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| 1 | Clinical implications and prognostic value of single and combined biomarkers in endometrial carcinoma显示文摘 | Li Mingzhu Zhao Lijun Shen Danhua Li Xiaoping Wang Jianliu Wei Lihui | 2014 | Chinese Medical Journal2014，，8： | 8 |
| 2 | The INO80 chromatin remodeling complex promotes thermo-morphogenesis by connecting H2A.Z eviction and active transcription in Arabidopsis.显示文摘Global warming imposes a major threat to plant growth and crop production. In some plants including Arabidopsis thaliana, elevated temperatures induce a series of morphological and developmental adjustments, termed thermomorphogenesis to facilitate plant cooling under high-temperature conditions. Plant thermal response is suppressed by histone variant H2A.Z. At warm temperatures, H2A.Z is evicted from nucleosomes at thermo-responsive genes, resulting in their expression changes. However, the mechanisms that regulate H2A.Z eviction and subsequent transcription changes are largely unknown. Here, we show that the INO80 chromatin remodeling complex (INO80-C) promotes thermomorphogenesis and activates the expression of thermo-responsive and auxin-related genes. INO80-C associates with PHYTOCHROME-INTERACTING FACTOR 4 (PIF4), a potent regulator in thermomorphogenesis, and mediates temperature-induced H2A.Z eviction at PIF4 targets. Moreover, INO80-C directly interacts with COMPASS-like and transcription elongation factors to promote active histone modification Histone H3 lysine 4 trimethylation (H3K4me3) and RNA Polymerase II (RNA Pol II) elongation, leading to the thermal induction of transcription. Notably, transcription elongation factors SPT4 and SPT5 are required for the H2A.Z eviction at PIF4 targets, suggesting the cooperation of INO80-C and transcription elongation in H2A.Z removal. Our results demonstrate that the (PIF4)-(INO80-C)-(COMPASS-like)-(transcription elongator) module controls plant thermal response, and establish a link between H2A.Z eviction and active transcription. | Xue Mande Zhang Huairen Zhao Fengyue Zhao Ting Li Hui Jiang Danhua | 2021 | Molecular Plant2021，14，11： | 8 |
| 3 | Audiological evaluation in Chinese patients with mitochondrial encephalomyopathies显示文摘 | Liu Yuhe Xue Junfang Zhao Danhua Chen Li Yuan Yun Wang Zhaoxia | 2014 | Chinese Medical Journal2014，，12： | 6 |
| 4 | Advances in COVID-19 mRNA vaccine development显示文摘To date,the coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)has determined 399,600,607 cases and 5,757,562 deaths worldwide.COVID-19 is a serious threat to human health globally.The World Health Organization(WHO)has declared COVID-19 pandemic a major public health emergency.Vaccination is the most effective and economical intervention for controlling the spread of epidemics,and consequently saving lives and protecting the health of the population.Various techniques have been employed in the development of COVID-19 vaccines.Among these,the COVID-19 messenger RNA(mRNA)vaccine has been drawing increasing attention owing to its great application prospects and advantages,which include short development cycle,easy industrialization,simple production process,flexibility to respond to new variants,and the capacity to induce better immune response.This review summarizes current knowledge on the structural characteristics,antigen design strategies,delivery systems,industrialization potential,quality control,latest clinical trials and real-world data of COVID-19 mRNA vaccines as well as mRNA technology.Current challenges and future directions in the development of preventive mRNA vaccines for major infectious diseases are also discussed. | Enyue Fang Xiaohui Liu Miao Li Zelun Zhang Lifang Song Baiyu Zhu Xiaohong Wu Jingjing Liu Danhua Zhao Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，4： | 5 |
