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| 1 | Surgical outcome after docetaxel-based neoadjuvant chemotherapy in locally-advanced gastric cancer显示文摘AIM:To investigate feasibility,morbidity and surgical mortality of a docetaxel-based chemotherapy regimen randomly administered before or after gastrectomy in patients suffering from locally-advanced resectable gastric cancer.METHODS:Patients suffering from locally-advanced(T3-4 any N M0 or any T N1-3 M0)gastric carcinoma,staged with endoscopic ultrasound,bone scan,computed tomography,and laparoscopy,were assigned to receive four 21 d/cycles of TCF(docetaxel 75 mg/m 2 day 1,cisplatin 75 mg/m 2 day 1,and fluorouracil 300 mg/m 2 per day for days 1-14),either before(Arm A)or after(Arm B)gastrectomy.Operative morbidity,overall mortality,and severe adverse events were compared by intention-to-treat analysis.RESULTS:From November 1999 to November 2005,70 patients were treated.After preoperative TCF(Arm A),thirty-two(94%)resections were performed,85% of which were R0.Pathological response was complete in 4 patients(11.7%),and partial in 18(55%).No surgical mortality and 28.5%morbidity rate were observed,similar to those of immediate surgery arm(P= 0.86).Serious chemotherapy adverse events tended to be more frequent in arm B(23%vs 11%,P=0.07),with a single death per arm.CONCLUSION:Surgery following docetaxel-based chemotherapy was safe and with similar morbidity to immediate surgery in patients with locally-advanced resectable gastric carcinoma. | Roberto Biffi Nicola Fazio Fabrizio Luca Antonio Chiappa Bruno Andreoni Maria Giulia Zampino Arnaud Roth Jan Christian Schuller Giancarla Fiori Franco Orsi Guido Bonomo Cristiano Crosta Olivier Huber | 2010 | World Journal of Gastroenterology2010，16，7： | 43 |
| 2 | p38α MAPK pathway:A key factor in colorectal cancer therapy and chemoresistance显示文摘Colorectal cancer(CRC)remains one of the most common malignancies in the world.Although surgical resection combined with adjuvant therapy is effective at the early stages of the disease,resistance to conventional therapies is frequently observed in advanced stages,where treatments become ineffective.Resistance to cisplatin,irinotecan and 5-fluorouracil chemotherapy has been shown to involve mitogen-activated protein kinase(MAPK)signaling and recent studies identified p38αMAPK as a mediator of resistance to various agents in CRC patients.Studies published in the last decade showed a dual role for the p38αpathway in mammals.Its role as a negative regulator of proliferation has been reported in both normal(including cardiomyocytes,hepatocytes,fibroblasts,hematopoietic and lung cells)and cancer cells(colon,prostate,breast,lung tumor cells).This function is mediated by the negative regulation of cell cycle progression and the transduction of some apoptotic stimuli.However,despite its anti-proliferative and tumor suppressor activity in some tissues,the p38αpathway may also acquire an oncogenic role involving cancer related-processes such as cell metabolism,invasion,inflammation and angiogenesis.In this review,we summarize current knowledge about the predominant role of the p38αMAPK pathway in CRC development and chemoresistance.In our view,this might help establish the therapeutic potential of the targeted manipulation of this pathway in clinical settings. | Valentina Grossi Alessia Peserico Tugsan Tezil Cristiano Simone | 2014 | World Journal of Gastroenterology2014，20，29： | 20 |
