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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | 5-Ethynyl-2′-deoxyuridine as a molecular probe of cell proliferation for high-content siRNA screening assay by “click” chemistry显示文摘Labelling and identification of proliferating cells is important for the study of physiological or pathological processes in high-content screening (HCS) assays. Here we describe ethynyl deoxyuridine (EdU) as a biomarker for the assessment of cell proliferation and clearly demonstrate the feasibility of the EdU-labelling method for use in HCS assays. EdU detection is highly robust, reproducible, technically simple, and well suited for automated segmentation, which provides an excellent al- ternative for setting up multiplexed HCS assays of siRNA, miRNA and small-molecule libraries. | CHEN MiaoJuan QU DeZhong CHI WeiLin WANG Wei REN XiaoShuai CONG ShuJie LIANG PeiZhou FENG ShiPeng ZHANG BiLiang | 2011 | Science China Chemistry2011，54，11： | 6 |
| 3 | RNA therapeutics:updates and future potential显示文摘Recent advancements in the production,modification,and cellular delivery of RNA molecules facilitated the expansion of RNAbased therapeutics.The increasing understanding of RNA biology initiated a corresponding growth in RNA therapeutics.In this review,the general concepts of five classes of RNA-based therapeutics,including RNA interference-based therapies,antisense oligonucleotides,small activating RNA therapies,circular RNA therapies,and messenger RNA-based therapeutics,will be discussed.Moreover,we also provide an overview of RNA-based therapeutics that have already received regulatory approval or are currently being evaluated in clinical trials,along with challenges faced by these technologies.RNA-based drugs demonstrated positive clinical trial results and have the ability to address previously“undruggable”targets,which delivers great promise as a disruptive therapeutic technology to fulfill its full clinical potentiality. | Caroline Zhang Biliang Zhang | 2023 | Science China(Life Sciences)2023，66，1： | 2 |
| 4 | A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts显示文摘 | Ronghui Li Jialiang Liang Su Ni Ting Zhou Xiaobing Qing Huapeng Li Wenzhi He Jiekai Chen Feng Li Qiang Zhuang Baoming Qin Jianyong Xu Wen Li Jiayin Yang Yi Gan Dajiang Qin Shipeng Feng Hong Song Dongshan Yang Biliang Zhang Lingwen Zeng Liangxue Lai Miguel | 2010 | Cell Stem Cell2010，，1： | 1 |
| 5 | A Mesenchymal-to-Epithelial Transition Initiates and Is Required for the Nuclear Reprogramming of Mouse Fibroblasts显示文摘 | Ronghui Li Jialiang Liang Su Ni Ting Zhou Xiaobing Qing Huapeng Li Wenzhi He Jiekai Chen Feng Li Qiang Zhuang Baoming Qin Jianyong Xu Wen Li Jiayin Yang Yi Gan Dajiang Qin Shipeng Feng Hong Song Dongshan Yang Biliang Zhang Lingwen Zeng Liangxue Lai Miguel | 2010 | Cell Stem Cell2010，，1： | 1 |
| 6 | The characteristics and failure mechanism of the largest landslide triggered by the Wenchuan earthquake, May 12, 2008, China显示文摘 | Runqiu Huang Xiangjun Pei Xuanmei Fan Weifeng Zhang Shigui Li Biliang Li | 2012 | Landslides2012，，1： | 1 |
| 7 | KPNB1 , XPO7 and IPO8 Mediate the Translocation of NF‐κB /p65 into the Nucleus显示文摘 | Peizhou Liang Haiyan Zhang Guoxin Wang Suping Li Shujie Cong Yingyun Luo Biliang Zhang | 2013 | Traffic2013，，11： | 1 |
| 8 | RNAi screen to identify protein phosphatases that regulate the NF-kappaB signaling显示文摘NF-kappaB plays a critical role in cell survival,apoptosis,and inflammatory responses.Serine/threoninespecific phosphatases(PPs)represent the second major class of enzymes that catalyze the dephosphorylation of proteins.The roles of PPs regulating NF-kappaB activities are poorly understood.Here we describe an RNAi-based screen to identify the PPs that involve in regulating NFkappaB signaling.Thirty-four candidate PPs siRNAs were synthesized and primarily screened by NF-kappaB reporter gene assay in HeLa cells.PHLPP,one of the protein phosphatase type 2C family members(PP2C),was identified as a positive regulator of NF-kappaB signaling.Knock-down of PHLPP dramatically attenuated TNFα-stimulated NF-kappaB transcriptional activation.Knockdown of PHLPP led to enhancement of NF-kappaB/p65 nuclear import and retention,but decreased TNFα-induced phosphorylation at Ser276 on p65.This critical phosphorylation was also drastically reduced by knock-down of PKCalpha and Akt1,two important serine/threonine kinases dephosphorylated by PHLPP.The results together suggest that PHLPP-Akt-PKC may represent an important signaling loop that activates NF-kappaB/p65 signaling through critical serine phosphorylation. | Guoxin WANG Suping LI Feifei WANG Shufang HUANG Xian LI Wei XIONG Biliang ZHANG | 2010 | Frontiers in Biology2010，5，3： | 0 |
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