|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Estimation of the Effects of Maize Straw Return on Soil Carbon and Nutrients Using Response Surface Methodology显示文摘Straw incorporation is generally considered an effective agricultural management practice that improves nutrient cycling and maintains soil fertility. To study the interactive effects of straw returning factors on soil organic carbon and available nutrients, a17-month(May 6, 2016 to October 6, 2017) experiment was conducted on straw incorporation by using response surface methodology under a three-factor(straw length, amount, and burying depth), five-level quadratic orthogonal rotation experimental design. Weight was assigned to each indicator for soil carbon and nutrients and then a comprehensive indicator was established. Then, a second-order polynomial model of the three straw returning factors was established using response surface methodology. Results indicated that17 months after straw incorporation, straw amount and burying depth had significant effects on the comprehensive indicator of soil carbon and nutrients. Straw length and the interactions of straw amount and burying depth showed no significant effects on the comprehensive indicator of soil carbon and nutrients. It was concluded that 17 months after straw incorporation, the highest value of the comprehensive indicator of soil carbon and nutrients was achieved when the straw length, amount, and burying depth were approximately 17–20 cm, 740–840 g m^(-2), and 9–13 cm, respectively, which can be recommended as the most suitable parameters for use in straw returning in the study area. | ZHOU Dongxing SU Ye NING Yucui RONG Guohua WANG Guangdong LIU Di LIU Liyan | 2018 | Pedosphere2018，28，3： | 12 |
| 2 | TRAP1 Shows Clinical Significance and Promotes Cellular Migration and Invasion through STAT3/MMP2 Pathway in Human Esophageal Squamous Cell Cancer显示文摘Tumor necrosis factor receptor-associated protein 1(TRAP1), an important member of mitochondrial heat shock protein 90 family, is involved in multiple biological processes in several types of tumors. However, its pathological role in esophageal squamous cell cancer(ESCC) remains unknown. Herein, we demonstrated the clinical value of TRAP1, and its role in apoptosis and motility in ESCC. The clinical potential of TRAP1 was investigated through immunohistochemical analysis in 328 ESCC samples, which revealed that strong TRAP1 expression was associated with increased risk of lymph node metastasis, while high TRAP1 expression correlated with poor prognosis. Expression of TRAP1 was found to be an independent prognostic factor for patients with ESCC. Additionally, the upregulation of TRAP1 antagonized cisplatin-induced apoptosis while its downregulation sensitized cells to cisplatin-induced apoptosis. As revealed by the transwell assay, TRAP1 overexpression promoted cellular migration and invasion as compared to the control groups. In contrast,silencing of endogenous TRAP1 expression attenuated the ability of migration and invasion. Finally, the molecular mechanism investigated in the present study demonstrated that TRAP1-mediated migration and invasion occurred through STAT3/MMP2 signaling pathway. In conclusion, TRAP1 may be considered as a molecular predictive marker for prognosis and a novel molecular candidate for therapeutic target in ESCC. | Yunwei Ou Lingyan Liu Liyan Xue Wei Zhou Zitong Zhao Bainan Xu Yongmei Song Qimin Zhan | 2014 | Journal of Genetics and Genomics2014，41，10： | 8 |
| 3 | Uniform Coverage of Fibres over Open-contoured Freeform Structure Based on Arc-length Parameter显示文摘这篇文章使用弧长度参数路径计划在开轮廓的结构上执行机器的纤维放置(RFP ) 。这允许由更简单的算术用一个相同数学方程和计算代表起始的路径和偏移量点。在古典微分几何学的帮助下,放纤维的路径的计算可以在参量的域(参量地定义的模子表面) 或在 3D 空格(含蓄地定义的模子表面) 被归结为一阶的平常的微分方程的起始值的问题的答案,显著地从而在存在方法上改善。与常规方法相比,除它的计算简洁以外,建议方法在计算起始的路径和偏移量点有更好的错误控制机制。数字实验也被执行在合成形成的进程并且也表明新方法的可行性它在计算机的潜在的应用程序用机器制造的数字控制(计算机数值控制) ,表面修剪,和另外的工业惯例。 | Wang Xiaoping An Luling Zhang Liyan Zhou Laishui | 2008 | Chinese Journal of Aeronautics2008，21，6： | 7 |