| 3 | Land Surface Displacement Geohazards Monitoring Using Multi-temporal InSAR Techniques显示文摘China has been affected by some of the world’s most serious geological disasters and experiences high economic damage every year.Geohazards occur not only in remote areas but also in highly populated cities.In the framework of the Dragon-432365 Project,this paper presents the main results and the major conclusions derived from an extensive exploitation of Sentinel-1,ALOS-2(Advanced Land Observing Satellite 2),GF-3(Gao Fen Satellite 3),and latest launched SAR(Synthetic Aperture Radar),together with methods that allow the evaluation of their importance for various geohazards.Therefore,in the scope of this project,the great benefits of recent remote sensing data(wide spatial and temporal coverage)that allow a detailed reconstruction of past displacement events and to monitor currently occurring phenomena are exploited to study different areas and geohazards problems,including:surface deformation of mountain slopes;identification and monitoring of ground movements and subsidence;landslides;ground fissure;and building inclination studies.Suspicious movements detected in the different study areas were cross validated with different SAR sensors and truth data. | Guang LIU Perski ZBIGNIEW Salvi STEFANO Thiebes BENNI Lixin WU Jinghui FAN Shibiao BAI Lianhuan WEI Shiyong YAN Rui SONG Bignami CHRISTIAN Tolomei CRISTIANO Stefan SCHNEIDERBAUER Joao Sousa JOAQUIM 无 | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 13 |
| 4 | Capsule endoscopy in celiac disease显示文摘Video capsule endoscopy is an attractive and patient- friendly tool that provides high quality images of the small bowel. Obscure gastrointestinal bleeding is the primary and most evaluated indication to capsule endoscopy;however,indications are expanding and a small number of preliminary reports have been presented concerning the role of video capsule endoscopy in the diagnosis of celiac disease. The purpose of this review is to update the current knowledge and to hypothesize on future perspectives of the use of video capsule endoscopy in patients with celiac disease. | Cristiano Spada Maria Elena Riccioni Riccardo Urgesi Guido Costamagna | 2008 | World Journal of Gastroenterology2008，14，26： | 8 |
| 5 | Treatment of periodontal patients - current clinical concepts显示文摘The main goal of the treatment of patients with periodontitis is to establish adequate infection control. To satisfy demands for acceptable aesthetics and chewing function with good long-term prognosis in patients with periodontitis requires the establishment of adequate infection control. Pocket instrumentation (scaling and root planing with or without flap elevation), combined with effective self-performed supragingival plaque control measures, constitutes the basic treatment modalities. | Cristiano Tomasi Claudio Soldini Jan L Wennstr(o|¨)m | 2007 | 上海口腔医学2007，16，2： | 8 |
| 6 | Laparoscopic Versus Open Subtotal Gastrectomy for Distal Gastric Cancer: Five-Year Results of a Randomized Prospective Trial显示文摘 | Cristiano G.S. Huscher Andrea Mingoli Giovanna Sgarzini Andrea Sansonetti Massimiliano Di Paola Achille Recher Cecilia Ponzano | 2005 | Annals of Surgery2005，，2： | 7 |
