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| 1 | Treatment of peri-anal fistula in Crohn's disease显示文摘Anal fistulas are a common manifestation of Crohn's disease(CD). The first manifestation of the disease is often in the peri-anal region, which can occur years before a diagnosis, particularly in CD affecting the colon and rectum. The treatment of peri-anal fistulas is difficult and always multidisciplinary. The European guidelines recommend combined surgical and medical treatment with biologic drugs to achieve best results. Several different surgical techniques are currently em-ployed. However, at the moment, none of these tech-niques appear superior to the others in terms of healing rate. Surgery is always indicated to treat symptomatic, simple, low intersphincteric fistulas refractory to medi-cal therapy and those causing disabling symptoms. Ut-most attention should be paid to correcting the balance between eradication of the fistula and the preservationof fecal continence. | Giuseppe S Sica Sara Di Carlo Giorgia Tema Fabrizio Montagnese Giovanna Del Vecchio Blanco Valeria Fiaschetti Giulia Maggi Livia Biancone | 2014 | World Journal of Gastroenterology2014，20，37： | 8 |
| 2 | Covert hepatic encephalopathy: Agreement and predictive validity of different indices显示文摘AIM:To investigate the agreement and prognosticvalue of different measures of covert hepatic encephalopathy(CHE).METHODS:One-hundred-and-thirty-two cirrhotic outpatients underwent electroencephalography(EEG),paper-and-pencil psychometry(PHES)and critical flicker frequency,scored on the original/modified(CFFo/CFFm)thresholds.Eighty-four patients underwent Dopplerultrasound to diagnose/exclude portal-systemic shunt.Seventy-nine were followed-up for 11±7 mo in relation to the occurrence of hepatic encephalopathy(HE)-related hospitalisations.RESULTS:On the day of study,36%had gradeⅠHE,42%abnormal EEG,33%abnormal PHES and 31/21%abnormal CFFo/CFFm.Significant associations were observed between combinations of test abnormalities;however,agreement was poor(Cohen’sκ<0.4).The prevalence of EEG,PHES and CFFo/CFFm abnormalities was significantly higher in patients with gradeⅠovert HE.The prevalence of EEG and CFFm abnormalities was higher in patients with shunt.The prevalence of EEG abnormalities was significantly higher in patients with a history of HE.During follow-up,10 patients died,10were transplanted and 29 had HE-related hospitalisations.GradeⅠHE(P=0.004),abnormal EEG(P=0.008)and abnormal PHES(P=0.04)at baseline all predicted the subsequent occurrence of HE;CFF did not.CONCLUSION:CHE diagnosis probably requires a combination of clinical,neurophysiological and neuropsychological indices. | Sara Montagnese Esmeralda Balistreri Sami Schiff Michele De Rui Paolo Angeli Giacomo Zanus Umberto Cillo Giancarlo Bombonato Massimo Bolognesi David Sacerdoti Angelo Gatta Carlo Merkel Piero Amodio | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Hepatitis C virus infection and health-related quality of life显示文摘Hepatitis C virus(HCV) hepatitis and other diseases related to HCV,such as cryoglobulinemia,lymphoma and renal failure,impair health-related quality of life(HRQoL).In addition,HCV per se might directly influence HRQoL via colonization of microglia in the brain or,indirectly,via the effect of systemic inflammatory cytokines which,in turn,can trigger brain interleukin production.The treatment of HCV-related disorders with interferon(IFN) has an effect on HRQoL.Initially,IFN causes a transient deterioration of HRQoL,due to the induction of depression and other side effects of treatment.Subsequently,the subjects who obtain a sustained virologic response experience an improvement in HRQoL.Only rarely does interferon treatment causes permanent detrimental effects on HRQoL,due to residual psychiatric or neurologic side effects.Liver transplantation is the only treatment for end-stage HCV-related liver disease.HRQoL generally improves massively a few months after transplantation,except in the case of serious complications of the transplant procedure.Furthermore,high levels of anxiety and neuroticism pre-transplant are associated with lower HRQoL one year after transplant.Additionally,six months after transplant,patients with HCV who experience virologic recurrence show significantly greater depression,anxiety,phobic anxiety,and paranoid ideation than anti-HCV-negative patients.In conclusion,optimal care for the overall well-being of patients with HCV infection requires adequate knowledge of their neurological and psychological status. | Piero Amodio Laura Salari Sara Montagnese Sami Schiff Daniele Neri Tonino Bianco Lina Minazzato | 2012 | World Journal of Gastroenterology2012，18，19： | 3 |
