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| 1 | Diabetic neuropathic pain:Physiopathology and treatment显示文摘Diabetic neuropathy is a common complication of both type 1 and type 2 diabetes,which affects over 90% of the diabetic patients.Although pain is one of the main symptoms of diabetic neuropathy,its pathophysiological mechanisms are not yet fully known.It is widely accepted that the toxic effects of hyperglycemia play an important role in the development of this complication,but several other hypotheses have been postulated.The management of diabetic neuropathic pain consists basically in excluding other causes of painful peripheral neuropathy,improving glycemic control as a prophylactic therapy and using medications to alleviate pain.First line drugs for pain relief include anticonvulsants,such as pregabalin and gabapentin and antidepressants,especial y those that act to inhibit the reuptake of serotonin and noradrenaline.In addition,there is experimental and clinical evidence that opioids can be helpful in pain control,mainly if associated with first line drugs.Other agents,including for topical application,such as capsaicin cream and lidocaine patches,have also been proposed to be useful as adjuvants in the control of diabetic neuropathic pain,but the clinical evidence is insufficient to support their use.In conclusion,a better understanding of the mechanisms underlying diabetic neuropathic pain will contribute to the search of new therapies,but also to the improvement of the guidelines to optimize pain control with the drugs currently available. | Anne K Schreiber Carina FM Nones Renata C Reis Juliana G Chichorro Joice M Cunha | 2015 | World Journal of Diabetes2015，6，3： | 34 |
| 2 | Increased secretion of pro-inflammatory cytokines by circulating polymorphonuclear neutrophills and regulation by interleukin 10 during intestinal inflammation显示文摘Increasedsecretionofproinflammatorycytokinesbycirculatingpolymorphonuclearneutrophilsandregulationbyinterleukin10duringintes... | S Nikolaus 1, J Bauditz 1, P Gionchetti 2, C Witt 3, H Lochs 1 and S Schreiber 1 1Charité University Hospital, 4th Medical Department, Humboldt University, Berlin, Germany 2Clinica Media I, Policlinico S. Orsola, University of Bolog | 1998 | World Journal of Gastroenterology1998，4，3： | 17 |
| 3 | The Arabidopsis DSO/ABCG 11 Transporter Affects Cutin Metabolism in Reproductive Organs and Suberin in Roots显示文摘除了它在对压力条件的保护的意义,表皮的盖子为在天线植物机关上形成的多样的表面结构的合适的开发是必要的。这层主要由一个角质矩阵组成,与表皮的蜡嵌入并且覆盖。在表皮的房间,角质和蜡跟随他们的生合成被建议被象 DSO/ABCG11 那样的 ABCG 类型 transporters 越过血浆膜出口到房间墙并且进一步到细胞外的矩阵。这里, DSO/ABCG11 功能的另外的方面被调查,主要在繁殖机关,它没在以前的报告被揭示。这被显示了相对微妙的词法、化学的显型的一根转基因的 DSO/ABCG11 silenced 线(dso-4 ) 的产生便于。这些包括的改变的花瓣和 silique 形态学,种子的熔化,和在在花和 siliques 的角质单体的层次的变化。dso-4 显型在胚胎外皮以及在发展中的种子的内乳纸巾对应于强壮的 DSO/ABCG11 基因表示。而且, DSO/ABCG11 蛋白质在胚胎 protoderm 显示了极的本地化。dso-4 异种叶子和茎的 Transcriptome 分析证明那项减少的 DSO/ABCG11 活动压制了很多联系表皮的基因的表示,暗示从血浆膜的表皮的类脂化合物的出口是在表皮新陈代谢的限制率的步。令人惊讶地, dso-4 的根软木脂作文被改变,以及二软木脂 biosynthetic 基因的根表示。一起拿,这研究在繁殖机关和根开发提供新卓见进角质和软木脂新陈代谢和他们的角色。 | David Panikashvili Jian Xin Shi Samuel Bocobza Rochus Benni Franke Lukas Schreiber Asaph Aharoni | 2010 | Molecular Plant2010，3，3： | 12 |
| 4 | A concept for multiterawatt fibre lasers based on coherent pulse stacking in passive cavities显示文摘Since the advent of femtosecond lasers,performance improvements have constantly impacted on existing applications and enabled novel applications.However,one performance feature bearing the potential of a quantum leap for high-field applications is still not available:the simultaneous emission of extremely high peak and average powers.Emerging applications such as laser particle acceleration require exactly this performance regime and,therefore,challenge laser technology at large.On the one hand,canonical bulk systems can provide pulse peak powers in the multi-terawatt to petawatt range,while on the other hand,advanced solid-state-laser