| 7 | 冒号囊内视镜检查法: 优点,限制和期望哪个新奇?显示文摘 Since the first reports almost ten years ago, wireless capsule endoscopy has gained new f ields of application. Colon capsule endoscopy represents a new diagnostic technology for colonic exploration. Clinical trials have shown that colon capsule endoscopy is feasible, accurate and safe in patients suffering from colonic diseases and might be a valid alternative to conventional colonoscopy in selected cases such as patients refusing conventional colonoscopy or with contraindications to colonoscopy or when colonoscopy is incomplete. Despite the enthusiasm surrounding this new technique, few clinical and randomized controlled trials are to be found in the current literature, leading to heterogeneous or controversial results. Upcoming studies are needed to prove the substantial utility of colon capsule endoscopy for colon cancer screening, especially in a low prevalence of disease population, and for other indications such as inflammatory bowel disease. Possible perspectives are critically analysed and reported in this paper. | Maria Elena Riccioni Riccardo Urgesi Rossella Cianci Alessandra Bizzotto Cristiano Spada Guido Costamagna | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，4： | 7 |
| 8 | Peritoneal carcinosis of ovarian origin显示文摘Epithelial ovarian cancer (EOC) is the second most common genital malignancy in women and is the most lethal gynecological malignancy,with an estimated five-year survival rate of 39%.Despite efforts to develop an effective ovarian cancer screening method,60% of patients still present with advanced disease.Comprehensive management using surgical cytoreduction to decrease the tumor load to aminimum,and intraperitoneal chemotherapy to eliminate microscopic disease on peritoneal surface,has the potential to greatly improve quality of life and to have an impact on survival in ovarian cancer patients.Despite achieving clinical remission after completion of initial treatment,most patients (60%) with advanced EOC will ultimately develop recurrent disease or show drug resistance;the eventual rate of curability is less than 30%.Given the poor outcome of women with advanced EOC,it is imperative to continue to explore novel therapies. | Anna Fagotti Valerio Gallotta Federico Romano Francesco Fanfani Cristiano Rossitto Angelica Naldini Massimo Vigliotta Giovanni Scambia | 2010 | World Journal of Gastrointestinal Oncology2010，2，2： | 5 |
| 9 | Y-chromosome microdeletions in nonobstructive azoospermia and severe oligozoospermia显示文摘现在的工作的目的是介绍病人的结果, Y 染色体 microdeletions 由 intracytoplasmic 精子注射(ICSI ) 对待,任何一个用新鲜(TESE ) 或结冰融化(TESE-C ) 阴囊的精子和呼喊的精子(EJAC ) 。这个工作的创见居住在在 Y-microdeletions (AZFa, AZFb,和 AZFc ) 和治疗的不同类型之间的比较,与详细说明人口统计,刺激,胚胎学、临床、新生(NB ) 结果。有 Y-microdeletions 的 125 个病人, 33 个病人介绍了严重 oligozoospermia (有呼喊的精子的 18 执行 ICSI ) 和 92 能分泌的精子缺乏(65 与 40 去了 TESE 有成功的精子检索并且执行了 ICSI ) 。有 51 个 TESE 治疗周期和 43 个 TESE-C 治疗周期,与 19 NB 的出生(2 在 AZFa/TESE-C, 12 在 AZFc/TESE,并且 5 在 AZFc/TESE-C ) 。29 个 EJAC 周期,有 8 NB 的出生(在 AZFc ) 。在 TESE 和 EJAC 周期,在胚胎学、临床的参数没有重要差别。在 TESE-C 周期,在 AZFc 有重要更低的卵母细胞成熟率和更低的授精率。在结论,尽管有 AZFc microdeletions 的病人介绍了高阴囊的精子恢复率和可接受的临床的结果,有 AZFa 和 AZFb microdeletions 的盒子介绍了差的预后。由于 microdeletions 的报导遗传,病人们应该在 NB 和使用 preimplantation 的可能性上关于不肥沃的后果被通知为女性的基因诊断选择。 | Carolina Goncalves Mariana Cunha Eduardo Rocha Susana Fernandess, Joaquina Silva Luis Ferraz Cristiano Oliveira Alberto Barros Mairio Sousa | 2017 | Asian Journal of Andrology2017，19，3： | 5 |
| 10 | Same-day 2-L PEG-citrate-simethicone plus bisacodyl vs split 4-L PEG: Bowel cleansing for late-morning colonoscopy显示文摘AIM: To evaluate the efficacy, tolerability, acceptability and feasibility of bisacodyl plus low volume polyethyleneglycol-citrate-simeticone(2-L PEG-CS) taken the same day as compared with conventional split-dose 4-L PEG for late morning colonoscopy. METHODS: Randomised, observer-blind, parallel group, comparative trial carried out in 2 centres. Out patients of both sexes, aged between 18 and 85 years, undergoing colonoscopy for diagnostic investigation, colorectal cancer screening or follow-up were eligible. The