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| 1 | Thermal energy storage:Challenges and the role of particle technology显示文摘Thermal energy is at the heart of the whole energy chain providing a main linkage between the primary and secondary energy sources.Thermal energy storage(TES)has a pivotal role to play in the energy chain and hence in future low carbon economy.However,a competitive TES technology requires a number of scientific and technological challenges to be addressed including TES materials,TES components and devices,and integration of TES devices with energy networks and associated dynamic optimization.This paper provides a perspective of TES technology with a focus on TES materials challenges using molten salts based phase change materials for medium and high temperature applications.Two key challenges for the molten salt based TES materials are chemical incompatibility and low thermal conductivity.The use of composite materials provides an avenue to meeting the challenges.Such composite materials consist of a phase change material,a structural supporting material,and a thermal conductivity enhancement material.The properties of the supporting material could determine the dispersion of the thermal conductivity enhancement material in the salt.A right combination of the salt,the structural supporting material,and the thermal conductivity enhancement material could give a hierarchical structure that is able to encapsulate the molten salt and give a substantial enhancement in the thermal conductivity.Understanding of the structure-property relationships for the composite is essential for the formulation design and fabrication of the composite materials.Linking materials properties to the system level performance is recommended as a key future direction of research. | Zhiwei Ge Yongliang Li Dacheng Li Ze Sun Yi Jin Chuanping Liu Chuan Li Guanghui Leng Yulong Ding | 2014 | Particuology2014，12，4： | 20 |
| 2 | Carbonate-salt-based composite materials for medium- and high-temperature thermal energy storage显示文摘This paper discusses composite materials based on inorganic salts for medium- and high-temperature thermal energy storage application.The composites consist of a phase change material(PCM),a ceramic material,and a high thermal conductivity material.The ceramic material forms a microstructural skeleton for encapsulation of the PCM and structural stability of the composites;the high thermal conductivity material enhances the overall thermal conductivity of the composites.Using a eutectic salt of lithium and sodium carbonates as the PCM,magnesium oxide as the ceramic skeleton,and either graphite flakes or carbon nanotubes as the thermal conductivity enhancer,we produced composites with good physical and chemical stability and high thermal conductivity.We found that the wettability of the molten salt on the ceramic and carbon materials significantly affects the microstructure of the composites. | Zhiwei Ge Feng Ye Hui Cao Guanghui Leng Yue Qin Yulong Ding | 2014 | Particuology2014，12，4： | 19 |
| 3 | Multi-walled carbon nanotubes added to Na_2CO_3/MgO composites for thermal energy storage显示文摘Na_2CO_3/MgO composites with added multi-walled carbon nanotubes(MWCNTs) were prepared and tested as phase change materials(PCMs) for thermal energy storage.Na_2CO_3/MgO composite PCMs were prepared and their chemical compatibility and thermal stability were studied.MWCNTs introduced with Na_2CO_3/MgO composite PCMs were also investigated and scanning electron microscopy(SEM) characterization was used to demonstrate the uniform dispersion of MWCNTs in Na2C03/MgO composite PCMs.The composites with added MWCNTs still display good thermal stability with mass losses lower than 5%.Introducing MWCNTs into composite Na_2CO_3/MgO PCMs by material formation/calcination significantly enhances the thermal conductivity of the composite PCMs.The thermal conductivity of the composite PCMs was found to increase with an increase in the weight fraction of the added MWCNTs and an increase in the testing temperature.This study may present a promising way to prepare high temperature phase change materials with superior properties such as improved thermal stability. | Feng Ye Zhiwei Ge Yulong Ding Jun Yang | 2014 | Particuology2014，12，4： | 13 |
