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| 1 | Multispherical interactions and their effects on the Tibetan Plateau's earth system: a review of the recent researches显示文摘The Tibetan Plateau(TP) is a regional Earth system showing very strong interactions among its lithosphere, hydrosphere, cryosphere, biosphere, atmosphere, and anthrosphere. hese interactions manifest TP's impact on surrounding regions and relect TP's response to the global change. Quantifying the multispherical interactions is critically important to understand the TP environment. Our recent years researches including the ongoing program entitled ‘Tibetan Multi-Spheres Interactions and heir Resource-Environment Signiicance(TIMI)', the completed program entitled. ‘Paleo-Altitudes of Tibetan Plateau and Environment(PATE)', as well as the other relating projects have focused on multidisciplinary research approaches and emphasized on three major pathways: Eurasia-Indian plates collision on deep-Earth dynamics, uplit impact on Earth's mantle–crust dynamics, and contemporary interface on land surface and atmospheric dynamics. Our researches have taken in situ measurement as priority and developed several platforms of data acquisition and analysis, including the platforms of water-phase transformations, and ecosystem observations. Our ield investigations have been conducted to obtain data about stratum, paleontology, paleoenvironment, genetic diferentiation of animals and plants. We have developed conceptual and mathematical models for crust uplit formation, paleoclimate, glacial melt,water–air interface lux, vegetation climate, and soil erosion. We have also assessed the anthropogenic impacts on environment. Our researches have achieved new and reliable redating of the mantle–crust interaction and initial formation of the TP, found the interaction between tectonics and uplit of the TP and resultant paleoaltitude acting as a spreading source; discovered the interaction between the westerlies and Indian monsoon acting as a control chain that dominates the TP's contemporary environment. he scientiic results can play fundamental roles in supporting the TP's resource exploration and societal sustainable development. | Tandong Yao Fuyuan Wu Lin Ding Jimin Sun Liping Zhu Shilong Piao Tao Deng Xijun Ni Hongbo Zheng Hua Ouyang | 2015 | National Science Review2015，2，4： | 35 |
| 2 | Stenting for symptomatic intracranial arterial stenosis in China:1-year outcome of a multicentre registry study显示文摘background and purpose A multicentre prospective registry study of individually tailored stenting for a patient with symptomatic intracranial atherosclerotic stenosis(ICAS)combined with poor collaterals in China showed that the short-term safety and efficacy of stenting was acceptable.However,it remained uncertain whether the low event rate could be of a long term.We reported the 1-year outcome of this registry study to evaluate the long-term efficacy of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Methods Patients with symptomatic ICAS caused by 70%-99% stenosis located at the intracranial internal carotid,middle cerebral,intracranial vertebral or basilar arteries combined with poor collaterals were enrolled.Balloon-mounted stent or balloon plus self-expanding stent were selected based on the ease of vascular access and lesion morphology determined by the operators.The primary outcome was the rate of 30-day stroke,transient ischaemic attack and death,and 12-month ischaemic stroke within the same vascular territory,haemorrhagic stroke and vascular death after stenting.results From September 2013 to January 2015,300 patients(ages 58.3±9.78 years)were recruited.Among them,159 patients were treated with balloon-mounted stent and 141 with balloon plus self-expanding stent.During the 1-year follow-up,25 patients had a primary end point event.The probability of primary outcome at 1 year was 8.1%(95% CI 5.3% to 11.7%).In 76 patients with digital subtraction angiography follow-up,27.6%(21/76)had re-stenosis≥50% and 18.4%(14/76)had