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| 1 | Extensive translation of circular RNAs driven by N6-methyladenosine显示文摘广泛的 pre-mRNA 拼接背在人的 transcriptome 产生众多的圆形的 RNA (circRNAs ) 。然而,这些 circRNAs 的生物功能仍然保持大部分不清楚。这里,我们报导那 N 6-methyladenosine (m 6 一) , RNA 的最丰富的基础修正,在人的房间从 circRNAs 支持蛋白质翻译的有效开始。我们发现那一致 m 6 A 主题在 circRNAs 和单个 m 6 一个地点是足够的驾驶翻译开始。这 m 6A 驱动的翻译要求开始因素 eIF4G2 和 m 6 读者 YTHDF3,并且被 methyltransferase METTL3/14 提高,在热吃惊之上由 demethylase FTO,和 upregulated 禁止了。通过介绍的 polysome 的进一步的分析,计算预言和集体 spectrometry 揭示那 m 6 circRNAs 的 A 驱动的翻译是普遍的,与有翻译潜力的几百内长的 circRNAs。我们的学习扩展人的 transcriptome 的编码风景,并且在对环境应力的细胞的回答建议导出 circRNA 的蛋白质的一个角色。 | Yun Yang Xiaojuan Fan Miaowei Mao Xiaowei Song Ping Wu6,7 Yang Zhang Yongfeng Jin Yi Yang Ling-Ling Chen Yang Wang Catherine CL Wong Xinshu Xiao Zefeng Wang | 2017 | Cell Research2017，27，5： | 246 |
| 2 | Efficient elimination of multidrug-resistant bacteria using copper sulfide nanozymes anchored to graphene oxide nanosheets显示文摘Antibacterial nanomaterials have attracted growing interest for bacterial infection therapy.However,most nanomaterials eliminate bacteria either physically or chemically,which hampers their efficacy when dealing with multidrug-resistant bacteria.To overcome this,we integrated copper sulfide(CuS)nanoparticles with active graphene oxide nanosheets(GO NSs)to synthesize a superior nanocomposite(CuS/GO NC)that acts both physically and chemically on the bacteria.CuS/GO NC was produced using a facile hydrothermal method,whereby the CuS nanoparticles grew and were uniformly dispersed on the GO NSs in situ.We found that the CuS/GO NC possesses a unique needle-like morphology that physically damages the bacterial cell membrane.CuS/GO NC also exhibits high oxidase-and peroxidase-like activity,ensuring efficient generation of the reactive oxygen species•OH from H2O2,which kills bacteria chemically.These features endow the CuS/GO NC with excellent antibacterial capabilities to kill multidrug-resistant bacteria such as methicillin-resistant Staphylococcus aureus(MRSA)with only a single dose.Additionally,it was found that the CuS/GO NC accelerated the healing of infected wounds in vivo owing to its good biocompatibility as well as facilitation of cell migration and collagen secretion.This study provides a new strategy to combine the physical and chemical antibacterial modes of nanomaterials to develop more effective therapies to combat multidrug-resistant bacterial infections. | Wanshun Wang Binglin Li Huili Yang Zefeng Lin Lingling Chen Zhan Li Jiayuan Ge Tao Zhang Hong Xia Lihua Li Yao Lu | 2020 | Nano Research2020，13，8： | 8 |
| 3 | SPSBl-mediated HnRNP A1 alternative splicing and cell ubiquitylation regulates migration in EGF signaling显示文摘细胞外的信号被显示了影响拼接的其他的 pre-mRNA;然而,分子的机制和导致信号的拼接的规定的生物意义仍然保持大部分未知。这里,我们报导那个表皮的生长因素(EGF ) 通过一个著名拼接管理者的 ubiquitylation 导致拼接的变化, hnRNP A1。EGF 发信号 upregulates 一个 E3 ubiquitin (Ub ) ligase 适配器,敏捷的包含域的 SOCS 盒子蛋白质 1 (SPSB1 ) ,它结合离氨酸 29 连接 polyUb 链到 hnRNP A1 上的成员 Elongin B/C-Cullin 建筑群。重要地, hnRNP A1 的 SPSB1 和 ubiquitylation 在驾驶 EGF 的房间移植有一个关键角色。机械学地,和 SR 蛋白质 kinases (SRPK ) 的激活的 hnRNP A1 的导致 EGF 的 ubiquitylation 导致拼接的 Rac1 的 upregulation isoform, Rac1b,支持房间活动性。这些调查结果解开在蛋白质 ubiquitylation 并且在 EGF/EGF 受体发信号的其他的拼接之间的新奇串音,并且在 modulating 房间移植识别新 EGF/SPSB1/hnRNP A1/Rac1 轴,它可以为癌症治疗有重要含意。 | Feng Wang Xing Fu Peng Chen Ping Wu Xiaojuan Fan Na Li Hong Zhu Ting-Ting Jia Hongbin Ji Zefeng Wang Catherine C L Wong Ronggui Hu Jingyi Hui | 2017 | Cell Research2017，27，4： | 5 |