| 4 | Industrialization prospects for hydrogen production by coal gasification in supercritical water and novel thermodynamic cycle power generation system with no pollution emission显示文摘Energy conversion and utilization, particularly carbon-based fuel burning in air phase, have caused great environmental pollution and serious problems to society. The reactions in water phase may have the potential to realize clean and efficient energy conversion and utilization. Coal gasification in supercritical water is a typical carbon-based fuel conversion process in water phase, and it takes the advantages of the unique chemical and physical properties of supercritical water to convert organic matter in coal to H2 and CO2. N, S, P, Hg and other elements are deposited as inorganic salts to avoid pollution emission. The State Key Laboratory of Multiphase Flow in Power Engineering has obtained extensive experimental and theoretical results based on coal gasification in supercritical water. Supercritical water fluidized bed reactor was developed for coal gasification and seven kinds of typical feedstock were selected. The hydrogen yield covers from 0.67 to 1.74 Nm3/kg and the carbon gasification efficiency is no less than 97%. This technology has a bright future in industrialization not only in electricity generation but also in hydrogen production and high value-added chemicals. Given the gas yield obtained in laboratory-scale unit, the hydrogen production cost is U.S.$ 0.111 Nm3 when the throughput capacity is 2000 t/d. A novel thermodynamic cycle power generation system based on coal gasification in supercritical water was proposed with the obvious advantages of high coal-electricity conversion efficiency and zero pollutant emission. The cost of U.S.$ 3.69 billion for desulfuration, denitration and dust removal in China in 2013 would have been saved with this technology. Five kinds of heat supply methods are analyzed and the rates of return of investment are roughly estimated. An integrated cooperative innovation center called a new type of high-efficient coal gasification technology and its large-scale utilization was founded to enhance the industrialization of the technology vigorously. | GUO LieJin JIN Hui GE ZhiWei LU YouJun CAO ChangQing | 2015 | Science China(Technological Sciences)2015，58，12： | 7 |
| 5 | Turbidite and bottom-current evolution revealed by anisotropy of magnetic susceptibility of redox sediments in the Ulleung Basin,Sea of Japan显示文摘Anisotropy of magnetic susceptibility(AMS) from above and below 7.31 m in a core from the southern Ulleung Basin shows clear differences on an equal area projection of the lower hemisphere.Rather concentrated steep inclination of K 3 and horizontal inclination of K 1 and K 2(K1 ≥K2 ≥K3) are located within the upper part,and the latter two axes lie perpendicular to each other near the bedding plane.In contrast,random distribution of the three axes and extremely high value of shape parameters(Q=(K1-K2)/[(K1+K2)/2-K3]) are evident in the lower part,indicating complete destruction of the original sedimentary structure.This result is consistent with data from X-radiographs,which show numerous conglomerates,distortions and cleavages in the lower part.According to age models by Liu et al.(2010) and Zou et al.(2010),the bottom age at 7.31 m is 48 cal ka BP,and the time domain is discussed below.The degree of AMS(P) is low,1-1.08,and linearly related to the foliation(F)(R2 =0.95,N=176).The relationship between F and linearity(L) implies oblate aligning patterns that are typically sedimentary in origin.At least five redox couplets were found with the aid of S ratios and other rock magnetic parameters,and in most cases,the original signals of climate survived early diagenesis.The paleomagnetically reoriented AMS show corresponding changes with millennial events in the last 48 cal ka.Clearly tilted K 3 directions and reduction of P and F occurred within DO1-BA warm events,when melt water pulse 1A nd the YD cold event took place.The turbulent conditions therein,synchronous with coarsening of sediments,provide evidence of strong bottom currents and possible directional changes,as evidenced by different K3 tilting directions.A NE current direction in the last 4.5 cal ka is consistent with in situ measurements of bottom currents.Responses of AMS,mainly to climatic modulation,show on the one hand,the limited influence of diagenesis on rock magnetic signals and,on the other hand,the dramatic change of hydrodynamic conditions and terrigenous inputs during rapid sea level rise during the last deglaciation. | GE ShuLan SHI XueFa LIU YanGuang WANG KunShan ZOU JianJun DIAO JingYu ZHU ZhiWei WANG ChunJuan | 2012 | Chinese Science Bulletin2012，57，6： | 7 |
