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| 1 | SHP2 promotes proliferation of breast cancer cells through regulating Cyclin D1 stabilityviathe PI3K/AKT/GSK3β signaling pathway显示文摘Objective:The tyrosine phosphatase SHP2 has a dual role in cancer initiation and progression in a tissue type-dependent manner.Several studies have linked SHP2 to the aggressive behavior of breast cancer cells and poorer outcomes in people with cancer.Nevertheless,the mechanistic details of how SHP2 promotes breast cancer progression remain largely undefined.Methods:The relationship between SHP2 expression and the prognosis of patients with breast cancer was investigated by using the TCGA and GEO databases.The expression of SHP2 in breast cancer tissues was analyzed by immunohistochemistry.CRISPR/Cas9 technology was used to generate SHP2-knockout breast cancer cells.Cell-counting kit-8,colony formation,cell cycle,and EdU incorporation assays,as well as a tumor xenograft model were used to examine the function of SHP2 in breast cancer proliferation.Quantitative RT-PCR,western blotting,immunofluorescence staining,and ubiquitination assays were used to explore the molecular mechanism through which SHP2 regulates breast cancer proliferation.Results:High SHP2 expression is correlated with poor prognosis in patients with breast cancer.SHP2 is required for the proliferation of breast cancer cellsin vitro and tumor growthin vivo through regulation of Cyclin D1 abundance,thereby accelerating cell cycle progression.Notably,SHP2 modulates the ubiquitin–proteasome-dependent degradation of Cyclin D1viathe PI3K/AKT/GSK3βsignaling pathway.SHP2 knockout attenuates the activation of PI3K/AKT signaling and causes the dephosphorylation and resultant activation of GSK3β.GSK3βthen mediates phosphorylation of Cyclin D1 at threonine 286,thereby promoting the translocation of Cyclin D1 from the nucleus to the cytoplasm and facilitating Cyclin D1 degradation through the ubiquitin–proteasome system.Conclusions:Our study uncovered the mechanism through which SHP2 regulates breast cancer proliferation.SHP2 may therefore potentially serve as a therapeutic target for breast cancer. | Yue Yuan Yanling Fan Zicong Gao Xuan Sun He Zhang Zhiyong Wang Yanfen Cui Weijie Song Zhaosong Wang Fei Zhang Ruifang Niu | 2020 | Cancer Biology & Medicine2020，17，3： | 11 |
| 2 | A Comparative Study on Different Parallel Solvers for Nonlinear Analysis of Complex Structures显示文摘 | Lei Zhang Guoxin Zhang Lixiang Wang Zhaosong Ma Shihai Li Zhiqiang Hu | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 3 | A GPU-Based Parallel Procedure for Nonlinear Analysis of Complex Structures Using a Coupled FEM/DEM Approach显示文摘 | Lixiang Wang Shihai Li Guoxin Zhang Zhaosong Ma Lei Zhang Zhiqiang Hu | 2013 | Mathematical Problems in Engineering2013，，： | 1 |
| 4 | Directional terahertz holography with thermally active Janus metasurface显示文摘Dynamic manipulation of electromagnetic(EM)waves with multiple degrees of freedom plays an essential role in enhancing information processing.Currently,an enormous challenge is to realize directional terahertz(THz)holography.Recently,it was demonstrated that Janus metasurfaces could produce distinct responses to EM waves from two opposite incident directions,making multiplexed dynamic manipulation of THz waves possible.Herein,we show that thermally activated THz Janus metasurfaces integrating with phase change materials on the meta-atoms can produce asymmetric transmission with the designed phase delays.Such reconfigurable Janus metasurfaces can achieve asymmetric focusing of THz wave and directional THz holography with free-space image projections,and particularly the information can be manipulated via temperature and incident THz wave direction.This work not only offers a common strategy for realizing the reconfigurability of Janus metasurfaces,but also shows possible applications in THz optical information encryption,data storage,and smart windows. | Benwen Chen Shengxin Yang Jian Chen Jingbo Wu Ke Chen Weili Li Yihui Tan Zhaosong Wang Hongsong Qiu Kebin Fan Caihong Zhang Huabing Wang Yijun Feng Yunbin He Biaobing Jin Xinglong Wu Jian Chen Peiheng Wu | 2023 | Light(Science & Applications)2023，12，6： | 1 |
| 5 | Application of deep- sea psychrotolerant bacteria in wastewater treatment by aerobic dynamic membrane bioreactors at low temperature 显示文摘 | Huang Zhaosong Qie Yan Wang Zhende | 2015 | Journal of Membrane Science2015，475，： | 1 |
| 6 | Verification and comparison of bed load transport formulas 显示文摘 | WANG Xingkui LI Danxun QU Zhaosong | 2001 | Journal of Hydrodynamics (B1)2001，，13： | 1 |
| 7 | Verification and Comparison of Bed Load Transport Formulas显示文摘 | Wang Xingkui Li Danxun Qu Zhaosong and Wang Dianchang | 2001 | Journal of Hydrodynamics (B1)2001，，13： | 1 |
| 8 | Application of deep- sea psychrotolerant bacteria in wastewater treatment by aerobic dynamic membrane bioreactors at low temperature 显示文摘 | Huang Zhaosong Qie Yan Wang Zhende | 2015 | Journal of Membrane Science2015，475，： | 1 |
