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| 1 | Non-alcoholic fatty liver disease:An expanded review显示文摘Non-alcoholic fatty liver disease(NAFLD) encompasses the simple steatosis to more progressive steatosis with associated hepatitis, fibrosis, cirrhosis, and in some cases hepatocellular carcinoma. NAFLD is a growing epidemic, not only in the United States, but worldwide in part due to obesity and insulin resistance leading to liver accumulation of triglycerides and free fatty acids. Numerous risk factors for the development of NAFLD have been espoused with most having some form of metabolic derangement or insulin resistance at the core of its pathophysiology. NAFLD patients are at increased risk of liver-related as well as cardiovascular mortality, and NAFLD is rapidly becoming the leading indication for liver transplantation. Liver biopsy remains the gold standard for definitive diagnosis, but the development of noninvasive advanced imaging, biochemical and genetic tests will no doubt provide future clinicians with a great deal of information and opportunity for enhanced understanding of the pathogenesis and targeted treatment. As it currently stands several medications/supplements are being used in the treatment of NAFLD; however, none seem to be the 'magic bullet' in curtailing this growing problem yet. In this review we summarized the current knowledge of NAFLD epidemiology, risk factors, diagnosis, pathogenesis, pathologic changes, natural history, and treatment in order to aid in further understanding this disease and better managing NAFLD patients. | Mark Benedict Xuchen Zhang | 2017 | World Journal of Hepatology2017，9，16： | 54 |
| 2 | Era of universal testing of microsatellite instability in colorectal cancer显示文摘Colorectal cancer (CRC) incidence and mortality are constantly decreasing, but CRC still remains the third most prevalent cancer and the third most common cause of cancer death in both males and females in the United States. Recent rapid declines in CRC incidence rates have largely been attributed to increases in screening that can detect and remove precancerous polyps, and the decrease in death rates for CRC largely reflects improvements in early detection, treatment and the understanding of molecular/genetic basis of CRC. One of the important molecular/genetic findings is the presence of microsatellite instability (MSI) in CRCs. Many studies have shown the importance of MSI testing in diagnosing Lynch syndrome and predicting prognosis and response to chemotherapeutic agents in CRCs. Increased emphasis has been placed on the importance of MSI testing for all newly diagnosed individuals with CRCs. Both immunohistochemical staining (IHC) and polymerase chain reaction (PCR)-based MSI testing show high sensitivity and specificity in detecting MSI. The current clinical guidelines and histopathology features are indicative of, but not reliable in diagnosing Lynch syndrome and CRCs with MSI. Currently, there are evidences that universal testing for MSI starting with either IHC or PCR-based MSI testing is cost effective, sensitive, specific and is getting widely accepted. | Xuchen Zhang Jia Li | 2013 | World Journal of Gastrointestinal Oncology2013，5，2： | 16 |
