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| 1 | The Genome of Medicinal Plant Macleaya cordata Provides New Insights into Benzylisoquinoline Alkaloids Metabolism显示文摘在动物农业和药的抗菌素的 overuse 引起了一系列潜在的威胁到公共健康。Macleaya cordata 是从 Papaveraceae 家庭的药用的植物种,提供为抗菌剂的制造的一个安全资源为家畜喂添加剂。从 M. 的活跃成分 ? cordata 被知道包括 benzylisoquinoline 碱(偏爱) 象 sanguinarine (圣) 和 chelerythrine (CHE ) 那样的 ?,而是他们的新陈代谢的小径还得在这非模型植物被学习。在 M. 的圣和 CHE 的活跃生合成 ? cordata 被喂 13标记 C 的酷氨酸。为了增加,推进卓见,我们 de novo 定序 M 的整个染色体。cordata,第一从 Papaveraceae 家庭被定序。M.? 盖住 378 Mb 的 cordata 染色体与 43.5%being 编码 22,328 预言的编码蛋白质的基因 transposable 元素。作为基础 eudicot 的一个成员, M.? cordata 染色体缺乏 ? 发生在几乎所有 eudicots 的 paleohexaploidy 事件。从 genomics 数据, 16 的一个完全的集合 ? 新陈代谢 ? 为圣和 CHE 生合成的基因被检索,并且 14 项他们的生物化学的活动被验证。这些 genomics 和新陈代谢的数据在 M. 显示出保存 BIA 新陈代谢的小径 ? cordata 并且由庄稼改进或微生物引起的小径重建为圣和 CHE 的未来生产提供知识基础。 | Xiubin Liu Yisong Liu Peng Huang Yongshuo Ma Zhixing Qing Qi Tang Huifen Cao Pi Cheng Yajie Zheng Zejun Yuan Yuan Zhou Jinfeng Liu Zhaoshan Tang Yixiu Zhuo Yancong Zhang Linlan Yu Jialu Huang Peng Yang Qiong Peng dinbo Zhang Wenkai Jiang Zhonghua Zhang Kui Lin Dae-Kyun Ro Xiaoya Chen Xingyao Xiong Yi Shang Sanwen Huang Jianguo Zeng | 2017 | Molecular Plant2017，10，7： | 19 |
| 2 | Initial study of biexponential model of intravoxel incoherent motion magnetic resonance imaging in evaluation of the liver fibrosis显示文摘 | Chen Cuiyun Wang Bin Shi Dapeng Fu Fangfang Zhang Jiliang Wen Zejun Zhu Shaocheng Xu Junling Lin Qing Li Jing Dou Shewei | 2014 | Chinese Medical Journal2014，，17： | 15 |
| 3 | Fabrication of Ti/Al/Mg laminated composites by hot roll bonding and their microstructures and mechanical properties显示文摘Ti/Al/Mg laminated composites were successfully fabricated by hot roll bonding.The effects of the rolling reduction on the microstructural evolution and mechanical properties of the composites were explored.The results show that Ti/Al/Mg laminated sheets exhibit good interfacial bonding.The rolling reduction has a significant effect on the deformation inhomogeneity through the thickness of the Al layer.The initial grains of the Al layer near the Ti/Al interface are fragmented into fine equiaxed grains,and the grains at the center and near the Al/Mg interface are elongated.The R-cube shear texture of the Al layer forms near the Ti/Al interface and permeates into the center layer in the samples with greater rolling reductions.The b-fiber rolling texture of the Al layer is observed near the Al/Mg interface and increases with the increase of rolling reduction.The stress–strain curves indicate that the fracture appears first in the Mg layer.With the increasing rolling reduction,the ultimate tensile and yield strength values increase,and the elongation up to the Mg layer fracture decreases. | Pengju WANG Zejun CHEN Hongtao HUANG Jianshu LIN Boxin LI Qing LIU | 2021 | Chinese Journal of Aeronautics2021，34，8： | 4 |
| 4 | In situ self-assembled organoid for osteochondral tissue regeneration with dual functional units显示文摘The regeneration of hierarchical osteochondral units is challenging due to difficulties in inducing spatial,directional and controllable differentiation of mesenchymal stem cells(MSCs)into cartilage and bone compartments.Emerging organoid technology offers new opportunities for osteochondral regeneration.In this study,we developed gelatin-based microcryogels customized using hyaluronic acid(HA)and hydroxyapatite(HYP),respectively for inducing cartilage and bone regeneration(denoted as CH-Microcryogels and OS-Microcryogels)through in vivo self-assembly into osteochondral organoids.The customized microcryogels showed good cytocompatibility and induced chondrogenic and osteogenic differentiation of MSCs,while also demonstrating the ability to self-assemble into osteochondral organoids with no delamination in the biphasic cartilage-bone structure.Analysis by mRNA-seq showed that CH-Microcryogels promoted chondrogenic differentiation and inhibited inflammation,while OS-Microcryogels facilitated osteogenic differentiation and suppressed the immune