| 5 | Traditional Chinese medicines and their active ingredients sensitize cancer cells to TRAIL-induced apoptosis显示文摘The rapidly developing resistance of cancers to chemotherapy agents and the severe cytotoxicity of such agents to normal cells are major stumbling blocks in current cancer treatments.Most current chemotherapy agents have significant cytotoxicity,which leads to devastating adverse effects and results in a substandard quality of life,including increased daily morbidity and premature mortality.The death receptor of tumor necrosis factor-related apoptosis-inducing ligand(TRAIL)can sidestep p53-dependent pathways to induce tumor cell apoptosis without damaging most normal cells.However,various cancer cells can develop resistance to TRAIL-induced apoptosis via different pathways.Therefore,it is critical to find an efficient TRAIL sensitizer to reverse the resistance of tumor cells to TRAIL,and to reinforce TRAIL’s ability to induce tumor cell apoptosis.In recent years,traditional Chinese medicines and their active ingredients have shown great potential to trigger apoptotic cell death in TRAIL-resistant cancer cell lines.This review aims to collate information about Chinese medicines that can effectively reverse the resistance of tumor cells to TRAIL and enhance TRAIL’s ability to induce apoptosis.We explore the therapeutic potential of TRAIL and provide new ideas for the development of TRAIL therapy and the generation of new anticancer drugs for human cancer treatment.This study involved an extensive review of studies obtained from literature searches of electronic databases such as Google Scholar and PubMed.'TRAIL sensitize'and'Chinese medicine'were the search keywords.We then isolated newly published studies on the mechanisms of TRAIL-induced apoptosis.The name of each plant was validated using certified databases such as The Plant List.This study indicates that TRAIL can be combined with different Chinese medicine components through intrinsic or extrinsic pathways to promote cancer cell apoptosis.It also demonstrates that the active ingredients of traditional Chinese medicines enhance the sensitivity of cancer cells to TRAIL-mediated apoptosis.This provides useful information regarding traditional Chinese medicine treatment,the development of TRAIL-based therapies,and the treatment of cancer. | Bingyu SUN Yongqiang LIU Danhua HE Jinke LI Jiawei WANG Wulin WENS Ming HONG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，3： | 3 |
| 6 | Core-satellite metal-organic framework@upconversion nanoparticle superstructures via electrostatic self-assembly for efficient photodynamic theranostics显示文摘The nanoplatforms based on upconversion nanoparticles(UCNPs)have shown great promise in amplified photodynamic therapy(PDT)triggered by near-infrared(NIR)light.However,their practical in vivo applications are hindered by the overheating effect of 980 nm excitation and low utilization of upconversion luminescence(UCL)by photosensitizers.To solve these defects,core-satellite metal-organic framework@UCNP superstructures,composed of a single metal-organic framework(MOF)NP as the core and Nd3+-sensitized UCNPs as the satellites,are designed and synthesized via a facile electrostatic self-assembly strategy.The superstructures realize a high co-loading capacity of chlorin e6(Ce6)and rose bengal(RB)benefitted from the highly porous nature of MOF NPs,showing a strong spectral overlap between maximum absorption of photosensitizers and emission of UCNPs.The in vitro and in vivo experiments demonstrate that the dual-photosensitizer superstructures have trimodal(magnetic resonance(MR)/UCL/fluorescence(FL))imaging functions and excellent antitumor effectiveness of PDT at 808 nm NIR light excitation,avoiding the laser irradiation-induced overheating issue.This study provides new insights for the development of highly efficient PDT nanodrugs toward precision theranostics. | Zhike Li Xi Qiao Guihua He Xin Sun Danhua Feng Liefeng Hu Hua Xu Hai-Bing Xu Shengqian Ma Jian Tian | 2020 | Nano Research2020，13，12： | 2 |
| 7 | Involvement of post?transcriptional regulation of FOXO1 by HuR in 5?FU?inducedapoptosis in breast cancer cells显示文摘 | Yunbo Li Jinhai Yu Danhua Du Shuanglin Fu Ye Chen Fang Yu Peng Gao | 2013 | Oncology Letters2013，，1： | 2 |
| 8 | Heterologous prime-boost with AdC68- and mRNA-based COVID-19 vaccines elicit potent immune responses in mice显示文摘Dear Editor An optimal vaccination program that can elicit Iong-lasting humoral and cellular immune response is key to Iong-term prevention of coronavirus disease 2019(COVID-19).Multiple variants of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)continue to emerge.The neutralizing capacities of available COVID-19 vaccines against these variants have declined.^(1) In such a scenario,heterologous prime-boost programs for COVID-19 vaccines have attracted considerable interest. | Wenjuan Li Xingxing Li Danhua Zhao Jingjinq Liu Ling Wang Miao Li Xinyu Liu Jia Li Xiaohong Wu Yuhua Li | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 1 |
