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| 1 | Mapping of qGL7-2, a grain length QTL on chromosome 7 of rice显示文摘剩余在米饭染色体上带在二 SSR loci RM11 和 RM134 之间的一个异质接合的片断的异质接合的线(RHL ) 7 从一套 recombinant 被选择从生气 D50 (javanica )/HB277 (indica ) 的生来的线。以前的父母比后者生产长得多的谷物。这种选择的 Selfed 子孙 genotypically 被分析(SSR ) 并且 phenotypically (谷物长度) 。谷物长度在印射的人口是不连续地可变的,允许在 4.8 厘米间隔以内的这 QTL qGL7-2 的放置由 RM351 和 RM234 定义。在这个区域以内的一套新标记被开发,它把 QTL 缩小了到标记 Indel1 和 RM21945 定义的 278 kb 区域。这个区域包含 49 预言的基因。结果也建议为谷物长度的新奇等位基因将被用于标记的应用程序为谷物长度的改进的帮助选择。 | Gaoneng Shao Shaoqing Tang Ju Luo Guiai Jiao Xiangjin Wei Ao Tang Jianli Wu Jieyun Zhuang Peisong Hu | 2010 | Journal of Genetics and Genomics2010，37，8： | 28 |
| 2 | Human umbilical cord blood stem cell transplantation for the treatment of chronic spinal cord injury Electrophysiological changes and long-term efficacy显示文摘Stem cell transplantation can promote functional restoration following acute spinal cord injury (injury time < 3 months), but the safety and long-term efficacy of this treatment need further exploration. In this study, 25 patients with traumatic spinal cord injury (injury time > 6 months) were treated with human umbilical cord blood stem cells via intravenous and intrathecal injection. The follow-up period was 12 months after transplantation. Results found that autonomic nerve functions were restored and the latent period of somatosensory evoked potentials was reduced. There were no severe adverse reactions in patients following stem cell transplantation. These experimental findings suggest that the transplantation of human umbilical cord blood stem cells is a safe and effective treatment for patients with traumatic spinal cord injury. | Liqing Yao Chuan He Ying Zhao Jirong Wang Mei Tang Jun Li Ying Wu Lijuan Ao Xiang Hu | 2013 | Neural Regeneration Research2013，8，5： | 14 |
| 3 | Original article: Arthroscopic treatment for osteochondral lesions of the talus: analysis of outcome predictors显示文摘背景与传统的关节切开术过程相比,为距骨的 osteochondral 损害的 arthroscopic 治疗有一些优点。然而,关于为这种外科的技术的结果预言者有可观的争论。这研究试图为距骨的 osteochondral 损害调查 arthroscopic 治疗的结果,并且分析它的结果 predictors.Methods 经历了脚关节 arthroscopy 的有距骨的 osteochondral 损害的 48 个病人的临床的数据被学习。Arthroscopic 清创术在所有病人上被执行,并且 microfracture 也在 36 种情况中被执行。一张主观满足问询表,为疼痛的视觉模拟规模(管) ,和美国矫形的脚与脚关节社会(AOFAS ) 脚关节上的分数和 hindfoot 分数在五个病人失去了列在后面起来的 surgery.Results 前后被获得。另外的 43 个病人,其中 8 个是运动员,被跟随在上面为 23.9 个月的一般水准。平均 AOFAS 手术后的分数是 90.16 ??????? 贼 ? 贼吗?? | GUO Qin-wei HU Yue-lin JIAO Chen YU Chang-long AO Ying-fang | 2010 | Chinese Medical Journal2010，，3： | 9 |
| 4 | Cholesterol transport through the peroxisome-ER membrane contacts tethered by PI(4,5)P2 and extended synaptotagmins显示文摘Most mammalian cells take up cholesterol from low-density lipoproteins(LDLs) via receptor-mediated endocytosis.After reaching lysosomes,LDL-derived cholesterol continues to transport to downstream organelles including the ER for specific structural and functional needs.Peroxisomes are recently found to receive cholesterol from lysosomes through lysosomeperoxisome membrane contacts.However,whether and how cholesterol is conveyed from peroxisomes to the ER remain unknown.Here,by combining high-resolution microscopic analyses and in vitro reconstitution of highly purified organelles or artificial liposomes,we demonstrate that peroxisomes form membrane contacts with the ER through the interaction between peroxisomal PI(4,5)P2 and ER-resident extended synaptotagmin-1,2 and 3(E-Syts).Depletion of peroxisomal PI(4,5)P2 or ESyts markedly decreases peroxisome-ER membrane contacts and induces cholesterol accumulation in lysosomes.Furthermore,we show that cholesterol is delivered from 3H-labeled peroxisomes or PI(4,5)P2-containing liposomes to the ER in vitro,and that the presence of peroxisomes augments cholesterol transfer from lysosomes to the ER.Together,our study reveals a new cholesterol transport pathway along the lysosome-peroxisome-ER membrane contacts in the cell. | Jian Xiao Jie Luo Ao Hu Ting Xiao Meixin Li Zekai Kong Luyi Jiang Zimu Zhou Yacheng Liao Chang Xie Beibei Chu Honghua Miao Boliang Li Xiongjie Shi Bao-Liang Song | 2019 | Science China(Life Sciences)2019，62，9： | 8 |