re-stenosis≥70%.No baseline characteristic was associated with the primary outcome.Conclusion The event rate remains low over 1 year of individually tailored stenting for patients with severe symptomatic ICAS combined with poor collaterals.Further randomised trial of comparing individually tailored stenting with best medical therapy is needed. | Ning Ma Yong Zhang Jie Shuai Changchun Jiang Qiyi Zhu Kangning Chen Li Liu Baomin Li Xiangqun Shi Lianbo Gao Yajie Liu Feng Wang Yongli Li Tieyan Liu Hongbo Zheng Dapeng Mo Feng Gao Yilong Wang Yongjun Wang Lei Feng Zhongrong Miao | 2018 | Stroke & Vascular Neurology2018，3，3： | 29 |
| 3 | Birth of the Yangtze River: age and tectonic-geomorphic implications显示文摘Large river systems are an integral and essential component of Earth dynamics. he development of large river systems in Asia is closely linked to the evolving topography driven by both near-ield and far-ield efects of the interplay among Indian, Eurasian and Paciic plates. Plate tectonics together with climatic changes during the Cenozoic is therefore believed to have determined the evolution of Asian large rivers,yet the age of the Yangtze, the largest in Asia, has been strongly debated over a century, with estimates ranging from 40–45 Ma to a more recent initiation postdating 750 ka. In this paper, I atempt to review the competing views about the age of the Yangtze, and evaluate the estimated pre-Miocene birth of the river based on the provenance of the luvial sediments from the lower reaches. I further present new geological evidence from the upper stream in southeastern Tibetan Plateau to show the existence of a possible southward paleo-Jinshajiang during the Paleogene, and exploit when and how it might deviated eastward to give birth to the modern Yangtze River. I propose that the present Yangtze River system formed in response to the continental-scale gradient driven by upliting Tibetan Plateau and regional extension throughout eastern China, synchronous with surface uplit in southeastern Tibet and strengthening of Asian summer monsoon. | Hongbo Zheng | 2015 | National Science Review2015，2，4： | 22 |
| 4 | Detrital zircon U-Pb ages of Late Cenozoic sediments from the Yangtze delta:Implication for the evolution of the Yangtze River显示文摘Detrital zircon grains of Late Cenozoic sediments dated back to ca.3.6 Ma from core DY03 in the Yangtze delta were dated by LA-ICP-MS,in order to investigate the sedimentary provenance and to find some clue for the evolution of the Yangtze River.Most of the detrital zircon U-Pb ages are distributed at 100 300 Ma,350 550 Ma,600 1000 Ma,1400 2000 Ma and 2200 2800 Ma,which correspond well with the main tectonic and magmatic events in the Yangtze drainage.The detrital zircon age patterns show distinct difference between the 3 samples below 189.8 m and other 6 above 189.8 m.43% 55% zircons in the 3 samples below 189.8 m fall within Cretaceous,while ages from 150 to 2800 Ma are distributed with no obvious peaks,which indicate the sedimentary provenance may be limited to the lower Yangtze drainage.The 6 samples above 189.8 m show similar age patterns,and the ages are relatively evenly distributed,indicating the sedimentary provenance broadened distinctly.All 6 samples deposited later than ca.3.2 Ma show age information from the upper Yangtze drainage (including the Emeishan large igneous province),indicating that the Three Gorges may have already been cut through by then. | JIA JunTao ZHENG HongBo HUANG XiangTong WU FuYuan YANG ShouYe | 2010 | Chinese Science Bulletin2010，55，15： | 20 |
