|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Lotus seed skin proanthocyanidin extract exhibits potent antioxidant property via activation of the Nrf2-ARE pathway显示文摘Lotus seed is well known as traditional food and medicine,but its skin is usually discarded.Recent studies have shown that lotus seed skin contains a high concentration of proanthocyanidins that have multi-functions,such as antioxidation,anti-inflammation,and anti-cancer effects.In the present study,we aimed to isolate and purify the proanthocyanidins from lotus seed skin by acetone extraction and rotary evaporation,identify their chemical structures by HPLC-MS-MS and NMR,and further investigate the antioxidant properties of the extract purified by macroporous resin (PMR) from lotus seed skin both in vitro and in vivo.The results showed that PMR mainly contained oligomeric proanthocyanidins,especially dimeric procyanidin B1 (PB1),procyanidin B2 and procyanidin B4.Although it had limited ability to directly scavenge radicals in vitro,PMR could significantly enhance the expressions of antioxidant proteins via activation of nuclear factory-related factor 2 (Nrf2)-antioxidant response element (ARE) pathway in HepG2 cells.Molecular data revealed that PB1,a major component in PMR,stabilized Nrf2 by inhibiting the ubiquitination of Nrf2,which led to subsequent activation of the Nrf2-ARE pathway,including the enhancements of Nrf2 nuclear translocation,Nrf2-ARE binding and ARE transcriptional activity.Moreover,the in vivo results in high fat diet-induced mice further verified the powerful antioxidant property of PMR.These results revealed that lotus seed skin is a promising resource for functional food development. | Tao Li Qili Li Weiguo Wu Yong Li De-xing Hou Hua Xu Baodong Zheng Shaoxiao Zeng Yang Shan Xiangyang Lu Fangming Deng Si Qin | 2019 | Acta Biochimica et Biophysica Sinica2019，51，1： | 8 |
| 2 | Thick Miocene eolian deposits on the Huajialing Mountains:The geomorphic evolution of the western Loess Plateau显示文摘The geomorphic evolution of northwestern China during the Cenozoic has been a subject of much geological interest because of its link with the uplift of the Himalayan-Tibetan complex.Much information about these changes is recoverable from the sedimentary sequences of the region.We report here on the thick eolian deposits mantling the Huajialing Mountains,a relatively flat mountain range in the western Loess Plateau.Correlation of magnetic susceptibility stratigraphy with the QA-I Miocene eolian sequence dates a 134.7 m section(NL-VII) for the interval from 18.7 to 11.8 Ma,as confirmed by micro-mammalian fossils.These eolian deposits demonstrate a much wider distribution of the Miocene eolian deposits,and also indicate that the topography contrasts in the western Loess Plateau,including the uplifts of the Huajialing Mountains and the bedrock highlands in the Qinan region,were formed by the early Miocene.The near-continuous Miocene eolian sequence from 18.7 to 11.8 Ma indicates that the substratum of Huajialing had not experienced any intense tectonic changes during this time interval,which suggests further,the relative tectonic stability of the nearby Tibetan Plateau. | ZHAN Tao GUO ZhengTang WU HaiBin GE JunYi ZHOU Xin WU ChunLin ZENG FangMing | 2011 | Science China Earth Sciences2011，54，2： | 7 |
| 3 | Aquatic Species Dominate Organic Matter in Qinghai Lake during the Holocene:Evidence from Eolian Deposits around the Lake显示文摘Total organic carbon(TOC) in lake sediments and its stable carbon isotope(δ^(13)C_(org)) are widely applied to investigate paleoenvironmental changes even though their implications are complicated and multi-explanatory. Organic geochemistry studies of lake sediments from Qinghai Lake have been investigated, but some interpretations are controversial. In this study, TOC of one Holocene eolian section and δ^(13)C_(org) of three eolian sections were studied around Qinghai Lake. Results indicate that the TOC content in eolian deposits was low during the Early Holocene, and gradually increased to high values during the Middle and Late Holocene. The variation in TOC content of eolian deposits is different from that in the lacustrine sequence from Qinghai Lake during the Holocene. The δ^(13)C_(org) values in the eolian sections were relatively stable, with oscillation amplitudes of ~4‰(ranging from-25.8‰ to-22.1‰), in contrast to ~10‰ variation s in δ^(13)C_(org) values(varying from-30‰ to-20‰) in lacustrine sediments. Through comparison of TOC and δ^(13)C_(org) values between eolian deposits and lacustrine sediments, we can confirm indications that the organic matter in Qinghai Lake sediments during the Holocene was primarily a contribution of the aquatic species in the lake. This is significant for understanding the origin of organic matter in lake sediments on the northeastern Qinghai-Tibetan Plateau and for paleoenvironmental inferences using such proxies. | Fangming Zeng Xiangjun Liu Xiangzhong Li Chongyi E | 2017 | Journal of Earth Science2017，28，3： | 6 |