| 5 | T cell infiltration is associated with kidney injury in patients with anti-glomerular basement membrane disease显示文摘Cell-mediated autoimmunity, particularly that involving autoreactive T cells, participates in mediating anti-glomerular basement membrane(GBM) disease. However, direct kidney injury mediated by renal infiltrated T cells has not been clearly elucidated in humans. The T cell profile(CD3, CD4, CD8, IL-17, and foxp3) and macrophage(CD68) were examined by immunohistochemistry on renal biopsy tissues from 13 patients with anti-GBM disease. The correlation between cell infiltration and clinical data was also analyzed. We found that the distribution of T cell infiltration was predominant in the peri-glomerular and interstitial areas. CD3^+ T cell infiltratrion around the glomeruli with cellular crescent formations was significantly higher than that around the glomeruli with mild mesangial proliferation. CD8^+ T cells significantly accumulated around the glomeruli with cellular crescents without Ig G deposits compared to those with Ig G deposits. The prevalence of infiltrating CD8^+ T cells was correlated with the percentage of ruptured Bowman's capsules. In conclusion, cellular immunity may play a crucial role in the inflammatory kidney injury in anti-GBM patients. The periglomerular infiltration of T cells, especially CD8^+ T cells, may participate in the pathogenic mechanism of glomerular damage. | Shui-Yi Hu Xiao-Yu Jia Jian-Nan Li Xin Zheng Jie Ao Gang Liu Zhao Cui Ming-Hui Zhao | 2016 | Science China(Life Sciences)2016，59，12： | 6 |
| 6 | Effects of inorganic arsenic on growth and microcystin production of a Microcystis strain isolated from an algal bloom in Dianchi Lake,China显示文摘Our previous data have shown that inorganic arsenic concentrations were high in Dianchi Lake,China,where Microcystis blooms often occur.To explore the relationship between arsenic and the growth of Microcystis,the effects of arsenite[As(III)]and arsenate[As(V)]on the growth and toxin production of M.aeruginosa strain FACHB 905 were tested.Results showed that M.aeruginosa FACHB 905 was tolerant to inorganic arsenic and its growth was not inhibited when the concentration of As(III)was below 10-5 mol L-1 or that of As(V)below 10-3 mol L-1.Total microcystin production was stimulated in the presence of 10-7 mol L-1 As(III)and the response of this M.aeruginosa strain to As(III)seemed to be a typical inverted U-shaped hormesis.The content increase of microcystin-LR per cell indicated that the toxicity was enhanced as M.aeruginosa FACHB 905 was exposed to As(V).Considering the relatively high concentration of inorganic arsenic in Dianchi Lake(139μg L-1 in epilimnetic water),the origin of the M.aeruginosa strain,inorganic arsenic favors survival of M.aeruginosa FACHB 905 and may stimulate its microcystin production and cellular toxicity. | GONG Yan AO HongYi LIU BiBo WEN Sheng WANG Zhi HU DingJing ZHANG XingZhong SONG LiRong LIU JianTong | 2011 | Chinese Science Bulletin2011，56，22： | 6 |