| 5 | Ferroptosis is essential for diabetic cardiomyopathy and is prevented by sulforaphane via AMPK/NRF2 pathways显示文摘Herein,we define the role of ferroptosis in the pathogenesis of diabetic cardiomyopathy(DCM)by examining the expression of key regulators of ferroptosis in mice with DCM and a new ex vivo DCM model.Advanced glycation end-products(AGEs),an important pathogenic factor of DCM,were found to induce ferroptosis in engineered cardiac tissues(ECTs),as reflected through increased levels of Ptgs2 and lipid peroxides and decreased ferritin and SLC7 A11 levels.Typical morphological changes of ferroptosis in cardiomyocytes were observed using transmission electron microscopy.Inhibition of ferroptosis with ferrostatin-1 and deferoxamine prevented AGE-induced ECT remodeling and dysfunction.Ferroptosis was also evidenced in the heart of type 2 diabetic mice with DCM.Inhibition of ferroptosis by liproxstatin-1 prevented the development of diastolic dysfunction at 3 months after the onset of diabetes.Nuclear factor erythroid 2-related factor 2(NRF2)activated by sulforaphane inhibited cardiac cell ferroptosis in both AGE-treated ECTs and hearts of DCM mice by upregulating ferritin and SLC7 A11 levels.The protective effect of sulforaphane on ferroptosis was AMP-activated protein kinase(AMPK)-dependent.These findings suggest that ferroptosis plays an essential role in the pathogenesis of DCM;sulforaphane prevents ferroptosis and associated pathogenesis via AMPK-mediated NRF2 activation.This suggests a feasible therapeutic approach with sulforaphane to clinically prevent ferroptosis and DCM. | Xiang Wang Xinxin Chen Wenqian Zhou Hongbo Men Terigen Bao Yike Sun Quanwei Wang Yi Tan Bradley B.Keller Qian Tong Yang Zheng Lu Cai | 2022 | Acta Pharmaceutica Sinica B2022，12，2： | 20 |
| 6 | Natural Variation in CCD4 Promoter Underpins Species-Specific Evolution of Red Coloration in Citrus Peel显示文摘Carotenoids and apocarotenoids act as phytohormones and volatile precursors that influence plant development and confer aesthetic and nutritional value critical to consumer preference.Citrus fruits display considerable natural variation in carotenoid and apocarotenoid pigments.In this study,using an integrated genetic approach we revealed that a 5;c/s-regulatory change at CCD4b encoding CAROTENOID CLEAVAGE DIOXYGENASE 4b is a major genetic determinant of natural variation in C3 0 apocarotenoids responsible for red coloration of citrus peel.Functional analyses demonstrated that in addition the known role in synthesizing 3-citraurin,CCD4b is also responsible for the production of another important C3 0 apocarotenoid pigment,p-citraurinene.Furthermore,analyses of the CCD4b promoter and transcripts from various citrus germplasm accessions established a tight correlation between the presence of a putative 5'c/s-regulatory enhancer within an MITE transposon and the enhanced allelic expression of CCD4b in C3 0 apocarotenoid-rich red-peeled accessions.Phylogenetic analysis provided further evidence that functional diversification of CCD4b and naturally occurring variation of the CCD4b promoter resulted in the stepwise evolution of red peels in mandarins and their hybrids.Taken together,our findings provide new insights into the genetic and evolutionary basis of apocarotenoid diversity in plants,and would facilitate breeding efforts that aim to improve the nutritional and aesthetic value of citrus and perhaps other fruit crops. | Xiongjie Zheng Kaijie Zhu Quan Sun Weiyi Zhang Xia Wang Hongbo Cao Meilian Tan Zongzhou Xie Yunliu Zeng Junli Ye Lijun Chai Qiang Xu Zhiyong Pan Shunyuan Xiao Paul D.Fraser Xiuxin Deng | 2019 | Molecular Plant2019，12，9： | 18 |
| 7 | High-speed femtosecond laser plasmonic lithography and reduction of graphene oxide for anisotropic photoresponse显示文摘Micro/nanoprocessing of graphene surfaces has attracted significant interest for both science and applications due to its effective modulation of material properties,which,however,is usually restricted by the disadvantages of the current fabrication methods.Here,by exploiting cylindrical focusing of a femtosecond laser on graphene oxide(GO)films,we successfully produce uniform subwavelength grating structures at high speed along with a simultaneous in situ photoreduction process.Strikingly,the well-defined structures feature orientations parallel to the laser polarization and significant robustness against distinct perturbations.The proposed model and simulations reveal that the structure formation is based on the transverse electric(TE)surface