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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H. Marx Lars Tharun Johanna Muth Ana-Maria Dancau Ronald Simon Emre Yekebas Jussuf T. Kaifi Martina Mirlacher Tim H. Brümmendorf Carsten Bokemeyer Jakob R. Izbicki Guido Sauter | 2009 | Human Pathology2009，，6： | 3 |
| 3 | Crossing the Rubicon: When Pancreatic Resection with Curative Intent Ends in an R2 Status显示文摘 | Maximilian Bockhorn MD Guellue Cataldegirmen MD Asad Kutup MD Andreas Marx MD Christoph Burdelski MD Jogesh K. Vashist MD Oliver Mann MD Lena Liebl MD Alexandra K?nig MD Jakob R. Izbicki MD Emre F. Yekebas MD | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 4 | Activated leukocyte cell adhesion molecule (CD166)—Its prognostic power for colorectal cancer patients显示文摘 | Michael Tachezy Hilke Zander Florian Gebauer Andreas Marx Jussuf T. Kaifi Jakob R. Izbicki Maximilian Bockhorn | 2012 | Journal of Surgical Research2012，，1： | 1 |
| 5 | Quantitative determination of carotene tereoisomers in carrot juices andvitamin supplemented (ATBC) drinks显示文摘 | MICHAELA MARX ANDREAS SCHIEBER REINHOLD CARLE | 2000 | Food Chemistry2000，，70： | 1 |
| 6 | En Bloc Vascular Resection for Locally Advanced Pancreatic Malignancies Infiltrating Major Blood Vessels: Perioperative Outcome and Long-term Survival in 136 Patients显示文摘 | Emre F. Yekebas Dean Bogoevski Guellue Cataldegirmen Christina Kunze Andreas Marx Yogesh K. Vashist Paulus G. Schurr Lena Liebl Sabrina Thieltges Karim A. Gawad Claus Schneider Jakob R. Izbicki | 2008 | Annals of Surgery2008，，2： | 1 |
| 7 | HER-2 amplification is highly homogenous in gastric cancer 显示文摘 | Andreas H Marx MD Lars Tharun | 2009 | Human Pathology2009，40，6： | 1 |
| 8 | Environmental assessment of a membrane-based air separation for a coal-fired oxyfuel power plant显示文摘 | Andrea Schreiber Josefine Marx Petra Zapp | 2013 | Journal of Membrane Science2013，，： | 1 |
| 9 | Quantitative determination of carotene stereoisomers in carrot juices and vitamin supplemented(ATBC) drinks显示文摘 | Michaela marx Andreas Schieber Reinhold Carle | 2000 | Food chemistry2000，70，： | 1 |
| 10 | Evaluation of the Stereotactic 8G Vacuum-Assisted Breast Biopsy in the Histologic Evaluation of Suspicious Mammography Findings (BI-RADS IV)显示文摘 | Thomas Diebold Tanja Hahn Christine Solbach Achim Rody Joern O. Balzer Martin L. Hansmann Andreas Marx Fernando Viana Jutta Peters Volkmar Jacobi Manfred Kaufmann Thomas J. Vogl | 2005 | Investigative Radiology2005，，7： | 1 |
| 11 | Quantitative deter- mination of carotene stereo isomers in carrot juices and vitamin supple- mented (ATBC) drinks 显示文摘 | Michaela Marx Andreas Schieber Reinhold Carle | 2000 | Food Chemistry2000，70，3： | 1 |
| 12 | Cigarette Smoking as a Determinant of High-Grade Carotid Artery Stenosis in Hispanic, Black, and White Patients With Stroke or Transient Ischemic Attack显示文摘 | Henning Mast John L.P. Thompson I-Feng Lin Christoph Hofmeister Andreas Hartmann Peter Marx Jay P. Mohr Ralph L. Sacco | 1998 | Stroke A Journal of Cerebral Circulation1998，，5： | 1 |
| 13 | Quantitative determination of carotene stereoisomers in carrot juices and vitamin supplemented (ATBC) drinks显示文摘 | Michaela marx Andreas Schieber Reinhold Carle | 2000 | Food chemistry2000，，： | 1 |
| 14 | Anti-inflammatory effects of pioglitazone and/or simvastatin in high cardiovascular risk patients with elevated high sensitivity C-reactive protein : The PIOSTAT study 显示文摘 | Markolf Hanefeld Nikolaus Marx Andreas Pftitzner | 2007 | J Am Coil Cardiol2007，49，3： | 1 |