| 7 | Effectiveness of vegetation on phosphorus removal from reclaimed water by a subsurface flow wetland in a coastal area显示文摘This work was conducted to evaluate the effectiveness and influence factors of vegetation on phosphorus (P) removal from reclaimed water in constructed wetlands.Comparisons were conducted between one pilot scale subsurface flow wetland (P-SSFW) and two demonstration subsurface flow wetlands,which were series-wound and named as first subsurface flow wetland (F-SSFW),and second subsurface flow wetland (S-SSFW),respectively.The three wetlands had the same vegetation and substrate,but different pH values,total dissolved solids (TDS) and P loads.Results showed that the P content in the vegetation shoots of the F-SSFW was 2.16 mg/g,while 2.31 mg/g in the S-SSFW and 2.69 mg/g in the P-SSFW.These differences were likely caused by the higher pH and TDS in the reclaimed water.The P content also differed among the tissues of the plant,which were 5.94-6.44 mg/g,2.20-2.77 mg/g,1.31-1.46 mg/g and 1.53-1.88 mg/g in the flowers,leaves,stems,and roots,respectively.The greatest discrepancy was observed in the leaves,indicating that the environment of the wetlands had the greatest influence on the leaves.When the total phosphorus (TP) load was lower,the proportion of P removed by vegetation assimilation was 16.17% in the P-SSFW,12.90% in the F-SSFW and 13.29% in the S-SSFW.However,the relative removal efficiency by vegetation among the three wetlands did not vary greatly from that observed in other studies.Moreover,the influence of pH,TDS and TP load was not as great as the influence of the vegetation species,type of substrate,influent style or climate. | Baoqing Shan Liang Ao Chunming Hu Jiayu Song | 2011 | Journal of Environmental Sciences2011，23，10： | 6 |
| 8 | Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia显示文摘好攻击的 NK 房间白血病(ANKL ) 是在从亚洲的人之中是更流行的 NK 房间瘤的一种稀罕形式并且中央并且南美洲。病人们通常在天以内死到月,甚至在收到迅速的治疗学的管理以后。这里,我们由集成整个染色体执行了 ANKL 的第一全面研究, transcriptome 并且定序指向,象功能的试金一样的 cytokine 数组。在 JAK-STAT 小径的变化在 48% 被识别(14/29 ) ANKL 病人,当细胞外的 STAT3 激发器 IL10 被 56 褶层的一般水准提高时(P < 0.0001 ) 在检查的所有病人的血浆。另外的经常变异的基因包括的 TP53 (34%) , TET2 (28%) , CREBBP (21%) 和 MLL2 (21%) 。耐心的 NK 白血病房间在多重新陈代谢的小径显示出 STAT3 phosphorylation, MYC 表示和 transcriptional 活动的突出的激活。机能上地, STAT3 激活和 MYC 表示为 ANKL 房间的增长和幸存是批评的。发信号的 STAT 调整了发信号的 MYC 抄写节目,和两 STAT, MYC 抄写被要求维持核苷酸合成和 glycolysis 的激活。一起, JAK-STAT 小径在 ANKL 为 genomic 改变和 IL10 刺激代表一个主要目标。这最新发现的 JAK/STAT-MYC-biosynthesis 轴可以在对待白血病的这种子类型为新奇治疗学的策略的发展提供机会。 | Liang Huang Dan Liu Na Wang Shaoping Ling Yuting Tang Jun Wu Lingtong Hao Hui Luo Xuelian Hu Lingshuang Sheng Lijun Zhu Di Wang Yi Luo Zhen Shang Min Xiao Xia Mao Kuangguo Zhou Lihua Cao Lili Dong Xinchang Zheng Pinpin Sui Jianlin He Shanlan Mo Jin Yan Qilin Ao Lugui Qiu Hongsheng Zhou Qifa Liu Hongyu Zhang Jianyong Li Jie Jin Li Fu Weili Zhao Jieping Chen Xin Du Guoliang Qing Hudan Liu Xin Liu Gang Huang Ding Ma Jianfeng Zhou Qian-fei Wang | 2018 | Cell Research2018，28，2： | 5 |
| 9 | Flow behavior of liquid metal in the connected fascial space: Intervaginal space injection in the rat wrist and mice with tumor显示文摘扁带和 fascial 空格能帮助提供天体的更好的理解。intervaginal 空间注射(ISI ) 提供要求进一步的调查的唯一的优点。包括生理的条件和肿瘤过程的一个上面的手足模型被选择在 ISI 以后决定液体金属的流动行为。在正常老鼠,在直到 intervaginal 空间的液体金属的注射以后包括腱,容器,和神经,磁性的回声成像和一个解剖实验显示没有容器或淋巴节点,在 fascial 空间附近并且最后包的液体金属到达了下游的指尖和除了神经与血管的捆在上游的腋窝。用环境扫描,电子显微镜学(ESEM ) 想象,我们发现液体金属在扁带的纤维附近被包并且向前搬到 microscale 或 nanoscale 区域。这些数据证实了一条基于扁带的小径。在肿瘤,液体金属通过损坏的点搬到肿瘤囊,在癌症房间破坏在正常房间和癌症房间之间的扁带的完整的地方。部分在肿瘤附近包并且把肿瘤与包围正常肌肉分开了的液体金属。ESEM 图象证明扁带的纤维渗透了肿瘤,因此形成液体金属通过渗透了肿瘤的一个网络。我们的学习在 ISI 以后在上面的手足说明了液体金属的生理、病理学的流动行为并且在扁带表明了一条 nonvascular 小径。ISI 可能为在 fascial 小径的临床的治疗是有用的。 | Nan Hu Yupeng Cao Zhuo Ao Xinxiao Han Qiang Zhang Wentao Liu Sidi Liu Fulong Liao Dong Han | 2018 | Nano Research2018，11，4： | 5 |
