|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Delivery of Tapasin-modified CTL epitope peptide via cytoplasmic transduction peptide induces CTLs by JAK/STAT signaling pathway in vivo显示文摘特定的细胞毒素的 T 淋巴细胞(CTL ) 玩的肝炎 B 病毒(HBV ) 在病毒的控制和清理的一个重要角色。最近的研究阐明了那 Tapasin, endoplasmic 蜂窝胃女伴,是看起来在装载肽的过程必要的一个著名分子。Janus kinase/signal 变换器和小径玩的抄写(JAK/STAT ) 的使活跃之物在有免疫力的反应的一个重要角色规定和 cytokines 分泌物。我们以前证实了熔化蛋白质 CTP-HBcAg 18-27-Tapasin 能便于骨头髓的成熟导出的树枝状的房间并且在 vitro 提高特定的 CTL 回答,它可能与 JAK/STAT 发信号的激活被联系小径。为了进一步探索 JAK/STAT 发信号小径是否参予了特定的有免疫力的回答,由我们压制了的 CTP-HBcAg 18-27-Tapasin, 调停了有在 vivo 的药理学禁止者(AG490 ) 的 JAK/STAT 小径。我们的研究证明 IFN-+-CD8+ T 房间的数字在被 AG490 堵住以后与另外的组相比显著地被减少。IFN-+-CD4+ T 房间和 IL-2-CD4 + T 房间的百分比也被减少。而且, Jak2, Tyk2, STAT1,和 STAT4 的更低的表示层次在 AG490 被检测组。另外,象 Th1 一样 cytokines 的分泌物层次被减少,更弱的特定的 T 房间回答在 AG490 组被观察。而且,在这条小径在 HBV 转基因的老鼠被禁止以后,在浆液的 HBV DNA 和 HBsAg 的层次和在肝纸巾的 HBsAg 和 HBcAg 的表示层次被提高。这些结果证明表明小径的 JAK/STAT 参予 CTP-HBcAg 18-27-Tapasin 导致的 Th1 面向的有免疫力的反应,这可能为 HBV 免疫疗法提供一个理论基础。 | Shanshan Wu Xiaohua Chen Yuyan Tang Yi Zhang Dan Li Jie Chen Jieling Wang Zhenghao Tang Guoqing Zang Yongsheng Yu | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 6 |
| 2 | Chemical probing reveals insights into the signaling mechanism of inflammasome activation显示文摘Caspase-1-mediated IL-1 尾生产被二条小径通常控制。像使用费的受体(TLR ) 认出导出病原体的产品并且导致 NF-魏 B 依赖者 pro-IL-1 尾抄写;像点头的受体(NLR ) 装配察觉到细菌的产品 / 危险信号的 caspase-1-activating inflammasome 建筑群。通过一幅指向的化学屏幕,我们识别 bromoxone,一个海洋的自然产品,一特定并且 caspase-1 小径的有势力禁止者。Bromoxone 在包括加 ATP/nigericin, cytosolic DNA, flagellin 和杆菌 anthracis 的 TLR ligands 的多样的煽动性的刺激上是有效的致命的毒素。Bromoxone 高效地也压制激活由细菌的感染的几种类型触发了的 caspase-1。在上游的 Bromoxone 行为或在以一种抄写无关的方式的 inflammasome 的水平。Bromoxone 也由在 TLR-NF-魏 B 小径指向 IKK 在上游的部件禁止 pro-IL-1 尾表示。bromoxone 的唯一的双活动被明确地堵住 Nalp3 inflammasome 激活的已知的 TAK1 禁止者分享。提示了从机械学并且 bromoxone 的药理学性质,我们进一步发现几个已知的 NF-魏 B 禁止者 IKK 在上游的那行为,然而并非下游地指向 IKK 或 IKK 的那些,是不同调停 NLRs 的 caspase-1 激活的有势力 blockers。我们的学习揭开可能的 non-transcriptional 在 NLR (Nalp3 ) 之间的分子的连接调停了 inflammasome 小径和 TLR-NF-魏 B 发信号,并且建议潜在的策略开发新反煽动性的药。 | Yi-Nan Gong Xiaoming Wang Jiayi Wang Zhenxiao Yang Shan Li Jieling Yang Liping Liu Xiaoguang Lei Feng Shao | 2010 | Cell Research2010，20，12： | 5 |
| 3 | High-temperature dielectric and microwave absorption performances of TiB2/Al2O3 ceramics prepared by spark plasma sintering显示文摘TiB_(2)/Al2O3 ceramics reinforced with Mg O are prepared by spark plasma sintering(SPS).The dielectric and microwave(MW)absorption properties are discussed.The results indicate that both the commercial TiB_(2)(C-TiB_(2))content and preparing temperature play important roles in the dielectric properties.Simultaneously,TiB_(2)/Al2O3 composite shows the best MW absorption property when the C-TiB_(2)content and preparing temperature are 9 wt%and 1400°C.To further improve the MW absorption properties,the composite containing 9 wt%synthesized TiB_(2)(S-TiB_(2))has been sintered at 1400°C.Its high-temperature complex permittivity is greater than that of TiB_(2)/Al2O3 composite with 9 wt%C-TiB_(2)sintered at 1400°C and is directly proportional to the temperature.Besides,TiB_(2)/Al2O3 composite with 9 wt%S-TiB_(2)possesses a better MW absorption at 25–500°C,its effective absorption bandwidth(RL<-5 dB)can reach 4.2 GHz at 25–500°C.And the minimum reflection loss(RLmin)value reaches-43.41 dB at the temperature of 800°C with a thickness of 1.45 mm for TiB_(2)/Al2O3 composite with 9 wt%C-TiB_(2).Consequently,the satisfying absorbing layer(d<1.75 mm),flexural strength,heat stability and considerable high-temperature MW absorption ability grant TiB_(2)/Al2O3 ceramics practical applications as high-temperature microwave absorption materials(MAMs). | LIU XiongZhang LUO Hui LI YinRui CHEN Fu LIU JieLing YANG WenTao WANG Xian GONG RongZhou | 2021 | Science China(Technological Sciences)2021，64，6： | 2 |
