|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hemiballism-hemichorea induced by ketotic hyperglycemia: case report with PET study and review of the literature显示文摘Hemiballism-hemichorea(HB-HC)is commonly used to describe the basal ganglion dysfunction in non-ketotic hyperglycemic elderly patients.Here we report two elderly female patients with acute onset of involuntary movements induced by hyperglycemia with positive urine ketones.We described the computed tomography and magnetic resonance imaging findings in these two patients,which is similar to that of non-ketotic hyperglycemic HB-HC patients.FDG-PET was performed and the glucose metabolism in the corresponding lesion in these two patients was contradictory with each other.We tried to clarify the underlying mechanisms of HB-HC and explain the contradictory neuroradiological findings in FDG-PET as being performed at different clinical stages. | Yuyan Tan Xiaoyu Xin Qin Xiao Shengdi Chen Li Cao Huidong Tang | 2014 | Translational Neurodegeneration2014，3，1： | 21 |
| 2 | Performance of dithiocarbamate-type flocculant in treating simulated polymer flooding produced water显示文摘Produced water from polymer flooding is difficult to treat due to its high polymer concentration,high viscosity,and emulsified characteristics.The dithiocarbamate flocculant,DTC (T403),was prepared by the amine-terminated polyoxypropane-ether compound known as Jeffamine-T403.The product was characterized by IR spectra and elemental analysis.The DTC agent chelating with Fe 2+ produced a network polymer matrix,which captured and removed oil droplets efficiently.Oil removal by the flocculent on simulated produced water with 0,200,500,900 mg/L of partially hydrolyzed polyacrylamide (HPAM) was investigated for aspects of effectiveness of DTC (T403) dosage and concentrations of HPAM and Fe 2+ ions in the wastewater.Results showed that HPAM had a negative influence on oil removal efficiency when DTC (T403) dosage was lower than 20 mg/L.However,residual oil concentrations in tested samples with different concentrations of HPAM all decreased below 10 mg/L when DTC (T403) dosage reached 30 mg/L.The concentration of Fe 2+ in the initial wastewater had a slight effect on oil removal at the range of 2-12 mg/L.Results showed that Fe 3+ could not be used in place of Fe 2+ as Fe 3+ could not react with DTC under flocculated conditions.The effects of mineral salts ions were also investigated. | Baoyu Gao | 2011 | Journal of Environmental Sciences2011，23，1： | 18 |
| 3 | Characteristics of Settings and Etiologic Agents of Foodborne Disease Outbreaks—China,2020显示文摘Introduction:Foodborne diseases are a growing public health problem and have caused a large burden of disease in China.This study analyzed epidemiological characteristics of foodborne diseases in China in 2020 to provide a scientific basis for prevention and control measures.Methods:Data were collected from 30 of 31 provincial-level administrative divisions(PLADs)in the mainland of China,excluding Xizang(Tibet)Autonomous Region,via the National Foodborne Disease Outbreaks Surveillance System・The number and proportion of outbreaks,illnesses,hospitalizations,deaths by setting,pathogen-food category pairs and etiology were calculated.Results:In 2020,7,073 foodborne disease outbreaks were reported,resulting in 37,454 illnesses and 143 deaths.Among the identified pathogens,microbial pathogens were the most common confirmed etiology,accounting for 41.7%of illnesses.Poisonous mushrooms caused the largest proportion of outbreaks(58.0%)and deaths(57.6%).For venues where foodborne disease outbreaks occur,household had the highest number of outbreaks(4,140)and deaths(128),and catering service locations caused the largest proportion of illnesses(59.9%).Outbreaks occurring between June and September accounted for 62.8%of total outbreaks.Conclusions:Foodborne disease outbreaks mainly occurred in households・Microbial pathogens remained the top cause of outbreak-associated illnesses.Poisonous mushrooms were ranked the top cause of deaths in private homes in China.The supervision and management of food safety and health education should be strengthened to reduce the burden of foodborne diseases・Publicity should be increased to reduce the incidence of mushroom poisonings in families,and supervision and management of food should be strengthened to reduce microbial contamination. | Hongqiu Li Weiwei Li Yue Dai Yuyan Jiang Junhua Liang Santao Wang Maoqiang Zhuang Zheng Huang Lizi Xu Bo Xue Jikai Liu Haihong Han Sara M.Pires Ping Fu Yunchang Guo | 2021 | China CDC weekly2021，3，42： | 14 |
