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    题名 作者 年代 出处 被引量
1Fundus artery occlusion caused by cosmetic facial injections显示文摘Chen Yanyun Wang Wenying Li Jipeng Yu Yajie Li Lin Lu Ning 2014Chinese Medical Journal2014,,8:35
2The application of nanoparticles in cancer immunotherapy:Targeting tumor microenvironment显示文摘The tumor development and metastasis are closely related to the structure and function of the tumor microenvironment(TME).Recently,TME modulation strategies have attracted much attention in cancer immunotherapy.Despite the preliminary success of immunotherapeutic agents,their therapeutic effects have been restricted by the limited retention time of drugs in TME.Compared with traditional delivery systems,nanoparticles with unique physical properties and elaborate design can efficiently penetrate TME and specifically deliver to the major components in TME.In this review,we briefly introduce the substitutes of TME including dendritic cells,macrophages,fibroblasts,tumor vasculature,tumor-draining lymph nodes and hypoxic state,then review various nanoparticles targeting these components and their applications in tumor therapy.In addition,nanoparticles could be combined with other therapies,including chemotherapy,radiotherapy,and photodynamic therapy,however,the nanoplatform delivery system may not be effective in all types of tumors due to the heterogeneity of different tumors and individuals.The changes of TME at various stages during tumor development are required to be further elucidated so that more individualized nanoplatforms could be designed.Muyue Yang Jipeng Li Ping Gu Xianqun Fan 2021Bioactive Materials2021,6,7:21
3Efficacy of integrated Traditional Chinese Medicine and anti-retroviral therapy on immunological nonresponse in patients with human immunodeficiency virus/acquired immunodeficiency syndrome: a Meta-analysis of randomized controlled trials显示文摘OBJECTIVE:To explore the efficacy of integrating Traditional Chinese Medicine(TCM)and anti-retroviral therapy(ART),a customized combination of different classes of medications which was also called cock-tail treatment,on the immunological nonresponse(INR)in people living with human immunodeficiency virus(HIV)(PLWH).METHODS:Relevant literature in databases such as China National Knowledge Infrastructure Database(CNKI),Wanfang Digital Journal,Chinese Medical Journal Database(CMJD),Chinese Biomedical Literature Database(CBM),Pub Med,Cochrane,and Embase was reviewed by two independent investigators.Data were extracted from the studies according to the eligible criteria and analyzed using Review Manager 5.3.RESULTS:Nine randomized controlled trials(RCTs)with 1078 patients were analyzed.Our analyses showed that CD4 T cell counts in the treatment group improved compared with that in the control group[mean difference(MD)=13.51,95%confidence interval(CI):7.42-19.60,P<0.0001].There was no significant difference between the treated and control groups after 3 months(MD=25.31,95%CI:-2.78 to 53.41,P=0.08).However,after 6 and 12 months,the response of the treatment group was superior to the control group(MD=27.45,95%CI:7.09-47.81,P=0.008 and MD=27.34,95%CI:6.31–48.37,P=0.01,respectively).The clinical efficacy of the treatment group was also higher than that of the control group(RR=1.75,95%CI:1.16-2.65,P=0.007).However,CD45 RO and CD45 RA T cell counts did not differ significantly between the two groups(MD=12.37,95%CI:-6.71 to 31.45,P=0.20 and MD=5.67,95%CI:-3.00 to14.35,P=0.20,respectively).CONCLUSION:The combined treatment strategy of integrated TCM and Western Medicine promotes long-term reconstitution of the immune system and thus,is beneficial and has potential use for improving INR in PLWH.However,large-scale RCTs are required to provide evidence for optimal intervention strategies.TAO Zhuang HUANG Xiaojie LIU Ying WANG Ru DONG Jipeng LIANG Biyan ZOU Wen GAO Guojian WANG Zhuo ZHANG Ke WU Hao ZHANG Tong WANG Jian 2021Journal of Traditional Chinese Medicine2021,41,5:6