concepts such as the thin disk,slab or fibre are well known for their high efficiency and their ability to emit high average powers in the kilowatt range with excellent beam quality.In this contribution,a compact laser system capable of simultaneously providing high peak and average powers with high wall-plug efficiency is proposed and analysed.The concept is based on the temporal coherent combination(pulse stacking)of a pulse train emitted from a high-repetition-rate femtosecond laser system in a passive enhancement cavity.Thus,the pulse energy is increased at the cost of the repetition rate while almost preserving the average power.The concept relies on a fast switching element for dumping the enhanced pulse out of the cavity.The switch constitutes the key challenge of our proposal.Addressing this challenge could,for the first time,allow the highly efficient dumping of joule-class pulses at megawatt average power levels and lead to unprecedented laser parameters. | Sven Breitkopf Tino Eidam Arno Klenke Lorenz von Grafenstein Henning Carstens Simon Holzberger Ernst Fill Thomas Schreiber Ferenc Krausz Andreas Tunnermann Ioachim Pupeza Jens Limpert | 2014 | Light(Science & Applications)2014，3，1： | 11 |
| 5 | 齿轮泵嫁接电动机显示文摘设计液压装置中压力产生单元的两大难题是可供使用的结构空间和所要遵守的噪声水平。结构空间可以通过十分简单的计算和绘图进行表现,这里从根本上需要的是寻找正确而合适的部件,并将其安装在整个设备上。噪声水平固然有需要遵守的准则和标准(比如欧盟噪声保护准则2003/10/EG), | Bernd Schreiber | 2005 | 现代制造2005，，20： | 11 |
| 6 | Heavy rockbursts due to longwall mining near protective pillars:A case study显示文摘Rockburst represents a very dangerous phenomenon in deep underground mining in unfavourable conditions such as great depth, high horizontal stress, proximity of important tectonic structures, and unmined pillars. The case study describes a recorded heavy rockburst in the Czech part of the Upper Silesian Coal Basin, which occurred during longwall mining near the protective pillar. The artificial dividing of geological blocks and creation of mining protective pillars(shaft pillars, crosscut pillars etc.) is a dangerous task in light of rockbursts occurring mainly due to overstressing of remaining pillars. A simple model of this situation is presented. Natural and mining conditions are analysed and presented in detail as well as registered seismicity during longwall mining in the area. Recorded rockbursts in the area of interest are described and their causes discussed. Many rockbursts near protective pillars were recorded in this mining region. Methodical instructions for rockburst prevention in proximity of protective pillars as well as for gates driving were devised based on the evaluation of rockburst causes. The paper presents these principles for prevention. | Petr Konicek Jan Schreiber | 2018 | International Journal of Mining Science and Technology2018，28，5： | 9 |
| 7 | Maintenance infliximab for Crohn’s disease: the ACCENT I randomised trial显示文摘 | Stephen B Hanauer Brian G Feagan Gary R Lichtenstein Lloyd F Mayer S Schreiber Jean Frederic Colombel Daniel Rachmilewitz Douglas C Wolf Allan Olson Weihang Bao Paul Rutgeerts | 2002 | The Lancet2002，，9317： | 6 |
| 8 | NOD2-mediated dysbiosis predisposes mice to transmissible colitis and colorectal cancer显示文摘 | Couturier-Maillard Aurélie Secher Thomas Rehman Ateequr Normand Sylvain De Arcangelis Adéle Haesler Robert Huot Ludovic Grandjean Teddy Bressenot Aude Delanoye-Crespin Anne Gaillot Olivier Schreiber Stefan Lemoine Yves Ryffel Bernhard Hot D | 2013 | Journal of Clinical Investigation2013，，2： | 5 |