| 4 | Enhancing light-matter interaction in 2D materials by optical micro/nano architectures for high-performance optoelectronic devices显示文摘Two-dimensional materials are a promising solution for next-generation electronic and optoelectronic devices due to their unique properties.Owing to the atomic thickness of 2D materials,the light-matter interaction length in 2D materials is much shorter than that in bulk materials,which limits the performance of optoelectronic devices composed of 2D materials.To improve the light-matter interactions,optical micro/nano architectures have been introduced into 2D material optoelectronic devices.In this review,we present a concise introduction and discussion of various strategies for the enhancement of lightmatter interaction in 2D materials,namely,the plasmonic effect,waveguide,optical cavity,and reflection architecture.We have outlined the current advances in high-performance 2D material optoelectronic devices(eg,photodetectors,electrooptic modulators,light-emitting diodes,and molecular sensors)assisted by these enhancement strategies.Finally,we have discussed the future challenges and opportunities of micro/nano photonic structure designs in 2D material devices. | Li Tao Zefeng Chen Zhiyong Li Jiaqi Wang Xin Xu Jian-Bin Xu | 2021 | InfoMat2021，3，1： | 5 |
| 5 | Raman micro-spectrometry as a technique for investigating heterogeneous reactions on individual atmospheric particles显示文摘Investigating the heterogeneous reaction on individual atmospheric particles is important because it approximates actual atmospheric conditions and can aid in reducing artifacts in elucidating real mechanisms and processes,and determining real kinetic parameters of the atmosphere relevance.This study developed a Raman microspectrometry method to investigate heterogeneous reactions on individual particles.The method was applied to the reaction of NO2 with individual CaCO3 particles.It was demonstrated that Raman microspectrometry can obtain information on both chemical composition and microscopic morphology at the same time,as well as information on chemical characteristics,such as the phase,which is useful for studying reaction processes.Raman spectra of individual particles deposited on a substrate showed no interference by morphological resonance,which is helpful for obtaining high-quality spectra.Moreover,Raman microspectrometry was compared with other methods for investigating heterogeneous reactions on individual particles and was found to have several advantageous characteristics. | ZHAO DeFeng,ZHU Tong,CHEN Qi,LIU YingJun & ZHANG ZeFeng State Key Joint Laboratory of Environmental Simulation and Pollution Control College of Environmental Sciences and Engineering,Peking University,Beijing 100871,China | 2011 | Science China Chemistry2011，54，1： | 5 |
| 6 | Efficient passivation of monolayer MoS2 by epitaxially grown 2D organic crystals显示文摘Monolayer molybdenum disulfide(Mo S2)is considered to be a promising candidate for field-effect transistors and photodetectors due to its direct bandgap and atomically thin properties.However,the Mo S2devices are impeded by the intrinsic surface defects and environmental adsorption such as H2O and O2.Here,we demonstrated a highly ordered,ultrathin(<5 nm)and scalable N,N0-ditridecylperylene-3,4,9,10-tetracarboxylic diimide(PTCDI-C13)passivation layer that can be epitaxially grown on Mo S2.The van der Waals interface between PTCDI-C13 and Mo S2can efficiently reduce the surface traps and isolate Mo S2from ambient.As a result,the passivated devices exhibit huge improvement in both carrier mobility(from 0.5 to 8.3 cm^2/(V s))and sub-threshold swing(from 16.7 to 1.6 V/dec).Also,the photodetector made on Mo S2after passivation has a much faster response speed(from 3 s to 10 ms)without significant sacrifice of the responsivity.Our method provides a facile approach to realize high-performance two-dimensional electronic and optoelectronic devices. | Xin Xu Zefeng Chen Beilei Sun Yu Zhao Li Tao Jian-Bin Xu | 2019 | Science Bulletin2019，64，22： | 1 |