4Unregulated emissions from diesel engine with particulate filter using Fe-based fuel borne catalyst显示文摘The alteration and formation of toxic compounds and potential changes in the toxicity of emissions when using after-treatment technologies have gained wide attention. Volatile organic compound(VOC), carbonyl compound and particle-phase polycyclic aromatic hydrocarbon(PAH) emissions were tested at European Steady State Cycle(ESC) to study unregulated emissions from a diesel engine with a fuel-borne catalyst and diesel particulate filter(FBC–DPF). An Fe-based fuel-borne catalyst was used for this study. According to the results, brake specific emissions of total VOCs without and with DPF were 4.7 and4.9 mg/kWh, respectively, showing a 4.3% increase. Benzene and n-undecane emissions increased and toluene emission decreased, while other individual VOC emissions basically had no change. When retrofitted with the FBC–DPF, total carbonyl compound emission decreased 15.7%, from 25.8 to 21.8 mg/kWh. The two highest carbonyls, formaldehyde and acetaldehyde, were reduced from 20.0 and 3.7 to 16.5 and 3.3 mg/kWh respectively. The specific reactivity(SR) with DPF was reduced from 6.68 to 6.64 mg/kWh. Total particle-phase PAH emissions decreased 66.4% with DPF compared to that without DPF. However, the Benzo[a]pyrene equivalent(BaPeq) with DPF had increased from 0.016 to 0.030 mg/kWh.Fluoranthene and Pyrene had the greatest decrease, 91.1% and 88.4% respectively. The increase of two- and three-ring PAHs with DPF indicates that the fuel-borne catalyst caused some gas-phase PAHs to adsorb on particles. The results of this study expand the knowledge of the effects of using a particulate filter and a Fe-based fuel-borne catalyst on diesel engine unregulated emissions.Hong Zhao Yunshan Ge Tiezhu Zhang Jipeng Zhang Jianwei Tan Hongxin Zhang 2014Journal of Environmental Sciences2014,26,10:5
5Data Aggregation-based Adaptive Data Reproductive Delivery Scheme for Delay Tolerant Mobile Sensor Networks显示文摘ZHANG Ket LIU Ming ZHU Jinqi SONG Jipeng ZENG Jiazhi 2010Chinese Journal of Electronics2010,19,1:4
6Enhanced extraction of essential oil from Cinnamomum cassia bark by ultrasound assisted hydrodistillation显示文摘Cinnamon essential oil with many bioactivities is an important raw material for the production of various chemicals,and the conventional hydrodistillation(HD)for cinnamon oil extraction always require a longer extraction time.In this work,ultrasound-assisted hydrodistillation extraction(UAHDE)technique was employed to enhance the extraction efficiency of essential oils from cinnamon barks.The parameters with significant effects on the essential oil extraction efficiency(ultrasound time,ultrasound power,extraction time,liquid–solid ratio)were optimized,and the proposed UAHDE was compared with the conventional HD extraction in terms of the extraction time,extraction yield,and physicochemical properties of extracted oils.Compared to the HD extraction,the UAHDE resulted in a shorter extraction time and a higher extraction yield.Using GC–MS analysis,the UAHDE provided more valuable essential oil with a high content of the vital trans-cinnamaldehyde compounds compared with the HD.Scanning electron micrograph(SEM)confirmed the efficiency of ultrasound irradiation for cinnamon oil extraction.In addition,the analysis of electric consumption and CO_(2) emission shows that the UAHDE process is a more economic and environment-friendly approach.Thus,UAHDE is an efficient and green technology for the cinnamon essential oil extraction,which could improve the quantity and quality of cinnamon oils.Guanghui Chen Fengrui Sun Shougui Wang Weiwen Wang Jipeng Dong Fei Gao 2021Chinese Journal of Chemical Engineering2021,34,8:4
7The use of Career Growth Scale in Chinese nurses:Validity and reliability显示文摘Purpose:To test the validity and reliability of a modified Career Growth Scale(CGS)to assess nurse career growth.Method:A cross-sectional design was used to analyze the use of the CGS to survey 600 fulltime registered nurses from Grade A hospitals in Tianjin.Results:A modified scale we called Career Growth of Nurse Scale(CGNS)is acceptable,valid,and reliable for the evaluation of nurse career growth in Chinese hospitals.This scale measured three main factors(career goal,career capacity,and career opportunity)and showed that nurse career growth differed across age,work seniority,and professional title.Conclusions:A three-dimensional scale of nurse career growth was presented.The results revealed CGNS has good validity and reliability.Jingying Liu Jipeng Yang Yanhui Liu Yang Yang Hongfu Zhang 2015International Journal of Nursing Sciences2015,2,1:4
