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| 1 | Effect of nitrogen on corrosion behaviour of a novel high nitrogen medium-entropy alloy CrCoNiN manufactured by pressurized metallurgy显示文摘A novel high nitrogen medium-entropy alloy CrCoNiN, which had higher strength and slightly lower ductility than CrCoNi alloy, was successfully manufactured by pressurized metallurgy. The microstructure and corrosion behaviour were investigated by microscopic, electrochemical and spectroscopic methods.The results indicated that nitrogen existed in the form of Cr_2N precipitates and uniformly distributed N atoms, and nitrogen alloying significantly refined the grain size. Besides, nitrogen enriched on the outmost surface of passive film and metal/film interface as ammonia(NH-_3 and NH_4^+) and CrN, respectively. The significant improvement of corrosion resistance of CrCoNiN was attributed to the lower metastable pitting susceptibility together with thicker, less defective and more compact passive film. | Hao Feng Huabing Li Xiaolei Wu Zhouhua Jiang Si Zhao Tao Zhang Dake Xu Shucai Zhang Hongchun Zhu Binbin Zhang Muxin Yang | 2018 | Journal of Materials Science & Technology2018，34，10： | 8 |
| 2 | A novel Cu-bearing high-entropy alloy with significant antibacterial behavior against corrosive marine biofilms显示文摘The design of novel high-entropy alloys(HEAs)provides a unique opportunity for the development of structure-function integrated materials with high mechanical and antimicrobial properties.In this study,by employing the antibacterial effect of copper,a novel Al0.4CoCrCuFeNi HEA with broad-spectrum antibacterial and strong mechanical properties was designed.High concentrations of copper ions released from the HEA prevented growth and biofilm formation by biocorrosive marine bacterial species.These findings serve as a proof-of-concept for further development of unique HEA materials with high antimicrobial efficiency and mechanical properties,compared to conventional antibacterial alloys. | Enze Zhou Dongxu Qiao Yi Yang Dake Xu Yiping Lu Jianjun Wang Jessica A.Smith Huabing Li Hongliang Zhao Peter K.Liaw Fuhui Wang | 2020 | Journal of Materials Science & Technology2020，42，11： | 6 |
| 3 | Effect of Cu Addition to 2205 Duplex Stainless Steel on the Resistance against Pitting Corrosion by the Pseudomonas aeruginosa Biofilm显示文摘The effect of copper addition to 2205 duplex stainless steel(DSS) on its resistance against pitting corrosion by the Pseudomonas aeruginosa biofilm was investigated using electrochemical and surface analysis techniques. Cu addition decreased the general corrosion resistance, resulting in a higher general corrosion rate in the sterile medium. Because DSS usually has a very small general corrosion rate, its pitting corrosion resistance is far more important. In this work, it was shown that 2205-3%Cu DSS exhibited a much higher pitting corrosion resistance against the P. aeruginosa biofilm compared with the 2205 DSS control, characterized by no significant change in the pitting potential and critical pitting temperature(CPT) values. The strong pitting resistance ability of 2205-3%Cu DSS could be attributed to the copper-rich phases on the surface and the release of copper ions, providing a strong antibacterial ability that inhibited the attachment and growth of the corrosive P. aeruginosa biofilm. | Ping Li Yang Zhao Yuzhi Liu Ying Zhao Dake Xu Chunguang Yang Tao Zhang Tingyue Gu Ke Yang | 2017 | Journal of Materials Science & Technology2017，33，7： | 5 |
| 4 | Enhanced resistance of 2205 Cu-bearing duplex stainless steel towards microbiologically influenced corrosion by marine aerobic Pseudomonas aeruginosa biofilms显示文摘An antibacterial 2205-Cu duplex stainless steel(DSS)was shown to inhibit the formation and growth of corrosive marine biofilms by direct contact with copper-rich phases and the release of Cu^(2+)ions from the2205-Cu DSS surface.In this work,the microbiologically influenced corrosion(MIC)resistance of 2205-Cu DSS in the presence of the corrosive marine bacterium Pseudomonas aeruginosa was investigated.The addition of copper improved the mechanical properties such as the yield strength,the tensile strength and