PEG-CS group received 3 bisacodyl tablets(4 tablets for patients with constipation) at bedtime and 2-L PEG-CS in the morning starting 5 h before colonoscopy. The control group received a conventional 4-L PEG formulation given as split regimen; the morning dose was taken with the same schedule of the low volume preparation. The Ottawa Bowel Preparation Scale(OBPS) score was used as the main outcome measure.RESULTS: A total of 164 subjects were enrolled and 154 completed the study; 78 in the PEG-CS group and 76 in the split 4-L PEG group. The two groups were comparable at baseline. The OBPS score in the PEG-CS group(3.09 ± 2.40) and in the PEG group(2.39 ± 2.55) were equivalent(difference +0.70; 95%CI:-0.09-1.48). This was confirmed by the rate of successful bowel cleansing in the PEG-CS group(89.7%) and in the PEG group(92.1%)(difference-2.4%; 95%CI:-11.406.70). PEG-CS was superior in terms of mucosa visibility compared to PEG(85.7% vs 72.4%, P = 0.042). There were no significant differences in caecum intubation rate, time to reach the caecum and withdrawal time between the two groups. The adenoma detection rate was similar(PEG-CS 43.6% vs PEG 44.7%). No serious adverse events occurred. No difference was found in tolerability of the bowel preparations. Compliance was equal in both groups: more than 90% of subjects drunk the whole solution. Willingness to repeat the same bowel preparations was about 90% for both regimes. CONCLUSION: Same-day PEG-CS is feasible, effective as split-dose 4-L PEG for late morning colonoscopy and does not interfere with work and daily activities the day before colonoscopy. | Annalisa de Leone Darina Tamayo Giancarla Fiori Davide Ravizza Cristina Trovato Giuseppe De Roberto Linda Fazzini Marco Dal Fante Cristiano Crosta | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，9： | 5 |
| 11 | Off-pump coronary artery bypass grafting versus optimal medical therapy alone:effectiveness of incomplete revascularization in high risk patients显示文摘有 multivessel 的 BackgroundGeriatric 病人冠的动脉疾病(CAD ) 是一个挑战性的组对待;这些盒子关于在这些病人上并且经常承担主要外科的实际利益在心队以内得到讨论导致放纵外科的选择。经皮的过程代表一种重要选择,但是冠的解剖可能是相反的。离开泵冠的动脉绕过(OPCAB ) 提供好质量没有暴露病人到的左前面的下降上的接枝(男孩) 心肺绕过,并且可能是在有多重 comorbidities 的病人的理想的选择,不是对合格经皮或在泵上过程。这研究的目的是没有经皮的选择在高风险的病人在中间的后续期间比较幸存,也与 OPCAB 对待或在回顾地从 2008 年 6 月评估到 2013 年 6 月的医药 therapy.MethodsWe 排出,有 multivessel CAD 的 83 个高风险的病人被包括:42 在男孩上用左内部乳房的动脉(LIMA ) 与不完全的离开泵 revascularization 被对待;41 在最佳的医药治疗(OMT ) 被解除,拒绝了外科。后续在 2015 年 3 月结束了,与一电话的会见。主要端点是从所有原因死亡的幸存;第二等的端点从非致命的主要不利心脏的事件(权标) 是从心脏相关的死亡和自由的幸存 .ResultsDuring 列在后面在上面,在 OPCAB 组的 11 死亡和在 OMT 组的 27 死亡发生了。死亡分别地由于在 6 和 15 个病人的心脏的因素。权标在 OMT 组在 OPCAB 组并且在 4 个病人在 6 个病人被观察。关于从所有原因死亡的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 <0.001 ) ,并且 OMT 组带倾向 3.862 的调整分数的危险比率(P <0.001 ) 。关于从心脏相关的事件的幸存,经历了多于那些熬过的 OPCAB 的病人在 OMT 排出(木头等级 = 0.002 ) ,并且 OMT 组带倾向 3.663 的调整分数的危险比率(P = 0.010 ) 。有关从权标的自由没有统计上重要的差别(木头等级 = 0.273 ).ConclusionsFor 有 multivessel CAD 的高风险的病人,不是对在泵上合格完全的 revascularization 外科或经皮的过程,有 OPCAB LIMA-on-LAD 提议的不完全的 revascularization 在幸存受益什么时候与 OMT 相比独自一个。 | Filippo Prestipino Cristiano Spadaccio Antonio Nenna Fraser WH Sutherland Gwyn W Beattie Mario Lusini Francesco Nappi Massimo Chello | 2016 | Journal of Geriatric Cardiology2016，13，1： | 4 |