| 4 | A scalable sulfuration of WS2 to improve cyclability and capability of lithium-ion batteries显示文摘二维的转变金属 dichalcogenides (WS 2 和 SnS 2) 最近加入了精力存储材料的家庭(为锂离子电池和 supercapacitors ) 由于他们的有利离子置闰。到目前为止,在阶段纯的 WS 2, 的合成的挑战严重地在 WS 2 nanosheets,低电子传导性,和 WS 2, 的易碎的性质之间重新叠限制它的使用 Li 离子电池申请。此处,我们开发灵巧的低温度解决方案硫化进程戏剧性地改进电池性能。硫化过程被表明在把 WO 3 杂质变换成 WS 2, 并且在修理硫空缺有效,到改进 cyclability 和率能力。锂离子电池大小证明 WS 2 阳极的稳定的能力能被 48.4% 经由硫化 reprocessing 提高,即,从在 0.8 的相对高的当前的密度的 381.7 ~ 566.8 mAh/g,在 50 以后的 A/g 骑车。我们进一步证明硫化进程能乐意地被扩大到另外的 dichalcogenides,并且可以为锂离子电池向万用的电极材料的一个类提供改进电气化学的特征。 | Liyan Zhou Shancheng Yan Lijia Pan Xinran Wang Yuqiao Wang Yi Shi | 2016 | Nano Research2016，9，3： | 7 |
| 5 | Multi-objective parameter optimization for a single-shaft series-parallel plug-in hybrid electric bus using genetic algorithm显示文摘最近,插件混合电的公共汽车(PHEB ) 的单个柄的系列平行 powertrain 为驾驶周期由于它的可改变的操作模式,优秀燃料经济和强壮的适应性成为了最流行的 powertrains 之一。为在开发阶段与单个柄的系列平行 powertrain 设置 PHEB,当选择并且匹配主要部件参数时,不过,它仍然比另外的配置面对更大的挑战。由这个问题激发了,全面多目的优化策略与典型 powertrain 为 PHEB 基于基因算法(GA ) 被开发。就公共汽车线路的重覆性和整齐而言,首先,离线的数据处理和数学统计的方法被采用,到获得一个代表性的开车周期,它能很好反映真实世界的公共汽车线路的一般特征。然后,节俭的优化目的被定义,它是由生产关键部件和精力消费的费用组成,并且与动态优化目的结合了,多客观的优化功能被提出。同时, GA 算法被用来优化参数,为新奇系列平行 powertrain 的最佳的部件联合。最后,有原型的比较被执行沿着驾驶周期验证优化 powertrain 的表演。模拟结果显示建议全面多目的优化策略获得的 powertrain 部件的参数可能得到更好的燃料经济,同时保证 PHEB 的动态性能。与原版相对照,费用在 18% 衰退了。因此,策略将为 PHEB 制造商在参数选择上提供理论指导。 | CHEN Zheng ZHOU LiYan SUN Yong MA ZiLin HAN ZongQi | 2016 | Science China(Technological Sciences)2016，59，8： | 4 |
| 6 | Characterization of a Novel Anti-DR5 Monoclonal Antibody WD1 with the Potential to Induce Tumor Cell Apoptosis显示文摘TNF-related apoptosis-inducing ligand (TRAIL) is a TNF family member capable of inducing apoptosis. Death receptor 5 (DR 5) is a key receptor of TRAIL and plays an important role in TRAIL-induced apoptosis. To prepare monoclonal antibodies (mAbs) against DR5,cDNA encoding soluble DR5 (sDR5) was firstly amplified by reverse transcriptase-polymerase chain reaction (RT-PCR) with specific primers,and then inserted into a prokaryotic expression vector pET-30a. The recombinant plasmid was expressed in Escherichia coli strain BL21 (DE3),and sDR5 was purified by nickel affinity chromatography. As an antigen,sDR5 was used to immunize mice. Hybridomas secreting antibodies against sDR5 were identified. One positive clone was selected to produce antibody,WD1. ELISA and immunofluorescence demonstrated that WD1 could bind recombinant sDR5 and membrane-bound DR5 (mDR5) on Jurkat and Molt-4 cells. ATPLite assays showed that Jurkat and Molt-4 cells were sensitive to the antibody in a dose dependent manner. The Annexin V/PI assays and Giemsa's staining both showed that WD1 could induce Jurkat cell apoptosis efficiently. Transient transfection of 293T cells and indirect immunofluorescence assay demonstrated that mAb (WD1) couldn't cross-react with DR4. Our findings indicated that the novel antibody,WD1 could act as a direct agonist,bind DR5 characteristically,and initiate efficient apoptotic signaling and tumor regression. Thus,WD1 would be a leading candidate for potential cancer therapeutics. | Jing Wang Zhou Lin Chunxia Qiao Ming Lv Ming Yu He Xiao Qingyang Wang Liyan Wang Jiannan Feng Beifen Shen Yuanfang Ma Yan Li | 2008 | Cellular & Molecular Immunology2008，5，1： | 4 |
| 7 | Phase Ⅲ Clinical Trials of the Cell Differentiation Agent-2 (CDA-2): Therapeutic Efficacy on Breast Cancer, Non-Small Cell Lung Cancer and Primary Hepatoma显示文摘 | Fengyi Feng Qing Lu Changquan Ling Yang Zhang Fengzhan Qin Huaqing Wang Wenxia Huang Shunchang Jiao Qiang Chen Mingzhong Li Yunzhong Zhu Meizhen Zhou Jun Ren Yetao Gao Jingpo Zhao Rongsheng Zheng Wenhua Zhao Zhiqiang Meng Fang Li Qizhong Zhang Dongli Zhao Liyan Xu Yongqiang Zhang Yanjun Zhang Zhenjiu Wang Shuonqi Liu Ming C. Liau | 2005 | Chinese Journal of Clinical Oncology2005，2，4： | 3 |