| 4 | A de novo Genome of a Chinese Radish Cultivar显示文摘Here, we report a high-quality draft genome of a Chinese radish(Raphanus sativus) cultivar. This draft contains 387.73 Mb of assembled scaffolds, 83.93% of the scaffolds were anchored onto nine pseudochromosomes and 95.09% of 43 240 protein-coding genes were functionally annotated. 184.75 Mb(47.65%) of repeat sequences was identified in the assembled genome. By comparative analyses of the radish genome against 10 other plant genomes, 2 275 genes in 780 gene families were found unique to R. sativus. This genome is a good reference for genomic study and of great value for genetic improvement of radish. | ZHANG Xiaohui YUE Zhen MEI Shiyong QIU Yang YANG Xinhua CHEN Xiaohua CHENG Feng WU Zhangyan SUN Yuyan JING Yi LIU Bo SHEN Di WANG Haiping CUI Na DUAN Yundan WU Jian WANG Jinglei GAN Caixia WANG Jun WANG Xiaowu LI Xixiang | 2015 | Horticultural Plant Journal2015，1，3： | 10 |
| 5 | SIDT1-dependent absorption in the stomach mediates host uptake of dietary and orally administered microRNAs显示文摘Dietary microRNAs have been shown to be absorbed by mammals and regulate host gene expression,but the absorption mechanism remains unknown.Here,we show that SIDT1 expressed on gastric pit cells in the stomach is required for the absorption of dietary microRNAs.SIDT1-deficient mice show reduced basal levels and impaired dynamic absorption of dietary microRNAs.Notably,we identified the stomach as the primary site for dietary microRNA absorption,which is dramatically attenuated in the stomachs of SIDT1-deficient mice.Mechanistic analyses revealed that the uptake of exogenous microRNAs by gastric pit cells is SIDT1 and low-pH dependent.Furthermore,oral administration of plant-derived miR2911 retards liver fibrosis,and this protective effect was abolished in SIDT1-deficient mice.Our findings reveal a major mechanism underlying the absorption of dietary microRNAs,uncover an unexpected role of the stomach and shed light on developing small RNA therapeutics by oral delivery. | Qun Chen Fan Zhang Lei Dong Huimin Wu Jie Xu Hanqin Li Jin Wang Zhen Zhou Chunyan Liu Yanbo Wang Yuyan Liu Liangsheng Lu Chen Wang Minghui Liu Xi Chen Cheng Wang Chunni Zhang Dangsheng Li Ke Zen Fangyu Wang Qipeng Zhang Chen-Yu Zhang | 2021 | Cell Research2021，31，3： | 10 |
| 6 | effective treatment of post-intubation subglottic stenosis in children with holmium laser therapy and cryotherapy via flexible bronchoscopy显示文摘Importance:Post-intubation subglottic stenosis(SGS)in children can be life threatening.Definitive treatment varies and lacks a universally accepted approach.Objective:We performed a prospective study to assess the safety and feasibility of holmium laser combined with cryotherapy delivered via flexible bronchoscopy for the treatment of post-intubation SGS in children.Methods:This study involved all patients with post-intubation SGS seen at the Interventional Pulmonology Department of Beijing Children's Hospital between July 2014 and December 2016.Holmium laser treatment and cryotherapy was then performed under flexible bronchoscopy,whose parents refused to accept the alternative standard treatment of tracheotomy and balloon dilation under direct laryngoscopy.results:Sixteen patients with post-intubation SGS were included in this study.Ages ranged from 2 months to 12.25 years old.According to the Cotton-Myer grading system,three cases were Grade II,12 cases were Grade III,and one case was Grade IV.According to the McCaffrey system,eight cases were Stage 1,two cases were Stage 2,and six cases were Stage 3.The average number of procedures was 4.88.Fifteen of the 16 patients achieved clinical cure.One patient achieved clinical improvement.The average treatment course duration was 55.31 days.No severe complications were seen.Post-treatment clinical symptoms,endoscopic findings and quality of life showed marked improvement.Interpretation:Our study supports the conclusion that holmium laser treatment combined with cryotherapy via flexible bronchoscopy appears to be a safe and feasible treatment for post-intubation SGS in children. | Anxia Jiao Fang Liu Andrew D.Lerner Xiaochun Rao Yan Guo Chenfang Meng Yuena Pan Gan Li Zheng Li Fang Wang Jing Zhao Yuyan Ma Xicheng Liu Xin Ni Kunling Shen | 2019 | Pediatric Investigation2019，3，1： | 10 |