| 10 | Review of blockchain-based DNS alternatives显示文摘DNS Protocol was originally designed with no security protection in place. Subsequent DNSSEC added a layer of trust on top of DNS by providing authentication, but it still did not address issues such as Do S/DDo S attacks and deployment difficulties. Blockchain technology offers an innovative perspective to tackle those challenges. By reviewing and analyzing two prevail blockchain-based DNS alternatives(Namecoin and Blockstack), it is concluded that although blockchain presently have problems that have to be solved, it is a promising approach to build decentralized, secure and human-friendly naming systems. | HU Wei-hong AO Meng SHI Lin XIE Jia-gui LIU Yang | 2017 | 网络与信息安全学报2017，3，3： | 5 |
| 11 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 12 | Cryo-self-assembled silk fibroin sponge as a biodegradable platform for enzyme-responsive delivery of exosomes显示文摘Although advances in protein assembly preparation have provided a new platform for drug delivery during tissue engineering,achieving long-term controlled exosome delivery remains a significant challenge.Diffusion-dominated exosome release using protein hydrogels results in burst release of exosomes.Here,a fibroin-based cryo-sponge was developed to provide controlled exosome release.Fibroin chains can self-assemble into silk I structures under ice-cold conditions when annealed above the glass transition temperature.Exosome release is enzyme-responsive,with rates primarily determined by enzymatic degradation of the scaffolds.In vivo experiments have demonstrated that exosomes remain in undigested sponge material for two months,superior to their retention in fibrin glue,a commonly used biomaterial in clinical practice.Fibroin cryo-sponges were implanted subcutaneously in nude mice.The exosome-containing sponge group exhibited better neovascularization and tissue ingrowth effects,demonstrating the efficacy of this exosome-encapsulating strategy by realizing sustained release and maintaining exosome bioactivity.These silk fibroin cryo-sponges containing exosomes provide a new platform for future studies of exosome therapy. | Muyang Sun Qi Li Huilei Yu Jin Cheng Nier Wu Weili Shi Fengyuan Zhao Zhenxing Shao Qingyang Meng Haifeng Chen Xiaoqing Hu Yingfang Ao | 2022 | Bioactive Materials2022，7，2： | 4 |
| 13 | Perfection of Perovskite Grain Boundary Passivation by Rhodium Incorporation for Efficient and Stable Solar Cells显示文摘Organic cation and halide anion defects are omnipresent in the perovskite films,which will destroy perovskite electronic structure and downgrade the properties of devices.Defect passivation in halide perovskites is crucial to the application of solar cells.Herein,tiny amounts of trivalent rhodium ion incorporation can help the nucleation of perovskite grain and passivate the defects in the grain boundaries,which can improve efficiency and stability of perovskite solar cells.Through first-principle calculations,rhodium ion incorporation into the perovskite structure can induce ordered arrangement and tune bandgap.In experiment,rhodium ion incorporation with perovskite can contribute to preparing larger crystalline and uniform film,reducing trap-state density and enlarging charge carrier lifetime.After optimizing the content of 1% rhodium,the devices achieved an efficiency up to 20.71% without obvious hysteresis,from 19.09% of that pristine perovskite.In addition,the unencapsulated solar cells maintain 92% of its initial efficiency after 500 h in dry air.This work highlights the advantages of trivalent rhodium ion incorporation in the characteristics of perovskite solar cells,which will promote the future industrial application. | Wei Liu Nanjing Liu Shilei Ji Hongfeng Hua Yuhui Ma Ruiyuan Hu Jian Zhang Liang Chu Xing’ao Li Wei Huang | 2020 | Nano-Micro Letters2020，12，9： | 4 |