8Chitosan Oligosaccharide-Ca Complex Accelerates the Depuration of Cadmium from Chlamys ferrari显示文摘This study investigated the effect of a chitosan oligosaccharide-Ca complex (COS-Ca) on the depuration of cadmium (Cd) from Chlamys ferrari. After exposure to 0.5 mg L-1 CdCl2 for 3 or 7 d, the scallops were treated by COS-Ca prior to determina-tion of Cd, calcium (Ca) and zinc (Zn) contents, Cd distribution in organs, malondialdehyde (MDA) content and antioxidant variables. Results showed that COS-Ca reduced Cd content in the viscera of the scallops, with highest Cd depuration rate (47%) observed on day 3. The COS-Ca concentration substantially affected Cd depuration, and the exposure to 8.75 mg L-1 COS-Ca led to significantly higher Cd depuration rate compared with those of lower COS-Ca concentrations (1.75, 3.5, 5.25, and 7.00 mg L-1). Distribution analysis of Cd in scallop organs indicated that COS-Ca significantly reduced Cd content in the kidney throughout the 5-d experiment, as well as in the gill during the early stage of Cd depuration. In addition, COS-Ca treatment decreased glutathione peroxidase (GSH-Px) activity and MDA content while increasing superoxide dismutase (SOD) and catalase (CAT) activities on different days. Our work suggested COS-Ca complex treatment as an effective method for acceleration of Cd depuration from Cd-contaminated bivalves.HUANG Guoqing SUN Jipeng WANG Dongfeng XU Ying XU Wei 2012Journal of Ocean University of China2012,11,2:3
9Additional symmetries of constrained CKP and BKP hierarchies显示文摘The additional symmetries of the constrained CKP (cCKP) and BKP (cBKP) hierarchies are given by their actions on the Lax operators, and their actions on the eigenfunction and adjoint eigenfunction {Φ i , Ψ i } are presented explicitly. Furthermore, we show that acting on the space of the wave operator, *k forms new centerless W cC 1+∞ and W cB 1+∞ -subalgebra of centerless W 1+∞ respectively. In order to define above symmetry flows *k of the cCKP and cBKP hierarchies, two vital operators Y k are introduced to revise the additional symmetry flows of the CKP and BKP hierarchies.TIAN KeLei HE JingSong CHENG JiPeng CHENG Yi 2011Science China Mathematics2011,54,2:3
10Proteomics provides individualized options of precision medicine for patients with gastric cancer显示文摘While precision medicine driven by genome sequencing has revolutionized cancer care,such as lung cancer,its impact on gastric cancer(GC)has been minimal.GC patients are routinely treated with chemotherapy,but only a fraction of them receive the clinical benefit.There is an urgent need to develop biomarkers or algorithms to select chemo-sensitive patients or apply targeted therapy.Here,we carried out retrospective analyses of 1,020 formalin-fixed,paraffin-embedded GC surgical resection samples from 5 hospitals and developed a mass spectrometry-based workflow for proteomic subtyping of GC.We identified two proteomic subtypes:the chemo-sensitive group(CSG)and the chemo-insensitive group(CIG)in the discovery set.The 5-year overall survival of CSG was significantly improved in patients who had received adjuvant chemotherapy after surgery compared with those who received surgery only(64.2%vs.49.6%;Cox P-value=0.002),whereas no such improvement was observed in CIG(50.0%vs.58.6%;Cox P-value=0.495).We validated these results in an independent validation set.Further,differential proteome analysis uncovered 9 FDA-approved drugs that may be applicable for targeted therapy of GC.A prospective study is warranted to test these findings for future GC patient care.Wenwen Huang Dongdong Zhan Yazhuo Li Nairen Zheng Xin Wei Bin Bai Kecheng Zhang Mingwei Liu Xuefei Zhao Xiaotian Ni Xia Xia Jinwen Shi Cheng Zhang Zhihao Lu Jiafu Ji Juan Wang Shiqi Wang Gang Ji Jipeng Li Yongzhan Nie Wenquan Liang Xiaosong Wu Jianxin Cui Yongsheng Meng Feilin Cao Tieliu Shi Weimin Zhu Yi Wang Lin Chen Qingchuan Zhao Hongwei Wang Lin Shen Jun Qin 2021Science China(Life Sciences)2021,64,8:3
