zhang Li-Ping Su Xiu-Ying Huang Bei-Qin Yu Qiao-Ming Zhi Cheng-Long Li Ya-Qing Wang Sara Tomei Qu Cai Jun Ji Jian-Fang Li Lotfi Chouchane Ying-Yan Yu Fang-Zhen Sun Zhi-Heng Xu Bing-Ya Liu Zheng-Gang Zhu | 2015 | Cell Research2015，25，5： | 24 |
| 3 | Snaill is involved in de novo cardiac fibrosis after myocardial infarction in mice显示文摘Epithelialmesenchymal 转变(EMT ) 是在心肌的梗塞(MI ) 以后的心脏的纤维变性的重要机制。然而,它仍然保持不清楚是否 Snail1, EMT 的一个重要管理者,涉及心脏的纤维变性。在这研究,我们在老鼠探索了 Snail1 和心脏的纤维变性 markerperiostinafter MI 的表示模式然后在老鼠在 MI 以后调查了在 Snail1 和 periostin 之间的合作表示。我们的结果证明 Snail1 和 periostin 的 mRNA 和蛋白质层次显著地在梗塞区域被增加。Snail1 表示模式看起来在在 MI 以后的 14 天以内寓言。另外在 MI 以后,所有 Snail1 积极的房间能表示 periostin。这些结果显示 Snail1 主要在梗塞区域被激活并且涉及 de novo 在在老鼠的 MI 以后的心脏的纤维变性。因此,它是在为在 MI 以后的室的改变的药干预的发展的一个潜在的分子的目标。 | Yajie Liu Jianlin Du Jin Zhang Minjie Weng Xiaoqun Li Di Pu Lingzhi Gao Songbai Deng Shuang Xia Qiang She | 2012 | Acta Biochimica et Biophysica Sinica2012，44，11： | 7 |
| 4 | A New Oviraptorid Dinosaur (Theropoda: Oviraptorosauria) from the Late Cretaceous of Jiangxi Province, Southern China显示文摘A new oviraptorid dinosaur Jiangxisaurus ganzhouensis gen. et sp. nov., is erected based on a partial skeleton from the Upper Cretaceous Nanxiong Formation of Ganzhou City, Jiangxi Province. The new taxon differs from other oviraptorids in the weakly downturned rostrum of the lower jaw, much-elongated mandible with a height-to-length ratio being about 20% and the length ratio of radius to humerus of about 0.70. This species not only adds a new member to oviraptorid dinosaurs, but also provides more information about oviraptorid paleogeographical distribution in southern China. | WEI Xuefang PU Hanyong XU Li LIU Di Lü Junchang | 2013 | Acta Geologica Sinica(English Edition)2013，87，4： | 6 |
| 5 | GEOLOGICAL AND GEOCHEMICAL STUDY ON THE GENESIS OF THE FANKOU Pb-Zn DEPOSIT显示文摘The super large Pb Zn deposit at Fankou is very complex in metallogenic mechanism. Syngenetic brine sedimentation, hot submarine spring eruption—accumulation, syngenetic sedimentation—vadose brine replacement had been supposed as the genetic models before. Under these models, syngenetic mineralization should be dominant in ore formation. However, a series of geological and geochemical properties investigated by authors of this paper are contrary to these models. Therefore, the authors here suggest that this deposit is a typical polygenetic compound ore deposit which share the properties of multistages of geotectonic evolution, multifactors of mineralization control, multisystem of material derivation of mineralization, multimodes of mineralization and multitypes of genesis. | ZHANG Shu gen 1, ZHAN Jian pu 1, HUANG Man xiang 1, FAN Zhong heng 1,WANG Li 1, MA Guo qiu 2, LIU Rui di 2, YANG Han zhuang 2, LIU Sheng bo 2, XU Shui ping 2 and LUO Wen sheng 2 (1. College of Mineral Resource, Environment and | 2001 | Geotectonica et Metallogenia2001，25，1： | 2 |
| 6 | Sustainable Investment Forecasting of Power Grids Based on theDeep Restricted Boltzmann Machine Optimized by the Lion Algorithm显示文摘This paper proposes a new power grid investment prediction model based on the deep restricted Boltzmann machine(DRBM)optimized by the Lion algorithm(LA).Firstly,two factors including transmission and distribution price reform(TDPR)and 5G station construction were comprehensively incorporated into the consideration of influencing factors,and the fuzzy threshold method was used to screen out critical influencing factors.Then,the LA was used to optimize the parameters of the DRBM model to improve the model’s prediction accuracy,and the model was trained with the selected influencing factors and investment.Finally,the LA-DRBM model was used to predict the investment