| 14 | Influence of MoSi_(2) on oxidation protective ability of TaB_(2)-SiC coating in oxygen-containing environments within a broad temperature range显示文摘TaB_(2)-SiC coating modified by different content of MoSi_(2) was fabricated on graphite substrate with SiC inner coating by liquid phase sintering to elevate the anti-oxidation capability of the TaB_(2)-SiC coatings.As compared to the sample with the TaB_(2)-40wt% SiC coating,the coating sample modified with MoSi_(2) exhibited a weight gain trend at lower temperatures,the fastest weight loss rate went down by 76%,and the relative oxygen permeability value reduced from about 1% to near 0.More importantly,the large amount of SiO_(2) glass phase produced over the coating during oxidation was in contact with the modification of MoSi_(2),which was proved to be beneficial to the dispersion of Ta-oxides.A concomitantly formed continuous Ta-Si-O-B compound glass layer showed excellent capacity to prevent oxygen penetration.However,when the TaB_(2) content was sacrificed to increase the MoSi_(2) content,the relative oxygen permeability of the coating increased instead of decreased.Thus,on the basis of ample TaB_(2) content,increasing the MoSi_(2) content of the coating is conducive to reducing the relative oxygen permeability of the coatings in a broad temperature region. | Xuanru REN Junshuai LV Wei LI Yuwen HU Ke SUN Can MA Hong’ao CHU Weiguang WANG Leihua XU Ziyu LI Peizhong FENG | 2020 | Journal of Advanced Ceramics2020，9，6： | 4 |
| 15 | A synthetic criterion for early recognition of cutting chatter显示文摘Cutting chatter is a violent self-excited vibration between a tool and a workpiece.Its negative effects mainly include poor surface quality,inferior dimensional accuracy,disproportionate tool wear or tool breakage,and excessive noise.Therefore,early recognition and online suppression of chatter vibration are necessary.This paper proposes a novel synthetic criterion(SC)for early chatter recognition.The proposed SC integrates standard deviation(STD)and one-step autocorrelation function(OSAF).Moreover,this paper revised the fast algorithm of OSAF.We can quantitatively divide a chatter vibration signal into three stages,which are stable stage,transition stage and chatter stage according to the SC.Compared with STD,the SC can improve the reliability of chatter recognition and the threshold of SC is not sensitive to variable cutting conditions.This paper presents an original algorithm of SC and its fast algorithm in detail.The fast algorithm of SC in this paper improves the computation efficiency compared with the original algorithm of SC.To validate the effectiveness of the proposed SC,a series of milling experiments were conducted under different cutting conditions.In these experiments,the vibration signals were acquired by two accelerometers mounted on the spindle house.The experimental results showed that the proposed SC could effectively recognize chatter vibration at an early stage of chatter vibration,which saved valuable time for online chatter suppression. | JIA GuangFei WU Bo HU YouMin XIE FengYun LIU Ao | 2013 | Science China(Technological Sciences)2013，56，11： | 3 |
| 16 | Celastrol suppresses colorectal cancer via covalent targeting peroxiredoxin 1显示文摘As a terpenoids natural product isolated from the plant Thunder God Vine,Celastrol is widely studied for its pharmacological activities,including anti-tumor activities.The clinical application of Celastrol is strictly limited due to its severe side effects,whereas previously revealed targets and mechanism of Celastrol seldom reduce its in vivo toxicity via structural optimization.Target identification has a far-reaching influence on the development of innovative drugs,and omics data has been widely used for unbiased target prediction.However,it is difficult to enrich target of specific phenotype from thousands of genes or proteins,especially for natural products with broad promising activities.Here,we developed a text-mining-based web-server tool to enrich targets from omics data of inquired