| 3 | Autophagy inhibition enhances apigenin-induced apoptosis in human breast cancer cells显示文摘Apigenin (4',5,7-trihydroxyflavone) is a member of the flavone subclass of flavonoids present in fruits and vegetables. The involvement of autophagy in the apigenin-induced apoptotic death of human breast cancer cells was investigated. Cell proliferation and viability were assessed by 3-(4,5-dimethylthiazol- 2-yl)-2,5-diphenyltetrazolium bromide (MTT) and clonogenic assays. Flow cytometry, fluorescent staining and Western blot analysis were employed to detect apoptosis and autophagy, and the role of autophagy was assessed using autophagy inhibitors. Apigenin dose- and time-dependently repressed the proliferation and clonogenic survival of the human breast cancer T47D and MDA-MB-231 cell lines. The death of T47D and MDA-MB-231 cells was due to apoptosis associated with increased levels of Caspase3, PARP cleavage and Bax/Bcl-2 ratios. The results from flow cytometry and fluorescent staining also verified the occurrence of apoptosis. In addition, the apigenin-treated cells exhibited autophagy, as characterized by the appearance of autophagosomes under fluorescence microscopy and the accumulation of acidic vesicular organelles (AVOs) by flow cytometry. Furthermore, the results of the Western blot analysis revealed that the level of LC3-II, the processed form of LC3-I, was increased. Treatment with the autophagy inhibitor, 3-methyladenine (3-MA), significantly enhanced the apoptosis induced by apigenin, which was accompanied by an increase in the level of PARP cleavage. Similar results were also confirmed by flow cytometry and fluorescence microscopy. These results indicate that apigenin has apoptosis-and autophagy-inducing effects in breast cancer cells. Autophagy plays a cyto-protective role in apigenin-induced apoptosis, and the combination of apigenin and an autophagy inhibitor may be a promising strategy for breast cancer control. | Xuchen Cao Bowen Liu Wenfeng Cao Weiran Zhang Fei Zhang Hongmeng Zhao Ran Meng Lin Zhang Ruifang Niu Xishan Hao Bin Zhang | 2013 | Chinese Journal of Cancer Research2013，25，2： | 12 |
| 4 | Preservation of black carbon in the shelf sediments of the East China Sea显示文摘Concentrations and carbon isotopic(14C,13C) compositions of black carbon(BC) were measured for three sediment cores collected from the Changjiang River estuary and the shelf of the East China Sea. BC concentrations ranged from 0.02 to 0.14 mg/g(dry weight) ,and accounted for 5% to 26% of the sedimentary total organic carbon(TOC) pool. Among the three sediment cores collected at each site,sediment from the Changjiang River estuary had relatively high BC contents compared with the sedi-ments from the East China Sea shelf,suggesting that the Changjiang River discharge played an im-portant role in the delivery of BC to the coastal region. Radiocarbon measurements indicate that the ages of BC are in the range of 6910 to 12250 years old B.P.(before present) ,that is in general,3700 to 9000 years older than the 14C ages of TOC in the sediments. These variable radiocarbon ages suggest that the BC preserved in the sediments was derived from the products of both biomass fire and fossil fuel combustion,as well as from ancient rock weathering. Based on an isotopic mass balance model,we calculated that fossil fuel combustion contributed most(60%―80%) of the BC preserved in these sediments and varied with depth and locations. The deposition and burial of this 'slow-cycling' BC in the sediments of the East China Sea shelf represent a significant pool of carbon sink and could greatly influence carbon cycling in the region. | WANG XuChen LI AnChun | 2007 | Chinese Science Bulletin2007，52，22： | 11 |