11Effect of Rubber Particles on Cement Stabilized Gravel System显示文摘The primary objective of this paper was to study the mechanical properties and durability of the cement stabilized gravel by different compact method. The influence of rubber particle content on mechanical properties of samples was studied by compaction tests and freezing thawing recycle tests. Pore structure and fractal characteristic of mixture were analyzed quantitatively using mercury intrusion porosimetry(MIP). X-ray diffraction(XRD) was adopted to identify the composition phases. The morphology analysis in micro scale and elemental analysis of samples were carried out by scanning electron microscope(SEM). The optimum compressive strengths of rubber cement stabilized gravel(RCSG) with static compaction method and with vibratory compaction method were obtained by controlling compaction degree and vibration time, respectively. From the compaction tests, the vibratory compaction method is preferred compared with the static compaction method as better compressive strength can be improved by about 340%-360%. Besides, test results also reveal that compressive strength of samples with vibratory compaction method or static compaction method will decrease with the rubber particle bulk content increasing. The freezing thawing recycle tests indicate that freezing thawing resistance has been improved(frozen stability coefficient K has been increased from 0.89 to 0.97) by the addition of rubber particles. MIP tests show that the mean pore diameter and porosity of mixture have been increased from 70 to 250 nm and 9% to 24% respectively, with the rubber particles content increasing. Component analysis shows that the calcium silicate hydrate(CSH) is the predominant hydrate product with or without the addition of rubber particles.杨若冲 李凯 ZHU Jipeng ZHU Tengkuo DONG Zheng WU Dengcheng 2014Journal of Wuhan University of Technology(Materials Science)2014,29,5:2
12Matrix Metalloproteinase-14 Is a Negative Prognostic Marker for Patients with Gastric Cancer显示文摘Liang He Dake Chu Xia Li Jianyong Zheng Shanhong Liu Jipeng Li Qingchuan Zhao Gang Ji 2013Digestive Diseases and Sciences2013,,5:2
13Association of systemic inflammation and body mass index with survival in patients with resectable gastric or gastroesophageal junction adenocarcinomas显示文摘Objective:The systemic inflammation index and body mass index(BMI)are easily accessible markers that can predict mortality.However,the prognostic value of the combined use of these two markers remains unclear.The goal of this study was therefore to evaluate the association of these markers with outcomes based on a large cohort of patients with gastric cancer.Methods:A total of 2,542 consecutive patients undergoing radical surgery for gastric or gastroesophageal junction adenocarcinoma between 2009 and 2014 were included.Systemic inflammation was quantified by the preoperative neutrophil-to-lymphocyte ratio(NLR).High systemic inflammation was defined as NLR≥3,and underweight was defined as BMI<18.5 kg/m2.Results:Among 2,542 patients,NLR≥3 and underweight were common[627(25%)and 349(14%),respectively].In the entire cohort,NLR≥3 or underweight independently predicted overall survival(OS)[hazard ratio(HR):1.236,95%confidence interval(95%CI):1.069–1.430;and HR:1.600,95%CI:1.350–1.897,respectively]and recurrence-free survival(RFS)(HR:1.230,95%CI:1.054–1.434;and HR:1.658,95%CI:1.389–1.979,respectively).Patients with both NLR≥3 and underweight(vs.neither)had much worse OS(HR:2.445,95%CI:1.853–3.225)and RFS(HR:2.405,95%CI:1.802–3.209).Furthermore,we observed similar results in subgroup analyses according to pathological stage,age,and postoperative chemotherapy.Conclusions:Our results showed that preoperative elevated NLR and decreased BMI had a significant negative effect on survival.Underweight combined with severe inflammation could enhance prognostication.Taking active therapeutic measures to reduce inflammation and increase nutrition may help improve outcomes.Xianchun Gao Yanan Pan Weili Han Caie Hu Chenchen Wang Ling Chen Yong Guo Yupeng Shi Yan Pan Huahong Xie Liping Yao Jianjun Yang Jianyong Zheng Xiaohua Li Xiaonan Liu Liu Hong Jipeng Li Mengbin Li Gang Ji Zengshan Li Jielai Xia Qingchuan Zhao Daiming Fan Kaichun Wu Yongzhan Nie 2021Cancer Biology & Medicine2021,18,1:2