compounds.Then peroxiredoxin 1(PRDX1)was identified as the ROS-manipulating target protein of Celastrol in colorectal cancer.Our solved high-resolution crystal structure revealed the unique covalent binding mode of Celastrol with PRDX1.New derivative compound 19-048 with improved potency against PRDX1 and selectivity towards PRDX2~PRDX6 were synthesized based on crystal structure analysis.Both Celastrol and 19-048 effectively suppressed the proliferation of colorectal cancer cells.The anti-tumor efficacy of Celastrol and 19-048 was significantly diminished on xenograft nude mice bearing PRDX1 knock-down colorectal cancer cells.Several downstream genes of p53 signaling pathway were dramatically up-regulated with Celastrol or 19-048 treatment.Our findings reveal that the side effects of Celastrol could be reduced via structural modification,and PRDX1 inhibition is promising for the treatment of colorectal cancer. | Heng Xu Hongfang Zhao Chunyong Ding Defang Jiang Zijie Zhao Yang Li Xiaoyu Ding Jing Gao Hu Zhou Cheng Luo Guoqiang Chen Ao Zhang Ying Xu Hao Zhang | 2023 | Signal Transduction and Targeted Therapy2023，8，3： | 3 |
| 17 | Genome-wide association study and genomic prediction of Fusarium ear rot resistance in tropical maize germplasm显示文摘Fusarium ear rot(FER)is a destructive maize fungal disease worldwide.In this study,three tropical maize populations consisting of 874 inbred lines were used to perform genomewide association study(GWAS)and genomic prediction(GP)analyses of FER resistance.Broad phenotypic variation and high heritability for FER were observed,although it was highly influenced by large genotype-by-environment interactions.In the 874 inbred lines,GWAS with general linear model(GLM)identified 3034 single-nucleotide polymorphisms(SNPs)significantly associated with FER resistance at the P-value threshold of 1×10^(-5),the average phenotypic variation explained(PVE)by these associations was 3%with a range from 2.33%to 6.92%,and 49 of these associations had PVE values greater than 5%.The GWAS analysis with mixed linear model(MLM)identified 19 significantly associated SNPs at the P-value threshold of 1×10^(-4),the average PVE of these associations was 1.60%with a range from 1.39%to 2.04%.Within each of the three populations,the number of significantly associated SNPs identified by GLM and MLM ranged from 25 to 41,and from 5 to 22,respectively.Overlapping SNP associations across populations were rare.A few stable genomic regions conferring FER resistance were identified,which located in bins 3.04/05,7.02/04,9.00/01,9.04,9.06/07,and 10.03/04.The genomic regions in bins 9.00/01 and 9.04 are new.GP produced moderate accuracies with genome-wide markers,and relatively high accuracies with SNP associations detected from GWAS.Moderate prediction accuracies were observed when the training and validation sets were closely related.These results implied that FER resistance in maize is controlled by minor QTL with small effects,and highly influenced by the genetic background of the populations studied.Genomic selection(GS)by incorporating SNP associations detected from GWAS is a promising tool for improving FER resistance in maize. | Yubo Liu Guanghui Hu Ao Zhang Alexander Loladze Yingxiong Hu Hui Wang Jingtao Qu Xuecai Zhang Michael Olsen Felix San Vicente Jose Crossa Feng Lin Boddupalli M.Prasanna | 2021 | The Crop Journal2021，9，2： | 3 |
