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| 1 | Effects of precipitation and landuse on runoff during the past 50 years in a typical watershed in the Loess Plateau, China显示文摘In the past century, great progress has been made worldwide in our understanding of forest-water relationship. The successful forestation programs implemented in China-which have improved the ecological environmental conditions-have gained the attention of many researchers and highlighted the relationship between forestation and water yields. The arid and semi-arid Loess Plateau has received attention from water engineers and eco-hydrological researchers in China because of a shortage in water resources. We selected one of the oldest stations conducting soil and water conservation experiments, the Xifeng soil and water conservation station, and chose the Nanxiaohe catchment and its paired catchments (Yangjiagou catchment and Dongzhuanggou catchment) as our research areas. Trends in precipitation, air temperature, streamflow over the past 50 years, and the effect of changing land use on streamflow were analyzed. The Mann-Kendall test showed that precipitation had a negative trend (downward trend), whereas air temperature showed a positive trend (upward trend) from the past to present in the Nanxiaohe catchment. However, the trends seen in precipitation, air temperature did not contain any 'jumping points.' The paired catchment approach is used to detect the effects of land cover change on hydrology in the Yangjiagou and the contrast catchment, i.e., Dongzhuanggou catchment in our study. The results showed a large change in land use in the Yangjiagou catchment from 1954 to 2008. An increase in forested land (from 0% to 40.08% from 1954 to 2008) and a reduction of bare land (from 51.26% to 5.50% from 1954 to 2008) accounted for a large part of the change in land use. However, the land use changed little in the contrast catchment. The comparison of streamflow in the paired catchments showed that forestation reduced streamflow by 49.63% (or 6.5 mm) each year. | Huaxing BI Bin LIU Jie WU Lei YUN Zhihan CHEN Zhewei CUI | 2009 | International Journal of Sediment Research2009，24，3： | 21 |
| 2 | Phosphorus oxoanion-intercalated layered double hydroxides for high-performance oxygen evolution显示文摘合理设计和为氧进化反应(OER ) 的有效、划算的电极的控制制造为探讨崭新的精力危机是批评的。有特定的夹层阴离子的镍铁分层的双氢氧化物(NiFe-LDHs )( 即磷酸盐,亚磷酸盐,和次磷酸盐) 被一个一起沉淀方法制作并且作为氧进化 electrocatalysts 调查了。磷 oxoanion 的置闰在一个碱的答案提高了 OER 活动;最佳的表演(即, 215 mV, 37.7 mV/dec 的一个小 Tafel 斜坡,和稳定的电气化学的行为的一个低发作潜力) 与设置次磷酸盐的 NiFe-LDH 催化剂被完成,在传统的设置碳酸盐的 NiFe-LDH 上的示威戏剧的改进以活动和耐久性。这提高的表演被归因于在设置的磷的 oxoanions 和分享边的瞬间 6 之间的相互作用(M = Ni, Fe ) 层,它修改表面 Ni 地点的电子结构。这个概念应该为更有效的基于 LDH 的氧进化 electrocatalysts 的设计是鼓舞人心的。 | Ma Luo Zhao Cai Cheng Wang Yongmin Bi Li Qian Yongchao Hao Li Li Yun Kuang Yaping Li Xiaodong Lei Ziyang HUO Wen Liu Hailiang Wang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，5： | 12 |
| 3 | Layered double hydroxides with atomic-scale defects for superior electrocatalysis显示文摘原子作文调节和缺点工程是有效策略 toenhance 由 improvingthe 的 multicomponent 催化剂的催化表演合作效果;然而,戏剧性地通过同时的缺点 engineeringat 在 multicomponent 材料上调节活跃地点仍然保持挑战性原子规模因为本地环境的类似。此处,把氧进化反应(OER ) 用作探查反应,我们 deliberatelyintroduced 底可溶的 Zn (II ) 或艾尔(III ) 地点进 NiFe 分层的双氢氧化物(LDH ) ,它是最好的 OER 催化剂之一。然后, Zn (II ) 或 siteswere 有选择地蚀刻创造原子 M (II ) 的艾尔(III )/M (III ) 背叛,哪个 dramaticallyenhanced OER 活动。在 20 妈的当前的密度?? | Oixian Xie Zhao Cai Pengsong Li Daojin Zhou Yongmin Bi Xuya Xiong Enyuan Hu Yaping Li Yun Kuang Xiaoming Sun | 2018 | Nano Research2018，11，9： | 8 |
| 4 | Effects of redox-active interlayer anions on the oxygen evolution reactivity of NiFe-layered double hydroxide nanosheets显示文摘镍铁分层的双氢氧化物(NiFe-LDH ) nanosheets 显示出最佳的氧进化反应(OER ) 性能;然而,在 OER 活动的设置的离子的角色仍然保持不清楚。在这个工作,我们证明 NiFe-LDHs 的活动能被设置的阴离子与不同氧化还原作用潜力定制。而 NiFe-LDHs 与高氧化还原作用潜力(低减少能力)的阴离子设置了,有低氧化还原作用潜力(高减少能力)的阴离子的置闰例如次磷酸盐,与 240 mV 的低 OER 过电位和 36.9 mV/dec 的一个小 Tafel 斜坡导致 NiFe-LDHs ,例如 fluorion ,显示出 370 mV 的高过电位和 80.8 mV/dec 的一个 Tafel 斜坡。OER 活动与标准氧化还原作用潜力显示出令人吃惊的线性关联。密度功能的理论计算和 X 光检查光电子光谱学分析显示设置的阴离子改变在表面暴露了的金属原子的电子结构。有低标准氧化还原作用潜力和强壮的减少能力的阴离子把更多的电子转移到氢氧化物层。这增加表面金属地点的电子密度并且稳定他们的高原子价的状态,其形成在 OER 过程以前作为关键步被知道。 | Daojin Zhou Zhao Cai Yongmin Bi Weiliang Tian Ma Luo Qian Zhang Qixian Xie Jindi Wang Yaping Li Yun Kuang Xue Duan Michal Bajdich Samira Siahrostami Xiaoming Sun | 2018 | Nano Research2018，11，3： | 6 |