the hardness of 2205 DSS.Electrochemical test results from linear polarization resistance(LPR),electrochemical impedance spectroscopy(EIS)and critical pitting temperature(CPT)measurements showed that 2205-Cu DSS possessed a larger polarization resistance(R_p),charge transfer resistance(R_(ct))and CPT values,indicating the excellent MIC resistance of 2205-Cu DSS against the corrosive P.aeruginosa biofilm.The live/dead staining results and the SEM images of biofilm confirmed the strong antibacterial ability of 2205-Cu DSS.The largest pit depth of 2205-Cu DSS was considerably smaller than that of 2205 DSS after 14 d in the presence of P.aeruginosa(2.2μm vs 12.5μm).2205-Cu DSS possessed a superior MIC resistance to regular 2205 DSS in the presence of aerobic P.aeruginosa. | Dake Xu Enze Zhou Ying Zhao Huabing Li Zhiyong Liu Dawei Zhang Chunguang Yang Hai Lin Xiaogang Li Ke Yang | 2018 | Journal of Materials Science & Technology2018，34，8： | 4 |
| 5 | Applicability of the Welch method for examining self-noise level parameters for broadband seismometers显示文摘Seismometer self-noise levels were determined using Sleeman's three-sensor method in combination with the Welch method for different parameter combinations. The self-noise levels decreased with the increasing segment window length, which is equivalent to the subwindow length, and with the increasing segment overlap rate for different frequency points at a fixed band. After the statistical examination of 9800 different parameter combinations, a zone of reasonable self-noise calculation parameter combinations was identified. Reasons for the unsuitability of certain parameter combinations were explored with respect to their distortion of the seismometer's self-noise levels. | Li Xiaojun Yang Dake Xie Jianbo Ma Jiemei Yuan Songyong Xu Weiwei Zhao Jianhe Li Dongsheng | 2015 | Geodesy and Geodynamics2015，6，3： | 3 |
| 6 | Two New C19-Diterpenoid Alkaloids with Anti-inflammatory Activity from Aconitum iochanicum显示文摘二新 C 19-diterpenoid 碱, 7,8-epoxy-franchetine (1 ) 和 N (19 )-en-austroconitine A (2 ) ,从 Aconitum iochanicum 被孤立。化合物 1 是有一个 7,8 环氧基树脂单位的新 C 19-diterpenoid 碱。他们的结构被包括的全面分光镜的分析阐明紫外,红外, MS, 1D 和 2D NMR。生物活动测试显示二新混合物对氮的氧化物展出了禁止的活动(没有) 在激活 LPS 的 RAW264.7 巨噬细胞的生产。与积极控制相比,二新混合物分别地与 27.3% 和 29.2% 的抑制率显示出弱反煽动性的效果。 | Ruihua Guo Chengxin Guo Dan He Dake Zhao Yong Shen | 2017 | Chinese Journal of Chemistry2017，35，10： | 3 |
| 7 | Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer显示文摘 | Liang He Dake Chu Xia Li Jianyong Zheng Shanhong Liu Jipeng Li Qingchuan Zhao Gang Ji | 2013 | Digestive Diseases and Sciences2013，，5： | 2 |
| 8 | Investigation of melt-growth alumina/aluminum titanate composite ceramics prepared by directed energy deposition显示文摘Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics with low thermal expansion properties are promising for the rapid preparation of large-scale and complex components by directed energy deposition-laser based(DED-LB)technology.However,the wider application of DED-LB technology is limited due to the inadequate understanding of process conditions.The shaping quality,microstructure,and mechanical properties of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13)(6 mol%TiO_(2))composite ceramics were systematically investigated as a function of energy input in an extensive process window.On this basis,the formation mechanism of solidification defects and the evolution process of microstructure were revealed,and the optimized process parameters were determined.Results show that high energy input improves the fluidity of the molten pool and promotes the uniform distribution and full growth of constituent phases,thus,facilitating the elimination of solidification defects,such as pores and strip gaps.In addition,the microstructure size is strongly dependent on the energy input,increasing when the energy input increases.Moreover,the morphology of theα-Al_(2)O_(3) phase gradually transforms from cellular into cellular dendrite with increasing energy input due to changing solidification conditions.Under the comprehensive influence of solidification defects and microstructure size,the fracture toughness and flexural strength of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics present a parabolic law behavior as the energy input increases.Optimal shaping quality and excellent mechanical properties are achieved at an energy input range of 0.36-0.54 W*min^(2) g^(-1) mm^(-1).Within this process window,the average microhardness,fracture toughness,and flexural strength of Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics are up to 1640 Hv,3.87 MPa m^(1/2),and 227 MPa,respectively.This study provides practical guidance for determining the process parameters of DED-LB of melt growth Al_(2)O_(3)/Al_(6)Ti_(2)O_(13) composite ceramics. | Yunfei Huang Dongjiang Wu Dake Zhao Fangyong Niu Guangyi Ma | 2021 | International Journal of Extreme Manufacturing2021，3，3： | 2 |
| 9 | Improved corrosion resistance and biofilm inhibition ability of copper-bearing 304 stainless steel against oral microaerobic Streptococcus mutans显示文摘304 stainless steel(SS) used as orthodontic wire during orthodontics faces the risk of microbiologically influenced corrosion(MIC) due to diverse flora environment. Hereinto, Streptococcus mutans(S. mutans)is the most important cariogenic bacteria. In this work, MIC behavior of a new 304-Cu SS in presence of S. mutans was studied by the observations using scanning electron microscopy(SEM) and confocal laser scanning microscopy(CLSM) including live/dead staining, extracellular polymeric substance(EPS)staining and pitting corrosion, electrochemical test, and X-ray photoelectron spectroscopy(XPS). Above results showed that 304-Cu SS possessed excellent biofilm inhibition ability and presented lower corrosion current density(icorr), larger polarization resistance(Rp) and charge transfer resistance(Rct) in the presence of S. mutans, indicating that 304-Cu SS had a better MIC resistance against S. mutans. It was further affirmed by XPS results that the presence of Cu-oxide in passive film of 304-Cu SS inhibited the formation of biofilm. | Hanyu Zhao Yupeng Sun Lu Yin Zhao Yuan Yiliang Lan Dake Xu Chunguang Yang Ke Yang | 2021 | Journal of Materials Science & Technology2021，，7： | 1 |
| 10 | Growth of single-walled carbon nanotubes from Ag15 cluster catalysts显示文摘Chirality-specific growth of single-walled carbon nanotubes(SWNTs) remains a challenge for their practical applications in electronics. Here, we explored the surface growth of SWNTs by utilizing the atomic-precise silver cluster complex [Ag_(15){1,3,5–(C:C)_3–C_6H_3}_2(Py[8])_3–(CF_3SO_3)_3](CF_3SO_3)_6(Py[8] is abbreviation for octamethylazacalix[8]pyridine) as a catalyst precursor. The diameters of most acquired SWNTs distributed in the range of 1.2–1.4 nm, which is suitable for making high performance field-effect transistors. The high quality of the obtained SWNTs was evidenced by Raman spectroscopy and electrical measurements. Successful growth of high quality SWNTs in this study foresees that rational design of metal-organic complexes as growth catalysts can open up a new avenue for the controllable synthesis of SWNTs. | Dake Hu Xin He Lifei Sun Guanchen Xu Liying Jiao Liang Zhao | 2016 | Science Bulletin2016，61，12： | 1 |
| 11 | Ecological and Environmental Protection Requirements in China s Regional Coordinated Development Strategy in the New Era显示文摘Starting from the historical evolution of China s regional coordinated development policy and practice,three stages of'enlightenment stage','development stage'and'maturity stage',as well as the connotation,characteristics and content of implementing regional coordinated development strategy were analyzed.On this basis,from different aspects of industrial distribution,pollutant characteristics and regional environmental protection policy,the existing ecological and environmental protection problems in China s regional coordinated development in the new era were analyzed,and some suggestions for the next step were put forward.It is necessary to follow the'four ones'concept from the overall point of view,implement'three lines and one list'from the perspective of the width of the access red line,strengthen'joint prevention and control'from the perspective of the depth of regional regulation,deepen the'planning environmental impact assessment'from the perspective of the breadth of industrial distribution,and promote the'green-way model'from the perspective of ecological low carbon. | Jie LI Dake LIU Wei ZHAO Sheng WANG | 2020 | Meteorological and Environmental Research2020，11，6： | 1 |