| 6 | Manipulation of Band Degeneracy and Lattice Strain for Extraordinary PbTe Thermoelectrics显示文摘Maximizing band degeneracy and minimizing phonon relaxation time are proven to be successful for advancing thermoelectrics.Alloying with monotellurides has been known to be an effective approach for converging the valence bands of PbTe for electronic improvements,while the lattice thermal conductivity of the materials remains available room for being further reduced.It is recently revealed that the broadening of phonon dispersion measures the strength of phonon scattering,and lattice dislocations are particularly effective sources for such broadening through lattice strain fluctuations.In this work,a fine control of MnTe and EuTe alloying enables a significant increase in density of electron states near the valence band edge of PbTe due to involvement of multiple transporting bands,while the creation of dense in-grain dislocations leads to an effective broadening in phonon dispersion for reduced phonon lifetime due to the large strain fluctuations of dislocations as confirmed by synchrotron X-ray diffraction.The synergy of both electronic and thermal improvements successfully leads the average thermoelectric figure of merit to be higher than that ever reported for p-type PbTe at working temperatures. | Yixuan Wu Pengfei Nan Zhiwei Chen Zezhu Zeng Siqi Lin Xinyue Zhang Hongliang Dong Zhiqiang Chen Hongkai Gu Wen Li Yue Chen Binghui Ge Yanzhong Pei | 2020 | Research2020，，1： | 6 |
| 7 | Chromosome-level genome of Himalayan yew provides insights into the origin and evolution of the paclitaxel biosynthetic pathway显示文摘Taxus,commonly known as yew,is a well-known gymnosperm with great ornamental and medicinal value.In this study,by assembling a chromosome-level genome of the Himalayan yew(Taxus wallichiana)with 10.9 Gb in 12 chromosomes,we revealed that tandem duplication acts as the driving force of gene family evolution in the yew genome,resulting in the main genes for paclitaxel biosynthesis,i.e.those encoding the taxadiene synthase,P450s,and transferases,being clustered on the same chromosome.The tandem duplication may also provide genetic resources for the nature to sculpt the core structure of taxoids at different positions and subsequently establish the complex pathway of paclitaxel by neofunctionalization.Furthermore,we confirmed that there are two genes in the cluster encoding isoenzymes of a known enzyme in the paclitaxel biosynthetic pathway.The reference genome of the Himalayan yew will serve as a platform for decoding the complete biosynthetic pathway of paclitaxel and understanding the chemodi-versity of taxoids in gymnosperms. | Jian Cheng Xiao Wang Xiaonan Liu Xiaoxi Zhu Zihe Li Huanyu Chu Qian Wang QianQian Lou Bijun Cai Yiqun Yang Xiaoyun Lu Kai Peng Dingyu Liu Yuwan Liu Lina Lu Huan Liu Ting Yang Qijin Ge Chengcheng Shi Guichun Liu Zhiwei Dong Xun Xu Wen Wang Huifeng Jiang Yanhe Ma | 2021 | Molecular Plant2021，14，7： | 6 |
| 8 | Starch grain analysis reveals Late Neolithic plant utilization in the middle reaches of the Ganjiang River显示文摘Plant utilization is poorly known in South China as compared to North China.Fanchengdui, Zhuweicheng, Shinianshan, and Yinjiaping, which date back to 5-4 ka BP, are typical Neolithic sites located at the middle reaches of the Ganjiang River in Jiangxi Province.Due to the lack of systematic plant archaeological work, only rice straw and husk residues have been found in some archaeological sites in Jiangxi Province.Thirteen stone tools excavated from these sites were examined in this study.The results showed that among the plants utilized are Coix spp., Oryza spp., Vigna spp., plants from the tribe Triticeae, roots from some plants of Zingiberaceae, and other species of roots and tubers.More than 457 grains were retrieved