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| 1 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 2 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 4 |
| 3 | Pathogenesis and management of hepatorenal syndrome in patients with cirrhosis显示文摘 | Paolo Angeli Carlo Merkel | 2008 | Journal of Hepatology2008，，： | 2 |
| 4 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 5 | Hemodynamic changes of systemic, hepatic, and splenic circulation following triglycyl-lysin-vasopressin administration in alcoholic cirrhosis显示文摘 | Dr. Carlo Merkel MD Angelo Gatta MD Massimo Bolognesi MD Gianfranco Finucci MD Giorgio Battaglia MD Paolo Angeli MD Renzo Zuin MD | 1988 | Digestive Diseases and Sciences1988，，9： | 1 |
| 6 | Sleep‐wake abnormalities in patients with cirrhosis显示文摘 | Sara Montagnese Cristiano De Pittà Michele De Rui Michela Corrias Matteo Turco Carlo Merkel Piero Amodio Rodolfo Costa Debra J. Skene Angelo Gatta | 2014 | Hepatology2014，，2： | 1 |
| 7 | Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis显示文摘 | Dr. Carlo Merkel MD Angelo Gatta MD Marco Zoli MD Massimo Bolognesi MD Paolo Angeli MD Tiziana Iervese MD Giulio Marchesini MD Arturo Ruol MD | 1991 | Digestive Diseases and Sciences1991，，9： | 1 |
| 8 | Incidence and natural history of small esophageal varices in cirrhotic patients显示文摘 | Manuela Merli Giorgia Nicolini Stefania Angeloni Vittorio Rinaldi Adriano De Santis Carlo Merkel Adolfo Francesco Attili Oliviero Riggio | 2002 | Journal of Hepatology2002，，3： | 1 |
| 9 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 10 | Pathogenesis and managenment of hepatorenal syndrome in patients with cirrhosis显示文摘 | Paolo Angeli Carlo merkel | 2008 | J Hepatology2008，48，1： | 1 |
| 11 | On the bimodal effects of silicic acids on calcite growth显示文摘 | Pina C M Carlos M Merkel | 2009 | Crystal Growth&Design2009，9，9： | 1 |
| 12 | Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis显示文摘 | Angelo Gatta Massimo Bolognesi Carlo Merkel | 2007 | Molecular Aspects of Medicine2007，，1： | 1 |
| 13 | Natural history of cirrhotic patients with small esophageal varices: a prospective study显示文摘 | Marco Zoli Carlo Merkel Donatella Magalotti Cristina Gueli Michele Grimaldi Angelo Gatta Mauro Bernardi | 2000 | The American Journal of Gastroenterology2000，，2： | 1 |
| 14 | Prognostic value of galactose elimination capacity, aminopyrine breath test, and ICG clearance in patients with cirrhosis显示文摘 | Dr. Carlo Merkel MD Angelo Gatta MD Marco Zoli MD Massimo Bolognesi MD Paolo Angeli MD Tiziana Iervese MD Giulio Marchesini MD Arturo Ruol MD | 1991 | Digestive Diseases and Sciences1991，，9： | 1 |
| 15 | Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis显示文摘 | Angelo Gatta Massimo Bolognesi Carlo Merkel | 2007 | Molecular Aspects of Medicine2007，，1： | 1 |
| 16 | Vasoactive factors and hemodynamic mechanisms in the pathophysiology of portal hypertension in cirrhosis显示文摘 | Angelo Gatta Massimo Bolognesi Carlo Merkel | 2007 | Molecular Aspects of Medicine2007，，1： | 1 |
| 17 | Different hemodynamic patterns of alcoholic and viral endstage cirrhosis: Analysis of explanted liver weight, degree of fibrosis and splanchnic Doppler parameters显示文摘 | Massimo Bolognesi David Sacerdoti Claudia Mescoli Giancarlo Bombonato Umberto Cillo Roberto Merenda Luciano Giacomelli Carlo Merkel Massimo Rugge Angelo Gatta | 2007 | Scandinavian Journal of Gastroenterology2007，，2： | 1 |
| 18 | Reversal of hepatic myelopathy after liver transplantation: Fifteen plus one显示文摘 | Umberto Baccarani Erika Zola Gian Luigi Adani Matteo Cavalletti Sami Schiff Annachiara Cagnin Carlo Poci Carlo Merkel Piero Amodio Sara Montagnese | 2010 | Liver Transpl2010，，11： | 1 |
| 19 | Cost-effectiveness analysis of beta-blockers vs endoscopic surveillance in patients with cirrhosis and small varices显示文摘AIM:To evaluate the most cost-effectiveness strategy for preventing variceal growth and bleeding in patients with cirrhosis and small esophageal varices.METHODS:A stochastic analysis based on decision trees was performed to compare the cost-effectiveness of beta-blockers therapy starting from a diagnosis of small varices(Strategy 1)with that of endoscopic surveillance followed by beta-blockers treatment when large varices are demonstrated(Strategy 2),for preventing variceal growth,bleeding and death in patients with cirrhosis and small esophageal varices.The basic nodes of the tree were gastrointestinal endoscopy,inpatient admission and treatment for bleeding,as required.All estimates were performed using a Monte Carlo microsimulation technique,consisting in simulating observations from known probability distributions depicted in the model.Eight-hundred-thousand simulations were performed to obtain the final estimates.All estimates were then subjected to Monte Carlo Probabilistic sensitivity analysis,to assess the impact of the variability of such estimates on the outcome distributions.RESULTS:The event rate(considered as progression of varices or bleeding or death)in Strategy 1[24.09%(95%CI:14.89%-33.29%)]was significantly lower than in Strategy 2[60.00%(95%CI:48.91%-71.08%)].The mean cost(up to the first event)associated with Strategy 1[823￡(95%CI:106￡-2036￡)]was not significantly different from that of Strategy 2[799￡(95%CI:0￡-3498￡)].The cost-effectiveness ratio with respect to this endpoint was equal to 50.26￡(95%CI:-504.37￡-604.89￡)per event avoided over the four-year follow-up.When bleeding episodes/deaths in subjects whose varices had grown were included,the mean cost associated with Strategy 1 was 1028￡(95%CI:122￡-2581￡),while 1699￡(95%CI:171￡-4674￡)in Strategy 2.CONCLUSION:Beta-blocker therapy turn out to be more effective and less expensive than endoscopic surveillance for primary prophylaxis of bleeding in patients with cirrhosis and small varices. | Lorenza Di Pascoli Alessra Buja Massimo Bolognesi Sara Montagnese Angelo Gatta Dario Gregori Carlo Merkel | 2014 | World Journal of Gastroenterology2014，20，30： | 0 |
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