| 12 | Strongly enhanced light trapping in a two-dimensional silicon nanowire random fractal array显示文摘We report on the unconventional optical properties exhibited by a two-dimensional array of thin Si nanowires arranged in a random fractal geometry and fabricated using an inexpensive,fast and maskless process compatible with Si technology.The structure allows for a high light-trapping efficiency across the entire visible range,attaining total reflectance values as low as 0.1%when the wavelength in the medium matches the length scale of maximum heterogeneity in the system.We show that the random fractal structure of our nanowire array is responsible for a strong in-plane multiple scattering,which is related to the material refractive index fluctuations and leads to a greatly enhanced Raman scattering and a bright photoluminescence.These strong emissions are correlated on all length scales according to the refractive index fluctuations.The relevance and the perspectives of the reported results are discussed as promising for Si-based photovoltaic and photonic applications. | Barbara Fazio Pietro Artoni Maria Antonia Iatì Cristiano D’Andrea Maria JosèLo Faro Salvatore Del Sorbo Stefano Pirotta Pietro Giuseppe Gucciardi Paolo Musumeci Cirino Salvatore Vasi Rosalba Saija Matteo Galli Francesco Priolo Alessia Irrera | 2016 | Light(Science & Applications)2016，5，1： | 4 |
| 13 | Heart rate variability: a new tool to predict complications in adult cardiac surgery显示文摘心率可变性(HRV ) 指在连续心跳之间的变化,它取决于自治神经系统的同情、副交感的分支的连续调整。HRV 被显示了作为在心肌的梗塞和糖尿病的神经病的早警告症状以后的风险的一个预言者有效,并且在心病学,背景是认出是为在医院承认以后并且在分泌物以后的风险层化的一个有用工具的现在。最近的证据建议 HRV 分析可能甚至在经历心脏的外科,和现在的评论的病人预言复杂并发症在当前的临床的实践为 HRV 使用在成年心脏的外科和观点总结 HRV 分析的重要性。尽管未来在 HRV 能在成年心脏的外科被包括进每日的临床的实践以前,更大的研究被保证, HRV 是可能在早手术后的阶段并且在医院停留期间检测自治不稳定性的一个新奇工具,因此预言或迅速诊断许多手术后的复杂并发症。 | Antonio Nenna Mario Lusini Cristiano Spadaccio Francesco Nappi Salvatore Matteo Greco Raffaele Barbato Elvio Covino Massimo Chello | 2017 | Journal of Geriatric Cardiology2017，14，11： | 4 |
| 14 | Split liver transplantation in adults显示文摘Split liver transplantation(SLT),while widely accepted in pediatrics,remains underutilized in adults. Advancements in surgical techniques and donor-recipient matching,however,have allowed expansion of SLT from utilization of the right trisegment graft to now include use of the hemiliver graft as well. Despite less favorable outcomes in the early experience,better outcomes have been reported by experienced centers and have further validated the feasibility of SLT. Importantly,more than two decades of experience have identified key requirements for successful SLT in adults. When these requirements are met,SLT can achieve outcomes equivalent to those achieved with other types of liver transplantation for adults. However,substantial challenges,such as surgical techniques,logistics,and ethics,persist as ongoing barriers to further expansion of this highly complex procedure. This review outlines the current state of SLT in adults,focusing on donor and recipient selection based on physiology,surgical techniques,surgical outcomes,and ethical issues. | koji hashimoto masato fujiki cristiano quintini federico n aucejo teresa diago uso dympna m kelly bijan eghtesad john j fung charles m miller | 2016 | World Journal of Gastroenterology2016，22，33： | 3 |
| 15 | Second-generation colon capsule endoscopy is feasible in the out-of-clinic setting显示文摘 | Samuel Nathan Adler Cesare Hassan Yoav Metzger Yishai Sompolinsky Cristiano Spada | 2014 | Surgical Endoscopy2014，，2： | 3 |
| 16 | 巴西南部第三中心早产儿视网膜病变(英文)显示文摘目的:评估2002-10/2006-10在巴西de Clinicasde Porto Alegre医院出生的所有早产儿的早产儿视网膜病变(ROP)的发生率,其治疗和预后的比率。方法:对323例出生体质量低于或等于1500g或者出生时孕龄等于或者少于32wk的早产儿进行前瞻性队列研究。所有的新生儿都在出生后6wk内进行开睑器开睑,瞳孔散大,间接检眼镜及28D透镜眼底检查,根据疾病的分类进行复查。结果由均数表示,发病率为于95%的可信区间,主要的临床结果为任何分期的ROP发生。结果:新生儿82例发生了ROP,发生率为25.7%。患者中只有17例((5.3%)发生了阈病变,他们的病变都累及后部第II区,需要激光治疗。除了3例经治疗的患儿需要两次激光治疗外,没有一个经过治疗的患儿有I区病变或者严重的后部病变。重复治疗组的1例患儿因发展成为4期ROP而需要行赤道部硅胶带巩膜环扎术。结论:ROP的发生率和阈病变同国际其它的研究结果类似。本研究显示了孕期28wk以内或出生后体重1000g的新生儿高生存率(70.1%)、高视网膜病变发病率和激光治疗的高度必要性。这组患儿需要眼科专家和新生儿专家为发现ROP进行仔细筛查和随访。本组患儿中没有确诊1例有I区后部病变,此点是本研究值得引起注意之处。 | Joao Borges Fortes Filho Cristiano Koch Barros Gabriela Unchalo Eckert Leticia Procianoy Renato S. Procianoy | 2007 | 国际眼科杂志2007，7，1： | 3 |
