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| 1 | 2019新型冠状病毒基因组特征和流行病学:病毒起源和受体结合的意义显示文摘研究者对来自9例新型冠状病毒肺炎住院患者的支气管肺泡灌洗液样本和培养的分离株进行了下一代测序。从这些个体中获得了严重急性呼吸综合征-冠状病毒2(severe acute respiratory syndrome-coronavirus 2,SARS-CoV-2)的完整和部分基因组序列。利用Sanger测序连接病毒重叠群以获得全长基因组,cDNA末端快速扩增确定终端区。对这些SARSCoV-2基因组和其他冠状病毒基因组进行了系统进化分析,以确定该病毒的进化史并有助于推断其可能的起源。 | 刘青(译) 刘莉(审校) Lu R Zhao X Li J Niu P Yang B Wu H Wang W Song H Huang B Zhu N Bi Y Ma X Zhan F Wang L Hu T Zhou H Hu Z Zhou W Zhao L Chen J Meng Y Wang J Lin Y Yuan J Xie Z Ma J Liu WJ Wang D Xu W Holmes EC Gao GF Wu G Chen W Shi W Tan W | 2020 | 中华高血压杂志2020，28，3： | 516 |
| 2 | SHRIMP U-Pb dating for a K-bentonite bed in the Tieling Formation,North China显示文摘A SHRIMP U-Pb zircon age of 1437±21 Ma was obtained for a recently discovered K-bentonite bed in the Tieling Formation,situated northeast of Beijing at the boundary between Liaoning and Hebei provinces,on the northern margin of the North China Craton(NCC).The SHRIMP U-Pb age places Tieling Formation near the end of the Calymmian Period of the early Mesoproterozoic Era.In addition,a SHRIMP U-Pb zircon date of 1372±18 Ma was acquired for K-bentonite beds in the overlying,dark-shale-dominated Xiamaling Formation from the same location northeast of Beijing.This date assigns a similar Mid-Mesoproterozoic(Ectasian Period) age for the Xiamaling Formation,as have previously determined dates from other sections northwest of Beijing.These dates indicate that the Tieling and Xiamaling formations,as well as the related succession in the eastern part of the Yanshan Mountains,represented by the well-known Meso-to Neoproterozoic standard section in Jixian,can be correlated well with sections northwest of Beijing in the western part of the Yanshan Mountains.In other words,the boundary between the Calymmian and Ectasian periods in the northern parts of the NCC is marked by the unconformity between the Tieling and Xiamaling formations in the northern NCC.This boundary was previously ascribed to the 'Qinyu Orogeny' and thought to be of Grenville age.In this regard,the conventional 'Qinyu Orogeny' should now be regarded as a short-lived regional uplift during Early Mesoproterozoic time,rather than a result from the Grenvillian assembly of the NCC to the Rodinia Supercontinent(~1.0 Ga). | SU WenBo LI HuaiKun HUFF W D ETTENSOHN F R ZHANG ShiHong ZHOU HongYing WAN YuSheng | 2010 | Chinese Science Bulletin2010，55，29： | 30 |
| 3 | Minimally invasive surgery for gastric cancer: A comparison between robotic, laparoscopic and open surgery显示文摘AIM To investigate the role of minimally invasive surgery for gastric cancer and determine surgical, clinical, and oncological outcomes.METHODS This is a propensity score-matched case-control study, comparing three treatment arms: robotic gastrectomy(RG), laparoscopic gastrectomy(LG), open gastrectomy(OG). Data collection started after sharing a specific study protocol. Data were recorded through a tailored and protected web-based system. Primary outcomes: harvested lymph nodes, estimated blood loss, hospital stay, complications rate. Among the secondary outcomes, there are: operative time, R0 resections, POD of mobilization, POD of starting liquid diet and soft solid diet. The analysis includes the evaluation of type and grade of postoperative complications. Detailed information of anastomotic leakages is also provided.RESULTS The present analysis was carried out of 1026 gastrectomies. To guarantee homogenous distribution of cases, patients in the RG, LG and OG groups were 1:1:2 matched using a propensity score analysis with a caliper = 0.2. The successful matching resulted in a total sample of 604 patients(RG = 151; LG = 151; OG = 302). The three groups showed no differences in all baseline patients