| 5 | Pristimerin protects against inflammation and metabolic disorder in mice through inhibition of NLRP3 inflammasome activation显示文摘Excessive activation of NLRP3 inflammasome is associated with the pathogenesis of inflammatory diseases.Pristimerin(Pri)is a quinonoid triterpene derived from traditional Chinese medical herb Celastraceae and Hippocrateaceae.Pri has shown antifungal,antibacterial,antioxidant,and anticancer activities.In this study we investigated whether NLRP3 inflammasome was associated with the anti-inflammatory activity of Pri.We showed that Pri(0.1−0.4μM)dose-dependently blocked caspase-1 activation and IL-1βmaturation in LPS-primed mouse bone-marrow-derived macrophages(BMDMs).Pri specifically inhibited NLRP3 inflammasome activation,had no visible effects on NLRC4 and AIM2 inflammasome activation.Furthermore,we demonstrated that Pri blocked the assembly of the NLRP3 inflammasome via disturbing the interaction between NEK7 and NLRP3;theα,β-unsaturated carbonyl moiety of Pri was essential for NLRP3 inflammasome inactivation.In LPS-induced systemic inflammation mouse model and MSU-induced mouse peritonitis model,preinjection of Pri(500μg/kg,ip)produced remarkable therapeutic effects via inhibition of NLRP3 inflammasome in vivo.In HFD-induced diabetic mouse model,administration of Pri(100μg·kg^(−1)·d^(−1),ip,for 6 weeks)reversed HFD-induced metabolic disorders via suppression of NLRP3 inflammasome activation.Taken together,our results demonstrate that Pri acts as a NLRP3 inhibitor,suggesting that Pri might be useful for the treatment of NLRP3-associated diseases. | Qun Zhao Yun Bi Jian Guo Ying-xiang Liu Jing Zhong Long-rui Pan Yan Tan Xian-jun Yu | 2021 | Acta Pharmacologica Sinica2021，42，6： | 6 |
| 6 | Induction of Endoplasmic Reticulum Stress by Cadmium and Its Regulation on Nrf2 Signaling Pathway in Kidneys of Rats显示文摘Objective This study was conducted to investigate the regulation of endoplasmic reticulum stress on Nrf2 signaling pathway in the kidneys of rats. Methods Rats were divided into twelve groups of six animals each. Some groups were pre-administered with bacitracin or tauroursodeoxycholic acid(TUDCA), and all of them were treated with 5-20 μmol/kg cadmium(Cd) for 48 h. The oxidative stress levels were analyzed using kits. The mRNA and protein expression levels of endoplasmic reticulum stress-related factors and Nrf2 signaling pathway-related factors were determined using RT-PCR and western blot. Results Cd exposure resulted in oxidative stress in the kidneys of rats and upregulated the expression of endoplasmic reticulum stress(ERS)-related factors and Nrf2 signaling pathway-related factors, especially at doses of 10 and 20 μmol/kg Cd, and the expression changes were particularly obvious. Moreover, after pretreatment with bacitracin, Cd upregulated the expression of ERS-related factors to a certain extent and, at higher doses, increased the mRNA expression of Nrf2. After pretreatment with TUDCA, Cd reduced the level of ERS to a certain extent; however, at these doses, there were no significant changes in the expression of Nrf2. Conclusion Cadmium can result in ERS and oxidative stress in the kidneys of rats, activate Nrf2, and upregulate the transcriptional expression of phase II detoxification enzymes under these experimental conditions. ERS has a positive regulation effect on Nrf2 signaling pathway but has little effect on the negative regulation of Nrf2 signaling pathway in cadmium toxicity. | CHEN Zhi Jian CHEN Jia Xing WU Li Kang LI Bi Yun TIAN Ya Feng XIAN Min HUANG Zi Pei YU Ri An | 2019 | Biomedical and Environmental Sciences2019，32，1： | 6 |