| 4 | A new device for stress monitoring in continuously welded rails using bi-directional strain method显示文摘The technology of continuously welded rails(CWRs) is important in modern railway track structures.To measure rail stress, resistance strain gauges are preferred due to their good stability, sensitivity, and resistance to external interference. Based on the bi-directional strain method, we present a new method for measuring longitudinal rail stress using resistance strain gauges and develop a monitoring device for rail stress to realize long-term and multi-point measurement. Also relevant experimental verification and analysis are conducted. Results indicate that under various constraints the rail stress–strain values can be calculated just with the measured total longitudinal strain and total vertical strain. Considering the measurement error caused by sectional feature of sensors, we put forward a correction equation applicable to different stress conditions. Although the temperature values of the four full-bridge stress gauges can offset each other, the measurement error caused by rail flexural strain can also be eliminated to a certain extent at the same time, the nonuniform distribution of rail cross section temperature and unbalanced flexural strain still affect the measurement error. The experimental results also show that the developed rail-stress-monitoring sensor is suitable for measuring rail stress with reliable working performance. | Ganzhong Liu Hao Liu Anqi Wei Jieling Xiao Ping Wang Shaozheng Li | 2018 | Journal of Modern Transportation2018，26，3： | 1 |
| 5 | Is Prehypertension Really Different from Normotension and Hypertension? A Case-Control Pilot Proteomic Study in Chinese显示文摘 | Zuoguang Wang Xiaoyun Peng Yanduo Tao Ya Liu Jieling Liu Xingjun Chen Shaojun Wen Zhaosu Wu | 2009 | Clinical and Experimental Hypertension2009，，4： | 1 |
| 6 | Reevaluation of pathogens causing Valsa canker on apple in China显示文摘 | WANG Xuli WEI Jieling HUANG Lili KANG Zhensheng | 2011 | Mycologia2011，103，2： | 1 |
| 7 | Tailoring the oxygen concentration in Ge-Sb-O alloys to enable femtojoule-level phase-change memory operations显示文摘Chalcogenide phase-change materials(PCMs),in particular,the flagship Ge2Sb2Te5(GST),are leading candidates for advanced memory applications.Yet,GST in conventional devices suffer from high power consumption,because the RESET operation requires melting of the crystalline GST phase.Recently,we have developed a conductive-bridge scheme for low-power phase-change application utilizing a self-decomposed Ge-Sb-O(GSO)alloy.In this work,we present thorough structural and electrical characterizations of GSO thin films by tailoring the concentration of oxygen in the phase-separating GSO system.We elucidate a two-step process in the as-deposited amorphous film upon the introduction of oxygen:with increasing oxygen doping level,germanium oxides form first,followed by antimony oxides.To enable the conductive-bridge switching mode for femtojoule-level RESET energy,the oxygen content should be sufficiently low to keep the antimony-rich domains easily crystallized under external electrical stimulus.Our work serves as a useful example to exploit alloy decomposition that develops heterogeneous PCMs,minimizing the active switching volume for low-power electronics. | Jiang-Jing Wang Xiaozhe Wang Yudong Cheng Jieling Tan Chao Nie Zhe Yang Ming Xu Xiangshui Miao Wei Zhang En Ma | 2022 | Materials Futures2022，1，4： | 1 |
| 8 | Efficient BAD equalizer in two-ray multipath fading channels 显示文摘 | Wang Jieling Yang Hong Yi Kechu | 2009 | IEEE Communications Letters2009，13，11： | 1 |
