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| 1 | N-butyl cyanoacrylate embolization for control of acute arterial hemorrhage显示文摘 | Kish JW Katz MD Marx MV | 2004 | J Vasc Interv Radiol2004，15，： | 1 |
| 2 | Crossing the Rubicon: When Pancreatic Resection with Curative Intent Ends in an R2 Status显示文摘 | Maximilian Bockhorn MD Guellue Cataldegirmen MD Asad Kutup MD Andreas Marx MD Christoph Burdelski MD Jogesh K. Vashist MD Oliver Mann MD Lena Liebl MD Alexandra K?nig MD Jakob R. Izbicki MD Emre F. Yekebas MD | 2009 | Annals of Surgical Oncology2009，，5： | 1 |
| 3 | Nucleotide sequence of SRV-1,a type D simian acquired immune deficiency syndrome retrovirus显示文摘 | Power MD Marx PA | 1986 | Science1986，231，4745： | 1 |
| 4 | HER-2 amplification is highly homogenous in gastric cancer 显示文摘 | Andreas H Marx MD Lars Tharun | 2009 | Human Pathology2009，40，6： | 1 |
| 5 | A pharmacokinetically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient显示文摘 | Reed MD Yamashita TS Marx CM | 1996 | Crit Care Med1996，24，9： | 1 |
| 6 | A pharmacokinetically based propofol dosing strategy for sedation Of the critically ill, mechanical- ly ventilated pediatric patient显示文摘 | Reed MD Yamashita TS Marx CM | 1996 | Crit Care Med1996，24，9： | 1 |
| 7 | A pharmacokineticallybased propofol dosing strategy for sedation of the critically ill,mechanically ventilated pediatric patient显示文摘 | Reed MD Yamashita TS Marx CM | 2006 | Crit Care Med2006，24，9： | 1 |
| 8 | The Effect of the Fourth- Generation Fluoroquinolones on Corneal Reepithelialization After Penetrating Keratoplasty显示文摘 | Majid Moshirfar MD FACS Douglas P marx | 2005 | Cornea2005，24，7： | 1 |
| 9 | A pharmacoki- netically based propofol dosing strategy for sedation of the critically ill, mechanically ventilated pediatric patient 显示文摘 | Reed MD Yamashita TS Marx CM | 2006 | Crit Care Med2006，24，9： | 1 |
| 10 | N-butylcyanoacrylate emboli- zation for control of acute arterial hemorrhage显示文摘 | Kish JW Katz MD Marx MV | 2004 | J Vasc Interv Ra- dio12004，15，7： | 1 |
| 11 | N-butylcyanoacrylate embo- lizatiou for control of acute arterial hemorrhage 显示文摘 | Kish JW Katz MD Marx MV | 2004 | J Vasc Interv Radiol2004，15，7： | 1 |
| 12 | N-butyl cyanoacry-late embolization for control of acute arterial hemor-rhage显示文摘 | Kish JW Katz MD Marx MV | 2004 | J Vase Interv Radiol2004，15，7： | 1 |
| 13 | Peroxisome proliferator-activated receptors显示文摘 | Ouliana Ziouzenkova PhD Stephane Perrey PhD Niko Marx MD Daniel Bacqueville PhD Jorge Plutzky MD | 2002 | Current Atherosclerosis Reports2002，，1： | 1 |
| 14 | A pharmacokinetically based propofol dosing strategy for sedation of the critically ill,mechanically ventilated pediatric patient显示文摘 | Reed MD Yamashita TS Marx CM | 1996 | Crit Care Med1996，24，9： | 1 |
| 15 | HER-2 amplification is highly homogenous in gastric cancer显示文摘 | Andreas H Marx MD Lars Tharun Johanna Muth | 2009 | Human Pathology2009，40，6： | 1 |
| 16 | Amphotericin B release rate is the link between drug status in the liposomal bilayer and toxicity显示文摘Amphotericin B(AmB)is an amphiphilic drug commonly formulated in liposomes and administered intravenously to treat systemic fungal infections.Recent studies on the liposomal drug product have shed light on the AmB aggregation status in the bilayer,which heat treatment(curing)modifies.Although toxicity was found related to aggregation status-loose aggregates significantly more toxic than tight aggregates-the precise mechanism linking aggregation and toxicitywas notwell understood.This study directlymeasured drug release rate fromvarious AmB liposomal preparations made with modified curing protocols to evaluate correlations among drug aggregation state,drug release,and in vitro toxicity.UV–Vis spectroscopy of these products detected unique curing-induced changes in the UV spectral features:a∼25nm blue-shift of the main absorption peak(λ_(max))in aqueous buffer and a decrease in the OD_(346)/OD_(322) ratio upon thermal curing,reflecting tighter aggregation.In vitro release testing(IVRT)data showed,by applying and fitting first-order release kinetic models for one or two pools,that curing impacts two significant changes:a 3–5-fold drop in the overall drug release rate and a ten-fold decrease in the ratio between the loosely aggregated and the tightly aggregated,more thermodynamically stable drug pool.The kinetic data thus corroborated the trend independently deduced from the UV–Vis spectral data.The in vitro toxicity assay indicated a decreased toxicity with curing,as shown by the significantly increased concentration,causing half-maximal potassium release(TC50).The data suggest that the release of AmB requires dissociation of the tight complexes within the bilayer and that the reduced toxicity relates to this slower rate of dissociation.This study demonstrates the relationship between AmB aggregation status within the lipid bilayer and drug release(directly measured rate constants),providing a mechanistic link between aggregation status and in vitro toxicity in the liposomal formulations. | Yuri Svirkin Jaeweon Lee Richard Marx Seongkyu Yoon Nelson Landrau Md Abul Kaisar Bin Qin Jin H.Park Khondoker Alam Darby Kozak Yan Wang Xiaoming Xu Jiwen Zheng Benjamin Rivnay | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 0 |
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