| 7 | Differences of Hydrocarbon Enrichment between the Upper and the Lower Structural Layers in the Tazhong Paleouplift显示文摘Tazhong paleouplift 被划分成上面并且更低的结构的层,在奥陶纪碳酸盐岩石的顶由不顺从表面跳了。在从不同部分的二层的水库在数字变化,类型和储备,而是机制以前很少被研究。因此,机制的解释将在 Tazhong paleouplift 支持石油探索。在学习进化和 Tazhong paleouplift 的水库分发以后,在晚古苏格兰的、迟了的 Hercynian 和喜玛拉雅的时期的进化导致了,这被结束上面并且更低的结构的层。这也被定义在上面的结构的层,结构并且, stratigraphic 重叠水库为更低的结构的层在顶和 paleouplift 的上面的部分被开发,它被油水库统治, lithological 水库在 paleouplift 的更低的部分被开发,它被煤气的水库,和更多统治储备在更低的结构的层被发现比上面。通过累积条件的比较分析上面并且更低的结构的层,丰富差别的机制清楚地被解释。更低的结构的层的水库和封口条件比上面的层的那些好,它是更多的水库在前者被发现了的原因。在搬运人系统类型,陷井类型和收费时期在之间的差别上面并且更低的结构的层在水库类型和分布导致差别。一个累积模型为 Tazhong paleouplift 被建立。为上面的结构的层,,结构的水库和 stratigraphic 重叠水库为更低的结构的层在 paleouplift 的上面的部分被形成,捱过的外壳水库在顶被形成,礁石公寓水库在侧面的边缘上被形成,石灰岩地区常见的地形和里面水库在 paleouplift 的更低的部分被形成。 | JIANG Zhenxue YANG Haijun LI Zhuo PANG Xiongqi HAN Jianfa LI Dongxu HUANG Yuyan | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 7 |
| 8 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 9 | Features analysis on Traditional Chinese Medicine syndromes in patients with diabetic peripheral neuropathy显示文摘OBJECTIVE:To study the features of the distribution and differentiation ofTraditional Chinese Medicine(TCM)syndromes in patients with diabetic peripheral neuropathy(DPN).METHODS:We collected clinical data on illness course,age,fasting blood glucose,saccharogenic hemoglobin,TCM syndromes,tongue,and pulse of238 DPN patients.Differentiated main syndromes(Yin deficiency and exuberant heat,invasion of spleen by damp-heat,deficiency of both Qi and Yins,and deficiency of both Yin and Yang)and accompanying syndromes(blood stasis and phlegm-dampness)of diabetes were also recorded.The features of DPN syndromes were then analyzed.RESULTS:Among the four main syndromes of diabetes,deficiency of both Yin and Yang was the most common in the 238 DPN patients,of which89%-96%had blood stasis.CONCLUSION:The method of differentiating syndromes of diabetes can be applied to DPN patients.Deficiency of both Yin and Yang,often accompanied by blood stasis,is commonly seen. | Mingdi Li Hao Su Yuyan Xiang Jingyi Zhang Jingjie Zhao Lan Lin | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 6 |
| 10 | Discussion on Validity of Rana maoershanensis Based on Partial Sequence of 16S rRNA Gene显示文摘Rana maoershanensis found in Mt.Maoershan in Guangxi,China was reported as a new species in 2007,but there was no molecular data for this frog.The partial sequences(543 bp) of 16S rRNA gene from 12 specimens of 3 brown frog species(Rana hanluica,R.maoershanensis and R.chensinensis) were analyzed with 17 specimens of 9 species from GenBank.The nucleotide sequence divergence between R.maoershanensis and the other brown frog species were 4.5%-6.5%,with 22-30 nucleotide substitutions at this locus.The phylogenetic relationships based on MP,ML,and Bayesian inference indicate that the brown frogs from Southern China were diverged into three groups(Clades A,B and C).R.maoershanensis was clustered together a well-supported subclade(B-1).It is suggested that R.maoershanensis is a valid species. | YANG Baotian LU Yuyan LI Pipeng | 2010 | Asian Herpetological Research2010，1，2： | 5 |
| 11 | Post-marketing safety surveillance and reevaluation of Motherwort injection:A clinical study of 10094 cases显示文摘OBJECTIVE:To investigate the safety profiles of Motherwort injection(MI).METHODS:A multi-center,prospective and drugderived hospital intensive monitoring method was conducted to assess the safety of MI in real world applications.This study was based on a very large population after the injection was approved and marketed in China.All patients using the injection in participating hospitals were monitored to determine the incidence,pattern,severity and outcome of associated adverse events.RESULTS:The post-marketing surveillance was performed in 10 094 female patients from April to December,2015.The incidence of adverse drug reactions(ADRs) was 0.79‰(8/10 094).Among the 8 