| 18 | Cholesterylation of Smoothened is a calcium-accelerated autoreaction involving an intramolecular ester intermediate显示文摘Hedgehog(Hh)is a morphogen that binds to its receptor Patched 1 and activates Smoothened(SMO),thereby governing embryonic development and postnatal tissue homeostasis.Cholesterol can bind and covalently conjugate to the luminal cysteine-rich domain(CRD)of human SMO at the D95 residue(D99 in mouse).The reaction mechanism and biological function of SMO cholesterylation have not been elucidated.Here,we show that the SMO-CRD undergoes auto cholesterylation which is boosted by calcium and involves an intramolecular ester intermediate.In cells,Hh stimulation elevates local calcium concentration in the SMO-localized endosomes through store-operated calcium entry.In addition,we identify the signaling-incompetent SMO D95E mutation,and the D95E mutant SMO can bind cholesterol but cannot be modifed or activated by cholesterol.The homozygous Smo^(O99E/D99E) knockin mice are embryonic lethal with severe developmental delay,demonstrating that cholesterylation of CRD is required for full-length SMO activation.Our work reveals the unique autocatalytic mechanism of SMO cholesterylation and an unprecedented role of calcium in Hh signaling. | Ao Hu Jing-Zan Zhang Jie Wang Chen-Chen Li Meng Yuan Gang Deng Zi-Cun Lin Zhi-Ping Qiu Hu-Yue Liu Xian-Wei Wang Peng-Cheng Wei Xiao He Xiaolu Zhao Wen-Wei Qiu Bao-Liang Song | 2022 | Cell Research2022，32，3： | 3 |
| 19 | Super-resolution of geosynchronous synthetic aperture radar images using dialectical GANs显示文摘Dear editor,The concept of geosynchronous synthetic aperture radar (GEO SAR) system was conceived in an effort to realize a quick observation of emergency disasters (e.g., landslides and earthquakes)[1].The novel GEO SAR system has the significant advantages of short-revisit time and large coverage and facilitates the nearly continuous observation of target regions, unlike the currently operatinglow earth orbit (LEO) SARs [2]. | Yuanhao LI Dongyang AO Corneliu Octavian DUMITRU Cheng HU Mihai DATCU | 2019 | Science China(Information Sciences)2019，62，10： | 3 |
| 20 | Development of an ANN-based building energy model for information-poor buildings using transfer learning显示文摘Accurate building energy prediction is vital to develop optimal control strategies to enhance building energy efficiency and energy flexibility.In recent years,the data-driven approach based on machine learning algorithms has been widely adopted for building energy prediction due to the availability of massive data in building automation systems(BASs),which automatically collect and store real-time building operational data.For new buildings and most existing buildings without installing advanced BASs,there is a lack of sufficient data to train data-driven predictive models.Transfer learning is a promising method to develop accurate and reliable data-driven building energy prediction models with limited training data by taking advantage of the rich data/knowledge obtained from other buildings.Few studies focused on the influences of source building datasets,pre-training data volume,and training data volume on the performance of the transfer learning method.The present study aims to develop a transfer learning-based ANN model for one-hour ahead building energy prediction to fill this research gap.Around 400 non-residential buildings’data from the open-source Building Genome Project are used to test the proposed method.Extensive analysis demonstrates that transfer learning can effectively improve the accuracy of BPNN-based building energy models for information-poor buildings with very limited training data.The most influential building features which influence the effectiveness of transfer learning are found to be building usage and industry.The research outcomes can provide guidance for implementation of transfer learning,especially in selecting appropriate source buildings and datasets for developing accurate building energy prediction models. | Ao Li Fu Xiao Cheng Fan Maomao Hu | 2021 | Building Simulation2021，14，1： | 3 |
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