| 9 | Child sexual abuse and its relationship with health risk behaviors among rural children and adolescents in Hunan, China显示文摘 | Danhua Lin Xiaoming Li Xinghua Fan Xiaoyi Fang | 2011 | Child Abuse & Neglect2011，，9： | 1 |
| 10 | The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients显示文摘 | Xinrui Liang Danhua Li Wenwen Geng Xuchen Cao Chunhua Xiao | 2013 | Tumor Biology2013，，2： | 1 |
| 11 | Alcohol Intoxication and Sexual Risk Behaviors among Rural to Urban Migrants in China 显示文摘 | Danhua Lin Xiaoming Li Hongmei Yang | 2005 | Drug Alcohol Depend2005，79，1： | 1 |
| 12 | cDNA microarray analysis and immunohistochemistry reveal a distinct molecular phenotype in serous endometrial cancer compared to endometrioid endometrial cancer显示文摘 | Yonghua Chen Yuanyang Yao Lili Zhang Xiaoping Li Yue Wang Lijun Zhao Jianliu Wang Gongwei Wang Danhua Shen Lihui Wei Jianqing Zhao | 2011 | Experimental and Molecular Pathology2011，，1： | 1 |
| 13 | Parental HIV/AIDS and psychosocial adjust ment among rural Chinese children 显示文摘 | Fang Xiaoyi Li Xiaoming Stanton Bonita Hong Yan Zhang Liying Zhao Guoxiang Zhao Junfeng Lin Xiuyun Lin Danhua | 2009 | Journal of Pediatric Psychology2009，，3410： | 1 |
| 14 | Characteristics of molecular classification in 52 endometrial cancer and atypical hyperplasia patients receiving fertility-sparing treatment显示文摘Objective To investigate the molecular classification of endometrial cancer(EC)and atypical endometrial hyperplasia(AEH)patients treated with fertility-sparing treatment(FST),and its relationship with clinicopathological factors and treatment efficacy.Methods:A total of 52EC and AEH patients who received FST and molecular classification tested by next generation sequencing in Peking University People's Hospital from June 2020 to December 2022,were retrospectively collected.We analyzed the relationship between molecular classification and clinicopathological factors and treatment outcomes.Results(1)Of the 52 patients,including 46EC and 6 AEH patients,42(80.8%)achieved complete remission(CR)after FST,with a median time to achieve CR of 9 months.Ten cases(23.8%)had recurrence.(2)Patients were distributed into 4 molecular subgroups as 39 cases(75%)of copy number low(CNL),7 cases(13.5%)of microsatellite instability-high(MSI-H),4 cases(7.7%)of POLE mutations(POLEmut),and 2 cases(3.8%)of copy number high(CNH).Patients with MSI-H subgroup had more family history of tumor(6/7),more with loss of expression of mismatch repair(MMR)protein(7/7),and higher expression level of Ki-67(3/3).(3)Patients with MSI-H subgroup had the lowest CR rate at 6 months(0/7,P=0.014),and survival analysis showed that such patients were less likely to achieve CR than those with CNL(P=0.022).For CNL patients,median 6-month CR rate was 40.6%.In addition,CR was obtained in 3(3/4)POLEmut patients and 2(2/2)CNH patients,respectively.Conclusions Molecular classification relates with the treatment response in patients with EC and AEH receiving FST.Patients with MSI-H subgroup have poor treatment efficacy,and patients with CNL need to be further divided to predict treatment benefit.There are also a few successful cases in POLEmut and CNH subtgroups,which needs further research. | Yiqin Wang Nan Kang Liwei Li Zhiqi Wang Rong Zhou Danhua Shen Jianliu Wang | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，1： | 1 |
| 15 | Summertime photochemical pollution in Beijing显示文摘 | TANG Xiaoyan LI Jinlong CHEN Danhua | 1995 | Pure Applied Chemistry1995，67，： | 1 |
| 16 | Simple and sensitive assay for nucleic acids by use of the resonancelight-scattering technique with copper phthalocyanine tetrasulfonic acid in the presence ofcetyltrimethylammonium bromide显示文摘 | Yongxin Li Yuqin Wu Jinlong Chen Changqin Zhu Lun Wang Sujuang Zhuo Danhua Zhao | 2003 | Analytical and Bioanalytical Chemistry2003，377，4： | 1 |
| 17 | Rural-to-Urban Migrants and the HIV Epidemic in China显示文摘 | Yan Hong Bonita Stanton Xiaoming Li Hongmei Yang Danhua Lin Xiaoyi Fang Jing Wang Rong Mao | 2006 | AIDS and Behavior2006，，4： | 1 |