| 9 | Endoscopic and non-endoscopic approaches for the management of radiation-induced rectal bleeding显示文摘Pelvic radiation is a commonly utilized treatment for malignancy of the genitourinary and lower gastrointestinal tract. Radiation proctitis and the resultant clinical picture varies from asymptomatic to potentially life threatening. Similarly, treatment options also vary greatly, from medical therapy to surgical intervention. Commonly utilized medical therapy includes sucralfate enemas, antibiotics, 5-aminosalicylic acid derivatives, probiotics, antioxidants, short-chain fatty acids, formalin instillation and fractionated hyperbaric oxygen. More invasive treatments include endoscopic-based, focally ablative interventions such as dilation, heater and bipolar cautery, neodymium/yttrium aluminum garnet argon laser, radiofrequency ablation or argon plasma coagulation. Despite its relatively common frequency, there is a dearth of existing literature reporting headto-head comparisons of the various treatment options via a randomized controlled approach. The purpose of our review was to present the reader a consolidation of the existing evidence-based literature with the goal of highlighting the comparative effectiveness and risks of the various treatment approaches. Finally, we outline a pragmatic approach to the treatment of radiation proctitis. In light of the lack of randomized data, our goal is to pursue as least invasive an approach as possible, with escalation of care tailored to the severity of the patient's symptoms. For those cases that are clinicallyasymptomatic or only mildly symptomatic, observation or medical management can be considered. Once a patient fails such management or symptoms become more severe, invasive procedures such as endoscopically based focal ablation or surgical intervention can be considered. Although not all recommendations are supported by level I evidence, reported case series and single-institutional studies in the literature suggest that successful treatment with cessation of symptoms can be obtained in the majority of cases. | Joseph Paul Weiner Andrew Thomas Wong David Schwartz Manuel Martinez Ayse Aytaman David Schreiber | 2016 | World Journal of Gastroenterology2016，22，31： | 5 |
| 10 | <ce:link locator='fx1'/> Adalimumab for Maintenance of Clinical Response and Remission in Patients With Crohn’s Disease: The CHARM Trial显示文摘 | Jean–Frédéric Colombel William J. Sandborn Paul Rutgeerts Robert Enns Stephen B. Hanauer Remo Panaccione Stefan Schreiber Dan Byczkowski Ju Li Jeffrey D. Kent Paul F. Pollack | 2007 | Gastroenterology2007，，1： | 4 |
| 11 | Open label trial of granulocyte apheresis suggests therapeutic efficacy in chronically active steroid refractory ulcerative colitis显示文摘AIM:To study the efficacy, safety, and feasibility of a granulocyte adsorptive type apheresis system for the treatment of patients with chronically active ulcerative colitis despite standard therapy.METHODS: An open label multicenter study was carried out in 39 patients with active ulcerative colitis (CAI6-8) despite continuous use of steroids (a minimum total dose of 400 mg prednisone within the last 4 wk).Patients received a total of five aphereses using a granulocyte adsorptive technique (Adacolumn(R), Otsuka Pharmaceutical Europe, UK). Assessments at wk 6 and during follow-up until 4 mo comprised clinical (CAI) and endoscopic (EI) activity index, histology, quality of life(IBDQ), and laboratory tests.RESULTS: Thirty-five out of thirty-nine patients were qualified for intent-to-treat analysis. After the apheresis treatment at wk 6, 13/35 (37.1%) patients achieved clinical remission and 10/35 (28.6%) patients had endoscopic remission (CAI<4, EI<4). Quality of life (IBDQ) increased significantly (24 points, P<0.01)at wk 6. Apheresis could be performed in all but one patient. Aphereses were well tolerated, only one patient experienced anemia.CONCLUSION: In patients with steroid refractory ulcerative colitis, five aphereses with a granulocyte/monocyte depleting filter show potential short-term efficacy. Tolerability and technical feasibility of the procedure are excellent. | Wolfgang Kruis Axel Dignass Elisabeth Steinhagen-Thiessen Julia Morgenstern Joachim M(o|¨)ssner Stephan Schreiber Maurizio Vecchi Alberto Malesci Max Reinshagen Robert L(o|¨)fberg | 2005 | World Journal of Gastroenterology2005，11，44： | 4 |