| 4 | Sr-Nd-Pb Isotopic Compositions of the Neogene Eolian Deposits in the Xining Basin and Implications for Their Dust Sources显示文摘The Neogene eolian deposits in the Xining Basin are valuable archive for studying the evolution of the Asian monsoon system and geomorphic processes of Northwest China. The Neogene eolian deposits that paleomagnetically dated at about 14 Ma probably were sourced from the middle and west Qinghai-Tibetan Plateau(QTP) as indicated by elemental compositions and magnetic properties. This study provides the Sr-Nd-Pb isotopic ratios of different sediments(gravels from the river terraces, Neogene eolian deposits and Quaternary loess) in the Xining Basin. The results show that:(1) Sr-Nd isotopic compositions of terrace gravels are different from those of the Neogene and Quaternary eolian deposits, although the Nd isotope ratios of gravel on the 10 th terrace(T10) and eolian deposits are similar.(2) Pb isotopic compositions of river gravels are obviously different from the eolian deposits in the Xining Basin. However, Pb isotopic compositions of eolian deposits in the basin are similar to those of eolian deposits in the central Chinese Loess Plateau.(3) Sr-Nd-Pb isotope results indicate that the Neogene eolian deposits in the Xining Basin were probably sourced from remote areas outside of the basin by long-distance transportation. The Qaidam Basin is probably an important source area for the eolian deposits in the Xining Basin. | Fangming Zeng Meiyan Liang Shuzhen Peng Dongmei Yu Shuyuan Xiang | 2015 | Journal of Earth Science2015，26，5： | 4 |
| 5 | Geochronology and Mineral Composition of the Pleistocene Sediments in Xitaijinair Salt Lake Region,Qaidam Basin:Preliminary Results显示文摘Xitaijinair(XT)Salt Lake,located in the western Qaidam Basin,is significant for reconstructing the evolution of inland drying climate.However,the chronological and mineralogical records from this lake are rare.This study investigated the chronology(accelerator mass spectrometry(AMS)14C ages and optically stimulated luminescence(OSL)ages)and mineral compositions of sediment in the 240-cm-deep XT Section of the Xitaijinair Salt Lake region.The conclusions are drawn as follows:(1)Nine AMS 14C ages,ranging between 33 and 40 cal ka BP,are obviously younger than the two OSL ages(57.9 and 69.1 ka).The 14C ages probably reflect contamination with modern carbon.(2)Both 14C and OSL ages indicate that the surface of Xitaijinair Salt Lake region has suffered erosion.(3)The sediments of XT Section are composed of silicates(quartz,muscovite,clinochlore and albite),carbonates(calcite,dolomite,and ankertie),halite and gypsum. | Fangming Zeng Shuyuan Xiang | 2017 | Journal of Earth Science2017，28，4： | 4 |
| 6 | Numerical reconstruction of microstructure of graphite anode of lithium-ion battery显示文摘Due to the presence of graphite flake cascades,the real graphite anode of Li-ion battery shows non-isotropic characteristic. The present work developed an ellipsoid-based simulated annealing method and numerically reconstructed the three-dimensional microstructure of a graphite anode. The reconstructed anode is a composite of three clearly distinguished phases: pore(or electrolyte),graphite, and solid additives, well representing the nonisotropic heterogeneous characteristic of real graphite anode. Characterization analysis of the reconstructed electrode gives information such as the connectivity of individual phase, the specific interfacial area between solid and pore phase, and the pore size distribution. The effects of the ellipsoid size on the structural characteristics of graphite anode were particularly studied. As the size of the ellipsoidal particle slightly increases, the average pore diameter increases and as a result the specific interfacial area between the solid and pore phase in the reconstructed area decreases; compared with the equatorial radius, the polar radius of ellipsoidal graphite particles has more significant influence on the characteristics of electrode microstructure. | Shaoyang He Jianbang Zeng Bereket Tsegai Habte Fangming Jiang | 2016 | Science Bulletin2016，61，8： | 2 |