of a power grid enterprise,and the final prediction result was obtained by modifying the initial result with the modifying factors.The LA-DRBMmodel compensates for the deficiency of the singlemodel,and greatly improves the investment prediction accuracy of the power grid.In this study,a power grid enterprise was taken as an example to carry out an empirical analysis to prove the validity of the model,and a comparison with the RBM,support vector machine(SVM),back propagation neural network(BPNN),and regression model was conducted to verify the superiority of the model.The conclusion indicates that the proposed model has a strong generalization ability and good robustness,is able to abstract the combination of low-level features into high-level features,and can improve the efficiency of the model’s calculations for investment prediction of power grid enterprises. | Qian Wang Xiaolong Yang Di Pu Yingying Fan | 2022 | Computer Modeling in Engineering & Sciences2022，，1： | 2 |
| 7 | GOLM1 restricts colitis and colon tumorigenesis by ensuring Notch signaling equilibrium in intestinal homeostasis显示文摘Intestinal epithelium serves as the first barrier against the infections and injuries that mediate colonic inflammation.Colorectal cancer is often accompanied with chronic inflammation.Differed from its well-known oncogenic role in many malignancies,we present here that Golgi membrane protein 1(G0LM1,also referred to as GP73)suppresses colorectal tumorigenesis via maintenance of intestinal epithelial barrier.G0LM1 deficiency in mice conferred susceptibility to mucosal inflammation and colitis-induced epithelial damage,which consequently promoted colon cancer.Mechanistically,depletion of G0LM1 in intestinal epithelial cells(lECs)led to aberrant Notch activation that interfered with IEC differentiation,maturation,and lineage commitment in mice.Pharmacological inhibition of Notch pathway alleviated epithelial lesions and restrained pro-tumorigenic inflammation in G0LM1-deficient mice.Therefore,G0LM1 maintains IEC homeostasis and protects against colitis and colon tumorigenesis by modulating the equilibrium of Notch signaling pathway. | Yang Pu Ya Song Mengdi Zhang Caifeng Long Jie Li Yanan Wang Yinzhe Xu Fei Pan Na Zhao Xinyu Zhang Yanan Xu Jianxin Cui Hongying Wang Yan Li Yong Zhao Di Jin Hongbing Zhang | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 2 |
| 8 | Thermal performance analysis of intermediate fluid vaporizer for liquefied natural gas显示文摘 | Liang Pu Zhiguo Qu Yuheng Bai Di Qi Kun Song Peng Yi | 2014 | Applied Thermal Engineering2014，，： | 2 |
| 9 | RHOBTB3 promotes proteasomal degradation of HIFa through facilitating hydroxylation and suppresses the Warburg effect显示文摘 | Chen-Song Zhang Qi Liu Mengqi Li Shu-Yong Lin Yongying Peng Di Wu Terytty Yang Li Qiang Fu Weiping Jia Xinjun Wang Teng Ma Yue Zong Jiwen Cui Chengfei Pu Guili Lian Huiling Guo Zhiyun Ye Sheng-Cai Lin | 2015 | Cell Research2015，25，9： | 2 |
| 10 | Protective role and related mechanism of Gnaq n neural cells damaged by oxidative stress显示文摘Gnaq 是 G 蛋白质家庭的一个成员并且富于大脑织物。它由于它变化的高比率在黑瘤吸引了许多研究人员的注意。我们以前报导了在老鼠前脑外皮的 Gnaq 的表示水平显著地与年龄被减少。氧化应力(OS ) 是导致大脑老化和相关疾病的主要原因。在在大脑的 antioxidation 的 Gnaq 的角色和机制充分没被探索。在现在的学习,基因 recombinant 技术和 lentivirus transfection 技术被用来产生结合的一个 Gnaq-overexpression 房间模型(Gnaq-SY5Y ) H 2 造一个 OS 模型的 O 2 。细胞,反应的氧种类(ROS ) 的集中, apoptosis 相关的蛋白质(Bcl-2 和 Bax ) ,和信号小径(NF-B 和 Erk1/2 ) 的生存能力在模型细胞和控制细胞之间被比较。结果证明 Gnaq-SY5Y 房间的抗氧化的能力显著地被改进。附随地,在 Gnaq-SY5Y 房间的 ROS 水平显著地被减少房间是否服从于到 H 2 O 2 处理。Anti-apoptotic 蛋白质 Bcl-2 是起来调整的,支持 apoptosis 蛋白质 Bax 在在有 H 2 O 2 。NF-B 和 phosphorylated Erk1/2 (p-Erk1/2 ) 在 Gnaq-SY5Y 房间是显著地下面调整的。H 2 O 2 处理减少了 Gnaq 表示但是在 Gnaq-SY5Y 房间的增加的 NF-B 和 p-Erk1/2 表情。Gnaq 在神经房间在 antioxidation 起一个枢轴的作用,这因此被结束。为这的机制将是 overexpressed Gnaq 禁止细胞的损坏效果的可能的 A 由 NF-B 和 Erk1/2 信号小径调停了。 | Nannan Jia Guoping Li Pu Huang Jiazhi Guo Lugang Wei Di Lu Shaochun Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，5： | 2 |