characteristics, type of surgery(P = 0.42) and stage of the disease(P = 0.16). Intraoperative blood loss was significantly lower in the LG(95.93 ± 119.22) and RG(117.91 ± 68.11) groups compared to the OG(127.26 ± 79.50, P = 0.002). The mean number of retrieved lymph nodes was similar between the RG(27.78 ± 11.45), LG(24.58 ± 13.56) and OG(25.82 ± 12.07) approach. A benefit in favor of the minimally invasive approaches was found in the length of hospital stay(P < 0.0001). A similar complications rate was found(P = 0.13). The leakage rate was not different(P = 0.78) between groups.CONCLUSION Laparoscopic and robotic surgery can be safely performed and proposed as possible alternative to open surgery. The main highlighted benefit is a faster postoperative functional recovery. | Amilcare Parisi Daniel Reim Felice Borghi Ninh T Nguyen Feng Qi Andrea Coratti Fabio Cianchi Maurizio Cesari Francesca Bazzocchi Orhan Alimoglu Johan Gagnière Graziano Pernazza Simone D'Imporzano Yan-Bing Zhou Juan-Santiago Azagra Olivier Facy Steven T Brower Zhi-Wei Jiang Lu Zang Arda Isik Alessandro Gemini Stefano Trastulli Alexander Novotny Alessandra Marano Tong Liu Mario Annecchiarico Benedetta Badii Giacomo Arcuri Andrea Avanzolini Metin Leblebici Denis Pezet Shou-Gen Cao Martine Goergen Shu Zhang Giorgio Palazzini Vito D'Andrea Jacopo Desiderio | 2017 | World Journal of Gastroenterology2017，23，13： | 17 |
| 4 | 通过监测乙型肝炎患者耐药突变株比例的变化推测cccDNA的快速更新周期显示文摘【据Hepatology 2021年1月报道】题:通过监测乙型肝炎患者耐药突变株比例的变化推测ccc DNA的快速更新周期(作者Huang Q等)来自南方医科大学南方医院的孙剑教授课题组利用两项已结束的随机对照临床研究样本,以拉米夫定耐药(LAMR)突变位点—rt M204I/V作为标记,以rt M204I/V耐药株相对于野毒株的比例变化,推测ccc DNA池的更新周期。 | 陆星宇 周彬孙 HUANG Q ZHOU B CAI D | 2021 | 临床肝胆病杂志2021，37，4： | 16 |
| 5 | Calcium phosphate cements for bone engineering and their biological properties显示文摘Calcium phosphate cements(CPCs) are frequently used to repair bone defects. Since their discovery in the 1980 s, extensive research has been conducted to improve their properties, and emerging evidence supports their increased application in bone tissue engineering. Much effort has been made to enhance the biological performance of CPCs, including their biocompatibility, osteoconductivity, osteoinductivity, biodegradability,bioactivity, and interactions with cells. This review article focuses on the major recent developments in CPCs,including 3 D printing, injectability, stem cell delivery, growth factor and drug delivery, and prevascularization of CPC scaffolds via co-culture and tri-culture techniques to enhance angiogenesis and osteogenesis. | Hockin HK Xu Ping Wang Lin Wang Chongyun Bao Qianming Chen Michael D Weir Laurence C Chow Liang Zhao Xuedong Zhou Mark A Reynolds | 2017 | Bone Research2017，5，4： | 14 |
| 6 | Influence of Garlic Intercropping or Active Emitted Volatiles in Releasers on Aphid and Related Beneficial in Wheat Fields in China显示文摘In order to develop biological control of aphids by a 'push-pull'approach, intercropping using repellent emitting plants was developed in different crop and associated plant models. Garlic is one of the potential plant that could be inserted in crops to decrease the pest occurrence in neighboring crop plots. In this study, field works were conducted in wheat fields in Langfang Experimental Station, Hebei Province in China from October 2009 to July 2010 during wheat developmental season. The effect of wheat intercropping with garlic but also the volatiles emission on the incidence of the English grain aphid, Sitobion avenae Fabricius (Homoptera: Aphididae) was assessed. Natural beneficial occurrence and global yields in two winter wheat varieties that were susceptible or resistant to cereal aphid were also determined comparing to control plots without the use of garlic plant intercrop nor semiochemical