| 7 | Improved two-step hydrothermal process for acetic acid production from carbohydrate biomass显示文摘An improved two-step process for converting carbohydrate biomass to acetic acid under hydrothermal conditions is proposed. The first step consists of the production of lactic acid from carbohydrate biomass, and the second step consists of conversion of the lactic acid obtained in the first step to acetic acid using CuO as an oxidant. The results indicated that CuO as an oxidant in the second step can significantly improve the production of high-purity acetic acid from lactic acid, and the maximum yield of acetic acid was 61%, with a purity of 90%. The yield of acetic acid obtained using the improved two-step hydrothermal process from carbohydrate biomass, such as glucose, cellulose and starch, was greater than that obtained using traditional two-step process with H2O2 orO2. In addition, a proposed pathway for the production of acetic acid from lactic acid in the second step with CuO was also discussed. The present study provides a useful two-step process for the production of acetic acid from carbohydrate biomass. | Zhibao Huo Yan Fang Guodong Yao Xu Zeng Dezhang Ren Fangming Jin | 2015 | Journal of Energy Chemistry2015，24，2： | 1 |
| 8 | Memory access integrity:detecting fine-grained memory access errors in binary code显示文摘As one of the most notorious programming errors,memory access errors still hurt modern software security.Particularly,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access errors.However,all existing works lack the ability to handle two challenges.First,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data structure.These errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program crash.Second,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary code.However,searching memory access errors in binary code is a very common scenario in software vulnerability detection and exploitation.In order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary executables.The core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the policy.The key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing policy.Based on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is violated.We evaluate our tool on popular CTF datasets and real world softwares.Compared with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and efficiently.As the practical impact,our tool has detected three 0-day memory access errors in an audio decoder. | Wenjie Li Dongpeng Xu WeiWu Xiaorui Gong Xiaobo Xiang Yan Wang Fangming gu Qianxiang Zeng | 2019 | Cybersecurity2019，2，1： | 1 |
| 9 | Dynamic expression of nine QTLs for tiller number detected with single segment substitution lines in rice显示文摘 | Guifu Liu Ruizhen Zeng Haitao Zhu Zemin Zhang Xiaohua Ding Fangming Zhao Wentao Li Guiquan Zhang | 2009 | Theoretical and Applied Genetics2009，，3： | 1 |
| 10 | Challenges and opportunities in remote sensing-based crop monitoring:a review显示文摘Building a more resilient food system for sustainable development and reducing uncertainty in global food markets both require concurrent and near-real-time and reliable crop information for decision making.Satellite-driven crop monitoring has become a main method to derive crop information at local,regional,and global scales by revealing the spatial and temporal dimensions of crop growth status and production.However,there is a lack of quantitative,objective,and robust methods to ensure the reliability of crop information,which reduces the applicability of crop monitoring and leads to uncertain and undesirable consequences.In this paper,we review recent progress in crop monitoring and identify the challenges and opportunities in future efforts.We find that satellite-derived metrics do not fully capture determinants of crop production and do not quantitatively interpret crop growth status;the later can be advanced by integrating effective satellite-derived metrics and new onboard sensors.We have identified that ground data accessibility and the negative effects of knowledge-based analyses are two essential issues in crop monitoring that reduce the applicability of crop monitoring for decisions on food security.Crowdsourcing is one solution to overcome the restrictions of ground-truth data accessibility.We argue that user participation in the complete process of crop monitoring could improve the reliability of crop information.Encouraging users to obtain crop information from multiple sources could prevent unconscious biases.Finally,there is a need to avoid conflicts of interest in publishing publicly available crop information. | Bingfang Wu Miao Zhang Hongwei Zeng Fuyou Tian Andries B Potgieter Xingli Qin Nana Yan Sheng Chang Yan Zhao Qinghan Dong Vijendra Boken Dmitry Plotnikov Huadong Guo Fangming Wu Hang Zhao Bart Deronde Laurent Tits Evgeny Loupian | 2023 | National Science Review2023，10，4： | 1 |