| 15 | Quantitative determination of carotene stereoisomers in carrot juices and vitamin supplemented (ATBC) drinks显示文摘 | Michaela Marx Andreas Schieber Reinhold Carle | 2000 | Food Chemistry2000，70，： | 1 |
| 16 | Association of aortic valve calcification severity with the degree of aortic regurgitation after transcatheter aortic valve implantation显示文摘 | Ralf Koos Andreas Horst Mahnken Guido Dohmen Kathrin Brehmer Rolf W. Günther Rüdiger Autschbach Nikolaus Marx Rainer Hoffmann | 2010 | International Journal of Cardiology2010，，： | 1 |
| 17 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H Marx MD Lars Tharun Johanna Muth | 2009 | Human Pathology2009，40，6： | 1 |
| 18 | Evaluation of aortic root for definition of prosthesis size by magnetic resonance imaging and cardiac computed tomography: Implications for transcatheter aortic valve implantation显示文摘 | Ralf Koos Ertunc Altiok Andreas Horst Mahnken Mirja Neizel Guido Dohmen Nikolaus Marx Harald Kühl Rainer Hoffmann | 2011 | International Journal of Cardiology2011，，3： | 1 |
| 19 | 铁路基础设施状态的可视化显示文摘铁路基础设施的运行与维护费用大约占整个寿命周期成本的65%(通常为30~50年),其中规划设计占5%,建造占28%,拆除占2%。如果要很好地控制基础设施所有权的全部成本,运行与维护是非常重要的一方面。 | Andreas Marx Kevin Fry 宋文伟 | 2011 | 西铁科技2011，，1： | 0 |
| 20 | EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon–Mann–Whitney Test显示文摘In many research disciplines, hypothesis tests are applied to evaluate whether findings are statistically significant or could be explained by chance. The Wilcoxon–Mann–Whitney(WMW) test is among the most popular hypothesis tests in medicine and life science to analyze if two groups of samples are equally distributed. This nonparametric statistical homogeneity test is commonly applied in molecular diagnosis. Generally, the solution of the WMW test takes a high combinatorial effort for large sample cohorts containing a significant number of ties. Hence, P value is frequently approximated by a normal distribution. We developed EDISON-WMW, a new approach to calculate the exact permutation of the two-tailed unpaired WMW test without any corrections required and allowing for ties. The method relies on dynamic programing to solve the combinatorial problem of the WMW test efficiently. Beyond a straightforward implementation of the algorithm, we presented different optimization strategies and developed a parallel solution. Using our program,the exact P value for large cohorts containing more than 1000 samples with ties can be calculated within minutes. We demonstrate the performance of this novel approach on randomly-generated data, benchmark it against 13 other commonly-applied approaches and moreover evaluate molecular biomarkers for lung carcinoma and chronic obstructive pulmonary disease(COPD). We foundthat approximated P values were generally higher than the exact solution provided by EDISONWMW. Importantly, the algorithm can also be applied to high-throughput omics datasets, where hundreds or thousands of features are included. To provide easy access to the multi-threaded version of EDISON-WMW, a web-based solution of our algorithm is freely available at http://gffzz5cf87394e3434f43hcqfknf0qpknx6x9c.ffgz.tsg.suse.edu.cn/software/wtest/. | Alexander Marx Christina Backes Eckart Meese Hans-Peter Lenhof Andreas Keller | 2016 | Genomics, Proteomics & Bioinformatics2016，14，1： | 0 |
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