| 5 | Calcifying fibrous tumor of the gastrointestinal tract: A clinicopathologic review and update显示文摘Calcifying fibrous tumor(CFT)is a rare mesenchymal lesion that has been documented throughout the gastrointestinal tract.Gastrointestinal CFTs may occur at virtually any age,with a predilection for adults and for females.They occur most commonly in the stomach and the small and large intestines.CFTs are most often found incidentally,cured by local resection,and have a low risk of recurrence.Histology shows three characteristic features:Spindle cell proliferations within a densely hyalinized stroma,scattered calcifications,and lymphoplasmacytic inflammation.CFTs are immunoreactive for CD34,vimentin and factor XIIIa,helping to distinguish them from other benign mesenchymal neoplasms.The differential diagnosis of CFTs includes sclerosing gastrointestinal stromal tumor,leiomyoma,schwannoma,solitary fibrous tumor,inflammatory myofibroblastic tumor,plexiform fibromyxoma,fibromatosis,sclerosing mesenteritis,and reactive nodular fibrous pseudotumor.The pathogenesis of CFTs remains unclear,but some have hypothesized that they may be linked to IgG4-related disease,inflammatory myofibroblastic lesions,hyaline vascular type Castleman disease,sclerosing angiomatoid nodular transformation of the spleen,or trauma. | Donald Turbiville Xuchen Zhang | 2020 | World Journal of Gastroenterology2020，26，37： | 9 |
| 6 | A preliminary analysis of phylogenetic relationships of Arundinaria and related genera based on nucleotide sequences of nrDNA (ITS region) and cpDNA (trnL-F intergenic spacer)显示文摘Phylogenetic relationships of Arundinaria and related genera (Pleioblastus, Pseudosasa, Oligostachyum, Bashania, Clavinodum, etc.) were assessed by analyzing the sequences of the nrDNA internal transcribed spacer (ITS) and the cpDNA trnL-F intergenic spacer (IGS). Comparison with trnL-F IGS sequence, the ITS region provided the higher number of parsimony informative characters, and the interspecific variation of the ITS sequence was higher than that of the trnL-F IGS sequence.The tree obtained by combining both sets of data showed that the species sampled in Arundinaria and the related genera were monophyletic and divided into two clades. The relationships and positioning of all the taxa surveryed (including A. oleosa, A. hsienchuensis, A. chino, A. amara, A. yixingensis, A. amabilis, A. fortunei, A. pygmaea, A. gramineus, A. fargesii, A. faberi, A. hupehense, Pseudosasa japonica cv. Tsutsumiana, P. japonica and Brachystachyum densiflorum) were also discussed. The results from the sequences were broadly consistent with morphological characters, appearing all these taxa sampled belong to the genus of Arundinaria. The topologies of the trees generated from individual data and the combined data were similar. | ZHUGEQiang DINGYu-long XUChen ZOUHui-yu HUANGMin-ren WANGMing-xiu | 2005 | Journal of Forestry Research2005，16，1： | 5 |
| 7 | Preparation and characterization of urea-formaldehyde resin]reactive kaolinite composites显示文摘 | Shiwei CheN Xuchen Lu Tizhuang Wang Zhimin Zhang | 2016 | Particuology2016，14，1： | 5 |
| 8 | A method to improve fluidization quality in gas-solid fluidized bed for fine coal beneficiation显示文摘Dry coal separation has become essential in China because it does not consume water and it reduces environmental pollution. In this study, a method for improving fluidization quality in a fluidized bed separator using a micropore sponge is proposed. The separator is used for fine coal beneficiation. The pressure drop across the distributor and bed fluidization characteristics were analyzed to evaluate fluidization quality. The beneficiation efficiency for fine coal was further investigated by using a laboratory-scale fluidized bed with and without a micropore sponge. With the sponge, the highest pressure drop fluctuation factor decreased from 0.23 to 0.16, indicating an improvement in density stability. The modified separation method reduced the ash content of a sample of fine coal from 23.83% to 10.70%. The probable error efficiency value E for -6 + 3 mm coal was 0.12g/cm^3, close to the efficiency error values reported for other dry-beneficiation techniques. The separation results show that using a sponge in the fluidized bed can readily improve the efficiency of fine coal beneficiation. | Chenyang Zhou Xuchen Fan Chenlong Duan Yuemin Zhao | 2019 | Particuology2019，17，2： | 4 |