| 12 | Endoscopic radiofrequency ablation for malignant biliary obstruction: a nationwide retrospective study of 84 consecutive applications显示文摘 | Werner Dolak Florian Schreiber Hubert Schwaighofer Michael Gschwantler Wolfgang Plieschnegger Alexander Ziachehabi Andreas Mayer Ludwig Kramer Andreas Kopecky Christiane Schrutka-K?lbl Gernot Wolkersd?rfer Christian Madl Frieder Berr Michael Trauner Andre | 2014 | Surgical Endoscopy2014，，3： | 3 |
| 13 | The Three Es of Cancer Immunoediting显示文摘 | Gavin P. Dunn Lloyd J. Old Robert D. Schreiber | 2004 | Annual Review of Immunology2004，，： | 3 |
| 14 | Lactobacilli,bifi dobacteria and E.coli nissle induce pro-and anti-inflammatory cytokines in peripheral blood mononuclear cells显示文摘AIM: To investigate whether the stimulation of peripher- al blood mononuclear cells (PBMNC) with the cell debris and cell extraction of different probiotic strains is similar or species specifi c. METHODS: Three strains of bifi dobacteria, 4 strains of lactobacilli, and E. coli nissle were sonicated and centri- fuged in order to divide them into cell extract and cell debris. PBMNC were separated by density gradient and incubated for 36 h with either the cell debris or the cell extract of single strains of probiotic bacteria in doses from 102 to 108 CFU/mL. Cell supernatants were taken and interleukin (IL)-10, IL-1β, and tumor necosis factor (TNF)-α were determined by ELISA. RESULTS: Depending on the species super-family, the strains had different stimulation patterns. Except for both L. casei strains, the cell extract of bifidobacteriaand lactobacilli had less stimulating capacity than cell debris, whereas the cell extract of E. coli nissle had simi- lar stimulating properties to that of the cell debris of the strain and significantly more stimulating capacity than that of bifi dobacteria and lactobacilli. The cell debris of bifi dobacteria stimulated more cytokine release than the cell debris of lactobacilli. The cell debris of lactobacilli did not have a stimulating capacity when lower concentra- tions were used. Neither cell extraction nor cell debris had an inhibitory effect on the production of the tested cytokines by stimulated PBMNC. CONCLUSION: The incubation of probiotic strains, which have been used in clinical trials for inflammatory diseases, with immunocompetent cells leads to different species specifi c reactions. High IL-10 response to cell de- bris of bifi dobacteria and E. coli nissle can be found. This corresponds to positive effects of bifi dobacteria and E. coli nissle in clinical trials for inflammatory bowel disease compared to negative outcomes obtained with lactoba- cilli. | Ulf Helwig Karen M Lammers Fernando Rizzello Patricia Brigidi Verena Rohleder Elisabetta Caramelli Paolo Giochetti Juergen Schrezenmeir Ulrich R Foelsch Stefan Schreiber Massimo Campieri | 2006 | World Journal of Gastroenterology2006，12，37： | 3 |
| 15 | Domestication and crop evolution of wheat andbarley: Genes, genomics, and future directions显示文摘Wheat and barley are two of the founder crops of the agricultural revolution that took place 10,000 years ago in the Fertile Crescent and both crops remain among the world's most important crops. Domestication of these crops from their wild ancestors required the evolution of traits useful to humans, rather than survival in their natural environment. Of these traits, grain retention and threshability, yield improvement, changes to photoperiod sensitivity and nutritional value are most pronounced between wild and domesticated forms. Knowledge about the geographical origins of these crops and the genes responsible for domestication traits largely pre-dates the era of nextgeneration sequencing, although sequencing will lead to new insights. Molecular markers were initially used to calculate distance(relatedness), genetic diversity and to generate genetic maps which