| 7 | Exosomes with low miR-34c-3p expression promote invasion and migration of non-small cell lung cancer by upregulating integrinα2β1显示文摘Exosomes play critical roles in regulating various physiological and pathological processes,including immune stimulation,immune suppression,cardiovascular diseases,and cancers.Recent studies show that exosomes that transport specific microRNAs(miRNAs)are involved in tumor development.However,the molecular mechanism by which tumor invasion and migration are regulated by exosomes from non-small cell lung cancer(NSCLC)is not well understood.Here,we show that exosomes shuttling low levels of miR-34c-3p are involved in NSCLC progression.Our results showed that exosomes derived from NSCLC cells carrying low levels of miR-34c-3p could be transported into the cytoplasm of NSCLC cells and accelerate NSCLC invasion and migration by upregulating integrinα2β1.A luciferase assay revealed that integrinα2β1 was the direct target of miR-34c-3p,and overexpression of integrinα2β1 could promote the invasion and migration of NSCLC cells.The analysis of exosomes derived from clinical serum samples indicated that the expression of miR-34c-3p was significantly downregulated in exosomes from NSCLC patients compared with that of normal controls.A549-derived exosomes promoted NSCLC cells lung metastases in vivo.Exosomes shuttling low levels of miR-34c-3p were associated with the progression of NSCLC in vitro and in vivo.Our data demonstrate that exosomes shuttling low levels of miR-34c-3p can accelerate the invasion and migration of NSCLC by upregulating integrinα2β1.MiR-34c-3p can be a diagnostic and prognostic marker for NSCLC.High expression of integrinα2β1 is positively related to the migration and metastasis of NSCLC cells. | Wenjing Huang Yanyan Yan Yun Liu Minting Lin Jinxiang Ma Wei Zhang Jianwei Dai Jiajun Li Qiaoru Guo Hubiao Chen Bolat Makabel Hong Liu Chaoyue Su Hong Bi Jianye Zhang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 5 |
| 8 | Smoking and Its Relation to Metabolic Status among Chinese Adults: Analysis of a Nationwide Survey显示文摘Objective To update the estimated prevalence rates of smoking and examine major metabolic diseases associated with smoking status in Chinese adults. Methods Using a complex, multistage, probability sampling design, we recruited a nationally representative sample of 98,658 Chinese adults aged ≥18 years in 2010. Information on current, former, never, and passive smoking status was obtained using a standard questionnaire. All estimates were weighted to represent the overall Chinese adult population. Results The estimated proportion of current smokers was 28.3% for Chinese adults aged ≥18 years. The corresponding values of former and passive smokers were 5.1% and 21.4%, respectively. Additionally, former smokers were found to have a less favorable metabolic risk profile among all categories of smoking status in both men and women. The prevalence of metabolic diseases such as diabetes and hypertension also increased with a greater number of smoking pack-years in men. Conclusion The prevalences of current smoking and passive smoking remain high in Chinese adults. | DING Lin XU Yu WANG Li Min JIANG Yong ZHANG Mei LI Yi Chong LU Jie Li XU Min WANG Tian Ge LI Mian ZHAO Zhi Yun DAI Meng WANG Wei Qing ZHAO Wen Hua WANG Lin Hong BI Yu Fang NING Guang 无 | 2016 | Biomedical and Environmental Sciences2016，29，9： | 5 |
| 9 | Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis显示文摘Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response outcomes.Although the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains unknown.Here,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.Pharmacological modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory injury.Mechanistically,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of MDSCs.Our studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation. | Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian Wang Zhengguo Zhang Yu Wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao Ruoning Wang Guangwei Liu | 2018 | Cellular & Molecular Immunology2018，15，6： | 4 |