| 9 | An Effective Method of UV-Oxidation of Dissolved Organic Carbon in Natural Waters for Radiocarbon Analysis by Accelerator Mass Spectrometry显示文摘Radiocarbon(14C) measurement of dissolved organic carbon(DOC) is a very powerful tool to study the sources, transformation and cycling of carbon in the ocean. The technique, however, remains great challenges for complete and successful oxidation of sufficient DOC with low blanks for high precision carbon isotopic ratio analysis, largely due to the overwhelming proportion of salts and low DOC concentrations in the ocean. In this paper, we report an effective UV-Oxidation method for oxidizing DOC in natural waters for radiocarbon analysis by accelerator mass spectrometry(AMS). The UV-oxidation system and method show 95%± 4% oxidation efficiency and high reproducibility for DOC in both river and seawater samples. The blanks associated with the method was also low(about 3 μg C) that is critical for 14 C analysis. As a great advantage of the method, multiple water samples can be oxidized at the same time so it reduces the sample processing time substantially compared with other UV-oxidation method currently being used in other laboratories. We have used the system and method for 14 C studies of DOC in rivers, estuaries, and oceanic environments and have received promise results. | XUE Yuejun GE Tiantian WANG Xuchen | 2015 | Journal of Ocean University of China2015，14，6： | 3 |
| 10 | Hydrothermal Synthesis and Crystal Structure of Zinc(Ⅱ) Dinicotinate Complex [Zn(nic)_2(H_2O)_4](nic=nicotinic acid):A Three-dimensional Hydrogen-bond Network显示文摘 | MAOHong-yan ZHANGZong-pei ZHANGHong-yun XUChen WANGEn-bo WUQing-an ZHUYu | 2004 | Chemical Research in Chinese Universities2004，20，3： | 2 |
| 11 | 解脲脲原体引起生殖细胞凋亡显示文摘目的:研究解脲脲原体感染对雄性大鼠生殖细胞凋亡的影响。方法:雄性大鼠人工感染解脲脲原体血清型8(T960)。光镜下观察曲细精管内和附睾腔内生殖细胞的形态变化;以荧光标记的Fas和Fas配基(PasL)多克隆抗体定位Fas和FasL;以碱性磷酸酶法进行生殖细胞和支持细胞的TUNEL染色;以KS400影像分析系统分析TUNEL染色阳性率(阳性细胞百分率)和TUNEL染色阳性区域(染色细胞占据的区域),以琼脂糖凝胶电泳法进行DNA梯度分析。结果:解脲脲原体感染大鼠后,导致:(1)脱落的生殖细胞显著增多,在曲细精管和附睾腔内可见多核巨细胞;(2)TUNEL染色阳性细胞和阳性区域显著增加;(3)在生殖细胞和支持细胞中Fas和FasL表达升调;(4)睾丸细胞中出现离散的DNA片断。结论:解脲脲原体感染增强了雄性大鼠生殖细胞的凋亡。 | XUChen LUMei-ge 等 | 2002 | 生殖与避孕2002，22，1： | 2 |
| 12 | Seasonal fluxes and source variation of organic carbon transported by two major Chinese Rivers: The Yellow River and Changjiang (Yangtze) River显示文摘 | Wang Xuchen Ma Haiqing Li Ronghua Song Zhensu Wu Jinping | 2012 | EN2012，，2： | 2 |
| 13 | Russell body duodenitis with immunoglobulin kappa light chain restriction显示文摘Russell bodies are eosinophilic intracytoplasmic globules which are likely the result of disturbed secretion of immunoglobulins that accumulate within the plasma cell. Russell body collections have been identified within the stomach, known as Russell body gastritis. Similar lesions within the duodenum are referred to as Russell body duodenitis, which is rare. Several Russell body gastritis case reports are associated with Helicobacter pylori. However, the etiology of Russell body duodenitis remains unclear. Here we report the first case of Russell body duodenitis with immunoglobulin light chain restriction in a background of peptic duodenitis. | William R Munday Lucy Harn Kapur Mina Xu Xuchen Zhang | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，1： | 2 |
| 14 | Goose Toll-like receptor 7 (TLR7), myeloid differentiation factor 88 (MyD88) and antiviral molecules involved in anti-H5N1 highly pathogenic avian influenza virus response显示文摘 | Liangmeng Wei Peirong Jiao Runyu Yuan Yafen Song Pengfei Cui Xuchen Guo Bofang Zheng Weixin Jia Wenbao Qi Tao Ren Ming Liao | 2013 | 2013 (1-2)2013，，1： | 1 |