patients,the reported adverse events mainly included systemic abnormalities,such as fever,chills and eyelid edema;skin and appendages disorders,such as pruritus and rash;gastrointestinal disorders,such as nausea,abdominal distension and pain;heart rate and rhythm disorders,such as palpitation and increased heart rate.All of these ADRs were mild in severity.CONCLUSION:In this study the ADRs incidence rate of MI is very low,which supports that it is generally safe for use in obstetric and gynecological diseases.However,the total number of 8 ADRs recorded over a relatively short time span seems limited,and the low number of reports could not represent an absolute guarantee of safety. | Cao Shan Zhang Wenhao Zhao Ziwei Heng Mingli Bu Huaien Wang Hongwu Liu Xinghui Wang Zhong Cai Yan Ma Yuyan Cui Shihong Deng Jihong Ding Guifeng Ding Yajuan Dong Linhong Duan Zhentao Fan Ling Fan Yang Fu Fen He Jing Ji Shuying Jin Lin Li Hong Li Hongying Liao Tao Lu Wei Luo Xiucui Lü Zhihui Ma Fengchun Ma Dafeng Shi Tianyun Sun Juying Sun Xiaotong Teng Hong Wang Jinhua Wang Ruihua Wang Ying Wang Zhengling Xi Jie Xu Minjuan Xu Zhihong Yan Qian Yang Cuirong Yang Yimei Yin Jie Yu Jinhua Yuan Wenjun Zhang Guanli Zhang Meihua Zhao Renfeng Zhong Yonghong Zhou Jian | 2018 | Journal of Traditional Chinese Medicine2018，38，4： | 4 |
| 12 | LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells显示文摘LIN28 is an RNA binding protein with important roles in early embryo development,stem cell differentiation/re-programming,tumorigenesis and metabolism.Previous studies have focused mainly on its role in the cytosol where it interacts with Let-7 microRNA precursors or mRNAs,and few have addressed LIN28's role within the nucleus.Here,we show that LIN28 displays dynamic temporal and spatial expression during murine embryo development.Maternal LIN28 expression drops upon exit from the 2-cell stage,and zygotic LIN28 protein is induced at the forming nucleolus during 4-cell to blas-tocyst stage development,to become dominantly expressed in the cytosol after implantation.In cultured pluripotent stem cells(PSCs),loss of LIN28 led to nucleolar stress and activation of a 2-cell/4-cell-like transcriptional program characterized by the expression of endogenous retrovirus genes.Mechanistically,LIN28 binds to small nucleolar RNAs and rRNA to maintain nucleolar integrity,and its loss leads to nucleolar phase separation defects,ribosomal stress and activation of P53 which in turn binds to and activates 2C transcription factor Dux.LIN28 also resides in a complex containing the nucleolar factor Nucleolin(NCL)and the transcrip-tional repressor TRIM28,and LIN28 loss leads to reduced occupancy of the NCL/TRIM28 complex on the Dux and rDNA loci,and thus de-repressed Dux and reduced rRNA expression.Lin28 knockout cells with nucleolar stress are more likely to assume a slowly cycling,translationally inert and anabolically inactive state,which is a part of previously unappreciated 2C-like transcriptional program.These findings elucidate novel roles for nucleolar LIN28 in PSCs,and a new mechanism linking 2C program and nucleolar functions in PSCs and early embryo development. | Zhen Sun Hua Yu Jing Zhao Tianyu Tan Hongru Pan Yuqing Zhu Lang Chen Cheng Zhang Li Zhang Anhua Lei Yuyan Xu Xianju Bi Xin Huang Bo Gao Longfei Wang Cristina Correia Ming Chen Qiming Sun Yu Feng Li Shen Hao Wu Jianlong Wang Xiaohua Shen George Q.Daley Hu Li Jin Zhang | 2022 | Protein & Cell2022，13，7： | 4 |
| 13 | Robust adaptive control of hypersonic flight vehicle with asymmetric AOA constraint显示文摘This paper investigates the state-constrained controller design of a hypersonic flight vehicle(HFV)based on an asymmetric barrier Lyapunov function(ABLF).The robust adaptive back-stepping controller with integral terms is applied for the HFV longitudinal dynamics.Considering the asymmetric angle of attack(AOA)constraint caused by the unique structure and scramjet,the controller is modified by constructing an ABLF,where the asymmetric constraint on AOA tracking error is introduced.Combined with the constraint on virtual control,the AOA is restricted to a predefined asymmetric interval.The system stability and the AOA constraint are guaranteed via Lyapunov analysis.Simulation results verify that the AOA can be kept in the given asymmetric interval while the altitude reference signal is tracked. | Yuyan GUO Bin XU Weixin HAN Shuai LI Yueping WANG Yu ZHANG | 2020 | Science China(Information Sciences)2020，63，11： | 4 |