| 17 | Assessing Ebola-related web search behaviour: insights and implications from an analytical study of Google Trends-based query volumes显示文摘Background:The 2014 Ebola epidemic in West Africa has attracted public interest worldwide,leading to millions of Ebola-related Internet searches being performed during the period of the epidemic.This study aimed to evaluate and interpret Google search queries for terms related to the Ebola outbreak both at the global level and in all countries where primary cases of Ebola occurred.The study also endeavoured to look at the correlation between the number of overall and weekly web searches and the number of overall and weekly new cases of Ebola.Methods:Google Trends(GT)was used to explore Internet activity related to Ebola.The study period was from 29 December 2013 to 14 June 2015.Pearson’s correlation was performed to correlate Ebola-related relative search volumes(RSVs)with the number of weekly and overall Ebola cases.Multivariate regression was performed using Ebola-related RSV as a dependent variable,and the overall number of Ebola cases and the Human Development Index were used as predictor variables.Results:The greatest RSV was registered in the three West African countries mainly affected by the Ebola epidemic.The queries varied in the different countries.Both quantitative and qualitative differences between the affected African countries and other Western countries with primary cases were noted,in relation to the different flux volumes and different time courses.In the affected African countries,web query search volumes were mostly concentrated in the capital areas.However,in Western countries,web queries were uniformly distributed over the national territory.In terms of the three countries mainly affected by the Ebola epidemic,the correlation between the number of new weekly cases of Ebola and the weekly GT index varied from weak to moderate.The correlation between the number of Ebola cases registered in all countries during the study period and the GT index was very high.Conclusion:Google Trends showed a coarse-grained nature,strongly correlating with global epidemiological data,but was weaker at country level,as it was prone to distortions induced by unbalanced media coverage and the digital divide.Global and local health agencies could usefully exploit GT data to identify disease-related information needs and plan proper communication strategies,particularly in the case of health-threatening events. | Cristiano Alicino Nicola Luigi Bragazzi Valeria Faccio Daniela Amicizia Donatella Panatto Roberto Gasparini Giancarlo Icardi Andrea Orsi | 2015 | Infectious Diseases of Poverty2015，4，1： | 3 |
| 18 | Evolution of Siderian juvenile crust to Rhyacian high Ba-Sr magmatism in the Mineiro Belt, southern S?o Francisco Craton显示文摘Plutonic rocks from the Mineiro Belt, Brazil record a delayed onset of the transition from TTG to sanukitoid-type magmatism(high Ba-Sr), starting during the Siderian magmatic lull when little juvenile magma was added to the continental crust. Rocks mostly belong to the calc-alkaline series, meta-to peraluminous and originally 'Ⅰ-type',meaning that oxidized magmas were formed by partial melting of subducted material. The temporal distribution and apparent secular changes of the magmas are consistent