| 4 | Neuropsychological alterations in hepatitis C infection:The role of inflammation显示文摘About 50% of patients with hepatitis C virus(HCV)infection complain of neuropsychiatric symptoms,'brain fog',weakness,fatigue,and exhibit some degree of quality of life impairment,irrespective of the severity of liver disease.Since the first observation of HCV-related cognitive deficits,10 studies have been published that have evaluated neuropsychiatric performance in patients with HCV infection and different degrees of hepatic impairment.Unfortunately,these have often included patients with cirrhosis,patients who had acquired the infection through previous intravenous drug misuse,who had a history of relatively recent treatment with interferon,or were on psychoactive medication.In addition,different neuropsychological batteries and tests that explored different cognitive domains were used,which makes the results of the studies difficult to compare.Finally,limited information is available on the pathogenesis of HCV-related cognitive impairment.Cerebral and/or systemic inflammation may be important players but their potential role has not been substantiated by experimental data.The present review outlines the available evidence of the presence of cognitive impairment in patients with HCV infection,with a focus on the potential relationship with cerebral and/or systemic inflammation. | Marco Senzolo Sami Schiff Cristina Maria D’Aloiso Chiara Crivellin Evangelos Cholongitas Patrizia Burra Sara Montagnese | 2011 | World Journal of Gastroenterology2011，17，29： | 2 |
| 5 | Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels: the Italian prospective study of the asymptomatic C carriers (ISACC) 显示文摘 | Puoti C CastelIacci R Montagnese F | 2002 | J Hepatol2002，37，1： | 1 |
| 6 | Otoplasty forprominent ears:a vcrsatilc combined technique to master the shape ofear显示文摘 | Salgarello M Gaspcroni C Montagnese A | 2007 | Otolryngol Head Neck Surg2007，137，2： | 1 |
| 7 | Disruption of smooth pursuit eye movements in cirrhosis:relationship to hepatic encephalopathy and its treatment显示文摘 | Montagnese S Gordon HM Jackson C | 2005 | Hepatology2005，42，4： | 1 |
| 8 | Character- istics of minimal hepatic encephalopathy 显示文摘 | AMODIO P MONTAGNESE S GATI-A A | 2004 | Metab Brain Dis2004，19，34： | 1 |
| 9 | Hepatic encephalopathy in patients with acute decompensation of cirrhosis and acute-on-chronic liver failure显示文摘 | Romero-Gmez M Montagnese S Jalan R | 2015 | J Hepatol2015，62，2： | 1 |
| 10 | Characteristics of minimal he-patic encephalopathy显示文摘 | Amodio P Montagnese S Gatta A | 2004 | Metab Brain Dis2004，19，34： | 1 |
| 11 | Hepaticencephalopathy in patients with acute decompensation of cirrhosisand acute - onchronicliver failure显示文摘 | ROMERO - GMEZ M MONTAGNESE S JALAN R | 2015 | J Hepatol2015，62，2： | 1 |
| 12 | Detection methods and clinical significance of free peritoneal tumor cells found during colorectal cancer surgery显示文摘Peritoneal washing is now part of the standard clinical practice in several abdominal and pelvic neoplasias. However, in colorectal cancer surgery, intra-peritoneal free cancer cells(IFCC) presence is not routinely investigated and their prognostic meaning is still unclear. When peritoneal washing results are positive for the presence of IFCC a worse outcome is usually expected in these colorectal cancer operated patients, but it what is not clear is whether it is associated with an increased risk of local recurrence. It is authors' belief that one of the main reasons why IFCC are not researched as integral part of the routine staging system for colon cancer is that there still isn't a diagnostic or detection method with enough sensibility and specificity. However, the potential clinical implications of a routine research for the presence IFCC in colon neoplasias are enormous: not only to obtain a more accurate clinical staging but also to offer different therapy protocols, based on the presence of IFCC. Based on this, adjuvant chemotherapy could be offered to those patients found to be positive for IFCC; also, protocols of proactive intraperitoneal chemotherapy could be applied. Although presence of IFCC appears to have a valid prognostic significance, further studies are needed to standardize detection and examination procedures, to determine if there are and which are the stages more likely to benefit from routine search for IFCC. | Simone Sibio Cristina Fiorani Carmine Stolfi Andrea Divizia Roberto Pezzuto Fabrizio Montagnese Giulia Bagaglini Paolo Sammartino Giuseppe Sigismondo Sica | 2015 | World Journal of Gastrointestinal Surgery2015，7，9： | 1 |
| 13 | Narco- lepsy and effectiveness of gamma-hydroxybutyrate (GHB) : a systematic review and meta-analysis of ran- domized controlled trials显示文摘 | Boscolo-Berto R Viel G Montagnese S | 2012 | Sleep Med Rev2012，16，5： | 1 |
| 14 | Sleep‐wake abnormalities in patients with cirrhosis显示文摘 | Sara Montagnese Cristiano De Pittà Michele De Rui Michela Corrias Matteo Turco Carlo Merkel Piero Amodio Rodolfo Costa Debra J. Skene Angelo Gatta | 2014 | Hepatology2014，，2： | 1 |
| 15 | Prognostic benefit of the addition of a quantitative index of gepatic encephalopa- thy to the MELD score:the MELD-EEG显示文摘 | Montagnese S De Rui M Schiff S | 2014 | Liver Int2014，35，5： | 1 |
| 16 | Histological and virological features and follow-up of hepatitis C virus carriers with normal aminotransferase levels:the Italian prospective study of the asymptomatic C carriers (ISACC)显示文摘 | Puoti C Castellacci R Montagnese F | 2002 | J Hepatol2002，37，： | 1 |
| 17 | Encephalopathy or hepatic eneephalopathy? 显示文摘 | Montagnese S Merkel C Amodio P | 2012 | J Hepatol2012，57，4： | 1 |
| 18 | Early is better? A new algorithm for early diagnosis in late onset Pompe disease (LOPD) 显示文摘 | Toscano A Montagnese F Musumeci O | 2013 | Acta Myol2013，32，2： | 1 |
| 19 | Oxyrrhis marina based models as a tool to interpret protozoan population dynamics显示文摘 | DAVIDSON K SAYEGH F MONTAGNES DJS | | 0，，04： | 1 |
| 20 | Neurological complications after orthotopic liver transplantation显示文摘 | P. Amodio A. Biancardi S. Montagnese P. Angeli P. Iannizzi U. Cillo D. D’Amico A. Gatta | 2007 | Digestive and Liver Disease2007，，8： | 1 |
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