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| 1 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 2 | Molecular Epidemiology of Echovirus 18 Circulating in China's Mainland from 2015 to 2016显示文摘Echovirus 18(E18), a serotype of Enterovirus B(EV-B) species, is an important pathogen in aseptic meningitis. E18 had rarely been detected in China's Mainland, but became the predominant pathogen associated with viral encephalitis(VE) and meningitis in Hebei province for the first time in 2015. To investigate the molecular epidemiology and genetic characteristics of E18 in China's Mainland, sixteen E18 strains from patient throat swabs with hand, foot, and mouth disease(HFMD) in six provinces in China collected between 2015 and 2016, and four E18 strains isolated from 18 patient cerebrospinal fluid specimens with VE in Hebei Province in 2015 were obtained and sequenced. Combined with the sequences from the GenBank database, we performed an extensive genetic analysis. Phylogenetic analysis of VP1 gene sequences revealed that all E18 strains from China's Mainland after 2015 belonged to subgenotype C2. There were no obvious specific differences in phylogenetic and variation analyses of E18 genome sequences between HFMD and VE/meningitis strains. Potential multiple recombination may have occurred in the 50-untranslated region and in the P2 and P3 nonstructural protein-encoding regions of E18 strains from China. The current E18 strains were potential multiplerecombinant viruses. Overall, these findings supported that E18 caused HFMD, VE, and meningitis, although there were no significant associations between clinical features and viral genomic characteristics. | Xiangpeng Chen Tianjiao Ji Jiayun Guo Wei Wang Wenbo Xu Zhengde Xie | 2019 | Virologica Sinica2019，34，1： | 10 |
| 3 | Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘Whether glucose is predomi nantly metabolized via oxidative phosphorylati on or glycolysis differs between quiesce nt versus proliferating cells,iincluding tumor cells.However,how glucose metabolism is coordinated with cell cycle in mammalian cells remains elusive.Here,we report that mammalian cells predominantly utilize the tricarboxylic acid(TCA)cycle in G1 phase,but prefer glycolysis in S phase.Mechanistically,coupling cell cycle with metabolism is largely achieved by timely destruction of IDH1/2,key TCA cycle enzymes,in a Skp2-dependent manner.As such,depleting SKP2 abolishes cell cycle-dependent fluctuation of IDH1 protein abundance,leading to reduced glycolysis in S phase.Furthermore,elevated Skp2 abundance in prostate cancer cells destabilizes IDH1 to favor glycolysis and subsequent tumorigenesis.Therefore,our study reveals a mechanistic link between two cancer hallmarks,aberrant cell cycle and addiction to glycolysis,and provides the underlying mechanism for the coupling of metabolic fluctuation with periodic cell cycle in mammalian cells. | Jing Liu Yunhua Peng Le Shi Lixin Wan Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wang Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfic John M.Asara William G.Kaelin Jr. Jjankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 2 |
| 4 | Sulfur in hierarchically pore-structured carbon pillars as cathode material for lithium–sulfur batteries显示文摘 | Xuefeng Wang Xiangpeng Fang Xianwei Guo Zhaoxiang Wang Liquan Chen | 2013 | Electrochimica Acta2013，，： | 1 |
| 5 | Capacitive Energy Storage on Fe/Li3PO4 Grain Boundaries 显示文摘 | Guo Xianwei Fang Xiangpeng Mao Ya | 2011 | J Phys Chem C2011，115，9： | 1 |
| 6 | Sulfur in hierarchically pore-structured carbon pillars as cathode material for lithium–sulfur batteries显示文摘 | Xuefeng Wang Xiangpeng Fang Xianwei Guo Zhaoxiang Wang Liquan Chen | 2013 | Electrochimica Acta2013，，： | 1 |
| 7 | SCFβ-TRCP E3 ubiquitin ligase targets the tumor suppressor ZNRF3 for ubiquitination and degradation显示文摘 | Yanpeng Ci Xiaoning Li Maorong Chen Jiateng Zhong Brian J. North Hiroyuki Inuzuka Xi He Yu Li Jianping Guo Xiangpeng Dai | 2018 | Protein & Cell2018，9，10： | 1 |
| 8 | Capacitive Energy Storage on Fe/Li3PC>4 Grain Boundaries显示文摘 | GUO Xianwei FANG Xiangpeng MAO Ya | 2011 | J Phys Chem C2011，115，9： | 1 |
| 9 | Author Correction:Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle显示文摘The author affiliations were mixed up in the previous published version.In addition,the author contribution section missed a statement of The idea was conceived by J.K.L.,W.W.and This correction does not affect the description of the results or the conclusion of this work.We apologize for any inconvenience this may have caused. | Jing Liuc Yunhua Peng Le Shi Lixin Wanc Hiroyuki Inuzuka Jiangang Long Jianping Guo Jinfang Zhang Min Yuan Shuangxi Zhang Xun Wangc Jing Gao Xiangpeng Dai Shozo Furumoto Lijun Jia Pier Paolo Pandolfi John M.Asara William G.Kaelin Jr. Jiankang Liu Wenyi Wei | 2021 | Cell Research2021，31，1： | 0 |
| 10 | Intricacies in the cross talk between metabolic enzymes,RNA,and protein translation显示文摘The development of tech niq ues allowing the systematic capture of the RNA-bound proteome has yielded many surprises.Among these,metabolic enzymes have been frequently detected as RNA-binding proteins(RBPs)by different profiling methodologies in various cell types(Hentze et al.,2018).Compared to previous-more simplistic-views,it is now known that cellular metabolism(not only limited to the tricarboxylic acid,TCA,cycle)is compartmentalized.In fact,metabolic enzymes translocate to the nucleus and are enriched at actively transcribed loci,where they sustain epigenetic/epitranscriptomic marks through localized metabolite production(Mews et al.,2017).It has been proposed that the in teraction with nascent RNAs facilitates the anchorage of metabolic enzymes at target loci(Bao et al.,2018),and it is plausible that mature RNAs work in the same way to assist metabolic reactions in the cytoplasm. | Yuan Lv Muqddas Tariq Xiangpeng Guo Shahzina Kanwal Miguel AEsteban | 2019 | Journal of Molecular Cell Biology2019，11，10： | 0 |
| 11 | Host cyclophilin A facilitates SARS-CoV-2 infection by binding and stabilizing spike on virions显示文摘Dear Editor,The novel coronavirus SARS-CoV-2 rapidly evolutes to increase its infectivity and transmissibility,facilitates its immune escape,impairs vaccine efficacy,and currently causes repeated infections in human,which is mainly determined by the accumulated mutations in spike(S).1 Transmembrane S is a heavily glycosylated protein on the surface of the virion as homotrimer,responsible for binding to human angiotensin-converting enzyme 2(hACE2)receptor.2 While the architecture of S trimers has been well studied,how the stability of S is regulated by potential host factors remains unknown. | Xiangpeng Sheng Fang Zhu Hong Peng Fan Yang Yi Yang Cong Yang Zhen Wang Wei Chen Deyin Guo Ronggui Hu | 2024 | Signal Transduction and Targeted Therapy2024，9，1： | 0 |
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