plasmons triggered by the gradient reduction of the GO film from its surface to the interior,which eventually results in interference intensity fringes and spatially periodic interactions.Further experiments prove that such a regular structured surface can cause enhanced optical absorption(>20%)and an anisotropic photoresponse(~0.46 ratio)for the reduced GO film.Our work not only provides new insights into understanding the laser-GO interaction but also lays a solid foundation for practical usage of femtosecond laser plasmonic lithography,with the prospect of expansion to other two-dimensional materials for novel device applications. | Tingting Zou Bo Zhao Wei Xin Ye Wang Bin Wang Xin Zheng Hongbo Xie Zhiyu Zhang Jianjun Yang Chunlei Guo | 2020 | Light(Science & Applications)2020，9，1： | 17 |
| 8 | Basement of the South China Sea Area:Tracing the Tethyan Realm显示文摘华南海( SCS )和邻近的区域的地下室能被划分成六个部门(区域)在 Beibu 海湾的古生代的 Erathem 指责graben 的地下室分割,在 Yinggehai 的古生代的 Erathem 罢工滑倒拉开流水,在东方海南的古生代的 Erathem 差错消沉,在北 Xisha ( Paracel )的古生代的 Erathem rifted ,古生代的 Erathem 罢工滑倒在在 Nansha 岛延长的南部的 Xisha ,和古生代中生代的 Erathem 延长( Spratly )水。在 SCS 和 Yunkai 大陆人区域的新生代前地下室在在新生代前时期的 Tethyan 构造领域以内是同时代的。他们在 Paleo-Tethyan 构造领域的背景上被形成,并且是东方 Tethyan multi-island-ocean 系统的重要部件。东方 Paleo-Tethys 构造领域,北方 Yunkai,诺思海南,和南方海南海盆的三个分支,演变为北方 Yunkai,诺思海南,和南方海南缝术地区分别地。这为新生代前地下室显示出本地化的一个特殊特征。 Qiongnan (即南方海南)华南海的北边缘上的缝术地区能被认为 Paleo-Tethys 的主要海洋盆的痕迹,并且与 Longmucuo-Shuanghu beltBitu 带 Changning-Menglian-Bentong-Raub 带的缝术地区连接了,华南海的西方上的 Bitu-Changning-MenglianChing Mai beltChanthaburi-Raub-Bentong 带的南方延期,并且与 Lianhua-Taidong 缝术地区(沿着在台湾的纵的山谷的东方方面的一个差错) Hida Qiongbei (诺思海南) 缝术地区可以向东沿着 Wangwu-Wenjiao 差错地区延长了,并且深与 Lufeng-Dapu-Zhenghe-Shangyu (Lianhuashan ) 连接通过珍珠河嘴盆的差错地区。Meso-Tethys 在华南海的南方上发展了。Nansha 马槽可以被认为 Meso-Tethys 的北架的痕迹。 Meso-Tethys 的海洋的外壳向南沿着 subduction-collision-thrust 有 subducted 有华南海的西方上的 Yarlung Zangbo-Mytkyina-Bago 地区的到那些的subduction杆反面的 Nansha 马槽的南部的边缘,并且 Meso-Tethyan (例如 Meso-Tethys 的北 Chichibu 海洋)在在西南日本的侏罗记早的白垩纪地球组的外部带的缝术地区 Butsozo 构造的线,在华南海的东方上。 | LIU Hailing ZHENG Hongbo WANG Yanlin LIN Qiujin WU Chaohua ZHAO Meisong DU Yunkong | 2011 | Acta Geologica Sinica(English Edition)2011，85，3： | 13 |
| 9 | The crucial roles of Th17-related cytokines/signal pathways in M. tuberculosis infection显示文摘Interleukin-17(IL-17),IL-21,IL-22 and IL-23 can be grouped as T helper 17(Th17)-related cytokines because they are either produced by Th17/Th22 cells or involved in their development.Here,we review Th17-related cytokines/Th17-like cells,networks/signals and their roles in immune responses or immunity against Mycobacterium tuberculosis(Mtb)infection.Published studies suggest that Th17-related cytokine pathways may be manipulated by Mtb microorganisms for their survival benefits in primary tuberculosis(TB).In addition,there is evidence that immune responses of the signal transducer and activator of transcription 3(STAT3)signal pathway and Th17-like T-cell subsets are dysregulated or destroyed in patients with TB.Furthermore,Mtb infection can impact upstream cytokines in the STAT3 pathway of Th17-like responses.Based on these findings,we discuss the need for future studies and the rationale for targeting Th17-related cytokines/signals as a potential adjunctive treatment. | Hongbo Shen Zheng W Chen | 2018 | Cellular & Molecular Immunology2018，15，3： | 13 |
| 10 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 11 | Placement Optimization of Caching UAV-Assisted Mobile Relay Maritime Communication显示文摘Recently, due to the deployment flexibility of unmanned aerial vehicles(UAVs), UAV-assisted mobile relay communication system has been widely used in the maritime communication. However, the performance of UAV-assisted mobile relay communication system is limited by the capacity of wireless backhaul link between base station and UAV. In this paper, we consider a caching UAV-assisted decode-and-forward relay communication system in a downlink maritime communication. For the general case with multiple users, the optimal placement of UAV is obtained by solving the average achievable rate maximization problem through the one-dimensional linear search. For a special case with single user, we derive a semi closedform expression of the optimal placement of UAV. Simulation results confirm the accuracy of analytical results and show that the optimal placement of UAV and the average achievable rate significantly depend on the cache capacity at UAV. We also show the difference between the performances of the air-to-ground model and the air-to-sea model. | Jun Zhang Fengzhu Liang Bin Li Zheng Yang Yi Wu Hongbo Zhu | 2020 | China Communications2020，17，8： | 10 |