from the 13 stone tools.The fact that Coix spp.were found in all stone tools suggests that these species were a major food source during the Neolithic era.In addition, 28 starch grains of Oryza spp.were found in 8 stone tools.The analysis also revealed that not only seeds of Gramineae but also those of Leguminosae, Zingiberaceae and other species of roots and tubers are among the plants utilized in the four Fanchengdui culture sites.These results indicate that ancient plant utilization was rather diverse, and this study elucidates the prehistoric agricultural systems of South China. | WAN ZhiWei YANG XiaoYan GE QuanSheng FAN ChangSheng ZHOU GuangMing JIANG MeiXin | 2012 | Science China Earth Sciences2012，55，12： | 5 |
| 9 | Deep-blue organic light-emitting diodes based on a doublet d-f transition cerium(Ⅲ) complex with 100% exciton utilization efficiency显示文摘Compared to red and green organic light-emitting diodes(OLEDs),blue OLEDs are still the bottleneck due to the lack of efficient emitters with simultaneous high exciton utilization efficiency(EUE)and short excited-state lifetime.Different from the fluorescence,phosphorescence,thermally activated delayed fluorescence(TADF),and organic radical materials traditionally used in OLEDs,we demonstrate herein a new type of emitter,cerium(Ⅲ)complex Ce-1 with spin-allowed and parity-allowed d-f transition of the centre Ce^(3+) ion.The compound exhibits a high EUE up to 100% in OLEDs and a short excited-state lifetime of 42 ns,which is considerably faster than that achieved in efficient phosphorescence and TADF emitters.The optimized OLEDs show an average maximum external quantum efficiency(EQE)of 12.4% and Commission Internationale de L’Eclairage(CIE)coordinates of(0.146,0.078). | Liding Wang Zifeng Zhao Ge Zhan Huayi Fang Hannan Yang Tianyu Huang Yuewei Zhang Nan Jiang Lian Duan Zhiwei Liu Zuqiang Bian Zhenghong Lu Chunhui Huang | 2020 | Light(Science & Applications)2020，9，1： | 3 |
| 10 | Efficient rare earth cerium(Ⅲ)complex with nanosecond d-f emission for blue organic light-emitting diodes显示文摘In the field of RGB diodes,development of a blue organic light-emitting diode(OLED)is a challenge because of the lack of an emitter which simultaneously has a short excited state lifetime and a high theoretical external quantum efficiency(EQE).We demonstrate herein a blue emissive rare earth cerium(III)complex Ce-2 showing a high photoluminescence quantum yield of 95%and a short excited state lifetime of 52.0 ns in doped film,which is considerably faster than that achieved in typical efficient phosphorescence or thermally activated delayed fluorescence emitters(typical lifetimes>1μs).The corresponding OLED shows a maximum EQE up to 20.8%and a still high EQE of 18.2%at 1000 cd m^(-2),as well as an operation lifetime 70 times longer than that of a classic phosphorescence OLED.The excellent performance indicates that cerium(III)complex could be a candidate for efficient and stable blue OLEDs because of its spin-and parity-allowed d-f transition from the Ce^(3+)ion. | Zifeng Zhao Liding Wang Ge Zhan Zhiwei Liu Zuqiang Bian Chunhui Huang | 2021 | National Science Review2021，8，2： | 3 |
| 11 | Recent Progress in Atmospheric Chemistry Research in China: Establishing a Theoretical Framework for the “Air Pollution Complex”显示文摘Atmospheric chemistry research has been growing rapidly in China in the last 25 years since the concept of the“air pollution complex”was first proposed by Professor Xiaoyan TANG in 1997.For papers published in 2021 on air pollution(only papers included in the Web of Science Core Collection database were considered),more than 24000 papers were authored or co-authored by scientists working in China.In this paper,we review a limited number of representative and significant studies on atmospheric chemistry in China in the last few years,including studies on(1)sources and emission inventories,(2)atmospheric chemical processes,(3)interactions of air pollution with meteorology,weather and climate,(4)interactions between the biosphere and atmosphere,and(5)data assimilation.The intention was not to provide a complete review of all progress made in the last few years,but rather to serve as a starting point for learning more about atmospheric chemistry research in China.The advances