14Transparent,Ultra-Stretching,Tough,Adhesive Carboxyethyl Chitin/Polyacrylamide Hydrogel Toward High-Performance Soft Electronics显示文摘To date,hydrogels have gained increasing attentions as a flexible conductive material in fabricating soft electronics.However,it remains a big challenge to integrate multiple functions into one gel that can be used widely under various conditions.Herein,a kind of multifunc-tional hydrogel with a combination of desirable characteristics,including remarkable transparency,high conductivity,ultra-stretchability,tough-ness,good fatigue resistance,and strong adhesive ability is presented,which was facilely fabricated through multiple noncovalent crosslinking strategy.The resultant versatile sensors are able to detect both weak and large deformations,which owns a low detection limit of 0.1%strain,high stretchability up to 1586%,ultrahigh sensitivity with a gauge factor up to 18.54,as well as wide pressure sensing range(0-600 kPa).Meanwhile,the fabrication of conductive hydrogel-based sensors is demonstrated for various soft electronic devices,including a flexible human-machine interactive system,the soft tactile switch,an integrated electronic skin for unprecedented nonplanar visualized pressure sensing,and the stretchable triboelectric nanogenerators with excellent biomechanical energy harvesting ability.This work opens up a simple route for multifunctional hydrogel and promises the practical application of soft and self-powered wearable electronics in various complex scenes.Jipeng Zhang Yang Hu Lina Zhang Jinping Zhou Ang Lu 2023Nano-Micro Letters2023,15,1:2
15Selective Hydrogenation of Butyne-1,4-diol to Butane-1,4-diol over Ni/Al_2O_3-SiO_2 Catalysts显示文摘Ni/Al_2O_3-SiO_2 catalysts were synthesized via one-step method employing SiO_2 as an additive for the selective hydrogenation of butyne-1,4-diol(B_3D) to butane-1,4-diol(B1D). The prepared catalysts were evaluated by a series of characterization techniques including BET, XRD, SEM, EDX-mapping, TEM, H_2-TPR, XPS, NH_3-TPD and Py-FTIR. Compared to Ni/Al_2O_3 catalyst, the SiO_2-doped samples exhibited better B_3D conversion. SiO_2 could help to form a strong interaction between NiO with the support, which inhibited Ni agglomeration at high temperature, improved the Ni dispersion, and enhanced the hydrogenation activity. B_1D selectivity was mainly influenced by the quantity of Lewis acid sites in addition to the Ni dispersion. The catalyst with a silica loading of 6.4% demonstrated an excellent selectivity of 75.18%(by 13% higher than the contrastive Ni/Al_2O_3 catalyst), which was attributed to the larger amount of Lewis acid sites and the moderate interaction between NiO with the support, which could facilitate the nickel dispersion on a preferable surface area of 176.3 m^2/g of support.Fang Jie Zhuang Changjian Meng Jipeng Cheng Lang Lu Jiangyin 2018China Petroleum Processing & Petrochemical Technology2018,20,4:2
16Scheduling Dual-Arm Cluster Tools With Multiple Wafer Types and Residency Time Constraints显示文摘Accompanying the unceasing progress of integrated circuit manufacturing technology, the mainstream production mode of current semiconductor wafer fabrication is featured with multi-variety, small batch, and individual customization, which poses a huge challenge to the scheduling of cluster tools with single-wafer-type fabrication. Concurrent processing multiple wafer types in cluster tools, as a novel production pattern, has drawn increasing attention from industry to academia, whereas the corresponding research remains insufficient. This paper investigates the scheduling problems of dual-arm cluster tools with multiple wafer types and residency time constraints. To pursue an easy-to-implement cyclic operation under diverse flow patterns,we develop a novel robot activity strategy called multiplex swap sequence. In the light of the virtual module technology, the workloads that stem from bottleneck process steps and asymmetrical process configuration are balanced satisfactorily. Moreover, several sufficient and necessary conditions with closed-form expressions are obtained for checking the system's schedulability. Finally, efficient algorithms with polynomial complexity are developed to find the periodic scheduling, and its practicability and availability are demonstrated by the offered illustrative examples.Jipeng Wang Hesuan Hu Chunrong Pan Yuan Zhou Liang Li 2020IEEE/CAA Journal of Automatica Sinica2020,7,3:2