| 10 | Machine Learning Models in Type 2 Diabetes Risk Prediction:Results from a Cross-sectional Retrospective Study in Chinese Adults显示文摘Type 2 diabetes mellitus (T2DM) has become a prevalent health problem in China,especially in urban areas.Early prevention strategies are needed to reduce the associated mortality and morbidity.We applied the combination of rules and different machine learning techniques to assess the risk of development of T2DM in an urban Chinese adult population.A retrospective analysis was performed on 8000 people with non-diabetes and 3845 people with T2DM in Nanjing.Multilayer Perceptron (MLP),AdaBoost (AD),Trees Random Forest (TRF),Support Vector Machine (SVM),and Gradient Tree Boosting (GTB) machine learning techniques with 10 cross validation methods were used with the proposed model for the prediction of the risk of development of T2DM.The performance of these models was evaluated with accuracy,precision,sensitivity,specificity,and area under receiver operating characteristic (ROC) curve (AUC).After comparison,the prediction accuracy of the different five machine models was 0.87,0.86,0.86,0.86 and 0.86 respectively.The combination model using the same voting weight of each component was built on T2DM,which was performed better than individual models.The findings indicate that,combining machine learning models could provide an accurate assessment model for T2DM risk prediction. | Xiao-lu XIONG Rong-xin ZHANG Yan BI Wei-hong ZHOU Yun YU Da-long ZHU | 2019 | Current Medical Science2019，39，4： | 4 |
| 11 | Reconstructing the size of individual trees using log data from cut-to-length harvesters in Pinus radiata plantations: a case study in NSW, Australia显示文摘With their widespread utilization, cut-to-length harvesters have become a major source of ‘‘big data'' for forest management as they constantly capture, and provide a daily flow of, information on log production and assortment over large operational areas. Harvester data afford the calculation of the total log length between the stump and the last cut but not the total height of trees. They also contain the length and end diameters of individual logs but not always the diameter at breast height overbark(DBHOB) of harvested stems largely because of time lapse, operating and processing issues and other system deficiencies. Even when DBHOB is extracted from harvester data, errors and/or bias of the machine measurements due to the variation in the stump height of harvested stems from that specified for the harvester head prior to harvesting and diameter measurement errors may need to be corrected. This study developed(1) a system of equations for estimating DBHOB of trees from diameter overbark(DOB) measured by a harvester head at any height up to 3 m above ground level and(2) an equation to predict the total height of harvested stems in P. radiata plantations from harvester data. To generate the data required for this purpose, cut-to-length simulations of more than 3000 trees with detailed taper measurements were carried out in the computer using the cutting patterns extracted from the harvester data and stump height survey data from clearfall operations. The equation predicted total tree height from DBHOB, total log length and the small end diameter of the top log. Prediction accuracy for total tree height was evaluated both globally over the entire data space and locally within partitioned subspaces through benchmarking statistics. These statistics were better than that of the conventional height-diameter equations for P. radiata found in the literature, even when they incorporated stand age and the average height and diameter of dominant trees in the stand as predictors. So this equation when used with harvester data would outperform the conventional equations in tree height prediction. Tree and stand reconstructions of the harvested forest is the necessary first step to provide the essential link of harvester data to conventional inventory, remote sensing imagery and Li DAR data. The equations developed in this study will provide such a linkage for the most effective combined use of harvester data in predicting the attributes of individual trees, stands and forests, and product recovery for the management and planning of P. radiata plantations in New South Wales, Australia. | Kuan Lu Huiquan Bi Duncan Watt Martin Strandgard Yun Li | 2018 | Journal of Forestry Research2018，29，1： | 4 |