releaser in the fields. S. avenae was found to be lower in garlic oil blend treatment (GOB), diallyl disulfide treatment (DD) and wheat-garlic intercropping treatment (WGI) when compared to the control plots for both two varieties (P<0.01). Both intercropping and application of volatile chemicals emitted by garlic could improve the population densities of natural enemies of cereal aphid, including ladybeetles and mummified aphids. Ladybeetle population density in WGI, GOB and mummified aphids densities in WGI, DD were significantly higher than those in control fields for both two varieties (P<0.05). There were significant interactions between cultivars and treatments to the population densities of S. avenae. The 1 000-grain weight and yield of wheat were also increased compared to the control. Due to their potential alternatives as a biological control agent against cereal aphid, garlic intercropping and related emitted volatiles are expected to contribute to the further improvement of integrated pest management systems and to potentially reduce the amount of traditional synthetic pesticides applied in wheat fields. | ZHOU Hai-bo CHEN Ju-lian LIU Yong Frédéric Francis Eric Haubruge Claude Bragard SUN Jing-rui CHENG Deng-fa | 2013 | Journal of Integrative Agriculture2013，12，3： | 12 |
| 7 | Existing drugs as broad-spectrum and potent inhibitors for Zika virus by targeting NS2B-NS3 interaction显示文摘Zika 病毒(ZIKV ) 的最近的爆发为治疗学加亮迫切需要。朊酶建筑群 NS2B-NS3 在 flaviviral polyprotein 处理期间起必要作用,并且因此代表一个吸引人的药目标。这里,我们开发了裂口酶识别直接指向 flavivirus NS2B-NS3 相互作用的 orthosteric 禁止者的基于互补的高产量的屏蔽试金。由屏蔽一个总数 2 816 同意了并且 investigational 药,我们识别了三个有势力候选人, temoporfin, niclosamide,和 nitazoxanide,,有 nanomolar 力量的 flavivirus NS2B-NS3 相互作用禁止者。显著地,在老鼠的在人的胎盘、神经的祖先房间的大多数有势力化合物, temoporfin,不是仅仅禁止的 ZIKV 复制,而且阻止的导致 ZIKV 的 viremia 和死亡当模特儿。结构的停靠建议 temoporfin 潜在地绑保持批评 NS2B 残余的 NS3 衣袋,因此禁止以一种非竞争的方式处理的 flaviviral polyprotein。当这些药已经在 USA 或另外的国家在另外的指示任何一个为临床的使用被同意了,他们由 ZIKV 和另外的 flaviviruses 为感染的管理代表有希望、容易开发的治疗。 | Zhong Li Matthew Brecher Yong-Qiang Deng Jing Zhang Srilatha Sakamuru Binbin Liu Ruili Huang Cheri A Koetzner Christina A Allen Susan A Jones Haiying Chen Na-Na Zhang Min Tian Fengshan Gao Qishan Lin Nilesh Banavali Jia Zhou Nathan Boles Menghang Xia Laura D Kramer Cheng-Feng Qin Hongmin Li | 2017 | Cell Research2017，27，8： | 11 |
| 8 | Bone tissue engineering via nanostructured calcium phosphate biomaterials and stem cells显示文摘Tissue engineering is promising to meet the increasing need for bone regeneration. Nanostructured calcium phosphate(CaP) biomaterials/scaffolds are of special interest as they share chemical/crystallographic similarities to inorganic components of bone. Three applications of nano-CaP are discussed in this review:nanostructured calcium phosphate cement(CPC); nano-CaP composites; and nano-CaP coatings. The interactions between stem cells and nano-CaP are highlighted, including cell attachment, orientation/morphology, differentiation and in vivo bone regeneration. Several trends can be seen:(i) nano-CaP biomaterials support stem cell attachment/proliferation and induce osteogenic differentiation, in some cases even without osteogenic supplements;(ii) the influence of nano-CaP surface patterns on cell alignment is not prominent due to non-uniform distribution of nano-crystals;(iii) nano-CaP can achieve better bone regeneration than conventional CaP biomaterials;(iv) combining stem cells with nano-CaP accelerates bone regeneration, the effect of which can be further enhanced by growth factors; and(v) cell microencapsulation in nano-CaP scaffolds is promising for bone tissue engineering. These understandings would help researchers to further uncover the underlying mechanisms and interactions in nano-CaP stem cell constructs in vitro and in vivo, tailor nano-CaP composite construct design and stem cell type selection to enhance cell function and bone regeneration, and translate laboratory findings to clinical treatments. | Ping Wang Liang Zhao Jason Liu Michael D Weir Xuedong Zhou Hockin H K Xu | 2014 | Bone Research2014，2，3： | 11 |