| 12 | Matrix metalloproteinase‐12 is associated with overall survival in Chinese patients with gastric cancer显示文摘 | Jianyong Zheng Dake Chu Desheng Wang Yongsheng Zhu Xiaoyin Zhang Gang Ji Haihong Zhao Guosheng Wu Jianjun Du Qingchuan Zhao | 2012 | J Surg Oncol2012，，7： | 1 |
| 13 | The expression of vascular endothelial growth factor in mast cells promotes the neovascularisation of human pterygia显示文摘 | Kun Liang Zhengxuan Jiang Bingying Zhao Jijia Shen Dake Huang Liming Tao | 2012 | British Journal of Ophthalmology2012，，9： | 1 |
| 14 | The expression of vascular endothelial growth factor in mast cells promotes the neovascularisation of human pterygia显示文摘 | Kun Liang Zhengxuan Jiang Bingying Zhao Jijia Shen Dake Huang Liming Tao | 2012 | British Journal of Ophthalmology2012，，9： | 1 |
| 15 | Microstructure and mechanical properties of melt-grown alumina-mullite/glass composites fabricated by directed laser deposition显示文摘Melt-grown alumina-based composites are receiving increasing attention due to their potential for aerospace applications;however,the rapid preparation of high-performance components remains a challenge.Herein,a novel route for 3D printing dense(<99.4%)high-performance melt-grown alumina-mullite/glass composites using directed laser deposition(DLD)is proposed.Key issues on the composites,including phase composition,microstructure formation/evolution,densification,and mechanical properties,are systematically investigated.The toughening and strengthening mechanisms are analyzed using classical fracture mechanics,Griffith strength theory,and solid/glass interface infiltration theory.It is demonstrated that the composites are composed of corundum,mullite,and glass,or corundum and glass.With the increase of alumina content in the initial powder,corundum grains gradually evolve from near-equiaxed dendrite to columnar dendrite and cellular structures due to the weakening of constitutional undercooling and small nucleation undercooling.The microhardness and fracture toughness are the highest at 92.5 mol%alumina,with 18.39±0.38 GPa and 3.07±0.13 MPa-m1/2,respectively.The maximum strength is 310.1±36.5 MPa at 95 mol%alumina.Strength enhancement is attributed to the improved densification due to the trace silica doping and the relief of residual stresses.The method unravels the potential of preparing dense high-performance melt-grown alumina-based composites by the DLD technology. | Dake ZHAO Dongjiang WU Jing SHI Fangyong NIU Guangyi MA | 2022 | Journal of Advanced Ceramics2022，11，1： | 1 |
| 16 | High Level of Notch1 Protein is Associated with Poor Overall Survival in Colorectal Cancer显示文摘 | Dake Chu MD Yunming Li MD Weizhong Wang MM Qingchuan Zhao MD Jipeng Li MD Yuanyuan Lu MD Mengbin Li MD Guanglong Dong MD Hongwei Zhang MD Huahong Xie MD Gang Ji MD | 2010 | Annals of Surgical Oncology2010，，5： | 1 |
| 17 | Correlation between 18F-FDG uptake and the expression of glucose transporter-1 and hypoxia-inducible factor-1α in transplanted VX2 tumors显示文摘 | Huiqin Xu Biao Li Wenjing Yu Hui Wang Xuefeng Zhao Yuanchun Yao Dake Huang | 2013 | Nuclear Medicine Communications2013，，10： | 1 |
| 18 | Biofilm inhibition and corrosion resistance of 2205-Cu duplex stainless steel against acid producing bacterium Acetobacter aceti显示文摘Acid producing bacterium Acetobacter aceti causes pitting corrosion of stainless steel(SS).This work investigated the enhanced resistance of 2205-Cu duplex stainless steel(DSS)against biocorrosion by A.aceti in comparison with 2205 DSS using electrochemical and surface analysis techniques.With the addition of Cu to 2205 DSS,biofilms on the 2205-Cu DSS surface were inhibited effectively.The largest pit depth on 2205-Cu DSS surface in the presence of A aceti was 2.6μm,smaller than 5.5μm for 2205 DSS surface.The i(corr)was 0.42±0.03μA cm^-2 for 2205-Cu DSS in the biotic medium,which was much lower than that for 2205 DSS(3.69±0.65μA cm^-2).All the results indicated that the A aceti biofilm was considerably inhibited by the release of Cu^2+ions from the 2205-Cu DSS matrix,resulting in the mitigation of biocorrosion by A aceti. | Dan Liu Ru Jia Dake Xu Hongying Yang Ying Zhao Msaleem Khan Songtao Huang Jiankang Wen Ke Yang Tingyue Gug | 2019 | Journal of Materials Science & Technology2019，35，11： | 0 |