| 7 | Effects of therapeutic mild hypothermia on patients with severe traumatic brain injury after craniotomy显示文摘 | Wusi Qiu Ying Zhang Hong Sheng Jianmin Zhang Weiming Wang Weiguo Liu Keyong Chen Junfu Zhou Zefeng Xu | 2007 | Journal of Critical Care2007，，3： | 1 |
| 8 | A theory of carbon currency显示文摘We propose a new international monetary system based on carbon currency(the carbon standard)to tackle two pressing externalities in today’s global economic and political context:the dangerous and irreversible effects caused by unconstrained green-house gas emissions and the cost to the rest of the world as a result of the U.S.dollar being the dominated global currency and the U.S.Federal Reserve increasingly implementing monetary policies not aligned with the global common interest.We define carbon currency as standardized carbon-related securities backed up by the right of one unit of carbon emissions.It can be used as a new global reserve currency and functions as an international unit of account.Through the trading of carbon currency,efficient carbon prices are established.By incorporating the cost of carbon emissions into decision making,carbon pricing provides incentives for countries to pursue low-carbon growth,which helps achieve the net zero emissions global goal set under the 2015 Paris Agreement.Under the carbon standard,the external shocks to the international financial system would come from variations of carbon emissions rather than the U.S.monetary policies.As such,monetary authorities’commitment to maintaining stable exchange rates comes together with monetary policies aiming at pursuing low-carbon growth.The new system potentially poses a plausible solution to the classical Mundellian Trilemma because the objectives of maintaining fixed exchange rate and implementing monetary policy become one.Although several hurdles are constraining the launch of carbon currency immediately,the carbon standard poses a feasible international monetary system as the world-wide campaign to achieve carbon neutrality progresses. | Qiao Liu Zefeng Chen Sylvia Xiaolin Xiao | 2022 | Fundamental Research2022，2，3： | 1 |
| 9 | Pijx confers broad-spectrum seedling and panicle blast resistance by promoting the degradation of ATP β subunit and OsRbohC-mediated ROS burst in rice显示文摘Rice blast,caused by the fungal pathogen Magnaporthe oryzae,is one of the most important diseases of rice.Utilization of blast-resistance genes is the most economical,effective,and environmentally friendly way to control the disease.However,genetic resources with broad-spectrum resistance(BSR)that is effective throughout the rice growth period are rare.In this work,using a genome-wide association study,we identify a new blast-resistance gene,Pijx,which encodes a typical CC-NBS-LRR protein.Pijx is derived from a wild rice species and confers BSR to M.oryzae at both the seedling and panicle stages.The functions of the resistant haplotypes of Pijx are confirmed by gene knockout and overexpression experiments.Mechanistically,the LRR domain in Pijx interacts with and promotes the degradation of the ATP synthase β subunit(ATPb)via the 26S proteasome pathway.ATPb acts as a negative regulator of Pijx-mediated panicle blast resistance,and interacts with OsRbohC to promote its degradation.Consistently,loss of ATPb function causes an increase in NAPDH content and ROS burst.Remarkably,when Pijx is introgressed into two japonica rice varieties,the introgression lines show BSR and increased yields that are approximately 51.59%and 79.31%higher compared with those of their parents in a natural blast disease nursery.In addition,we generate PPL^(Pijx Pigm) and PPL^(Pijx Piz-t) pyramided lines and these lines also have higher BSR to panicle blast compared with Pigm-or Piz-t-containing rice plants.Collectively,this study demonstrates that Pijx not only confers BSR to M.oryzae but also maintains high and stable rice yield,providing new genetic resources and molecular targets for breeding rice varieties with broad-spectrum blast resistance. | Ning Xiao Yunyu Wu Xiaoxiang Zhang Zeyun Hao Zichun Chen Zefeng Yang Yue Cai Ruyi Wang Ling Yu Zhiping Wang Yue Lu Wei Shi Cunhong Pan Yuhong Li Changhai Zhou Jianju Liu Niansheng Huang Guangqing Liu Hongjuan Ji Shuhao Zhu Shuai Fang Yuese Ning Aihong Li | 2023 | Molecular Plant2023，16，11： | 0 |