reviewed in this paper have enabled a theoretical framework for the air pollution complex to be established,provided robust scientific support to highly successful air pollution control policies in China,and created great opportunities in education,training,and career development for many graduate students and young scientists.This paper further highlights that developing and low-income countries that are heavily affected by air pollution can benefit from these research advances,whilst at the same time acknowledging that many challenges and opportunities still remain in atmospheric chemistry research in China,to hopefully be addressed over the next few decades. | Tong ZHU Mingjin TANG Meng GAO Xinhui BI Junji CAO Huizheng CHE Jianmin CHEN Aijun DING Pingqing FU Jian GAO Yang GAO Maofa GE Xinlei GE Zhiwei HAN Hong HE Ru-Jin HUANG Xin HUANG Hong LIAO Cheng LIU Huan LIU Jianguo LIU Shaw Chen LIU Keding LU Qingxin MA Wei NIE Min SHAO Yu SONG Yele SUN Xiao TANG Tao WANG Tijian WANG Weigang WANG Xuemei WANG Zifa WANG Yan YIN Qiang ZHANG Weijun ZHANG Yanlin ZHANG Yunhong ZHANG Yu ZHAO Mei ZHENG Bin ZHU Jiang ZHU | 2023 | Advances in Atmospheric Sciences2023，40，8： | 2 |
| 12 | Expression of sulfur uptake assimilation-related genes in response to cadmium,bensulfuron-methyl and their co-contamination in rice roots显示文摘The responses of sulfur(S) uptake assimilation-related genes' expression in roots of two rice cultivars to cadmium(Cd), bensulfuron-methyl(BSM) and their co-contamination(Cd+BSM) were investigated by gene-chip microarray analysis and quantitative real-time PCR(QRT-PCR) technology. Treatments of Cd and Cd+BSM induced expression of sulfate transporter and permease genes, and promoted sulfate uptake in rice roots. Cd+BSM could alleviate Cd toxicity to cv. Fengmeizhan seedlings, probably due to Cd+BSM promoting greater S absorption by seedlings. Cd and Cd+BSM induced expression of sulfate assimilation-related genes, and thus activated the sulfur assimilation pathway. Cd and Cd+BSM induced expression of phytochelatin synthase and metallothionein genes, and induced expression of glutathione S-transferases(GSTs), glutathione synthase(GS) and antioxidation enzyme genes, which detoxified Cd2+. It is suggested that(to cope with the toxicity of Cd, BSM and their co-contamination) the S uptake and assimilation pathway was activated in rice roots by increased expression of related genes, thus enhancing the supply of organic S for synthesis of Cd or BSM resistance-related substances. | Jian Zhou Zegang Wang Zhiwei Huang Chao Lu Zhuo Han Jianfeng Zhang Huimin Jiang Cailin Ge Juncheng Yang | 2014 | Journal of Environmental Sciences2014，26，3： | 2 |
| 13 | Prognostic Significance of SOX2 Expression in Nasopharyngeal Carcinoma显示文摘 | Xin Wang Yi Liang Qiong Chen Hui-Min Xu Nan Ge Rong-Zhen Luo Jian-Yong Shao Zhiwei He Yi-Xin Zeng Tiebang Kang Jing-Ping Yun Fangyun Xie | 2012 | Cancer Investigation2012，，1： | 1 |
| 14 | Experimental study on Zhundong coal gasification in supercritical water with a quartz reactor: Reaction kinetics and pathway显示文摘 | Xiaohui Su Hui Jin Liejin Guo Simao Guo Zhiwei Ge | 2015 | International Journal of Hydrogen Energy2015，，24： | 1 |
| 15 | Soil respiration in poplar plantations in northern China at different for- est ages显示文摘 | Gong Jirui Ge Zhiwei An Ran | 2012 | Plant Soil2012，360，1： | 1 |
| 16 | A novel long-term intravenous combined with local treatment with human amnion-derived mesenchymal stem cells for a multidisciplinary rescued uremic calciphylaxis patient and the underlying mechanism显示文摘Calciphylaxis is a rare disease characterized histologically by microvessel calcification and microthrombosis,with high mortality and no proven therapy.Here,we reported a severe uremic calciphylaxis patient with progressive skin ischemia,large areas of painful malodorous ulcers,and mummified legs.Because of the worsening symptoms and signs refractory to conventional therapies,treatment with human amnion-derived mesenchymal stem cells(hAMSCs)was approved.Preclinical release inspections of hAMSCs,efficacy,and safety assessment,including cytokine secretory ability,immunocompetence,tumorigenicity,and genetics analysis in vitro,were introduced.We further performed acute and long-term hAMSC toxicity evaluations in