| 12 | Advances in the slurry reactor technology of the anthraquinone process for H2O2 production显示文摘 | Hongbo Li Bo Zheng Zhiyong Pan Baoning Zong Minghua Qiao | 2018 | Frontiers of Chemical Science and Engineering2018，12，1： | 10 |
| 13 | A 600-year flood history in the Yangtze River drainage:Comparison between a subaqueous delta and historical records显示文摘Based on grain size analysis and high-resolution elemental scanning of core YD0901,taken from the subaqueous Yangtze River delta,a 600-year flood history was reconstructed for the Yangtze River drainage system.Zr/Rb ratios were chosen as a proxy for Yangtze River floods.Zr resides mainly in the coarse-grained minerals,and Rb is found in the fine-grained minerals.When floods occur,the discharge of the Yangtze River increases,which carries more coarse-grained minerals into the East China Sea.Therefore,deposition of coarse-grained minerals significantly increases relative to fine-grained minerals on the subaqueous delta,and subsequently the Zr/Rb ratios also increase.The higher the Zr/Rb peaks,the greater number of coarse particles deposited by saltation processes.Zr/Rb peaks correlate very well with historical records for Yangtze River floods.Especially at about AD 1870,the Zr/Rb ratio reached a maximum value over the last 600 years,which is consistent with 'the extreme flood event' in the upper and middle reaches of the Yangtze River in AD 1870,as indicated in the historical records.Results show that floods have occurred at a relatively high frequency over the last 600 years,which is consistent with historical records when,during the Ming-Qing Dynasty,floods occurred once every 4 years.In addition,spectral analysis of the Zr/Rb ratio showed that there is close link between the Yangtze River floods and ENSO intensity. | WANG MinJie ZHENG HongBo XIE Xin FAN DaiDu YANG ShouYe ZHAO QuanHong WANG Ke | 2011 | Chinese Science Bulletin2011，56，2： | 9 |
| 14 | The 5.5 cal ka BP climate event, population growth, circumscription and the emergence of the earliest complex societies in China显示文摘The emergence of complex society is a milestone in the history of human society evolution. China is one of the few regions in the world where the earliest complex society appeared; however, its driving mechanisms remain unresolved. On the base of available evidence from both archaeology and Holocene climate, in combination with agency theory, this study attempts to address the driving mechanisms for the simultaneous emergence of complex societies in multiple areas of China around 5.5 cal ka BP. It is hypothesized that three factors, including climate change, population growth, and circumscription, jointly act and cause regional population-resource imbalance and trigger inter-group conflicts and wars. Such competitions provide the opportunity for some power-pursuing agents to break the restriction of social leveling mechanism and to become the centralized decision-making leaders, which further lead to the emergence of incipient large-scale complex societies. Increase in extreme climate events during 6.0–5.0 cal ka BP cooling period causes frequent occurrence of resource stress and increase in the frequency of inter-group competitions, which creates conditions for the legitimation, institutionalization, and persistence of centralized leadership, and finally leads to the formation of persistent institutionalized inequity. Our research result can explain not only the process and mechanism of complex society formation, but also two phenomena which cannot be reasonably explained by previous theories, that are, why the earliest complex societies in China emerge around 5.5 cal ka BP, and why they appear simultaneously in multiple regions. | WU WenXiang ZHENG HongBo HOU Mei GE QuanSheng | 2018 | Science China Earth Sciences2018，61，2： | 8 |