| 9 | A STUDY OF STRUCTURE AND PROPERTY CHANGES OF BIODEGRADABLE POLYGLYCOLIDE AND POLY(GLYCOLIDE-co-LACTIDE)FIBERS DURING PROCESSING AND IN VITRO DEGRADATION显示文摘Structure and properties of bioabsorbable polyglycolide (PGA) and poly(glycolide-co-lactide) (PGA-co-PLA)fibers were investigated during several industrial processing stages and in vitro degradation by means of wide-angle X-ray diffraction (WAXD), dynamic mechanical analysis (DMA) and mechanical property tests. In the orientation stage, the PGA fibers were found to have higher degrees of crystallinity than corresponding PGA-co-PLA samples produced under similar conditions. In the hot-stretching and post-annealing stages, after fibers were braided, PGA samples were found to gain more crystallinity and higher Tg than PGA-co-PLA samples. The higher crystallinity in PGA fibers resulted in a slower rate of degradation. DMA results showed that a great deal of internal stress that was built during orientation and hot-stretching stages was released in the post-annealing stage for all PGA and PGA-co-PLA samples. During earlier stages ofin vitro degradation, both PGA and PGA-co-PLA samples exhibited the typical cleavage-induced crystallization mechanism. The heat shrinkage in the glass transition area was found to disappear after 6-8 days of degradation for all PGA and PGA-co-PLA samples, indicating the amorphous portions of the polymers lost orientation after a short period in the buffer solution, most likely due to relaxation of the cleaved chains. | Bruce X.Fu Benjamin S.Hsiao Gavin Chen Jack Zhou Susan Lin Jenny Yuan Ilya Koyfman Dennis D Jamiolkowski Edward Dormier | 2003 | Chinese Journal of Polymer Science2003，21，2： | 9 |
| 10 | One-year water-ageing of calcium phosphate composite containing nano-silver and quaternary ammonium to inhibit biofilms显示文摘Dental composites are commonly used restorative materials; however, secondary caries due to bio?lm acids remains a major problem. The objectives of this study were(1) to develop a composite containing quaternary ammonium dimethacrylate(QADM),nanoparticles of silver(NAg), and nanoparticles of amorphous calcium phosphate(NACP), and(2) to conduct the ?rst investigation of the mechanical properties, bio?lm response and acid production vs water-ageing time from 1 day to 12 months.A 4 × 5 design was utilized, with four composites(NACP-QADM composite, NACP-NAg composite, NACP-QADM-NAg composite,and a commercial control composite), and ?ve water-ageing time periods(1 day, and 3, 6, 9, and 12 months). After each waterageing period, the mechanical properties of the resins were measured in a three-point ?exure, and antibacterial properties were tested via a dental plaque bio?lm model using human saliva as an inoculum. After 12 months of water-ageing, NACP-QADMNAg had a ?exural strength and elastic modulus matching those of the commercial control(P40.1). Incorporation of QADM or NAg into the NACP composite greatly reduced bio?lm viability, metabolic activity and acid production. A composite containing both QADM and NAg possessed a stronger antibacterial capability than one with QADM or NAg alone(Po0.05). The anti-bio?lm activity was maintained after 12 months of water-ageing and showed no signi?cant decrease with increasing time(P40.1). In conclusion, the NACP-QADM-NAg composite decreased bio?lm viability and lactic acid production, while matching the loadbearing capability of a commercial composite. There was no decrease in its antibacterial properties after 1 year of water-ageing.The durable antibacterial and mechanical properties indicate that NACP-QADM-NAg composites may be useful in dental restorations to combat caries. | Lei Cheng Ke Zhang Chen-Chen Zhou Michael D Weir Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，3： | 8 |