C57BL/6 mice and rats,abnormal immune response tests in C57BL/6 mice,and tumorigenicity tests in neonatal Balbc-nu nude mice.After the preclinical research,the patient was treated with hAMSCs by intravenous and local intramuscular injection and external supernatant application to the ulcers.When followed up to 15 months,the blood-based markers of bone and mineral metabolism improved,with skin soft tissue regeneration and a more favorable profile of peripheral blood mononuclear cells.Skin biopsy after 1-month treatment showed vascular regeneration with mature noncalcified vessels within the dermis,and 20 months later,the re-epithelialization restored the integrity of the damaged site.No infusion or local treatment-related adverse events occurred.Thus,this novel long-term intravenous combined with local treatment with hAMSCs warrants further investigation as a potential regenerative treatment for uremic calciphylaxis due to effects of inhibiting vascular calcification,stimulating angiogenesis and myogenesis,anti-inflammatory and immune modulation,multidifferentiation,re-epithelialization,and restoration of integrity. | Lianju Qin Jing Zhang Yujie Xiao Kang Liu Yugui Cui Fangyan Xu Wenkai Ren Yanggang Yuan Chunyan Jiang Song Ning Xiaoxue Ye Ming Zeng Hanyang Qian Anning Bian Fan Li Guang Yang Shaowen Tang Zhihong Zhang Juncheng Dai Jing Guo Qiang Wang Bin Sun Yifei Ge Chun Ouyang Xueqiang Xu Jing Wang Yaoyu Huang Hongqing Cui Jing Zhou Meilian Wang Zhonglan Su Yan Lu Di Wu Jingping Shi Wei Liu Li Dong Yinbing Pan Baiqiao Zhao Ying Cui Xueyan Gao Zhanhui Gao Xiang Ma Aiqin Chen Jie Wang Meng Cao Qian Cui Li Chen Feng Chen Youjia Yu Qiang Ji Zhiwei Zhang Mufeng Gu Xiaojun Zhuang Xiaolin Lv Hui Wang Yanyan Pan Ling Wang Xianrong Xu Jing Zhao Xiuqin Wang Cuiping Liu Ningxia Liang Changying Xing Jiayin Liu Ningning Wang | 2022 | Journal of Molecular Cell Biology2022，14，2： | 1 |
| 17 | Experimental Investigation on Hydrophobic Behavior of Carbon Spheres Coated Surface Made from Microplastics显示文摘In this paper,a simple method to plate a hydrophobic coating on the inner surface of a small-scaled tube was proposed,where the coating consisted of carbon microspheres.Three common plastics polystyrene,polycarbonate and polyethylene were used as the feedstocks to be processed in supercritical water in a quartz tubular reactor.After reaction,the contact angle of droplet on the inner surface of the quartz tube was turned out to be over 100°,significantly larger than that of the blank tube 54°.When processing polystyrene in the 750℃ supercritical water for 10 min,the largest contact angle was obtained,up to 145°.Besides,in this sample,the size of carbon spheres was smallest,about 2.09μm diameter on average.When comparing among different types of plastics under the same condition,the contact angle of surface made from PC took the dominant position over that of PS and PE,124°,100°and 90°,respectively.In the sample made from PC,carbon spheres adhered into a mountainlike shape,producing a binary geometric structure.Furthermore,this research could be helpful in the discussion of plastic waste management and carbon spheres fabrication with low cost. | Peng Liu Bin Bai Cui Wang Yunan Chen Zhiwei Ge Wenwen Wei Hui Jin | 2021 | Journal of Renewable Materials2021，9，12： | 0 |
| 18 | Prmt1 upregulated by Hdc deficiency aggravates acute myocardial infarction via NETosis显示文摘Neutrophils are mobilized and recruited to the injured heart after myocardial infarction,and neutrophil count has been clinically implicated to be associated with coronary disease severity.Histidine decarboxylase(HDC)has been implicated in regulating reactive oxidative species(ROS)and the differentiation of myeloid cells.However,the effect of HDC on neutrophils after myocardial infarction remains unclear.Here,we found that neutrophils were disorderly recruited into the ischemic injured area of the myocardium of Hdc deficiency(Hdc^(−/−))mice.Moreover,Hdc deficiency led to attenuated adhesion but enhanced migration and augmented ROS/neutrophil extracellular traps(NETs)production in neutrophils.Hdc^(−/−)mouse-derived NETs promoted cardiomyocyte death and cardiac fibroblast proliferation/migration.Furthermore,protein arginine methyltransferase 1(PRMT1)was increased in Hdc^(−/−)mouse-derived