| 9 | Role of Thermolysin in Catalytic-Controlled Self-Assembly of Fmoc-Dipeptides显示文摘In recent years,short peptide self-assembled materials,prepared under the control of the thermolysin catalyst,have been investigated extensively and shown to acquire various morphologies and functions as building blocks for a wide range of biomaterials and device applications.However,the role played by thermolysin in this enzymatically triggered peptide self-assembly is still ambiguous.Herein,we designed a series of Fmoc-dipeptide amphiphiles to explore the catalytic role of thermolysin. | Meiyue Wang Qiansen Zhang Honglei Jian Shijie Liu Jieling Li Anhe Wang Qianqian Dong Peng Ren Xin Li Shuo Bai | 2020 | CCS Chemistry2020，2，4： | 0 |
| 10 | Gradient CNT/PVDF piezoelectric composite with enhanced force-electric coupling for soccer training显示文摘Real-time monitoring of ball–shoe interactions can provide essential information for high-quality instruction in personalized soccer training,yet existing monitoring systems struggle to reflect specific forces,loci,and durations of action.Here,we design a self-powered piezoelectric sensor constructed by the gradient carbon nanotube/polyvinylidene fluoride(CNT/PVDF)composite to monitor the interactions between the ball and the shoe.Two-dimensional Raman mapping demonstrates the gradient structure of CNT/PVDF prepared by programmable electrospinning combined with a hot pressing.Benefitting from the synergistic effect of local polarization caused by the enrichment of CNT and the reduced diffusion of silver patterns in gradient structure,the as-prepared composite exhibits enhanced force-electric coupling with an excellent sensitivity of 80 mV/N and durability over 15,000 cycles.On this basis,we conformally attach a 3×3 sensor array to a soccer shoe,enabling real-time acquisition of kick position and contact force,which could provide quantitative assessment and personalize guidance for the training of soccer players.This self-powered piezoelectric sensor network system offers a promising paradigm for wearable monitoring under strong impact forces. | Wanghong Zeng Weili Deng Tao Yang Shenglong Wang Yue Sun Jieling Zhang Xiarong Ren Long Jin Lihua Tang Weiqing Yang | 2023 | Nano Research2023，16，8： | 0 |
| 11 | Preparation of conductive and transparent dipeptide hydrogels for wearable biosensor显示文摘Conductive and transparent dipeptide hydrogels are desirable building blocks to prepare soft electronic devices and wearable biosensors due to their excellent biocompatibility,multi-functionality,and physiochemical properties similar to those of body tissues.However,the preparation of such hydrogels featuring high conductivity and transparency is a huge challenge because of the hydrophobic feature of conductive additives making the doping process difficult.To overcome this issue,hydrophilic conductive polydopamine(PDA)-doped polypyrrole(PPy)nanoparticles are introduced into the dipeptide hydrogel networks to form conductive nanofibrils in situ to achieve a good level of hydrophilic templating of the hydrogel networks.This tech-nique creates a complete conductive network and allows visible light to pass through.The strategy proposed herein not only endows the dipeptide hydrogel with good conductivity and high transparency,but also provides a great potential application of conductive dipeptide hydrogels for body-adhered signal detection,as evidenced by the experimental data. | Yafeng Jing Anhe Wang Jieling Li Qi Li Qingquan Han Xuefang Zheng Hongyu Cao Shuo Bai | 2022 | Bio-Design and Manufacturing2022，5，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员