| 10 | Novel recombinant R-spondin1 promotes hair regeneration by targeting the Wnt/β-catenin signaling pathway显示文摘Roof plate-specific spondin 1(R-spondin1,RSPO1)is a Wnt/β-catenin signaling pathway activator that binds with Wnt ligands to stimulate the Wnt/β-catenin signaling pathway,which is key to hair regeneration.However,it is not clear whether recombinant RSPO1(rRSPO1)affects hair regeneration.Here,we treat C57BL/6 male mice with rRSPO1 and investigate the expression of the Wnt/β-catenin signaling pathway and the activation of hair follicle stem cells in the dorsal skin.The mouse skin color score and hair-covered area are determined to describe hair growth,and the skin samples are subjected to H&E staining,western blot analysis and immunofluorescence staining to evaluate hair follicle development and the expressions of Wnt/β-catenin signaling pathway-related proteins.We find that rRSPO1 activates mouse hair follicle stem cells(mHFSCs)and accelerates hair regeneration.rRSPO1 increases the hair-covered area,the number of hair follicles,and the hair follicle diameter and length.Moreover,rRSPO1 enhances the activity of Wnt/β-catenin signaling pathway-related proteins and the expressions of HFSC markers,as well as mHFSC viability.These results indicate that subcutaneous injection of rRSPO1 can improve hair follicle development by activating the Wnt/β-catenin signaling pathway,thereby promoting hair regeneration.This study demonstrates that rRSPO1 has the potential to treat hair loss by activating the Wnt/β-catenin signaling pathway. | Yijun Chen Zhujin Lu Jiaxin Feng Zefeng Chen Zejian Liu Xiuqi Wang Huichao Yan Chunqi Gao | 2023 | Acta Biochimica et Biophysica Sinica2023，55，8： | 0 |
| 11 | Micheliolide exerts effects in myeloproliferative neoplasms through inhibiting STAT3/5 phosphorylation via covalent binding to STAT3/5 proteins显示文摘Ruxolitinib is a cornerstone of management for some subsets of myeloproliferative neoplasms(MPNs);however,a considerable number of patients respond suboptimally.Here,we evaluated the efficacy of micheliolide(MCL),a natural guaianolide sesquiterpene lactone,alone or in combination with ruxolitinib in samples from patients with MPNs,JAK2V617F-mutated MPN cell lines,and a Jak2V617F knock-in mouse model.MCL effectively suppressed colony formation of hematopoietic progenitors in samples from patients with MPNs and inhibited cell growth and survival of MPN cell lines in vitro.Co-treatment with MCL and ruxolitinib resulted in greater inhibitory effects compared with treatment with ruxolitinib alone.Moreover,dimethylaminomicheliolide(DMAMCL),an orally available derivative of MCL,significantly increased the efficacy of ruxolitinib in reducing splenomegaly and cytokine production in Jak2V617F knock-in mice without evident effects on normal hematopoiesis.Importantly,MCL could target the Jak2V617F clone and reduce mutant allele burden in vivo.Mechanistically,MCL can form a stable covalent bond with cysteine residues of STAT3/5 to suppress their phosphorylation,thus inhibiting JAK/STAT signaling.Overall,these findings suggest that MCL is a promising drug in combination with ruxolitinib in the setting of suboptimal response to ruxolitinib. | Huijun Huang Jinqin Liu Lin Yang Yiru Yan Meng Chen Bing Li Zefeng Xu Tiejun Qin Shiqiang Qu Liang Wang Gang Huang Yue Chen Zhijian Xiao | 2023 | Blood Science2023，5，4： | 0 |