| 15 | Spatial and temporal distribution of Neolithic sites in coastal China:Sea level changes, geomorphic evolution and human adaption显示文摘The East China coastal plain is one of the most important Neolithic culture areas in China, where rich archaeological sites including those producing the earliest domesticated rice are observed. It is also a place where landscape has experienced dramatic evolution during the Holocene when both sea level and climate changed, such that it is an ideal place for studying human-environment interaction. This study investigated over 2000 sites of pre-history and Shang and Zhou Dynasties, with 655 of which being Neolithic ages, by using DEM and GIS methods. The results suggest that the spatial and temporal distribution of Neolithic sites has largely been controlled by landscape evolution(particularly changes in coastal line), which ultimately governed by sea level changes. During early Holocene, Neolithic sites sparsely distributed in the intermountain basins of east Zhejiang Province, far from the influence of ocean. Over the period of 9–7 ka, the coastal plain(including the shelf) was largely submerged,only the feet of low hills to the south and southwest of the study area, and islands protruding the estuary, cradled limited number of settlements with characteristic 'maritime components'. At about 7 ka, sea level rise decelerated prominently, while sediments supply in the drainage remained high value, the combination of which led to land formation and propagation. Vast space during this period facilitated the growth of settlements in both size and number. In the mean time, however, the coastal plain was vulnerable to extreme environmental events such as storms and flooding owning to its geomorphic nature, which exerted great influence on the rise and fall of Neolithic culture. | ZHENG HongBo ZHOU YouSheng YANG Qing HU ZhuJun LING GuangJiu ZHANG JuZhong GU ChunGuang WANG YingYing CAO YeTing HUANG XianRong CHENG Yue ZHANG XiaoYu WU WenXiang | 2018 | Science China Earth Sciences2018，61，2： | 7 |
| 16 | Niobium alloying effect in high carbon equivalent grey cast iron显示文摘The effect of niobium on the formation of NbC phase and solidification structure in high carbon equivalent grey cast iron was investigated.The experimental results indicated that an increase in the niobium content is favorable to refining the graphite and eutectic cell;and the pearlite lamellar spacing is reduced.Based on the thermodynamic calculation the formation of NbC is prior to the eutectic reaction.The reduction in the pearlite lamellar spacing is mainly attributed to the decrease of eutectic temperature with the addition of niobium.Additionally,properties including hardness and wear resistance were improved after the addition of niobium. | Zhou Wenbin Zhu Hongbo Zheng Dengke Zheng Hongxing Hua Qin Zhai Qijie | 2011 | China Foundry2011，8，1： | 7 |
| 17 | A lentiviral vector-based therapeutic vaccine encoding Ag85B-Rv3425 potently increases resistance to acute tuberculosis infection in mice显示文摘为 multidrug 抵抗的肺结核(TB ) 和到为 TB 的新奇治疗学的途径的发展的广泛地药抵抗的 TB 电话注意的很少处理选择。因为他们能导致抗原特定的细胞的有免疫力的回答,治疗学的疫苗正在答应候选人,它在 Mycobacterium 肺结核(鱼雷快艇) 的消除起一个重要作用。在这研究,新奇 lentiviral 向量为交付鱼雷快艇特定的熔化蛋白质 Ag85B-Rv3425 的治疗学的疫苗被构造。结果证明这支 recombinant lentivirus 疫苗单个注射的能在老鼠触发抗原特定的 Th1 类型有免疫力的回答。更重要地,有急性感染的老鼠在肺和脾由显著地减少的鱼雷快艇负担从这支疫苗的一个单个剂量的政府有益于很多以及与未经治疗的老鼠相比在肺稀释了损害。这些结果为 TB 的免疫疗法显示了这支新奇疫苗的好前景。 | Enzhuo Yang Feifei Wang Ying Xu Honghai Wang Yong Hu Hongbo Shen Zheng W. Chen | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 6 |