| 11 | 中药复方联合恩替卡韦治疗HBeAg阳性慢性乙型肝炎的随机对照试验显示文摘在我国,对慢性乙型肝炎患者予以核苷类似物联合中药的双重处方已经被广泛接受和应用。在这项我国开展的随机、双盲、多中心对照试验中,研究者将对恩替卡韦(ETV)联合中药“调肝益脾颗粒”和“调肝健脾解毒颗粒”是否能提高血清HBeAg转阴率进行了评价。研究共纳入596例符合条件的受试者,所有受试者按1∶1比例随机分为2组:试验组给予ETV加中药复方治疗,对照组给予ETV加中药安慰剂治疗。研究主要结局指标为治疗108周后2组受试者的HBeAg转阴率,次要结局指标包括疗程第108周2组受试者的HBsAg水平、HBV DNA低于检测下限(<500 IU/ml)受试者比例和血清肝酶(ALT、AST、GGT等)水平。 | LI X ZHOU D CHI X 杜宏波 叶永安 | 2021 | 临床肝胆病杂志2021，37，3： | 8 |
| 12 | 代谢健康的肥胖和腹型肥胖与高血压风险增加相关显示文摘代谢健康型肥胖是指具有正常代谢特征的肥胖人群。研究者在中国农村地区队列研究(the rural Chinese cohort study)的成年人中,探究了代谢健康型肥胖与高血压风险的关系。这项前瞻性队列研究纳入中国成人9137名,在基线时(2007-2008年)无高血压、2型糖尿病或血脂异常,在2013-2014年进行随访。 | 周卫(译) 袁源(审校) Zhao Y Qin P Sun HH Liu Y Liu D Zhou Q Guo C Li Q Tian G Wu X Hu D Sun X Zhang M | 2020 | 中华高血压杂志2020，28，9： | 7 |
| 13 | A draft sequence of the rice (Oryza sativa ssp. indica) genome显示文摘The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a 'whole genome shotgun' approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in China and many other regions of Asia. The draft genome sequence is constructed from over 4.3 million successful sequencing traces with an accumulative total length of 2214.9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 million successful sequencing traces with a total length of 1797.4 Mb from an indica variant cultivar 93-11, giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package | YU Jun, HU Songnian, WANG Jun,LI Songgang WONG Ka-Shu Gane, LIU Bin,DENG Yajun, DAI Li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, LIU Jing,SUN Jiandong , TANG Jiabin, CHEN Yanjiong,HUANG Xiaobing, LIN Wei, YE Chen, TONG Wei,CONG Lijuan, GENG Jianing, HAN Yujun, LI Lin,LI Wei, HU Guangqiang, HUANG Xiangang,LI Wenjie, LI Jian, LIU Zhanwei, LI Long,LIU Jianping, Ql Qiuhui, LIU Jinsong, LI Li,WANG Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,LI Xianran, WANG Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG Wanyong,TAO Lin, CHEN Xuewei, HE Jun, LIU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,LI Gang, GAO Hui, LI Ping, CHEN Wei ,WANG Xudong, ZHANG Yong, HU Jianfei,WANG Jing, LIU Song, YANG Jian,ZHANG Guangyu, XIONG Yuqing, LI Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,LI Guojie, LIU Siqi, HUANG Guyang,TAO Ming, WANG Jian, ZHU Lihuang,YUAN Longping& YANG HuanmingBeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang University/Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China Institute of Genetics, Chinese Academy of Sciences, Beijing 100101, China National Hybrid Rice R & D Center, Changsha 410125, China Laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China College of Life Sciences, Peking University, Beijing 100871, China Institute of Theoretical Physics, Chinese Academy of Sciences, Beijing 1Q0080, China Digital China Ltd., Beijing 100080, China Institute of Computing Technology, Chinese Academy of Sciences, Beijing 100080, China Medical College, Xi’an Jiaotong University, Xi’an 710061, ChinaThese authors contributed equally to this work.Corresponding author.Corresponden | 2001 | Chinese Science Bulletin2001，46，23： | 6 |
| 14 | Mutation analysis of autosomal dominant polycystic kidney disease genes in Han Chinese显示文摘 | Zhang S Mei C Zhang D Dai B Tang B Sun T Zhao H Zhou Y Li L Wu Y Wang W Shen X Song J | 2005 | 第二军医大学学报2005，26，8： | 6 |