response,by regulating specific signaling pathways.Finally,the in vivo engraftment of pre-differentiated customized microcryogels into canine osteochondral defects resulted in the spontaneous assembly of an osteochondral unit,inducing simultaneous regeneration of both articular cartilage and subchondral bone.In conclusion,this novel approach for generating self-assembling osteochondral organoids utilizing tailor-made microcryogels presents a highly promising avenue for advancing the field of tissue engineering. | Zhen Yang Bin Wang Wei Liu Xiaoke Li Kaini Liang Zejun Fan Jiao Jiao Li Yudi Niu Zihao He Hui Li Du Wang Jianjing Lin Yanan Du Jianhao Lin Dan Xing | 2023 | Bioactive Materials2023，，9： | 2 |
| 5 | An improved YOLOv3-tiny algorithm for vehicle detection in natural scenes显示文摘YOLO(You Only Look Once),as a target detection algorithm with good speed and precision,is widely used in the industry.In the process of driving,the vehicle image captured by the driving camera is detected and it extracts the license plate and the front part of the vehicle.Compared with the network structure of YOLOv3-tiny algorithm,the acquisition method of anchor box is improved by combining the Birch algorithm.In order to improve the real-time performance,the original two-scale detection is added to the multi-scale prediction of three-scale detection to ensure its accuracy.Finally,the experimental results show that the improved YOLOv3-tiny network structure proposed in this study can improve the performance of mean-average-precision,intersection over union and speed by 5.99%,17.52%and 48.4%,respectively,and the algorithm has certain robustness. | Bingqiang Huang Haiping Lin Zejun Hu Xinjian Xiang Jiana Yao | 2021 | IET Cyber-Systems and Robotics2021，3，3： | 2 |
| 6 | DPPH radicalsca- venging activity of ten natural p-terphenyl derivatives obtained from three edible mushrooms indigenous to China显示文摘 | Hu Jikai Hu Lin Dong Zejun | 2004 | Chem Biodiversi2004，，1： | 1 |
| 7 | Targeting cellular senescence prevents glucocorticoid-induced bone loss through modulation of the DPP4-GLP-1 axis显示文摘Dear Editor,Glucocorticoids(GCs)often cause detrimental side effects,including osteoporosis and osteonecrosis,with no specific drugs available to circumvent these problems.1 Cellular senescence plays an essential role in bone loss,2,3 where senescent cells release various factors,termed senescence-associated secretory phenotype(SASP),which influences neighboring cells and disrupts normal tissues.2 Glucocorticoids can induce senescence in bone cells in young mice;2 however,the effects of GCs on senescence and SASP during bone metabolism in adult mice are unclear. | Tiantian Wang Lin Yang Zejun Liang Lin Wang Feijing Su Xiangxiu Wang Xuanhe You Chengqi He | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 8 | Length of the ORF, position of the first AUG and the Kozak motif are important factors in potential dual-coding transcripts显示文摘一个单个哺乳动物的抄本通常编码一蛋白质,但是 GNAS (G 蛋白质伪 - 子单元) 的抄本包含二个读物框架并且生产二在结构上无关的蛋白质, XL 伪 s 和 ALEX。没有其它证实象 GNAS 一样双编码的抄本迄今为止被报导了,尽管许多如此的候选人基因被生物信息学分析预言了。在这研究,我们构造了一系列向量测试二个蛋白质产品怎么在 vitro 从一个单个抄本被翻译。ORF (开的读框架) 的长度,第一 8 月的位置和 Kozak 主题被发现是重要因素。这些因素,以及 55-bp NMD (调停胡说八道的 mRNA 腐烂) 规则,为候选人在生物信息学搜索被使用双编码的抄本。分别地, 1307, 750 和 474 个 two-ORF-containing 抄本的一个总数分别地, 170, 89 和 70 哪个被发现是潜在的双编码的抄本在人,老鼠和老鼠被发现。大多数抄本在种类之中显示出低保存。有趣地,双编码的抄本显著地从锌手指蛋白质家庭为抄本被充实,它通常是涉及抄写过程的规定的 DNA 有约束力的蛋白质。 | Heng Xu Ping Wang Yujie Fu Yufang Zheng Quan Tang Lizhen Si Jin You Zhenguo Zhang Yufei Zhu Li Zhou Zejun Wei Bin Lin Landian Hu Xiangyin Kong | 2010 | Cell Research2010，20，4： | 1 |
| 9 | DPPH radical scavenging activity of ten natural p-terphenyl derivatives obtained from three edible mushrooms indigenous to China显示文摘 | Hu Jikai Hu Lin Dong Zejun | 2004 | Chem Biodiversi2004，1，： | 1 |
| 10 | An efficient approach for dynamic impedance of surface footing on layered half-space显示文摘 | Gao Lin Zejun Han Jianbo Li | 2013 | Soil Dynamics and Earthquake Engineering2013，，： | 1 |