| 18 | If We Don’t Let the Environment Down,the Environment Won’t Let Us Down显示文摘On April 21,2020,President Xi Jinping paid a special visit to Nuwa Phoenix Modern Tea Industry Demonstration Park in the remote mountain village of Jiangjiaping.After talking with a number of tea growers there,he made the following heartfelt statement:“If we don’t let the environment down,the environment won’t let us down.Lucid waters and lush mountains are not only natural riches,but also material riches.I hope that you keep following a path of green development that makes protecting the environment the priority,and use tea as the means of growing your businesses and wealth so that you can shake off poverty and reach moderate prosperity.” | Zhou Luming Li Danhua | 2020 | Qiu Shi2020，12，6： | 0 |
| 19 | Biomimetic hybrid hydrogel for hemostasis,adhesion prevention and promoting regeneration after partial liver resection显示文摘Partial liver resection is an established treatment for hepatic disorders.However,surgical bleeding,intra-abdominal adhesion and rapid liver regeneration are still major challenges after partial liver resection,associated with morbidity and mortality.Herein,a biomimetic hybrid hydrogel,composed of oxidized hyaluronic acid,glycol chitosan and MenSCs-derived conditioned medium(CM),is presented to address these issues.The hybrid hydrogel is formed through reversible Schiff base,and possesses injectability and self-healing capability.Moreover,hybrid hydrogel exhibits the capabilities of hemostasis,anti-infection,tissue adhesion and controllable release of cargoes.Based on in vivo studies of the multifunctional hybrid hydrogel,it is demonstrated that acute bleeding in partial liver resection can be ceased immediately by virtue of the hemostasis features of hybrid hydrogel.Also,a significant reduction of intra-abdominal adhesion is confirmed in hybrid hydrogel-treated resection surface.Furthermore,upon the treatment of hybrid hydrogel,hepatic cell proliferation and tissue regeneration can be significantly improved due to the controllably released cytokines from MenSCs-derived CM,exerting the effects of mitogenesis and anti-inflammation in vivo.Thus,the biomimetic hybrid hydrogel can be a promising candidate with great potential for application in partial liver resection. | Zuhong Li Yalei Zhao Xiaoxi Ouyang Ya Yang Yangjun Chen Qixia Luo Yanhong Zhang Danhua Zhu Xiaopeng Yu Lanjuan Li | 2022 | Bioactive Materials2022，7，5： | 0 |
| 20 | Neuroendocrine carcinoma of the cervix:A comprehensive clinicopathologic study and literature review显示文摘Aims Neuroendocrine carcinoma of the cervix(NECC)is a rare variant of cervical cancer.This study aims to investigate the clinicopathological features and prognosis of NECC.Methods A retrospective analysis was conducted on twenty-one patients diagnosed with NECC between May 2008 and September 2021at Peking University People's Hospital.The study involved histopathological examination,immunohistochemistry,ThinPrep cytology test(TCT),and high-risk HPV hybrid capture 2(HC2)assay.Follow-up was conducted through telephone interviews and medical records for a range of 3–160 months,with an average follow-up period of 49.8 months.Results The average age of the patients was 48.6 years(range:33–69 years).Seventeen patients were diagnosed with neuroendocrine carcinoma through biopsy.Nine cases underwent TCT and HC2 tests before biopsy,and TCT results of four cases showed high-grade squamous intraepithelial lesion(HSIL).High-risk HPV(HR-HPV)positive was detected in seven cases.The cancer cells exhibited consistent morphological features,including sparse cytoplasm,intensely stained nuclei,and extensive neoplastic necrosis.Thirteen cases were classified as pure NECC(61.9%),while eight cases were mixed types(38.1%).Three cases were associated with squamous cell carcinoma(SCC),and five cases were associated with adenocarcinoma.Prognosis varied significantly among these subtypes(p<0.05).The overall survival rate in the follow-up period was 66.7%(12/18).Conclusions NECC is an extremely rare and highly aggressive tumor with a poor prognosis,particularly in cases of mixed histology.It is strongly associated with HPV infection.TCT and HPV testing significantly enhance the detection rate before the biopsy.The diagnosis of NECC relies on histological and immunohistochemical examinations.This study provides valuable clinical observations on NECC and emphasizes the importance of early detection and accurate diagnosis for improved patient outcomes. | Xiaobo Zhang Mingzhu Li Guo Zhang Danhua Shen | 2023 | Gynecology and Obstetrics Clinical Medicine2023，3，3： | 0 |
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