| 15 | Evaluation of three-dimensional biofilms on antibacterial bonding agents containing novel quaternary ammonium methacrylates显示文摘Antibacterial adhesives are promising to inhibit biofilms and secondary caries.The objectives of this study were to synthesize and incorporate quaternary ammonium methacrylates into adhesives,and investigate the alkyl chain length effects on three-dimensional biofilms adherent on adhesives for the first time.Six quaternary ammonium methacrylates with chain lengths of 3,6,9,12,16 and 18were synthesized and incorporated into Scotchbond Multi-Purpose.Streptococcus mutans bacteria were cultured on resin to form biofilms.Confocal laser scanning microscopy was used to measure biofilm thickness,live/dead volumes and live-bacteria percentage vs.distance from resin surface.Biofilm thickness was the greatest for Scotchbond control;it decreased with increasing chain length,reaching a minimum at chain length 16.Live-biofilm volume had a similar trend.Dead-biofilm volume increased with increasing chain length.The adhesive with chain length 9 had 37%live bacteria near resin surface,but close to 100%live bacteria in the biofilm top section.For chain length 16,there were nearly 0%live bacteria throughout the three-dimensional biofilm.In conclusion,strong antibacterial activity was achieved by adding quaternary ammonium into adhesive,with biofilm thickness and live-biofilm volume decreasing as chain length was increased from 3 to 16.Antibacterial adhesives typically only inhibited bacteria close to its surface;however,adhesive with chain length 16 had mostly dead bacteria in the entire three-dimensional biofilm.Antibacterial adhesive with chain length 16 is promising to inhibit biofilms at the margins and combat secondary caries. | Han Zhou Michael D Weir Joseph M Antonucci Gary E Schumacher Xue-Dong Zhou Hockin H K Xu | 2014 | International Journal of Oral Science2014，6，2： | 5 |
| 16 | Effect of anti-biofilm glass–ionomer cement on Streptococcus mutans biofilms显示文摘Dental restorative materials with antimicrobial properties can inhibit bacterial colonization, which may result in a reduction of caries at tooth-filling interaction zones. This study aimed to develop antibacterial glass–ionomer cements(GIC) containing a quaternary ammonium monomer(dimethylaminododecyl methacrylate, DMADDM), and to investigate their effect on material performance and antibacterial properties. Different mass fractions(0, 1.1% and 2.2%) of DMADDM were incorporated into the GIC. The flexure strength, surface charge density, surface roughness and fluoride release were tested. A Streptococcus mutans biofilm model was used. Exopolysaccharides(EPS) staining was used to analyze the inhibitory effect of DMADDM on the biofilm matrix. In addition, biofilm metabolic activity, lactic acid metabolism and the expression of glucosyltransferase genes gtf B, gtf C and gtf D were measured. GIC containing 1.1% and 2.2% DMADDM had flexural strengths matching those of the commercial control(P40.1). DMADDM was able to increase the surface charge density but reduced surface roughness(Po0.05). The incorporation of 1.1% and 2.2% DMADDM elevated the release of fluoride by the GIC in the first 2 days(Po0.05). The novel DMADDM-modified GIC significantly reduced biofilm metabolic activity(Po0.05) and decreased lactic acid production(Po0.05). The quantitative polymerase chain reaction(q PCR) results showed that the expression of gtf B, gtf C and gtf D decreased when mass fractions of DMADDM increased(Po0.05). EPS staining showed that both the bacteria and EPS in biofilm decreased in the DMADDM groups. The incorporation of DMADDM could modify the properties of GIC to influence the development of S. mutans biofilms. In this study, we investigated the interface properties of antibacterial materials for the first time. GIC containing DMADDM can improve material performance and antibacterial properties and may contribute to the better management of secondary caries. | Su-Ping Wang Yang Ge Xue-Dong Zhou Hockin HK Xu Michael D Weir Ke-Ke Zhang Hao-Hao Wang Matthias Hannig Stefan Rupf Qian Li Lei Cheng | 2016 | International Journal of Oral Science2016，8，2： | 5 |