| 18 | Effect of Dahuang Zhechong pills on long non-coding RNA growth arrest specific 5 in rat models of hepatic fibrosis显示文摘OBJECTIVE: To investigate the involvement of growth arrest specific 5(GAS5), a long non-coding RNA, in the anti-hepatic fibrosis process induced by Dahuang Zhechong pill(DHZCP) in rats.METHODS: Thirty adult rats were divided into three groups, including a control group, a CCl4-induced fibrosis group and a DHZCP-treated fibrosis group. Hematoxylin-eosin and Masson staining were used for histopathological study. Serum enzymes, cytokines and cell proliferation were assayed using commercially available kits. A GAS5 lenti-virus vector was constructed to further investigate the role of GAS5 in the anti-hepatic fibrosis effect of DHZCP in rats.RESULTS: Our results revealed that the proliferation of hepatic stellate cells cultured in serum derived from rats treated with DHZCP was significantly decreased, compared with cells treated with serum from the untreated rats. DHZCP alleviated the CCl4-induced hepatic fibrosis. Additionally, DHZCP can restore the expression of GAS5,which was significantly decreased in the CCl4-induced group, and markedly suppress the expression of p-p38 and p-Erk induced by CCl4, but not p-Jnk. Cell proliferation was significantly arrested when cells overexpressed GAS5. Thus,DHZCP can inhibit the expression of p-p38 and p-Erk, while GAS5 can only inhibit the expression of p-Erk.CONCLUSIONS: DHZCP can alleviate hepatic fibrosis by increasing the expression of GAS5 to suppress p-Erk and regulating other factors to inhibit p-p38. | Gong Zhenghua Deng Chaowen Xiang Tianxin Tao Lili Xiao Hongbo Peng Yanzhong Zheng Jie Hu Guoxin | 2018 | Journal of Traditional Chinese Medicine2018，38，2： | 6 |
| 19 | The Interplay between Artificial Intelligence and Fog Radio Access Networks显示文摘The interplay between artificial intelligence(AI) and fog radio access networks(F-RANs) is investigated in this work from two perspectives: how F-RANs enable hierarchical AI to be deployed in wireless networks and how AI makes F-RANs smarter to better serve mobile devices. Due to the heterogeneity of processing capability, the cloud, fog, and device layers in F-RANs provide hierarchical intelligence via centralized, distributed, and federated learning. In addition, cross-layer learning is also introduced to further reduce the demand for the memory size of the mobile devices. On the other hand, AI provides F-RANs with technologies and methods to deal with massive data and make smarter decisions. Specifically, machine learning tools such as deep neural networks are introduced for data processing, while reinforcement learning(RL) algorithms are adopted for network optimization and decisions. Then, two examples of AI-based applications in F-RANs, i.e., health monitoring and intelligent transportation systems, are presented, followed by a case study of an RL-based caching application in the presence of spatio-temporal unknown content popularity to showcase the potential of applying AI to F-RANs. | Wenchao Xia Xinruo Zhang Gan Zheng Jun Zhang Shi Jin Hongbo Zhu | 2020 | China Communications2020，17，8： | 6 |
| 20 | Palaeoenvironmental implication of the Plio-Pleistocene loess deposits in southern Tarim Basin显示文摘The sedimentary characteristics, grain-size distribution, geochemical composition and surface characteristics of quartz grains, together with palaeoenvironmental reconnaissance, all point to an aeolian origin for the intercalated siltstone beds in the Plio-Pleistocene Artux and Xiyu Formations along the southern margins of the Tarim Basin, indicating that loess deposition in the region started, at least, in the Early Pliocene. Loess deposition in the southern Tarim Basin was a response to the global deterioration, which might be attributed to the uplift of the Tibetan Plateau. | ZHENG Hongbo, CHEN Huizhong & CAO JunjiLaboratory of Marine Geology, Tongji University, Shanghai 200092, China Institute of Earth Environment, Chinese Academy of Sciences, Xi’an 710054, China Institute of Environment and Engineering of Cold and Arid Regio | 2002 | Chinese Science Bulletin2002，47，8： | 6 |
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