| 12 | Topotactic reduction of layered double hydroxides for atomically thick two-dimensional non-noble-metal alloy显示文摘Layered double hydroxides (LDHs) have been widely used as catalysts owingto their tunable structure and atomic dispersion of high-valence metal ions;however, limited tunability of electronic structure and valence states havehindered further improvement in their catalytic performance. Herein, we reducedultrathin LDH precursors in situ and topotactically converted them to atomicallythick (N2 nm) two-dimensional (2D) multi-metallic, single crystalline alloynanosheets with highly tunable metallic compositions. The as-obtained alloynanosheets not only maintained the vertically aligned ultrathin 2D structure,but also inherited the atomic dispersion of the minor metallic compositions ofthe LDH precursors, even though the atomic percentage was higher than 20%,which is far beyond the reported percentages for single-atom dispersions (usuallyless than 0.1%). Besides, surface engineering of the alloy nanosheets can finely tunethe surface electronic structure for catalytic applications. Such in situ topotacticconversion strategy has introduced a novel approach for atomically dispersedalloy nanostructures and reinforced the synthetic methodology for ultrathin 2Dmetal-based catalysts. | Pengsong Li Qixian Xie Lirong Zheng Guang Feng Yingjie Li Zhao Cai Yongmin Bi Yaping Li Yun Kuang Xiaoming Sun Xue Duan | 2017 | Nano Research2017，10，9： | 4 |
| 13 | Felodipine attenuates vascular inflammation in a fructose-induced rat model of metabolic syndrome via the inhibition of NF-κB activation显示文摘瞄准:新陈代谢的症候群与动脉粥样硬化的增加的发生被联系。临床的研究证明了钙隧道块 ers (CCB ) 禁止动脉粥样硬化的前进。然而,内在的机制是不清楚的。我们在粘附上调查了 felodipine 的禁止的效果在高果糖美联储的老鼠(FFR ) 的主动脉的分子的表示和巨噬细胞渗入。方法:男 Wistar 老鼠被给 10% 在喝水果糖。在 32 星期高果糖的喂以后,他们与 felodipine 被对待(为 6 个星期的 5 mg · k g -1 · d-1) 。控制老鼠被给一本正常食谱和水。细胞间的粘附 molecule-1 (ICAM-1 ) 和脉管的房间粘附 molecule-1 (VCAM-1 ) 和巨噬细胞的渗入的大动脉的表示被即时 RT-PCR 或免疫组织化学测量。NF-κB 活动被 electrophoretic 活动性移动试金(EMSA ) 测量。结果:在 32 星期高果糖的喂以后,显示的 FFR 增加了身体重量,收缩血压(SBP ) ,浆液胰岛素,和 triglycerides 什么时候与控制老鼠相比。ICAM-1 和 VCAM-1 的大动脉的表达式显著地比在控制老鼠在 FFR 被增加并且由 NF-κB 的增加的活动伴随了。也显著地显示出的 FFR 在大动脉的墙中增加了 CD68 积极的巨噬细胞。在有 felodipine, SBP,浆液胰岛素,和动态平衡模型的处理以后,评价显著地减少了。除了减少 ICAM-1 和 VCAM-1, felodipine 减少了在大动脉的墙中的巨噬细胞。EMSA 表明 felodipine 在 FFR 禁止了 NF-κB 激活。结论:Felodipine 禁止了容器墙发炎。NF-κB 的抑制可以被 CCB 在新陈代谢的症候群涉及脉管的煽动性的反应的调整。 | Hong-wei TAN | 2008 | Acta Pharmacologica Sinica2008，29，9： | 3 |
| 14 | Association between Selenium in Soil and Diabetes in Chinese Residents Aged 35–74 Years:Results from the 2010 National Survey of Chronic Diseases and Behavioral Risk Factors Surveillance显示文摘Objective To explore the association between soil selenium levels and the risk of diabetes in Chinese adults aged 35–74 years.Methods Data for this study were derived from the China Chronic Diseases and Behavioral Risk Factors Surveillance 2010 survey.Selenium concentrations in soil were obtained from the Atlas of Soil Environmental Background Values in China.A two-level binary logistic regression model was used to determine the association between soil selenium concentrations and the risk of diabetes,with participants nested within districts/counties.Results A total of 69,332 participants aged 35–74 years,from 158 districts/counties were included in the analysis.Concentrations of selenium in soil varied greatly across the 158 districts/counties,with a median concentration of 0.219 mg/kg(IQR:0.185–0.248).The results showed that both Quartile 1(0.119–0.185 mg/kg)and Quartile 4(0.249–0.344 mg/kg)groups