| 17 | Rapid health transition in China, 1990–2010: findings from the Global Burden of Disease Study 2010显示文摘 | Gonghuan Yang Yu Wang Yixin Zeng George F Gao Xiaofeng Liang Maigeng Zhou Xia Wan Shicheng Yu Yuhong Jiang Mohsen Naghavi Theo Vos Haidong Wang Alan D Lopez Christopher JL Murray | 2013 | The Lancet . 2013 (9882)2013，，9882： | 4 |
| 18 | Establishment and Applications of Epstein-Barr Virus-based Episomal Vectors in Human Embryonic Stem Cells显示文摘 | Ren C Zhao M Yang X Li D Jiang X Wang L Shan W Yang H Zhou L Zhou W Zhang H | 2006 | 中国生物学文摘2006，20，7： | 4 |
| 19 | Osteopontin protects against hyperoxia-induced lung injury by inhibiting nitric oxide synthases显示文摘到超过 95% O_2 的成年老鼠的背景暴露到 72 个小时生产致命的损害。氮的氧化物 synthase (NOS ) 被认为贡献鼠科的导致 hyperoxia 的尖锐的肺损害(ALI ) 的 pathophysiology。Osteopontin (OPN ) 是巨噬细胞主要生产的 phosphorylated glycoprotein。OPN 禁止可诱导的氮的氧化物 synthase (iNOS ) ,它产生大量氮的氧化物生产。然而,在氮的氧化物之间的关系和在肺织物的内长的 OPN 还没在 导致hyperoxia 的 ALI 期间被阐明了,因此,我们检验了 OPN 在有 NOS.Methods 的 导致hyperoxia 的肺损害和它的关系起的作用 144 只 osteopontin 大美人(击倒)老鼠和他们的匹配的野类型背景控制( WT )在封上的笼子被暴露>为 24-72 小时的95%氧或房间空气,并且肺损害的严厉被估计;OPN 的表示, endothelial 氮的氧化物 synthase (eNOS ) 和在在 hyperoxia 的 24,48 和 72 个小时的肺纸巾的 iNOS mRNA 被反向的抄写聚合酶链反应(RT-PCR ) 学习;immunohistochemistry (IHC ) 被执行因为在肺 tissues.Results OPN 击倒老鼠的 iNOS, eNOS,和 OPN 蛋白质的察觉在 72 小时 hyperoxia 开发了更严重的尖锐的肺损害。湿 / 干燥的重量比率增加了到 6. | ZHANG Xiang-feng LIU Shuang ZHOU Yu-jie ZHU Guang-fa Hussein. D Foda | 2010 | Chinese Medical Journal2010，，7： | 4 |
| 20 | Primer containing dimethylaminododecyl methacrylate kills bacteria impregnated in human dentin blocks显示文摘Antibacterial dimethylaminododecyl methacrylate(DMADDM) was recently synthesized. The objectives of this study were to:(1)investigate antibacterial activity of DMADDM-containing primer on Streptococcus mutans impregnated into dentin blocks for the first time, and(2) compare the antibacterial efficacy of DMADDM with a previous quaternary ammonium dimethacrylate(QADM).Scotchbond Multi-Purpose(SBMP) bonding agent was used. DMADDM and QADM were mixed into SBMP primer. Six primers were tested: SBMP control primer P, P+2.5% DMADDM, P+5% DMADDM, P+7.5% DMADDM, P+10% DMADDM, and P+10% QADM.S. mutans were impregnated into human dentin blocks, and each primer was applied to dentin to test its ability to kill bacteria in dentinal tubules. Bacteria in dentin were collected via a sonication method, and the colony-forming units(CFU) and inhibition zones were measured. The bacterial inhibition zone of P+10% DMADDM was 10 times that of control primer(Po0.05). CFU in dentin with P+10% DMADDM was reduced by three orders of magnitude, compared with control. DMADDM had a much stronger antibacterial effect than QADM, and antibacterial efficacy increased with increasing DMADDM concentration. Dentin shear bond strengths were similar among all groups(P40.1). In conclusion, antibacterial DMADDM-containing primer was validated to kill bacteria inside dentin blocks, possessing a much stronger antibacterial potency than the previous QADM. DMADDM-containing bonding agent was effective in eradicating bacteria in dentin, and its efficacy was directly proportional to DMADDM mass fraction. Therefore, DMADDM may be promising for use in bonding agents as well as in other restorative and preventive materials to inhibit bacteria. | Chen Chen Lei Cheng Michael D Weir Nancy J Lin Sheng Lin-Gibson Xue-Dong Zhou Hockin HK Xu | 2016 | International Journal of Oral Science2016，8，4： | 4 |
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