| 14 | Distributed Flow Shop Scheduling with Sequence-Dependent Setup Times Using an Improved Iterated Greedy Algorithm显示文摘To meet the multi-cooperation production demand of enterprises,the distributed permutation flow shop scheduling problem(DPFSP)has become the frontier research in the field of manufacturing systems.In this paper,we investigate the DPFSP by minimizing a makespan criterion under the constraint of sequence-dependent setup times.To solve DPFSPs,significant developments of some metaheuristic algorithms are necessary.In this context,a simple and effective improved iterated greedy(NIG)algorithm is proposed to minimize makespan in DPFSPs.According to the features of DPFSPs,a two-stage local search based on single job swapping and job block swapping within the key factory is designed in the proposed algorithm.We compare the proposed algorithm with state-of-the-art algorithms,including the iterative greedy algorithm(2019),iterative greedy proposed by Ruiz and Pan(2019),discrete differential evolution algorithm(2018),discrete artificial bee colony(2018),and artificial chemical reaction optimization(2017).Simulation results show that NIG outperforms the compared algorithms. | Xue Han Yuyan Han Qingda Chen Junqing Li Hongyan Sang Yiping Liu Quanke Pan Yusuke Nojima | 2021 | Complex System Modeling and Simulation2021，1，3： | 4 |
| 15 | Survival difference between EGFR Del19 and L858R mutant advanced non-small cell lung cancer patients receiving gefitinib:a propensity score matching analysis显示文摘Objective: Although superior clinical benefits of epidermal growth factor receptor(EGFR) tyrosine kinase inhibitors(TKIs) in the treatment of advanced non-small-cell lung cancer(NSCLC) had been reported,the survival difference between exon 19 deletion(Del19) and exon 21 Leu858 Arg substitution(L858 R) remains controversial.The purpose of this study is to investigate the differences in progression-free survival(PFS) and overall survival(OS) between different EGFR mutant subtypes among advanced NSCLC patients receiving gefitinib.Methods: There were 204 advanced NSCLC patients with EGFR mutations treated with gefitinib were enrolled in this retrospective cohort study.Patients were divided into the EGFR Del19 group and the L858 R mutated group according to their mutant subtype.Propensity score matching(PSM) was conducted by using a nearest-neighbor algorithm(1:1) to adjust for demographical and clinical covariates.Survival curves were constructed with the Kaplan-Meier method and compared by using the log-rank test.Results: The PFS in Del19 group was similar to that in the L858 R group [before PSM 8.6 vs.7.2 months,P=0.072; after PSM 7.3 vs.7.2 months,P=0.155].No differences were detected in OS between the L858 R and the Del19 group(before PSM 17.8 vs.13.1 months,P=0.253; after PSM 16.9 vs.13.1 months,P=0.339).The Del19 group was significantly younger compared with the L858 R mutation group in age(P=0.015).Conclusions: No significant difference was found in the PFS or OS between the Del19 and L858 R mutant NSCLC patients receiving gefitinib.The age gap might contribute to the survival differences between Del19 and L858 R groups.PSM is of important value to the elimination of potential bias. | Minglei Zhuo Qiwen Zheng Jun Zhao Meina Wu Tongtong An Yuyan Wang Jianjie Li Shuhang Wang Jia Zhong Xue Yang Hanxiao Chen Bo Jia Zhi Dong Emei Gao JingjingWang Ziping Wang | 2017 | Chinese Journal of Cancer Research2017，29，6： | 4 |
