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| 1 | Reduced anoctamin 7(ANO7) expression is a strong and independent predictor of poor prognosis in prostate cancer显示文摘Objective:Anoctamin 7(ANO7)is a calcium2+-dependent chloride ion channel protein.Its expression is restricted to prostate epithelial cells.The exact function is unknown.This study aimed to analyze ANO7 expression and its clinical significance in prostate cancer(PCa).Methods:ANO7 expression was assessed by immunohistochemistry in 17,747 clinical PCa specimens.Results:ANO7 was strongly expressed in normal prostate glandular cells but often less abundant in cancer cells.ANO7 staining was interpretable in 13,594 cancer tissues and considered strong in 34.4%,moderate in 48.7%,weak in 9.3%,and negative in 7.6%.Reduced staining was tightly linked to adverse tumor features[high classical and quantitative Gleason grade,lymph node metastasis,advanced tumor stage,high Ki67 labeling index,positive surgical margin,and early biochemical recurrence(P<0.0001 each)].The univariate Cox hazard ratio for prostate-specific antigen(PSA)recurrence after prostatectomy in patients with negative vs.strong ANO7 expression was 2.98(95%confidence interval 2.61–3.38).The prognostic impact was independent of established pre-or postoperatively available parameters(P<0.0001).Analysis of annotated molecular data showed that low ANO7 expression was linked to TMPRSS2:ERG fusions(P<0.0001),elevated androgen receptor expression(P<0.0001),as well as presence of 9 of 11 chromosomal deletions(P<0.05 each).A particularly strong association of low ANO7 expression with phosphatase and tensin homolog(PTEN)deletion may indicate a functional relationship with the PTEN/AKT pathway.Conclusions:These data identify reduced ANO7 protein expression as a strong and independent predictor of poor prognosis in PCa.ANO7 measurement,either alone or in combination,might provide clinically useful prognostic information in PCa. | Andreas Marx Lena Koopmann Doris Hoflmayer Franziska Büscheck Claudia Hube-Magg Stefan Steurer Till Eichenauer Till S.Clauditz Waldemar Wilczak Ronald Simon Guido Sauter Jakob R.Izbicki Hartwig Huland Hans Heinzer Markus Graefen Alexander Haese Thorsten Schlomm Christian Bernreuther Patrick Lebok Sarah Bonk | 2021 | Cancer Biology & Medicine2021，18，1： | 3 |
| 2 | Reproducibility of Immunohistochemical Scoring for Epidermal Growth Factor Receptor Expression in Non-Small Cell Lung Cancer: Round Robin Test显示文摘 | R?schoff Josef Kerr Keith M Grote Hans J Middel Peter von Heydebreck Anja Alves Ven?ncio A Baldus Stephan E B?ttner Reinhard Carvalho Lina Fink Ludger Jochum Wolfram Lo Anthony W I L?pez-R?os Fernando Marx Alexander Molina Thierry J Olszews | 2013 | Archives of Pathology & Laboratory Medicine2013，，9： | 1 |
| 3 | Reoperation for parathy- roid adenoma: a contemporary experience显示文摘 | Powell A C Alexander H R Chang R Marx S J Ska- rulis M Pingpank J F | 2009 | Surgery2009，146，： | 1 |
| 4 | Reoperation for parathy- roid adenoma: a contemporary experience显示文摘 | Powell A C Alexander H R Chang R Marx S J Ska- rulis M Pingpank J F | 2009 | Surgery2009，146，： | 1 |
| 5 | Fine needle aspiration and core needle biopsy in the diagnosis of lymphadenopathy of unknown aetiology显示文摘 | Georgia Metzgeroth Sven Schneider Christoph Walz Sebastian Reiter Wolf-Karsten Hofmann Alexander Marx Jan Hastka | 2012 | Annals of Hematology2012，，9： | 1 |
| 6 | Modulators of the urokinase-type plasminogen activation system for cancer显示文摘 | Ralf Hildenbrand Heike Allgayer Alexander Marx Philipp Stroebel | 2010 | Expert Opinion on Investigational Drugs2010，，5： | 1 |
| 7 | Cryorecanalization: a new approach for the immediate management of acute airway obstruction显示文摘 | Martin Hetzel Juergen Hetzel Christian Schumann Nikolaus Marx Alexander Babiak | 2004 | The Journal of Thoracic and Cardiovascular Surgery2004，，5： | 1 |
| 8 | EDISON-WMW: Exact Dynamic Programing Solution of the Wilcoxon–Mann–Whitney Test显示文摘In many research disciplines, hypothesis tests are applied to evaluate whether findings are statistically significant or could be explained by chance. The Wilcoxon–Mann–Whitney(WMW) test is among the most popular hypothesis tests in medicine and life science to analyze if two groups of samples are equally distributed. This nonparametric statistical homogeneity test is commonly applied in molecular diagnosis. Generally, the solution of the WMW test takes a high combinatorial effort for large sample cohorts containing a significant number of ties. Hence, P value is frequently approximated by a normal distribution. We developed EDISON-WMW, a new approach to calculate the exact permutation of the two-tailed unpaired WMW test without any corrections required and allowing for ties. The method relies on dynamic programing to solve the combinatorial problem of the WMW test efficiently. Beyond a straightforward implementation of the algorithm, we presented different optimization strategies and developed a parallel solution. Using our program,the exact P value for large cohorts containing more than 1000 samples with ties can be calculated within minutes. We demonstrate the performance of this novel approach on randomly-generated data, benchmark it against 13 other commonly-applied approaches and moreover evaluate molecular biomarkers for lung carcinoma and chronic obstructive pulmonary disease(COPD). We foundthat approximated P values were generally higher than the exact solution provided by EDISONWMW. Importantly, the algorithm can also be applied to high-throughput omics datasets, where hundreds or thousands of features are included. To provide easy access to the multi-threaded version of EDISON-WMW, a web-based solution of our algorithm is freely available at http://gffzz5cf87394e3434f43hxvvpw90w0upn6u9n.ffgz.tsg.suse.edu.cn/software/wtest/. | Alexander Marx Christina Backes Eckart Meese Hans-Peter Lenhof Andreas Keller | 2016 | Genomics, Proteomics & Bioinformatics2016，14，1： | 0 |
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