| 9 | Rapid Detection ofK-ras Gene Point Mutation at Codon 12 by PCR-SSPin Pancreatic Adenocarcinom a显示文摘To evaluate the feasibility and clinical significance of the PCR SSP technique in detecting K ras gene mutation at codon 12 in pancreatic adenocarcinoma tissues. 80 specimens of surgical resection or biopsy samples were tested at our hospital from January 1994 to September 1995. Three different special sequence primers (SSP) synthesized according to mutation styles of CGT, GTT, GAT were respectively prepared. Three amplification reactions were performed for each sample. The amplification products were analyzed by conventional polyacrylamide gel electrophoresis, stained with ethidium bromide and observed under UV transillumination. Results: All of the 34 pancreatic adenocarcinoma samples had positive PCR results with the mutation rate 100%. 7 cases were CGT mutation, 18 GGT and 17 GAT mutation, in which 2 types of mutation existed in 8 cases. No mutation appeared in 13 normal pancreatic tissues, 6 insulinomas, 6 chronic pancreatitis, 5 benign pancreatic cysts, 7 bile duct carcinoma, 5 ampulla carcinoma and 4 carcinomas of duodenal papilla. Conclusion: Pancreatic adenocarcinoma is one of the commonly encounted tumors and is still very difficult to diagnose at the early stage and to distinguish from other lesions preoperatively. Our study indicates that PCR SSP is an ideal assay in comparison with other methods to detect K ras gene mutation. It is simple, rapid, specific, sensitive and easily generalized for clinical application on preoperative diagnosis. | Liu Xunliang (刘训良) Dai Cuncai (戴存才) Du Jinghui (杜竞辉) Miao Yi (苗 毅) Zhang Zhaosong (张兆松) 1 Cheng Shuzhen (陈淑贞) 1 Wang Xiang (王 翔) 1 Department of General Surgery, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, P.R. China 1Molecular Biology Research Center, Nanjing Medical University, Nanjing 210029, P.R. China | 1999 | The Journal of Biomedical Research1999，23，2： | 0 |
| 10 | VIS+AI: integrating visualization with artificial intelligence for efficient data analysis显示文摘Visualization and artificial intelligence(AI)are well-applied approaches to data analysis.On one hand,visualization can facilitate humans in data understanding through intuitive visual representation and interactive exploration.On the other hand,AI is able to learn from data and implement bulky tasks for humans.In complex data analysis scenarios,like epidemic traceability and city planning,humans need to understand large-scale data and make decisions,which requires complementing the strengths of both visualization and AI.Existing studies have introduced AI-assisted visualization as AI4VIS and visualization-assisted AI as VIS4AI.However,how can AI and visualization complement each other and be integrated into data analysis processes are still missing.In this paper,we define three integration levels of visualization and AI.The highest integration level is described as the framework of VIS+AI,which allows AI to learn human intelligence from interactions and communicate with humans through visual interfaces.We also summarize future directions of VIS+AI to inspire related studies. | Xumeng WANG Ziliang WU Wenqi HUANG Yating WEI Zhaosong HUANG Mingliang XU Wei CHEN | 2023 | Frontiers of Computer Science2023，17，6： | 0 |
| 11 | Asymmetric quantum well broadband thyristor laser显示文摘A broadband thyristor laser based on InGaAs/GaAs asymmetric quantum well(AQW) is fabricated by metal organic chemical vapor deposition(MOCVD). The 3-μm-wide Fabry–Perot(FP) ridge-waveguide laser shows an S-shape I-V characteristic and exhibits a flat-topped broadband optical spectrum coverage of ~27 nm(Δ_(-10) dB) at a center wavelength of ~1090 nm with a total output power of 137 mW under pulsed operation. The AQW structure was carefully designed to establish multiple energy states within, in order to broaden the gain spectrum. An obvious blue shift emission, which is not generally acquired in QW laser diodes, is observed in the broadening process of the optical spectrum as the injection current increases. This blue shift spectrum broadening is considered to result from the prominent band-filling effect enhanced by the multiple energy states of the AQW structure, as well as the optical feedback effect contributed by the thyristor laser structure. | Zhen Liu Jiaqi Wang Hongyan Yu Xuliang Zhou Weixi Chen Zhaosong Li Wei Wang Ying Ding Jiaoqing Pan | 2017 | Journal of Semiconductors2017，38，11： | 0 |
| 12 | InP-based monolithically integrated few-mode devices显示文摘Mode-division multiplexing(MDM) has become an increasingly important technology to further increase the transmission capacity of both optical-fiber-based communication networks, data centers and waveguidebased on-chip optical interconnects. Mode manipulation devices are indispensable in MDM system and have been widely studied in fiber, planar lightwave circuits, and silicon and InP based platforms. InP-based integration technology provides the easiest accessibility to bring together the functions of laser sources, modulators, and mode manipulation devices into a single chip, making it a promising solution for fully integrated few-mode transmitters in the MDM system. This paper reviews the recent progress in InP-based mode manipulation devices, including the few-mode converters, multiplexers, demultiplexers, and transmitters. The working principle, structures, and performance of InP-based few-mode devices are discussed. | Dan Lu Yiming He Zhaosong Li Lingjuan Zhao Wei Wang | 2018 | Journal of Semiconductors2018，39，10： | 0 |
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