| 8 | A study of peroxyacetyl nitrate at a rural site in Beijing based on continuous observations from 2015 to 2019 and the WRFChem model显示文摘Peroxyacetyl nitrate(PA N)is one of the most important photochemical pollutants and has aroused much concern in China in recent decades.However,few studies described the long-term variations in PAN in China.In this study,we continuously monitored the PAN,03 and NOx concentrations at a regional background site near Beijing from August 2015 to February 2019.Based on the observed concentrations and climate data,w e analyzed the seasonal PAN variations.The results revealed that the monthly mean PAN concentration ranged from 0.33-2.41 ppb,with an average value of 0.94 ppb.The PAN concentration exhibited a distinct seasonal variation,with high values in spring and low values in winter.After analyzing the corresponding meteorological data,we found that stronger ultraviolet(UV)radiation,a relatively longer lifetime and a higher background PAN concentration contributed to the high PAN concentrations in spring.In addition,with the utilization of the WRF-Chem(Weather Research and Forecasting with Chemistry)model,the cause of the extremely high PAN concentration in spring 2018 wa s determined.The model results demonstrated that an anomalously low pressure and the southwesterly winds in northern China might be the main causes of the increased PAN concentration in Beijing and its surrounding area in spring 2018. | Yulu Qiu Zhiqiang Ma Weili Lin Weijun Quan Weiwei Pu Yingruo Li Liyan Zhou Qingfeng Shi | 2020 | Frontiers of Environmental Science & Engineering2020，14，4： | 3 |
| 9 | Constructing G^2 Continuous Curve on Freeform Surface with Normal Projection显示文摘This article presents a new method for G~2 continuous interpolation of an arbitrary sequence of points on an implicit or parametric surface with prescribed tangent direction and curvature vector,respectively,at every point.First,a G~2 continuous curve is constructed in three-dimensional space.Then the curve is projected normally onto the given surface.The desired interpolation curve is just the projection curve,which can be obtained by numerically solving the initialvalue problems for a system of first-order ordinary differential equations in the parametric domain for parametric case or in three-dimensional space for implicit case.Several shape parameters are introduced into the resulting curve,which can be used in subsequent interactive modification so that the shape of the resulting curve meets our demand.The presented method is independent of the geometry and parameterization of the base surface.Numerical experiments demonstrate that it is effective and potentially useful in numerical control (NC) machining,path planning for robotic fibre placement,patterns design on surface and other industrial and research fields. | Wang Xiaoping,An Luling,Zhou Laishui,Zhang Liyan Jiangsu Key Laboratory of Precision and Macro-manufacturing Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China | 2010 | Chinese Journal of Aeronautics2010，23，1： | 3 |
| 10 | Design and demonstration of a dynamic wireless power transfer system for electric vehicles显示文摘The usage of electric vehicles is being globally promoted with the development of clean energy. However, the development of electric vehicles is limited by the battery capacity and the charging techtechnology.Traditional charging facilities mainly involve plugging invehicles in an electrical interface,which is inconvenient and inherently hazardous.When compared with the traditional charging methods,the wireless charging method can solve several problems,such as the interface limitation,and will be gradually developed as the main charging mode for elec trie vehicles[1].Based on the driving stales of electric vehicles,the wireless charging technologies can be mainly classified as static wireless charging and dynamic wireless charging. | Ze ZHOU Liyan ZHANG Zhitao LIU Longhua MA Miao HUANG Hongye SU | 2019 | Science China(Information Sciences)2019，62，12： | 2 |