| 12 | COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors显示文摘Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie nts.Mecha nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid metabolism.Furthermore,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin resistance.Taken together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications. | Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 13 | High-Q collective Mie resonances in monocrystalline silicon nanoantenna arrays for the visible light显示文摘Dielectric optical antennas have emerged as a promising nanophotonic architecture for manipulating the propagation and localization of light.However,the optically induced Mie resonances in an isolated nanoantenna are normally with broad spectra and poor��-factors,limiting their performances in sensing,lasing,and nonlinear optics.Here,we dramatically enhance the��-factors of Mie resonances in silicon(Si)nanoparticles across the optical band by arranging the nanoparticles in a periodic lattice.We select monocrystalline Si with negligible material losses and develop a unique method to fabricate nanoparticle arrays on a quartz substrate.By extinction dispersion measurements and electromagnetic analysis,we can identify three types of collective Mie resonances with��-factors∼500 in the same nanocylinder arrays,including surface lattice resonances,bound states in the continuum,and quasi-guided modes.Our work paves the way for fundamental research in strong light-matter interactions and the design of highly efficient light-emitting metasurfaces. | Zhenghe Zhang Pengbo Liu Wanli Lu Ping Bai Bingchang Zhang Zefeng Chen Stefan A.Maier Jaime Gómez Rivas Shaojun Wang Xiaofeng Li | 2023 | Fundamental Research2023，3，5： | 0 |
| 14 | Improved hydrogen storage kinetics of MgH_(2) using TiFe_(0.92)Mn_(0.04)Co_(0.04) with in-situ generated α-Fe as catalyst显示文摘While TiFe alloy has recently attracted attention as the efficient catalyst to enhance de/hydrogenation rates of Mg/MgH_(2),the difficulty of its activation characteristics has hindered further improvement of reaction kinetics.Herein,we report that the TiFe_(0.92)Mn_(0.04)Co_(0.04) catalyst can overcome the abovementioned challenges.The synthesized MgH_(2)-30 wt% TiFe_(0.92)Mn_(0.04)Co_(0.04) can release 4.5 wt%of hydrogen in 16 min at 250℃,three times as fast as MgH_(2).The activation energy of dehydrogenation was as low as 84.6 kJ mol^(-1),which is 46.8%reduced from pure MgH_(2).No clear degradation of reaction rates and hydrogen storage capacity was observed for at least 30 cycles.Structural studies reveal that TiFe_(0.92)Mn_(0.04)Co_(0.04) partially decomposes to in-situ generatedα-Fe particles dispersed on TiFe_(0.92)Mn_(0.04)Co_(0.04).The presence ofα-Fe reduces the formation of an oxide layer on TiFe_(0.92)Mn_(0.04)Co_(0.04),enabling the activation processes.At the same time,the hydrogen incorporation capabilities of TiFe_(0.92)Mn_(0.04)Co_(0.04) can provide more hydrogen diffusion paths,which promote hydrogen dissociation and diffusion.These discoveries demonstrate the advanced nature and importance of combining the in-situ generatedα-Fe with TiFe_(0.92)Mn_(0.04)Co_(0.04).It provides a new strategy for designing highly efficient and stable catalysts for Mg-based hydrogen storage materials. | Zefeng Li Yangfan Lu Jingfeng Wang Yu'an Chen Qian Li Fushen Pan | 2024 | Materials Reports(Energy)2024，4，1： | 0 |