17Scale-up of biomass conversion using 1-ethyl-3-methylimidazolium acetate as the solvent显示文摘This scale-up study demonstrated the feasibility of an ionic liquid(IL)pretreatment process at 40 kg scale,using the IL 1-ethyl-3-methylimidazolium acetate([C2C1Im][OAc])as the solvent.The pretreatment was followed by enzymatic hydrolysis through which the process efficiency for biomass conversion to monomeric sugars was determined.The results show that 43 wt%of switchgrass was dissolved in IL after 2 h of pretreatment at 160℃ with 15 wt%solid loading.A 120 h enzymatic hydrolysis of the pretreated switchgrass results in 96%glucan and 98%xylan conversion.[C2C1Im][OAc]pretreatment has been successfully scaled up to 40 kg with improved sugar titers and yields relative to bench scale(6 kg).The mass flow of the overall process was established and the major scale-up challenges of the process were identified.Ling Liang Jipeng Yan Qian He Tina Luong Todd R.Pray Blake A.Simmons Ning Sun 2019Green Energy & Environment2019,4,4:2
18Survivin反义寡核苷酸对宣威肺腺癌细胞凋亡的影响(英文)显示文摘Objective:The aim of the study was to investigate the effects of Survivin antioligonucleotide on the proliferation,apoptosis and cell cycle of Xuanwei lung adenocarcinoma cell XWLC-05.Methods:Specific targeting Survivin ASODN was composed firstly.XWLC-05 would be divided into 4 groups:Group Sham(blank),Group Lip(simple liposome),Group Lip-SODN(transfected sense oligonucleotide) and Group Lip-ASODN(transfected ASODN).All groups had been transfected under the same condition for 48 hours.Then West blotting was used to check the expression of Survivin in cells from different groups and flow cytometer was used to find out the apoptosis rate of cells in different groups.Results:The expression of XWLC-05 Survivin in Group Lip-ASODN decreased obviously and apoptosis rate was significantly higher than that of other groups(P < 0.05).Conclusion:XWLC-05 transfected by Survivin ASODN could down regulate the expression of Survivin and lower expression of Survivin might lead to the apoptosis of XWLC-05 and restrain the proliferation of cancer cells.Weiwei Wang Gaofeng Li Zhipeng Hong Ruibing Cheng Jipeng Zhang Lianhua Ye 2011The Chinese-German Journal of Clinical Oncology2011,10,5:1
19Fundamental study on plasma deposition manufacturing显示文摘Zhang Haiou Xu Jipeng Wang Guilan 2003Sur- face and Coatings Technology2003,171,:1
20One-dimensional ZnSe@N-doped carbon nanofibers with simple electrospinning route for superior Na/K-ion storage显示文摘One-dimensional carbon nanofibers are widely applied as anode material in the energy storage field due to its unique structure and high conductivity. In this work, one-dimensional ZnSe@N-doped carbon nanofibers(ZnSe@NC NFs) are successfully synthesized by electrospinning and annealed without extra troublesome conditions. ZnSe nanocrystals are enfolded in the N-doped carbon nanofibers, which can act as a protective layer to avoid the volume expansion of active material and promote ion transport during the cycling process. More importantly, the as-synthesized ZnSe@NC NFs are served as the anode material and display the admirable storage properties for Na/K-ion batteries. The one-dimensional Zn Se@NC NFs material shows the high capacity of 237 mAh/g for Na-ion batteries at a current density of 1 A/g for 2000cycles. Meanwhile, it also delivers a high discharge capacity of 337 mAh/g for K-ion batteries at 0.2 A/g for 300 cycles. Additionally, it is confirmed that the pseudocapacitive contribution of the nano-structure material is up to 54.5% at a scan rate of 0.6 m V/s through the cyclic voltammetry(CV) measurement in K-ion batteries.Di Huang Daxiong Wu Jixing Zhu Jinyu Xie Jipeng Wu Jiaojiao Liang 2023Chinese Chemical Letters2023,34,2:1
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