| 11 | A pore-scale smoothed particle hydrodynamics model for lithiumion batteries显示文摘A mesoscopic pore-scale model of multi-disciplinary processes coupled with electrochemical reactions in lithium-ion batteries is established via a relatively novel numerical method—smoothed particle hydrodynamics(SPH)method.This model is based on mesoscopic treatment to the electrode(including separator)micro-pore structures and solves a group of inter-coupled SPH equations,including charge(ion in electrolyte phase and electron in solid phase),species(Li?in electrolyte phase and lithium in solid active materials),and energy conservation equations.Model parameters,e.g.the physicochemical properties are location-dependent,directly associated with the local component of the medium.The electrochemical reactions are prescribed to occur exactly at the interface of solid active materials and electrolyte.Simulations to isothermal discharge processes of a battery of 2-dimensional idealized micro-pore structure in electrodes and separator preliminarily corroborate the reasonability and capability of the developed SPH model. | Jianbang Zeng Fangming Jiang Zhi Chen | 2014 | Chinese Science Bulletin2014，59，23： | 1 |
| 12 | Lead, zinc and cadmium accumulation in herbaceous species and soils in Lanping Pb/Zn mining area,Yunnan Province, China显示文摘 | Yetao TANG Rongliang QIU Xiaowen ZENG Xiaohang FANG Xiaoyong ZHOU Fangming YU Yudu WU | 2006 | Chinese Journal Of Geochemistry2006，25，B08： | 1 |
| 13 | SARS-CoV-2-specific immune response in COVID-19 convalescent individuals显示文摘We collected blood from coronavirus disease 2019(COVID-19)convalescent individuals and investigated SARS-CoV-2-specific humoral and cellular immunity in these discharged patients.Follow-up analysis in a cohort of 171 patients at 4-11 months after the onset revealed high levels of IgG antibodies.A total of 78.1%(164/210)of the specimens tested positive for neutralizing antibody(NAb).SARS-CoV-2 antigen peptide pools-stimulated-IL-2 and-IFN-y response can distinguish COVID-19 convalescent individuals from healthy donors.Interestingly,NAb survival was significantly affected by the antigen peptide pools-stimulated-IL-2 response,-IL-8 response,and-IFN-y response.The antigen peptide pools-activated CD8+T cell counts were correlated with NAb.The antigen peptide pools-activated natural killer(NK)cell counts in convalescent individuals were correlated with NAb and disease severity.Our data suggested that the development of NAb is associated with the activation of T cells and NK cells.Our work provides a basis for further analysis of the protective immunity to SARS-CoV-2 and for understanding the pathogenesis of COVID-19.It also has implications for the development of an effective vaccine for SARS-CoV-2 infection. | Yunbao Pan Xianghu Jiang Liu Yang Liangjun Chen Xiaojiao Zeng Guohong Liu Yueting Tang Chungen Qian Xinming Wang Fangming Cheng Jun Lin Xinghuan Wang Yirong Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 14 | Correction:SARS-CoV-2-specific immune response in COYID-19 convalescent individuals显示文摘After online publication of the article1 the authors noticed an error in the figure legends of Fig.1 and Supplementary Materials Fig.S2,where the'*P<0.05,0.05<**P<0.001,***P<0.001W.should be replaced by n*P<0.05,**P<0.01,***P<0.001M.The original article has been corrected. | Yunbao Pan Xianghu Jiang Liu Yang Liangjun Chen Xiaojiao Zeng Guohong Liu Yueting Tang Chungen Qian Xinming Wang Fangming Cheng Jun Lin Xinghuan Wang Yirong Li | 2021 | Signal Transduction and Targeted Therapy2021，6，8： | 0 |
| 15 | Memory access integrity:detecting fine-grained memory access errors in binary code显示文摘As one of the most notorious programming errors,memory access errors still hurt modern software security.Particularly,they are hidden deeply in important software systems written in memory unsafe languages like C/C++.Plenty of work have been proposed to detect bugs leading to memory access errors.However,all existing works lack the ability to handle two challenges.First,they are not able to tackle fine-grained memory access errors,e.g.,data overflow inside one data structure.These errors are usually overlooked for a long time since they happen inside one memory block and do not lead to program crash.Second,most existing works rely on source code or debugging information to recover memory boundary information,so they cannot be directly applied to detection of memory access errors in binary code.However,searching memory access errors in binary code is a very common scenario in software vulnerability detection and exploitation.In order to overcome these challenges,we propose Memory Access Integrity(MAI),a dynamic method to detect finegrained memory access errors in off-the-shelf binary executables.The core idea is to recover fine-grained accessing policy between memory access behaviors and memory ranges,and then detect memory access errors based on the policy.The key insight in our work is that memory accessing patterns reveal information for recovering the boundary of memory objects and the accessing policy.Based on these recovered information,our method maintains a new memory model to simulate the life cycle of memory objects and report errors when any accessing policy is violated.We evaluate our tool on popular CTF datasets and real world softwares.Compared with the state of the art detection tool,the evaluation result demonstrates that our tool can detect fine-grained memory access errors effectively and efficiently.As the practical impact,our tool has detected three 0-day memory access errors in an audio decoder. | Wenjie Li Dongpeng Xu WeiWu Xiaorui Gong Xiaobo Xiang YanWang Fangming gu Qianxiang Zeng | 2018 | Cybersecurity2018，1，1： | 0 |