| 11 | Erratum to 'Uniform Coverage of Fibres over Open-contoured Freeform Structure Based on Arc-length Parameter' [Chinese Journal of Aeronautics 21(2008)571-577]显示文摘It is regretted that the author corrections requested at the proof stage were not made accurately. There are some incorrect typings in two equations which will lead to inaccurate results if readers perform calculations directly | Wang Xiaoping An Luling Zhang Liyan Zhou Laishui | 2009 | Chinese Journal of Aeronautics2009，22，3： | 2 |
| 12 | Protective humoral immunity in SARS-CoV-2 infected pediatric patients显示文摘After the rapid spread of SARS-CoV-2 in Wuhan,China,at the beginning of 2020,about 1.5 million confirmed cases and over 80,000 deaths have been reported around 200 countries and territories all over the world and the number continues to increase.However,we still have limited knowledge of this new coronavirus,especially the interaction between SARS-CoV-2 and our immune system. | Yaguang Zhang Jin Xu Ran Jia Chunyan Yi Wangpeng Gu Pengcheng Liu Xinran Dong Hao Zhou Bo Shang Shipeng Cheng Xiaoyu Sun Jing Ye Xuezhen Li Jia Zhang Zhiyang Ling Liyan Ma Bingbing Wu Mei Zeng Wenhao Zhou Bing Sun | 2020 | Cellular & Molecular Immunology2020，17，7： | 2 |
| 13 | Efficient procedure for isolating methylated catechins from green tea and effective simultaneous analysis of ten catechins, three purine alkaloids, and gallic acid in tea by high-performance liquid chromatography with diode array detection显示文摘 | Bing Hu Lin Wang Bei Zhou Xin Zhang Yi Sun Hong Ye Liyan Zhao Qiuhui Hu Guoxiang Wang Xiaoxiong Zeng | 2009 | Journal of Chromatography A2009，，15： | 2 |
| 14 | Comparison of the inactivation kinetics of pectin methylesterases from carrot and peach by high-pressure carbon dioxide显示文摘 | ZHOU Liyan ZHANG Yan HU Xiaosong | | 0，，02： | 1 |
| 15 | Sinomenine derivatives with embedment of nitrogen-containing heterocycles exhibiting potent TNF-inhibitory activity显示文摘Inhibitory effect on tumor necrosis factor-(TNF-) production by sinomenine derivatives with embedment of small drug-like nitrogen hetereocyclic moieties has been studied in this work.Several new sinomenine derivatives having chlorophenyl substituent have been found to exhibit much more potent TNF-α inhibitory activity than natural sinomenine and other derivatives. | WANG Meng MA LiYan LOU YangTong BIAN Chao ZHOU TingTing ZHOU HaiBin LIAO HongZe MA Zhao YIN DongSheng CHEN AiZhong WANG ShaoZhong YANG ZhenYu SUN Bing YAO ZhuJun | 2012 | Science China Chemistry2012，55，12： | 1 |
| 16 | A method for improving dispersion of starch nanocrystals in water through crosslinking modification with sodium hexametaphosphate显示文摘 | Lili Ren Man Jiang Liyan Wang Jiang Zhou Jin Tong | 2011 | Carbohydrate Polymers2011，，2： | 1 |
| 17 | Identification and characterization of loop7 motif and its role in regulating biological function of human APOBEC3G through molecular modeling and biological assay显示文摘Human APOBEC3G(h A3G) is a cytidine deaminase which inhibits HIV-1 replication. The HIV-1 accessory protein viral infectivity factor(Vif) counteracts with hA3G by targeting it for proteasomal degradation. In this work, we constructed and optimized molecular models of the hA3G dimer and the h A3G–Vif complex. The molecular modeling study revealed that the loop7 motif of hA3G appears on the interfaces of both the h A3G–Vif complex and the hA3G dimer. Biochemical analysis provided evidence suggesting that binding of Vif to hA3G results in steric blocking of hA3G dimerization, implying