with the onset of subduction-driven plate tectonics due to an increase of the subduction angle and opening of the mantle wedge. New isotopic analyses(Sm-Nd whole rock and Lu-Hf in zircon)corroborate the restricted juvenile nature of the Mineiro Belt and confirm the genetic link between the Lagoa Dourada Suite,a rare ca. 2350 Ma high-Al tonalite-trondhjemite magmatic event, and the sanukitoid-type ca. 2130 Ma Alto Maranhao Suite. U-Pb dating of zircon and titanite constrain the crystallisation history of plutonic bodies; coupled with major and trace element analyses of the host rocks, they distinguish evolutionary trends in the Mineiro Belt. Several plutons in the region have ages close to 2130 Ma but are distinguished by the lower concentration of compatible elements in the juvenile high Ba-Sr suite. | Hugo Moreira Luís Seixas Craig Storey Mike Fowler Stephanie Lasalle Ross Stevenson Cristiano Lana | 2018 | Geoscience Frontiers2018，9，4： | 3 |
| 19 | Amyloid fragments and their toxicity on neural cells显示文摘The formation of amyloid fibrils from soluble proteins is a common form of self-assembly phenomenon that has fundamental connections with biological functions and human diseases.Lysozyme was converted from its soluble native state into highly organized amyloid fibrils.Ultrasonic treatment was used to break amyloid fibrils to fibrillar fragments–seeds.Atomic force microscopy and fluorescence microscopy was employed to characterize the morphology of the amyloid assemblies and neural cells–amyloid complexes.Our results demonstrate that prefibrillar intermediated and their mixture with proteins exhibit toxicity,although native proteins and fibrils appear to have no effect on number of cells.Our findings confirm that innocuous hen lysozyme can be engineered to produce both cytotoxic fibrillar fragments and non-toxic mature amyloid fibrils.Our work further strengthens the claim that amyloid conformation,and not the identity of the protein,is key to cellular toxicity and the underlying specific cell death mechanism. | Eva Bystrenova Zuzana Bednarikova Marianna Barbalinardo Cristiano Albonetti Francesco Valle Zuzana Gazova | 2019 | Regenerative Biomaterials2019，6，2： | 2 |
| 20 | Colon capsule endoscopy:What we know and what we would like to know显示文摘Colonoscopy is usually perceived as an invasive and potentially painful procedure,being also affected by a small,but definite,risk of major complications(cardiopulmonary complications,perforation,hemorrhage)and even mortality.To improve both acceptability and safety,Pill Cam Colon Capsule Endoscopy(CCE)(Given Imaging Ltd,Yoqneam,Israel)has been developed.CCE represents a non-invasive technique that is able to explore the colon without sedation and air insufflation.The Second Generation of Colon Capsule Endoscopy(Pill Cam Colon 2)(CCE-2)was proven to be an accurate tool to detect colonic neoplastic lesions when used in average risk individuals.To date,the evidence supports the use of CCE-2 in case of colonoscopy failure,in patients unwilling to perform colonoscopy and when colonoscopy is contraindicated.Other potential applications,such as colorectal cancer screening or diagnostic surveillance ofinflammatory bowel disease need to be clarified.In this paper,the current'state of the art',potential application of CCE and future needs are evaluated. | Cristiano Spada Federico Barbaro Gianluca Andrisani Leonardo Minelli Grazioli Cesare Hassan Isabella Costamagna Mariachiara Campanale Guido Costamagna | 2014 | World Journal of Gastroenterology2014，20，45： | 2 |
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