were positively associated with diabetes compared to a soil selenium concentration of 0.186–0.219 mg/kg(Quartile 2),crude odds ratios(ORs)(95%CI)were 1.227(1.003–1.502)and 1.280(1.048–1.563).The P values were 0.045 and 0.013,for Quartile 1 and Quartile 4 groups,respectively.After adjusting for all confounding factors of interest,the Quartile 1 group became non-significant,and the Quartile 4 group had an adjusted OR(95%CI)of 1.203(1.018–1.421)relative to the reference group(Quartile 2),the P values was 0.030.No significant results were seen for the Quartile 3 group(0.220–0.248 mg/kg)compared to the reference group.Conclusion Excessive selenium concentrations in soil could increase the risk of diabetes among Chinese adults aged 35–74 years. | WANG Qi Qi YU Shi Cheng XU Cheng Dong LIU Jian Jun LI Yuan Qiu ZHANG Man Hui LONG Xiao Juan LIU Yun Ning BI Yu Fang ZHAO Wen Hua YAO Hong Yan | 2020 | Biomedical and Environmental Sciences2020，33，4： | 3 |
| 15 | Progress and prospects of horizontal well fracturing technology for shale oil and gas reservoirs显示文摘By systematically summarizing horizontal well fracturing technology abroad for shale oil and gas reservoirs since the “13th Five-Year Plan”, this article elaborates new horizontal well fracturing features in 3D development of stacked shale reservoirs, small well spacing and dense well pattern, horizontal well re-fracturing, fracturing parameters optimization and cost control. In light of requirements on horizontal well fracturing technology in China, we have summarized the technological progress in simulation of multi-fracture propagation, horizontal well frac-design, electric-drive fracturing equipment, soluble tools and low-cost downhole materials and factory-like operation. On this basis, combined with the demand analysis of horizontal well fracturing technology in the “14th Five-Year Plan” for unconventional shale oil and gas, we suggest strengthening the research and development in the following 7 aspects:(1) geology-engineering integration;(2) basic theory and design optimization of fracturing for shale oil and gas reservoirs;(3) development of high-power electric-drive fracturing equipment;(4) fracturing tool and supporting equipment for long horizontal section;(5) horizontal well flexible-sidetracking drilling technology for tapping remaining oil;(6) post-frac workover technology for long horizontal well;(7) intelligent fracturing technology. | LEI Qun XU Yun CAI Bo GUAN Baoshan WANG Xin BI Guoqiang LI Hui LI Shuai DING Bin FU Haifeng TONG Zheng LI Tao ZHANG Haoyu | 2022 | Petroleum Exploration and Development2022，49，1： | 3 |
| 16 | Association between Coronary Atherosclerotic Plaque Composition and Cardiovascular Disease Risk显示文摘Objective The objective of this study is to determine whether coronary atherosclerotic plaque composition is associated with cardiovascular disease(CVD) risk in Chinese adults. Methods We performed a cross-sectional analysis in 549 subjects without previous diagnosis or clinical symptoms of CVD in a community cohort of middle-aged Chinese adults. The participants underwent coronary computed tomography(CT) angiography for the evaluation of the presence and composition of coronary plaques. CVD risk was evaluated by the Framingham risk score(FRS) and the 10-year atherosclerotic cardiovascular disease(ASCVD) risk score. Results Among the 549 participants, 267(48.6%) had no coronary plaques, 201(36.6%) had noncalcified coronary plaques, and 81(14.8%) had calcified or mixed coronary plaques. The measures of CVD risk including FRS and ASCVD risk score and the likelihood of having elevated FRS significantly increased across the groups of participants without coronary plaques, with noncalcified coronary plaques, and with calcified or mixed coronary plaques. However, only calcified or mixed coronary plaques were significantly associated with an elevated ASCVD risk score [odds ratio(OR) 2.41; 95% confidence interval(CI) 1.09-5.32] compared with no coronary plaques, whereas no significant association was found for noncalcified coronary plaques and elevated ASCVD risk score(OR 1.25; 95% CI 0.71-2.21) after multivariable adjustment. Conclusion Calcified or mixed coronary plaques might be more associated with an elevated likelihood of having CVD than noncalcified coronary plaques. | LI Lin WANG Long LIU Shan Shan ZHAO Zhi Yun LI Mian WANG Tian Ge XU Min LU Jie Li CHEN Yu Hong WANG Shuang Yuan DAI Meng HOU Ya Nan WU Xue Yan MA Li Na WANG Wei Qing XU Yu BI Yu Fang | 2019 | Biomedical and Environmental Sciences2019，32，2： | 3 |