that monomeric hA3G serves as a substrate for Vif-mediated degradation.Furthermore, we presented evidence for the important roles of the loop7 motif, especially the central residues within the region, in hA3G dimerization, h A3G–Vif interaction, Vif-mediated hA3G degradation as well as subcellular localization of hA3G. This work highlights a multiple-task interface formed by loop7 motif, which regulates biological function of hA3G, thus providing the feasibility of the strategy of blocking Vif-mediated A3 G degradation by targeting the putative site around loop7. | Congjie Zhai Ling Ma Zhixin Zhang Jiwei Ding Jing Wang Yongxin Zhang Xiaoyu Li Fei Guo Liyan Yu Jinming Zhou Shan Cen | 2017 | Acta Pharmaceutica Sinica B2017，7，5： | 1 |
| 18 | Multi-platform omics analysis reveals molecular signature for COVID-19 pathogenesis,prognosis and drug target discovery显示文摘Disease progression prediction and therapeutic drug target discovery for Coronavirus disease 2019(COVID-19)are particularly important,as there is still no effective strategy for severe COVID-19 patient treatment.Herein,we performed multi-platform omics analysis of serial plasma and urine samples collected from patients during the course of COVID-19.Integrative analyses of these omics data revealed several potential therapeutic targets,such as ANXA1 and CLEC3B.Molecular changes in plasma indicated dysregulation of macrophage and suppression of T cell functions in severe patients compared to those in non-severe patients.Further,we chose 25 important molecular signatures as potential biomarkers for the prediction of disease severity.The prediction power was validated using corresponding urine samples and plasma samples from new COVID-19 patient cohort,with AUC reached to 0.904 and 0.988,respectively.In conclusion,our omics data proposed not only potential therapeutic targets,but also biomarkers for understanding the pathogenesis of severe COVID-19. | Yuming Li Guixue Hou Haibo Zhou Yanqun Wang Hein Min Tun Airu Zhu Jingxian Zhao Fei Xiao Shanwen Lin Dongdong Liu Dunrong Zhou Lang Mai Lu Zhang Zhaoyong Zhang Lijun Kuang Jiao Guan Qiushi Chen Liyan Wen Yanjun Zhang Jianfen Zhuo Fang Li Zhen Zhuang Zhao Chen Ling Luo Donglan Liu Chunke Chen Mian Gan Nanshan Zhong Jincun Zhao Yan Ren Yonghao Xu | 2021 | Signal Transduction and Targeted Therapy2021，6，5： | 1 |
| 19 | Progress in use of surfactant in nearly static conditions in natural gas hydrate formation显示文摘Natural gas hydrate is an alternative energy source with a great potential for development.The addition of surfactants has been found to have practical implications on the acceleration of hydrate formation in the industrial sector.In this paper,the mechanisms of different surfactants that have been reported to promote hydrate formation are summarized.Besides,the factors influencing surfactant-promoted hydrate formation,including the type,concentration,and structure of the surfactant,are also described.Moreover,the effects of surfactants on the formation of hydrate in pure water,brine,porous media,and systems containing multiple surfactants are discussed.The synergistic or inhibitory effects of the combinations of these additives are also analyzed.Furthermore,the process of establishing kinetic and thermodynamic models to simulate the factors affecting the formation of hydrate in surfactant-containing solutions is illustrated and summarized. | Zhen PAN Yi WU Liyan SHANG Li ZHOU Zhien ZHANG | 2020 | Frontiers in Energy2020，14，3： | 1 |
| 20 | Effect of total phenolics from Laggera alata on acute and chronic inflammation models显示文摘 | Yihang Wu Changxin Zhou Liyan Song Xiangping Li Shuyun Shi Jianxia Mo Haiyong Chen Hua Bai Xiumei Wu Jun Zhao Rongping Zhang Xiaojiang Hao Handong Sun Yu Zhao | 2006 | Journal of Ethnopharmacology2006，，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员