| 15 | A Vaccine Based on the Receptor-Binding Domain of the Spike Protein Expressed in Glycoengineered Pichia pastoris Targeting SARS-CoV-2 Stimulates Neutralizing and Protective Antibody Responses显示文摘In 2020 and 2021,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),a novel coronavirus,caused a global pandemic.Vaccines are expected to reduce the pressure of prevention and control,and have become the most effective strategy to solve the pandemic crisis.SARS-CoV-2 infects the host by binding to the cellular receptor angiotensin converting enzyme 2(ACE2)via the receptor-binding domain(RBD)of the surface spike(S)glycoprotein.In this study,a candidate vaccine based on a RBD recombinant subunit was prepared by means of a novel glycoengineered yeast Pichia pastoris expression system with characteristics of glycosylation modification similar to those of mammalian cells.The candidate vaccine effectively stimulated mice to produce high-titer anti-RBD specific antibody.Furthermore,the specific antibody titer and virus-neutralizing antibody(NAb)titer induced by the vaccine were increased significantly by the combination of the double adjuvants Al(OH)_(3) and CpG.Our results showed that the virus-NAb lasted for more than six months in mice.To summarize,we have obtained a SARS-CoV-2 vaccine based on the RBD of the S glycoprotein expressed in glycoengineered Pichia pastoris,which stimulates neutralizing and protective antibody responses.A technical route for fucose-free complex-type N-glycosylation modified recombinant subunit vaccine preparation has been established. | Bo Liu Ying Yin Yuxiao Liu Tiantian Wang Peng Sun Yangqin Ou Xin Gong Xuchen Hou Jun Zhang Hongguang Ren Shiqiang Luo Qian Ke Yongming Yao Junjie Xu Jun Wu | 2022 | Engineering2022，8，6： | 1 |
| 16 | The prognosis of synchronous and metachronous bilateral breast cancer in Chinese patients显示文摘 | Xinrui Liang Danhua Li Wenwen Geng Xuchen Cao Chunhua Xiao | 2013 | Tumor Biology2013，，2： | 1 |
| 17 | Functions of the nicotinamide adenine dinucleotide phosphate oxidase family in G anoderma lucidum : an essential role in ganoderic acid biosynthesis regulation, hyphal branching, fruiting body development, and oxidative‐stress resistance显示文摘 | Dashuai Mu Chenyang Li Xuchen Zhang Xiongbiao Li Liang Shi Ang Ren Mingwen Zhao | 2014 | Environ Microbiol2014，，6： | 1 |
| 18 | Fluorescence characterization and microbial degradation of dissolved organic matter leached from salt marsh plants in the Yellow River Delta显示文摘盐沼植被是沿海水体中溶解有机物(Dissolved Organic Matter,DOM)的重要贡献者。然而,不同盐沼植物释放DOM的动力学特征尚缺乏系统研究和比较。黄河三角洲湿地是中国东海岸面积最大,保护最完善的沿海生态系统之一。本论文研究了2016年10月从黄河三角洲(Yellow River Delta,YRD)盐沼中采集的三种常见沼泽植物(芦苇(Phragmites australis),碱蓬(Suaeda salsa)和獐茅(Aeluropus littoralis)的DOM释放过程。通过测定溶解有机碳(Dissolved Organic Carbon,DOC)和溶解氮(Dissolved Nitrogen,DN)发现,植物叶片释放的DOM浓度远高于其根和茎。在27天的培养期内,平均有15%的生物碳和30%的生物氮以DOC和DN的形式通过植物叶片释放。从植物中释放的DOM非常不稳定,在27天的培养期内,细菌共消耗了92.4%-98.1%的DOC和88.0%-94.6%的DN。植物释放DOM的荧光特性表明,发色溶解的有机物(Chromophoric Dissolved Organic Matter,CDOM)是DOM的主要组分,而类蛋白组分是植物释放CDOM的主要组分。细菌的降解作用改变了DOM的荧光性质和化学组成。上述的室内研究结果得到了实地调查的充分支撑,表明在深秋时期黄河口湿地有大量DOM溢出。本研究结果表明,盐沼植物释放的DOM是沼泽和沿海水域DOC和DN的重要来源,而且易降解DOC和DN为黄河口湿地和邻近沿海水域中的微生物群落提供了重要的食物来源。 | Tao Zhang Zhihua Feng Chunle Luo Yixin Sun Jinzhen Li Juntian Xu Xuchen Wang | 2020 | Journal of Plant Ecology2020，13，5： | 1 |
| 19 | Clinical benefits of mastectomy on treatment of occult breast carcinoma presenting axillary metastases显示文摘 | Xin W Ying Z Xuchen C | 2010 | The Breast Journal2010，16，1： | 1 |
| 20 | Synthesis and Crys- tallization Kinetics of ZSM-5 Without Organic Template from Coal-Series Kaolinite 显示文摘 | Pan Fend Lu Xuchen Wang Yun | 2014 | Microporous Mesoporous Mater2014，184，15： | 1 |
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