| 15 | Knowledge Graph Representation Learning Based on Automatic Network Search for Link Prediction显示文摘Link prediction,also known as Knowledge Graph Completion(KGC),is the common task in Knowledge Graphs(KGs)to predict missing connections between entities.Most existing methods focus on designing shallow,scalable models,which have less expressive than deep,multi-layer models.Furthermore,most operations like addition,matrix multiplications or factorization are handcrafted based on a few known relation patterns in several wellknown datasets,such as FB15k,WN18,etc.However,due to the diversity and complex nature of real-world data distribution,it is inherently difficult to preset all latent patterns.To address this issue,we proposeKGE-ANS,a novel knowledge graph embedding framework for general link prediction tasks using automatic network search.KGEANS can learn a deep,multi-layer effective architecture to adapt to different datasets through neural architecture search.In addition,the general search spacewe designed is tailored forKGtasks.We performextensive experiments on benchmark datasets and the dataset constructed in this paper.The results show that our KGE-ANS outperforms several state-of-the-art methods,especially on these datasets with complex relation patterns. | Zefeng Gu Hua Chen | 2023 | Computer Modeling in Engineering & Sciences2023，，6： | 0 |
| 16 | Recurring Real-Time Monitoring of Inflammations in Living Mice with a Chemiluminescent Probe for Hypochlorous Acid显示文摘Probes for in vivo imaging of hypochlorous acid(HOCl),one of the most important reactive oxygen species in innate immunity,are urgently needed to understand the pathogenesis of autoimmune and neuroinflammatory disorders.As a strong oxidant,HOCl could bleach near-infrared sensors and inactivate luciferase readily,making in vivo imaging overwhelmingly challenging.Via fine-tuning of a selective HOCl sensing moiety,HOCl stable spacer,and bright chemiluminescent scaffold,we have developed HOCl-CL-510 as a highly selective and sensitive probe for HOCl detection both in vitro and in vivo.In particular,we achieved recurring real-time monitoring of HOCl in both acute and chronic inflammation models in living mice,providing a new chemical tool for dynamic monitoring of disease development with reduced usage of experimental animals. | Sen Ye Bowei Yang Meiling Wu Zefeng Chen Jiangang Shen Doron Shabat Dan Yang | 2022 | CCS Chemistry2022，4，6： | 0 |
| 17 | Oleophobic modification of clay minerals to improve encapsulation ratios of shape-stabilized phase change materials:A universal method显示文摘Liquid-solid phase change materials(PCMs) show reversible storage and release of latent heat, which has attracted extensive interests in applications for thermal energy storage. However, stubborn leakage issue may cause corrosion and extra thermal resistance. The non-wettability of melted paraffin on the oleophobic surface of diatomite has been reported by authors earlier, and the result showed that the encapsulation ratio(84.5%) of diatomite@paraffin shape-stabilized PCM greatly increased. Here, in order to prove this method equally applicable to other PCMs and porous natural clay minerals, diatomite and sepiolite were oleophobically modified to encapsulate melted stearic acid and paraffin, to form shape-stabilized PCMs. The results showed that the encapsulation ratios of 67.8% and 56.6% for diatomite@stearic acid and sepiolite@paraffin were higher than that reported in the references(28.9% and 36.8%). In addition, the encapsulation ratios of diatomite-based shapestabilized PCMs can be also increased using different PCMs, such as n-octadecane and polyethylene glycol via the same approach. Therefore, this is a universal method for improving encapsulation ratios of shape-stabilized PCMs. | Pan Zhang Zefeng Cheng Zhang Chen Yanfeng Gao | 2021 | Progress in Natural Science:Materials International2021，31，6： | 0 |
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