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| 1 | Chromosome-Level Reference Genome and Population Genomic Analysis Provide Insights into the Evolution and Improvement of Domesticated Mulberry (Morns alba)显示文摘Mulberry(Morns spp.)is the sole plant consumed by the domesticated silkworm.However,the genome of domesticated mulberry has not yet been sequenced,and the ploidy level of this species remains unclear.Here,we report a high-quality,chromosome-level domesticated mulberry(Morus alba)genome.Analysis of genomic data and karyotype analyses confirmed that M.alba is a diploid with 28 chromosomes(2/7=2x=28).Population genomic analysis based on resequencing of 134 mulberry accessions classified domesticated mulberry into three geographical groups,namely,Taihu Basin of southeastern China(Hu mulberry),northern and southwestern China,and Japan.Hu mulberry had the lowest nucleotide diversity among these accessions and demonstrated obvious signatures of selection associated with environmental adaptation.Further phylogenetic analysis supports a previous proposal that multiple domesticated mulberry accessions previously classified as different species actually belong to one species.This study expands our understanding of genome evolution of the genus Morus and population structure of domesticated mulberry,which would facilitate mulberry breeding and improvement. | Feng Jiao Rongsong Luo Xuelei Dai Hui Liu Gang Yu Shuhua Han Xin Lu Chao Su Qi Chen Qinxia Song Caiting Meng Fanghong Li Hongmei Sun Rui Zhang Tian Hui Yonghua Qian Aichun Zhao Yu Jiang | 2020 | Molecular Plant2020，13，7： | 10 |
| 2 | Different contribution of SBP and DBP variability to vascular events in patients with stroke显示文摘Background High blood pressure variability(BPV)is a novel risk factor for cardiovascular disease.However,the heterogeneity of systolic blood pressure variability(SBPV)and diastolic blood pressure variability(DBPV)for different vascular events remains unclear.This study aims to investigate whether SBPV or DBPV has different contribution to vascular events in patients with acute ischaemic stroke(IS)or transient ischaemic attack(TIA).Methods Data from the BOSS(blood pressure and clinical outcome in TIA or IS)study were examined for vascular events at 3-month and 1-year follow-up.BPV was defined as the SD and coefficient of variation(CV)of day-to day measurements within 3 months after IS/TIA.Vascular events include cardiovascular events(myocardial infarction,unstable angina,cardiac death and congestive heart failure)and cerebrovascular events(ischaemic or haemorrhagic stroke).Logistic regression model was used to test the associations between BPV and vascular events.results Of 2325 patients with IS or TIA,103(4.43%)experienced a recurrent stroke and 64(2.75%)had cardiovascular events within 3 months.Day-to day SBPV was only associated with stroke recurrence(BPVSD:OR,1.72,95%CI 1.09 to 2.71;BPVCV:1.86,95%CI 1.19 to 2.92),but not cardiovascular events(BPVSD:1.67,95%CI 0.94 to 2.94;BPVCV:1.51,95%CI 0.86 to 2.64).However,DBPV seems to be related to both stroke(BPVSD:1.60,95%CI 1.02 to 2.49;BPVCV:1.53,95%CI 0.99 to 2.37)and cardiovascular events(BPVSD:2.48,95%CI 1.37 to 4.48;BPVCV:1.92,95%CI 1.09 to 3.36).Similar results were found at 1 year.Conclusions For patients with IS/TIA,stroke recurrence was associated with both SBPV and DBPV;however,cardiovascular events seem to be only related to DBPV. | Liye Dai Aichun Cheng Xiwa Hao Jie Xu Yingting Zuo Anxin Wang Xia Meng Hao Li Yilong Wang Xingquan Zhao Yongjun Wang | 2020 | Stroke & Vascular Neurology2020，5，2： | 6 |
| 3 | Preparation of silver tin oxide powders by hydrothermal reduction and crystallization显示文摘Silver tin oxide composite powders were synthesized by the hydrothermal method with a silver ammine solution and a Na2SnO3 solution as raw materials. H2C2O4 was used as the co-precipitator of silver ions and tin ions. The co-precipitation conditions were investigated. The results show that the co-precipitate of Ag2C2O4 and Sn(OH)4 is available when the pH value of the solution is 4.27-8.36. Using the obtained precipitate as precursor,the reduction of Ag+ and the crystallization of tin oxide were carried out simultaneously by the hydrothermal method and silver tin oxide composite powders were obtained. The composite powders were characterized by X-ray diffraction (XRD) analysis,scanning electron microscope (SEM),and energy spectrum analysis. The results show that the silver tin oxide composite powders are small with a diameter of about 2 μm and with homogeneous distribution of tin. | DU Zuojuan YANG Tianzu GU Yingying QIU Xiaoyong DOU Aichun | 2007 | Rare Metals2007，26，5： | 4 |