were useful in cloning major domestication genes. Both crops are characterized by large,complex genomes which were long thought to be beyond the scope of whole-genome sequencing. However, advances in sequencing technologies have improved the state of genomic resources for both wheat and barley. The availability of reference genomes for wheat and some of its progenitors,as well as for barley, sets the stage for answering unresolved questions in domestication genomics of wheat and barley. | Matthew Haas Mona Schreiber Martin Mascher | 2019 | Journal of Integrative Plant Biology2019，61，3： | 3 |
| 16 | Printing proteins as microarrays for high-throughput function determination显示文摘 | MacBeath G Schreiber SL | | 0，，： | 2 |
| 17 | Aktualisierte Leitlinie zur Diagnostik und Therapie der Colitis ulcerosa 2011 – Ergebnisse einer Evidenzbasierten Konsensuskonferenz显示文摘 | A. Dignass J. Prei? D. Aust F. Autschbach A. Ballauff G. Barretton B. Bokemeyer S. Fichtner-Feigl S. Hagel K. Herrlinger G. Jantschek A. Kroesen W. Kruis T. Kucharzik J. Langhorst M. Reinshagen G. Rogler D. Schleiermacher C. Schmidt S. Schreiber H. Schulz | 2011 | Z Gastroenterol2011，，09： | 2 |
| 18 | Effects of torpedo blasting on rockburst prevention during deep coal seam mining in the Upper Silesian Coal Basin显示文摘In the Upper Silesian Coal Basin(USCB),coal seams are exploited under progressively more difficult geological and mining conditions(greater depth,higher horizontal stress,more frequent occurrence of competent rock layers,etc.).Mining depth,dislocations and mining remnants in coal seams are the most important factors responsible for the occurrence of rockburst hazards.Longwall mining next to the mining edges of neighbouring coal seams is particularly disadvantageous.The levels of rockburst hazards are minimised via the use of rockburst prevention methods.One active prevention method is torpedo blasting in roof rocks.Torpedo blastings are performed in order to decrease local stress concentrations in rock masses and to fracture the roof rocks to prevent or minimise the impact of high-energy tremors on excavations.The estimation of the effectiveness of torpedo blasting is particularly important when mining is under difficult geological and mining conditions.Torpedo blasting is the main form of active rockburst prevention in the assigned colliery in the Polish part of the USCB.The effectiveness of blasting can be estimated using the seismic effect method,in which the seismic monitoring data and the mass of explosives are taken into consideration.The seismic effect method was developed in the Czech Republic and is always being used in collieries in the Czech part of the coal basin.Now,this method has been widely adopted for our selected colliery in the Polish part of the coal basin.The effectiveness of torpedo blastings in the faces and galleries of the assigned longwall in coal seam 506 has been estimated.The results show that the effectiveness of torpedo blastings for this longwall was significant in light of the seismic effect method,which corresponds to the in situ observations.The seismic effect method is regularly applied to estimating the blasting effectiveness in the selected colliery. | L. Wojtecki P. Konicek J. Schreiber | 2017 | Journal of Rock Mechanics and Geotechnical Engineering2017，9，4： | 2 |
| 19 | Mucosal flora in inflammatory bowel disease显示文摘 | Alexander Swidsinski Axel Ladhoff Annelie Pernthaler Sonja Swidsinski Vera Loening-Baucke Marianne Ortner Jutta Weber Uwe Hoffmann Stefan Schreiber Manfred Dietel Herbert Lochs | 2002 | Gastroenterology2002，，1： | 2 |
| 20 | A New Look at Framing Effects: Distribution of Effect Sizes, Individual Differences, and Independence of Types of Effects显示文摘 | Irwin P. Levin Gary J. Gaeth Judy Schreiber Marco Lauriola | 2002 | Organizational Behavior and Human Decision Processes2002，，1： | 2 |
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