| 19 | Multi-omics analysis reveals the evolutionary origin of diterpenoid alkaloid biosynthesis pathways in Aconitum显示文摘Diterpenoid alkaloids(DAs) have been often utilized in clinical practice due to their analgesic and anti-infammatory properties. Natural DAs are prevalent in the family Ranunculaceae, notably in the Aconitum genus. Nevertheless, the evolutionary origin of the biosynthesis pathway responsible for DA production remains unknown.In this study, we successfully assembled a highquality, pseudochromosome-level genome of the DA-rich species Aconitum vilmorinianum(A.vilmorinianum)(5.76 Gb). An A. vilmorinianumspecific whole-genome duplication event was discovered using comparative genomic analysis,which may aid in the evolution of the DA biosynthesis pathway. We identified several genes involved in DA biosynthesis via integrated genomic, transcriptomic, and metabolomic analyses. These genes included enzymes encoding target ent-kaurene oxidases and aminotransferases, which facilitated the activation of diterpenes and insertion of nitrogen atoms into diterpene skeletons, thereby mediating the transformation of diterpenes into DAs. The divergence periods of these genes in A. vilmorinianum were further assessed, and it was shown that two major types of genes were involved in the establishment of the DA biosynthesis pathway. Our integrated analysis offers fresh insights into the evolutionary origin of DAs in A.vilmorinianum as well as suggestions for engineering the biosynthetic pathways to obtain desired DAs. | Dake Zhao Ya Zhang Huanxing Ren Yana Shi Ding Dong Zonghang Li Guanghong Cui Yong Shen Zongmin Mou Edward JKennelly Luqi Huang Jue Ruan Suiyun Chen Diqiu Yu Yupeng Cun | 2023 | Journal of Integrative Plant Biology2023，65，10： | 0 |
| 20 | Common Postzygotic Mutational Signatures in Healthy Adult Tissues Related to Embryonic Hypoxia显示文摘Postzygotic mutations are acquired in normal tissues throughout an individual’s lifetime and hold clues for identifying mutagenic factors.Here,we investigated postzygotic mutation spectra of healthy individuals using optimized ultra-deep exome sequencing of the time-series samples from the same volunteer as well as the samples from different individuals.In blood,sperm,and muscle cells,we resolved three common types of mutational signatures.Signatures A and B represent clocklike mutational processes,and the polymorphisms of epigenetic regulation genes influence the proportion of signature B in mutation profiles.Notably,signature C,characterized by C>T transitions at GpCpN sites,tends to be a feature of diverse normal tissues.Mutations of this type are likely to occur early during embryonic development,supported by their relatively high allelic frequencies,presence in multiple tissues,and decrease in occurrence with age.Almost none of the public datasets for tumors feature this signature,except for 19.6%of samples of clear cell renal cell carcinoma with increased activation of the hypoxia-inducible factor 1(HIF-1)signaling pathway.Moreover,the accumulation of signature C in the mutation profile was accelerated in a human embryonic stem cell line with drug-induced activation of HIF-1α.Thus,embryonic hypoxia may explain this novel signature across multiple normal tissues.Our study suggests that hypoxic condition in an early stage of embryonic development is a crucial factor inducing C>T transitions at GpCpN sites;and individuals’genetic background may also influence their postzygotic mutation profiles. | Yaqiang Hong Dake Zhang Xiangtian Zhou Aili Chen Amir Abliz Jian Bai Liang Wang Qingtao Hu Kenan Gong Xiaonan Guan Mengfei Liu Xinchang Zheng Shujuan Lai Hongzhu Qu Fuxin Zhao Shuang Hao Zhen Wu Hong Cai Shaoyan Hu Yue Ma Junting Zhang Yang Ke Qian-Fei Wang Wei Chen Changqing Zeng | 2022 | Genomics, Proteomics & Bioinformatics2022，20，1： | 0 |
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