| 16 | Pan-genome of Raphanus highlights genetic variation and introgression among domesticated,wild,and weedy radishes显示文摘Post-polyploid diploidization associated with descending dysploidy and interspecific introgression drives plant genome evolution by unclear mechanisms.Raphanus is an economically and ecologically important Brassiceae genus and model system for studying post-polyploidization genome evolution and introgres-sion.Here,we report the de novo sequence assemblies for 11 genomes covering most of the typical sub-species and varieties of domesticated,wild and weedy radishes from East Asia,South Asia,Europe,and America.Divergence among the species,sub-species,and South/East Asian types coincided with Quaternary glaciations.A genus-level pan-genome was constructed with family-based,locus-based,and graph-based methods,and whole-genome comparisons revealed genetic variations ranging from single-nucleotide polymorphisms(SNPs)to inversions and translocations of whole ancestral karyotype(AK)blocks.Extensive gene flow occurred between wild,weedy,and domesticated radishes.High fre-quencies of genome reshuffling,biased retention,and large-fragment translocation have shaped the genomic diversity.Most variety-specific gene-rich blocks showed large structural variations.Extensive translocation and tandem duplication of dispensable genes were revealed in two large rearrangement-rich islands.Disease resistance genes mostly resided on specific and dispensable loci.Variations causing the loss of function of enzymes modulating gibberellin deactivation were identified and could play an important role in phenotype divergence and adaptive evolution.This study provides new insights into the genomic evolution underlying post-polyploid diploidization and lays the foundation for genetic improve-ment of radish crops,biological control of weeds,and protection of wild species'germplasms. | Xiaohui Zhang Tongjin Liu Jinglei Wang Peng Wang Yang Qiu Wei Zhao Shuai Pang Xiaoman Li Haiping Wang Jiangping Song Wenlin Zhang Wenlong Yang Yuyan Sun Xixiang Li | 2021 | Molecular Plant2021，14，12： | 3 |
| 17 | Application of immune checkpoint targets in the anti-tumor novel drugs and traditional Chinese medicine development显示文摘Immune checkpoints are the crucial regulators of immune system and play essential roles in maintaining self-tolerance,preventing autoimmune responses,and minimizing tissue damage by regulating the duration and intensity of the immune response.Furthermore,immune checkpoints are usually overexpressed in cancer cells or noninvasive cells in tumor tissues and are capable of suppressing the antitumor response.Based on substantial physiological analyses as well as preclinical and clinical studies,checkpoint molecules have been evaluated as potential therapeutic targets for the treatment of multiple types of cancers.In the last few years,extensive evidence has supported the immunoregulatory effects of traditional Chinese medicines(TCMs).The main advantage of TCMs and natural medicine is that they usually contain multiple active components,which can act on multiple targets at the same time,resulting in additive or synergistic effects.The strong immune regulation function of traditional Chinese medicine on immune checkpoints has also been of great interest.For example,Astragalus membranaceus polysaccharides can induce anti-PD-1 antibody responses in animals,and these antibodies can overcome the exhaustion of immune cells under tumor immune evasion.Furthermore,many other TCM molecules could also be novel and effective drug candidates for the treatment of cancers.Therefore,it is essential to assess the application of immune checkpoints in the development of new drugs and TCMs.In this review,we focus on research progress in the field of immune checkpoints based on three topics:(1)immune checkpoint targets and pathways,(2)development of novel immune checkpoint-based drugs,and(3)application of immune checkpoints in the development of TCMs. | Yuli Wang Xingyan Zhang Yuyan Wang Wenjing Zhao Huling Li Lixing Zhang Xinping Li Tiejun Zhang Hongbing Zhang He Huang Changxiao Liu | 2021 | Acta Pharmaceutica Sinica B2021，11，10： | 3 |
| 18 | Novel lift enhancement method based on zero-mass-flux jets and its adaptive controlling laws design显示文摘For lessening the weight and volume of flow control system,enlarging the circulation control applying area of angle of attack(AOA),and achieving nice controlling characteristics,a novel lift enhancement method based on dual synthetic jet actuators(DSJAs)and synthetic jet actuator(SJA),and an adaptive proportional integral and differential(PID)algorithm based on radial basis function neural network are introduced.DSJAs are uniformly located along the chord to suppress the separation and trailing-edge SJA is applied to achieve the high circulation.Velocities of actuators are modulated to realize the real speed profile and on–off controlling laws of DSJAs are designed.Numerical simulations show that DSJAs and SJA could suppress the separation completely and move leading-edge stagnation point and trailing-edge separation point downstream even at AOA of 19°,hence achieve the highest lift and nose-down moment augmentation(ΔCl_(max)=0.92,ΔCm_(max)=0.02534),andΔL/D can reach 11.39 at AOA of 18°.Stalling is delayed to more than 19°.Linear lift area and pitch-break angle are both increased to 16°.