| 16 | Adsorption,in vitro digestion and human gut microbiota regulation characteristics of three Poria cocos polysaccharides显示文摘Poria cocos(PC)is a famous traditional Chinese medicine(TCM)and a widely used healthcare ingredient,which has antiobesity,enhancing immunity and improving sleep effects.Traditionally,only water-soluble poria polysaccharide(WSP)is extracted and applied for clinical application,while insoluble polysaccharide(alkali-soluble poria polysaccharide,ASP)is discarded as herb residue.However,the whole PC has also been historically utilized as functional herbal food.Considering the beneficial role of dietary fiber and the traditional use of PC,ASP may also contribute substantially to the therapy function of PC.Compared to WSP,little attention has been paid to ASP and ASP modified product carboxymethyl poria polysaccharide(CMP)which has been used as an antitumor adjuvant drug.In this study,the oil,cholesterol,metal ions and polyphenols adsorption ability,in vitro simulated digestive and the gut microbiota fermentation characteristics of WSP,ASP and CMP were studied to evaluate the functional values of three P.cocos polysaccharides(PCPs).The results showed that all three PCPs had good adsorption capacity on cholesterol,polyphenols and metal ions(Cd^(2+)/Zn^(2+)/Mg^(2+)),among which ASP showed the highest capacity than WSP and CMP.The adsorption capacity of all three PCPs on heavy metal ions(Cd^(2+)/Zn^(2+))was stronger than that of non-heavy metal ions(Mg^(2+));The in vitro digestibility of all three PCPs was very low,but WSP was slightly higher than ASP and CMP;Moreover,the indigestible residue of all three PCPs could improve the richness and diversity of gut microbiota,among which ASP had the greatest influence.In general,ASP and CMP could significantly promote the proliferation of some probiotics and inhibit the growth of some harmful bacteria.The gut microbiota diversity of CMP was reduced,but the richness of probiotics,especially Parabacteroides distasonis was significantly enhanced compared with the ASP group,and the growth of harmful bacteria Klebsiella pneumoniae was inhibited after CMP treatment.The short-chain fatty acids(SCFAs)analysis results showed that all three PCPs could significantly promote the production of acetic acid,propionic acid and the total acid content compared with blank control group,and SCFAs producing activity was positively correlated with the proliferative capacity of probiotics.Taken together,the good adsorption characteristics and gut microbiota regulatory activity of ASP may lay foundation for its lipid-lowering and immune-improving function.Additionally,the probiotic effect of CMP and ASP indicated that except for only use the water extract of PC in clinic,CMP and ASP also can be used in healthcare to take full advantage of this valuable medicine. | Fangming Zhang Hui Zheng Tao Zheng Pan Xu Yao Xu Yuxin Cao Fan Jia Yiqiong Zeng Yubing Fan Kai He Xinwen Dai Fengfei Hou Yong Yang | 2024 | Food Science and Human Wellness2024，13，3： | 0 |
| 17 | A novel insulator defect detection scheme based on Deep Convolutional Auto-Encoder for small negative samples显示文摘This paper presents a novel insulator defect detection scheme based on Deep Convolutional Auto-Encoder(DCAE)for small negative samples.The proposed DCAE scheme combines the advantages of supervised learning and unsupervised learning.In order to reduce the high cost of training Deep Neural Networks,this paper pre-trained the Convolutional Neural Networks(CNN)through open labelled datasets.Through transferring learning,the encoder part of the traditional Convolutional Auto-Encoder was replaced by the first three layers of the CNN,and a small number of defect samples were used to fine-tune the parameters.A threshold discrimination scheme was designed to evaluate the model detection,realising the self-explosion detection of insulator by judging the residual result and abnormal score.The experimental results show that compared with the existing insulator self-explosion detection schemes,the proposed scheme can reduce the model training time by up to 40%,and the recognition accuracy can reach 97%.Moreover,this model does not need a large number of insulator labelled data and is especially suitable for small negative sample application. | Fangming Deng Wei Luo Baoquan Wei Yong Zuo Han Zeng Yigang He | 2022 | High Voltage2022，7，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员