| 11 | A culture-free method for detection of Vibrio vulnif icus from coastal seawater based on loop-mediated isothermal amplification targeting vcgC gene显示文摘Vibrio vulnificus is an opportunistic pathogen widely distributed in estuarine and coastal seawaters.In this study,a culture-free method was developed to rapid detection of V.vulnificus in all seasons,based on loop-mediated isothermal amplification(LAMP) targeting virulent-correlated gene(vcg).The new assay method allows differentiation between the virulent and non-virulent strain of V.vulnificus accurately.This method also allows effective detection of the pathogeny in winter when the bacterium lives in the viable but non-culturable(VBNC) state.A total of 30 costal seawater samples collected in all seasons were used for the evaluation of this method.The results show that the method is sensitive,accurate and convenient. | LI Yongjun ZHENG Zejun ZHAO Yulong WEI Xiaona ZHU Lin HUANG Xitai | 2010 | Acta Oceanologica Sinica2010，29，2： | 1 |
| 12 | DPPH radical scavenging activity of ten natural p-terphenyl derivatives obtained from three edible mushrooms indigenous to China显示文摘 | Liu Jikai Hu Lin Dong Zejun | 2004 | Chem Biodiversity2004，1，： | 1 |
| 13 | Water-soluble ions in hailstones in northern and southwestern China显示文摘Natural hailstones were collected and analyzed in the laboratory not only for their physical properties (e.g., structure, density,shape, and air bubbles), but also for their chemical properties(e.g., organic particles, biological particles, and water-soluble ions),which can help a clear understanding on microphysics and development of hailstorms [1–4]. Aerosol particles were carried up from the atmospheric boundary layer to the free atmosphere into | Xiaofei Li Qinghong Zhang Tong Zhu Zejun Li Jipei Lin Tian Zou | 2018 | Science Bulletin2018，63，18： | 1 |
| 14 | DPPH radical scavenging activity of ten natural p-terphenyl derivatives obtained from three edible mushroom indigenous to China显示文摘 | LIU Jikai HU Lin DONG Zejun | 2004 | Chem Biodiversi2004，，1： | 1 |
| 15 | 番茄育种重建果实代谢组显示文摘文章简介人类的生存和文明的发展密切依赖于几十种植物的驯化和育种改良,为了系统地揭示番茄育种对果实代谢组的影响。本研究中产生了一个多组学的数据集,包括几百份材料的基因组、转录组和代谢组,对番茄驯化和育种改良开展了多组学的研究。 | 祝光涛 王守创 Zejun Huang Shuaibin Zhang Qinggang Liao Chunzhi Zhang Tao Lin Mao Qin Meng Peng Chenkun Yang Xue Cao Xu Han Xiaoxuan Wang Esther van der Knaap Zhonghua Zhang Xia Cui Harry Klee Alisdair R.Fernie 罗杰 黄三文 | 2019 | 科学新闻2019，0，2： | 0 |
| 16 | Short-term inhalation exposure evaluations of airborne antibiotic resistance genes in environments显示文摘Antibiotic resistance is a sword of Damocles that hangs over humans.In regards to airborne antibiotic resistance genes(AARGs),critical knowledge gaps still exist in the identification of hotspots and quantification of exposure levels in different environments.Here,we have studied the profiles of AARGs,mobile genetic elements(MGEs)and bacterial communities in various atmospheric environments by high throughput q PCR and 16S r RNA gene sequencing.We propose a new AARGs exposure dose calculation that uses short-term inhalation(STI).Swine farms and hospitals were high-risk areas where AARGs standardised abundance was more abundant than suburbs and urban areas.Additionally,resistance gene abundance in swine farm worker sputum was higher than that in healthy individuals in other environments.The correlation between AARGs with MGEs and bacteria was strong in suburbs but weak in livestock farms and hospitals.STI exposure analysis revealed that occupational intake of AARGs(via PM10)in swine farms and hospitals were 110 and 29 times higher than in suburbs,were 1.5×10^(4),5.6×10^(4)and 5.1×10^(2)copies,i.e.,61.9%,75.1%and 10.7%of the overall daily inhalation intake,respectively.Our study comprehensively compares environmental differences in AARGs to identify high-risk areas,and forwardly proposes the STI exposure dose of AARGs to guide risk assessment. | Zhenchao Zhou Xinyi Shuai Zejun Lin Lingxuan Meng Xiaoliang Ba Mark AHolmes Hong Chen | 2022 | Journal of Environmental Sciences2022，34，12： | 0 |
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