ΔCl/C_(μ) can reach 76.7,indicating the greatest control efficiency.The results of adaptive PID control,whose controlling effects are proved better than PID,indicate that lift could track the objective with the rise time of 0.0325 s and finally keep steady,suggesting the nice stability and rapidness. | Zhijie Zhao Zhenbing Luo Bin Xu Xiong Deng Yuyan Guo Wenqiang Peng Shiqing Li | 2021 | Acta Mechanica Sinica2021，37，10： | 3 |
| 19 | Laser irradiation construction of nanomaterials toward electrochemical energy storage and conversion:Ongoing progresses and challenges显示文摘The emerging use of laser irradiation in synthesis smartly bridges“nanotech-nology”and“light”,and has attracted enormous attention as an efficient syn-thetic methodology for versatile nanomaterials toward electrochemical energy storage and conversion devices(ESCDs).In this review,recent contributions and progress regarding the laser-induced nanomaterials for ESCDs are com-prehensively summarized,with a special focus on their practical utilization in rechargeable batteries,supercapacitors and electrocatalysis.The laser-induced synthesis strategies and corresponding mechanisms involved in nano-architecture generation/regulation,including pulsed laser deposition and laser irradiation in liquid,are also discussed in detail.With the in-depth insights into the mechanisms and revolutionary advancements of laser irradiation tech-nology,the comprehensive performances of ESCDs have been strikingly opti-mized.Finally,the existing challenges and future directions in this booming research field are outlined.This review will exert the significant guidance for future design and purposeful fabrication of advanced laser-induced nano-materials with appealing properties for advanced ESCDs and beyond. | Li Li Jinyang Zhang Yuyan Wang Fakhr Uz Zaman Yaming Zhang Linrui Hou Changzhou Yuan | 2021 | InfoMat2021，3，12： | 2 |
| 20 | Pathways and assays for DNA double-strand break repair by homologous recombination显示文摘Double strand breaks(DSBs)are the most detrimental type of DNA damage that must be repaired to ensure genome integrity and cell survival.Unrepaired or improperly repaired DSBs can potentially cause tumorigenesis or cell death.DSBs are primarily repaired by non-homologous end joining or homologous recombination(HR).The HR pathway is initiated by processing of the 5′-end of DSBs to generate 3′-end single-strand DNA(ssDNA).Furthermore,the intermediate is channeled to one of the HR sub-pathways,including:(i)double Holliday junction(dHJ)pathway,(ii)synthesis-dependent strand annealing(SDSA),(iii)break-induced replication(BIR),and(iv)single-strand annealing(SSA).In the dHJ sub-pathway,the 3′-ssDNA coated with Rad51 recombinase performs homology search and strand invasion,forming a displacement loop(D-loop).Capture of the second end by the D-loop generates a dHJ intermediate that is subsequently dissolved by DNA helicase or resolved by nucleases,producing non-crossover or crossover products.In SDSA,the newly synthesized strand is displaced from the D-loop and anneals to the end on the other side of the DSBs,producing non-crossovers.In contrast,BIR repairs one-end DSBs by copying the sequence up to the end of the template chromosome,resulting in translocation or loss of heterozygosity.SSA takes place when resection reveals flanking homologous repeats that can anneal,leading to deletion of the intervening sequences.A variety of reporter assays have been developed to monitor distinct HR sub-pathways in both Saccharomyces cerevisiae and mammals.Here,we summarize the principles and representative assays for different HR sub-pathways with an emphasis on the studies in the budding yeast. | Jinbao Li Huize Sun Yulin Huang Yali Wang Yuyan Liu Xuefeng Chen | 2019 | Acta Biochimica et Biophysica Sinica2019，51，9： | 2 |
您所在的机构暂未开通此部分的功能，请联系管理员