| 11 | Magnetic-field-induced birefringence and particle agglomeration显示文摘 | DI Z Y CHEN X F PU S L | 2006 | Appl Phys Lett2006，89，21： | 1 |
| 12 | Cardiac aging, calcium overload, and arrhythmias显示文摘 | Carbonin PU Di Gennaro M Pahor M | 1990 | Exp Gerontol1990，25，3： | 1 |
| 13 | Relaxation property of the magnetic-fluid-based fiber-optic evanescent field modulator显示文摘 | Pu S L Chen X F Di Z Y | | 0，，05： | 1 |
| 14 | Relaxation property of the magnetic-fluid-based fiber-optic evanescent field modulator显示文摘 | Pu Sheng-li Chen Xian-feng Di Ziyun | 2007 | J Appl Phys2007，101，05： | 1 |
| 15 | Temporomandibular Joint osteoarthrosis and intemal derangement partⅡ addjtional treatment options显示文摘 | Stegenga B Di jkstra PU de Bont LG | 1990 | Int Dent J1990，40，： | 1 |
| 16 | Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer显示文摘 | Eva Budinska Vlad Popovici Sabine Tejpar Giovanni D’Ario Nicolas Lapique Katarzyna Otylia Sikora Antonio Fabio Di Narzo Pu Yan John Graeme Hodgson Scott Weinrich Fred Bosman Arnaud Roth Mauro Delorenzi | 2013 | J. Pathol2013，，1： | 1 |
| 17 | Unsupervised object detection with scene-adaptive concept learning显示文摘Object detection is one of the hottest research directions in computer vision,has already made impressive progress in academia,and has many valuable applications in the industry.However,the mainstream detection methods still have two shortcomings:(1)even a model that is well trained using large amounts of data still cannot generally be used across different kinds of scenes;(2)once a model is deployed,it cannot autonomously evolve along with the accumulated unlabeled scene data.To address these problems,and inspired by visual knowledge theory,we propose a novel scene-adaptive evolution unsupervised video object detection algorithm that can decrease the impact of scene changes through the concept of object groups.We first extract a large number of object proposals from unlabeled data through a pre-trained detection model.Second,we build the visual knowledge dictionary of object concepts by clustering the proposals,in which each cluster center represents an object prototype.Third,we look into the relations between different clusters and the object information of different groups,and propose a graph-based group information propagation strategy to determine the category of an object concept,which can effectively distinguish positive and negative proposals.With these pseudo labels,we can easily fine-tune the pretrained model.The effectiveness of the proposed method is verified by performing different experiments,and the significant improvements are achieved. | Shiliang PU Wei ZHAO Weijie CHEN Shicai YANG Di XIE Yunhe PAN | 2021 | Frontiers of Information Technology & Electronic Engineering2021，22，5： | 1 |
| 18 | Gene expression patterns unveil a new level of molecular heterogeneity in colorectal cancer显示文摘 | Eva Budinska Vlad Popovici Sabine Tejpar Giovanni D’Ario Nicolas Lapique Katarzyna Otylia Sikora Antonio Fabio Di Narzo Pu Yan John Graeme Hodgson Scott Weinrich Fred Bosman Arnaud Roth Mauro Delorenzi | 2013 | J Pathol2013，，1： | 1 |
| 19 | Cardiac aging, calcium overload, and arrhythmias显示文摘 | Carbonin PU Di Gennaro M Pahor M | 1990 | Exp Gerontol1990，25，： | 1 |
| 20 | Relaxation property of the magnetic- fluid-based fiber-optic evanescent field modulator显示文摘 | Pu S L Chen X F Di Z Y | 2007 | Journal of Applied Physics2007，101，05： | 1 |
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