| 4 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 5 | Environmental archaeology on Longshan Culture (4500-4000 aBP) at Yuhuicun Site in Bengbu, Anhui Province显示文摘Based on the samples collected from the west wall of the ABYT2004 at Yuhuicun Site in Bengbu,Anhui Province,the multi-environmental substitute indexes such as the grain-size,Rb/Sr,zircon crystal morphology and magnetic susceptibility were analyzed.The age of archaeological strata was determined by AMS14C dating.According to the results,combined with the information of the ancient human activities and the cultural heritage data obtained from the Longshan cultural archaeological strata,it can be concluded that(1) Before 4500 aBP,the climate was humid and water level was high in the Huaihe River and its tributaries,the drainage basin and its surrounding areas were even flooded,so the site area was submerged and there were no human activities around the site.(2) About 4500 aBP,the climate began to become drier and water level of the Huaihe River and its tributaries began to decline,thus floodplain gradually appeared,Yuhuicun Site and Longshan Culture began to appear.(3) Around 4100 aBP,the climate was humid and rainfall was abundant,which resulted in frequent flood disasters in the whole Huaihe River Basin.(4) After 4100 aBP,the climate gradually transited to be cold and dry,agricultural production was constrained to reduce the food source,Yuhuicun Site was almost abandoned.(5) The environmental information in sedimentary strata and historical records based on ancient books agree with each other.In addition,Yuhuicun Site was related to Dayu Zhishui(Yu the Great in taming the floods) in ancient books. | ZHANG Guangsheng ZHU Cheng WANG Jihuai ZHU Guangyao MA Chunmei ZHENG Chaogui ZHAO Lanhui LI Zhongxuan LI Lan JIN Aichun | 2010 | Journal of Geographical Sciences2010，20，3： | 3 |
| 6 | Deformation and failure characteristics of sandstone under uniaxial compression using distributed fiber optic strain sensing显示文摘This paper investigates the deformation and fracture propagation of sandstone specimen under uniaxial compression using the distributed fiber optic strain sensing(DFOSS)technology.It shows that the DFOSS-based circumferential strains are in agreement with the data monitored with the traditional strain gage.The DFOSS successfully scans the full-field view of axial and circumferential strains on the specimen surface.The spatiotemporal strain measurement based on DFOSS manifests crack closure and elastoplastic deformation,detects initialization of microcrack nucleation,and identifies strain localization within the specimen.The DFOSS well observes the effects of rock heterogeneity on rock deformation.The advantage of DFOSS-based strain acquisition includes the high spatiotemporal resolution of signals and the ability of full-surface strain scanning.The introduction to the DFOSS technology yields a better understanding of the rock damage process under uniaxial compression. | Lingfan Zhang Duoxing Yang Zhonghui Chen Aichun Liu | 2020 | Journal of Rock Mechanics and Geotechnical Engineering2020，12，5： | 3 |
| 7 | Abnormal event detection via the analysis of multi-frame optical flow information显示文摘Security surveillance of public scene is closely relevant to routine safety of individual.Under the stimulus of this concern,abnormal event detection is becoming one of the most important tasks in computer vision and video processing.In this paper,we propose a new algorithm to address the visual abnormal detection problem.Our algorithm decouples the problem into a feature descriptor extraction process,followed by an AutoEncoder based network called cascade deep AutoEncoder(CDA).The movement information is represented by a novel descriptor capturing the multi-frame optical flow information.And then,the feature descriptor of the normal samples is fed into the CDA network for training.Finally,the abnormal samples are distinguished by the reconstruction error of the CDA in the testing procedure.We validate the proposed method on several video surveillance datasets. | Tian WANG Meina QIAO Aichun ZHU Guangcun SHAN Hichem SNOUSSI | 2020 | Frontiers of Computer Science2020，14，2： | 2 |