neutrophils but decreased with exogenous histamine treatment.Its expression could be rescued by blocking histamine receptor 1(H1R),inhibiting ATP synthesis or reducing SWItch/sucrose non fermentable(SWI/SNF)chromatin remodeling complex.Accordingly,histamine or MS023 treatment could decrease ROS and NETs ex vivo,and ameliorated cardiac function and fibrosis,along with the reduced NETs in plasma in vivo.Together,our findings unveil the role of HDC in NETosis by histamine–H1R–ATP–SWI/SNF–PRMT1–ROS signaling and provide new biomarkers and targets for identifying and tuning the detrimental immune state in cardiovascular disease. | Zhiwei Zhang Suling Ding Zhe Wang Xiaowei Zhu Zheliang Zhou Weiwei Zhang Xiangdong Yang Junbo Ge | 2022 | Acta Pharmaceutica Sinica B2022，12，4： | 0 |
| 19 | SARS-CoV-2 N protein enhances the anti-apoptotic activity of MCL-1 to promote viral replication显示文摘Viral infection in respiratory tract usually leads to cell death,impairing respiratory function to cause severe disease.However,the diversity of clinical manifestations of SARS-CoV-2 infection increases the complexity and difficulty of viral infection prevention,and especially the high-frequency asymptomatic infection increases the risk of virus transmission.Studying how SARS-CoV-2 affects apoptotic pathway may help to understand the pathological process of its infection.Here,we uncovered SARS-CoV-2 imployed a distinct anti-apoptotic mechanism via its N protein.We found SARS-CoV-2 virus-like particles(trVLP)suppressed cell apoptosis,but the trVLP lacking N protein didn’t.Further study verified that N protein repressed cell apoptosis in cultured cells,human lung organoids and mice.Mechanistically,N protein specifically interacted with anti-apoptotic protein MCL-1,and recruited a deubiquitinating enzyme USP15 to remove the K63-linked ubiquitination of MCL-1,which stabilized this protein and promoted it to hijack Bak in mitochondria.Importantly,N protein promoted the replications of IAV,DENV and ZIKV,and exacerbated death of IAV-infected mice,all of which could be blocked by a MCL-1 specific inhibitor,S63845.Altogether,we identifed a distinct anti-apoptotic function of the N protein,through which it promoted viral replication.These may explain how SARS-CoV-2 effectively replicates in asymptomatic individuals without cuasing respiratory dysfunction,and indicate a risk of enhanced coinfection with other viruses.We anticipate that abrogating the N/MCL-1-dominated apoptosis repression is conducive to the treatments of SARS-CoV-2 infection as well as coinfections with other viruses. | Pan Pan Weiwei Ge Zhiwei Lei Wei luo Yuqing Liu Zhanwen Guan Lumiao Chen Zhenyang Yu Miaomiao Shen Dingwen Hu Qi Xiang Wenbiao Wang Pin Wan Mingfu Tian Yang Yu Zhen Luo Xulin Chen Heng Xiao Qiwei Zhang Xujing Liang Xin Chen Yongkui Li Jianguo Wu | 2023 | Signal Transduction and Targeted Therapy2023，8，6： | 0 |
| 20 | Effect of calcination temperature on B-site vacancy content of La0.75Sr0.25Mn0.92△0.08O3-δperovskite显示文摘Lanthanum manganite with cation vacancies from nominal La_(0.75)Sr_(0.25)Mn_(0.92)△_(0.08)O_(3-δ) nanocrystalline powder was successfully prepared at different calcination temperatures using the sol-gel method. X-ray diffraction shows that as the calcination temperature(T_(Cal)) increases, the crystal particle diameter increases, but the B-site vacancy content decreases. According to a powder diffraction profile fitting technique and transmission electron microscopy results, the vacancy content can be estimated as 0.08,0.01, and 0.005 for T_(Cal) = 1073,1273, and 1473 K, respectively. Magnetization versus temperature curves show that the magnetic transition temperatures, including the Curie temperature, are influenced by both B-site vacancies and double-exchange interaction between Mn^(3+) and Mn^(4+) cations. A core-shell model is proposed for vacancies located on the surfaces of the crystal particles. As an application, the magnetic moment angle θ_(ij) between Mn^(3+) and Mn^(4+) cations on the surface, which decreases with decreasing vacancy content, can be obtained. | Denghui Ji Shuling Wang Xingze Ge Xinju Xiao Liwei Wang Zhiwei Zeng Congmin Zhang | 2018 | Journal of Rare Earths2018，36，3： | 0 |
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