| 8 | Chromosome-level Genomes Reveal the Genetic Basis of Descending Dysploidy and Sex Determination in Morus Plants显示文摘Multiple plant lineages have independently evolved sex chromosomes and variable karyotypes to maintain their sessile lifestyles through constant biological innovation.Morus notabilis,a dioecious mulberry species,has the fewest chromosomes among Morus spp.,but the genetic basis of sex determination and karyotype evolution in this species has not been identified.In this study,three high-quality genome assemblies were generated for Morus spp.[including dioecious M.notabilis(male and female)and Morus yunnanensis(female)]with genome sizes of 301–329 Mb and were grouped into six pseudochromosomes.Using a combination of genomic approaches,we found that the putative ancestral karyotype of Morus species was close to 14 protochromosomes,and that several chromosome fusion events resulted in descending dysploidy(2n=2x=12).We also characterized a~6.2-Mb sex-determining region on chromosome 3.Four potential male-specific genes,a partially duplicated DNA helicase gene(named MSDH)and three Ty3_Gypsy long terminal repeat retrotransposons(named MSTG1/2/3),were identified in the Y-linked area and considered to be strong candidate genes for sex determination or differentiation.Population genomic analysis showed that Guangdong accessions in China were genetically similar to Japanese accessions of mulberry.In addition,genomic areas containing selective sweeps that distinguish domesticated mulberry from wild populations in terms of flowering and disease resistance were identified.Our study provides an important genetic resource for sex identification research and molecular breeding in mulberry. | Zhongqiang Xia Xuelei Dai Wei Fan Changying Liu Meirong Zhang Peipei Bian Yuping Zhou Liang Li Baozhong Zhu Shuman Liu Zhengang Li Xiling Wang Maode Yu Zhonghuai Xiang Yu Jiang Aichun Zhao | 2022 | Genomics, Proteomics & Bioinformatics2022，20，6： | 1 |
| 9 | Study on the new type of teaching mode based on 'flipped classroom'显示文摘 | Zhang Qiliang Wang Aichun | 2014 | 42014，4，： | 1 |
| 10 | Qos for storage subsystems using IEEE-1394 显示文摘 | Huang Chihyuan Kuo Teiwei Pang Aichun | 2009 | ACM Transactions on Storage2009，4，4： | 1 |
| 11 | Gynecology and obstetrics nursing quality defects causeand the prevention cotmtermeasures显示文摘 | Aichun liu | 2014 | Journal of medical equipment2014，27，01： | 1 |
| 12 | Ground-dwelling birds near the Qinghai-Tibet highway and railway显示文摘 | Zhongqiu Li Chen Ge Jing Li Yankuo Li Aichun Xu Kexin Zhou Dayuan Xue | 2010 | Transportation Research Part D2010，，8： | 1 |
| 13 | The small-island effect in amphibian assemblages on subtropical land-bridge islands of an inundated lake显示文摘 | Yanping WANG Xi WANG Qiang Wu Cangsong CHEN Aichun Xu Ping DING | 2018 | Current Zoology2018，64，3： | 1 |
| 14 | Regulation of the expression of MHC classⅠandⅡby class Ⅱ transactivator(CⅡTA) in hematopoietic cells 显示文摘 | Aichun L Masuhiro T Ken T | 1999 | Hematol Oncol1999，17，1： | 1 |
| 15 | Protein secondary structures in water from second-derivative amide I infrared spectra 显示文摘 | AICHUN D PING H WINSLOW S C | 1990 | Biochemistry1990，29，13： | 1 |
| 16 | Leukemia blast-induced T-cell anergy demonstrated by leukemia-derived dendritic cells in acute myelogenous leukemia显示文摘 | Miwako Narita Masuhiro Takahashi Aichun Liu | 2001 | Experimental Hematology2001，29，： | 1 |
| 17 | Regulation of the expression of MHC class Ⅰ and Ⅱ by class Ⅱ transactivator ( C Ⅱ TA) in hematopoietic cells 显示文摘 | Aichun L Masuhiro T Ken T | 1999 | Hematol Oncol1999，17，4： | 1 |
| 18 | Inhibition of Sixl promotes apoptesis, suppresses proliferation, and migration of osteosarcoma cells 显示文摘 | Hua L Fan L Aichun W | 2014 | Tumor Biol2014，35，3： | 1 |
| 19 | Inhibition of Six1 promotes apoptosis,suppresses proliferation, and migration of osteosarcoma ceils 显示文摘 | Hua L Fan L Aichun W | 2014 | Tumour Biol2014，35，3： | 1 |
| 20 | Energy-efficient video multicast in 4G wireless systems显示文摘 | Yu Yaju Hsiu P C Pang Aichun | 2012 | IEEE Trans on Mobile Computing2012，11，10： | 1 |
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