| 17 | Peripheral Artery Disease and Risk of Fibrosis Deterioration in Nonalcoholic Fatty Liver Disease:A Prospective Investigation显示文摘Objective Liver fibrosis is an important predictor of mortality in nonalcoholic fatty liver disease(NAFLD).Peripheral artery disease(PAD)and liver fibrosis share many common metabolic dysfunctions.We aimed to explore the association between PAD and risk of fibrosis deterioration in NAFLD patients.Methods The study recruited 1,610 NAFLD patients aged≥40 years from a well-defined community at baseline in 2010 and followed up between August 2014 and May 2015.Fibrosis deterioration was defined as the NAFLD fibrosis score(NFS)status increased to a higher category at the follow-up visit.PAD was defined as an ankle-brachial index of<0.90 or>1.40.Results During an average of 4.3 years’follow-up,618 patients progressed to a higher NFS category.PAD was associated with 92%increased risk of fibrosis deterioration[multivariable-adjusted odds ratio(OR):1.92,95%confidence interval(CI):1.24,2.98].When stratified by baseline NFS status,the OR for progression from low to intermediate or high NFS was 1.74(95%CI:1.02,3.00),and progression from intermediate to high NFS was 2.24(95%CI:1.05,4.80).There was a significant interaction between PAD and insulin resistance(IR)on fibrosis deterioration(P for interaction=0.03).As compared with non-PAD and non-IR,the coexistence of PAD and IR was associated with a 3.85-fold(95%CI:2.06,7.18)increased risk of fibrosis deterioration.Conclusion PAD is associated with an increased risk of fibrosis deterioration in NAFLD patients,especially in those with IR.The coexistence of PAD and IR may impose an interactive effect on the risk of fibrosis deterioration. | ZHU Wen DENG Chan Juan XUAN Li Ping DAI Hua Jie ZHAO Zhi Yun WANG Tian Ge LI Mian LU Jie Li XU Yu CHEN Yu Hong WANG Wei Qing BI Yu Fang XU Min | 2020 | Biomedical and Environmental Sciences2020，33，4： | 2 |
| 18 | S Phase Cell Percentage Normalized BrdU Incorporation Rate, a New Parameter for Determining S Arrest显示文摘In this study,a new parameter,S phase cell percentage(S fraction)normalized BrdU(SFN-BrdU)incorporation rate,was introduced to detect S arrest.The results showed a positive linear correlation between the BrdU incorporation rate and the S fraction in unperturbed 16HBE cells.Theoretical analysis indicated that only S | ZHAO Peng FU Juan Ling YAO Bi Yun JIA Yong Rui ZHOU Zong Can | 2014 | Biomedical and Environmental Sciences2014，27，3： | 2 |
| 19 | A New Pyrone Derivative from Fungus Cephalosporium sp. AL031显示文摘A novel pyrone derivative was isolated from the ethyl acetate extract of a culture broth of a strain of the fungus Cephalosporium sp. AL031. Its structure was characterized as 7-hydroxy-9-methoxyl-10-methyl-2H, 4aH, 6H, 10bH-pyrano[5, 6-c][2]benzopyran-2, 6-dione by spectroscopic analysis including IR, MS, 1D and 2D NMR spectra. | Yun Mei BI Xu Bin BI Qian Rong ZHAO Fang A Ye Gao CHEN | 2006 | Chinese Chemical Letters2006，17，3： | 2 |
| 20 | Cancer-testis Antigen OY-TES-1 Expression and Immunogenicity in Hepatocellular Carcinoma显示文摘Summary:Cancer testis(CT)antigens have received particular attention in cancer immunotherapy.OY-TES-1 is a member of CT antigens.This study was to evaluate OY-TES-1 expression and immunogenicity in hepatocelluar carcinoma(HCC).OY-TES-1 mRNA expression was detected in 56 HCC tissues and 5 normal liver tissues by reverse transcriptase PCR(RT-PCR).Of the 56 cases of HCC tissues tested,37 cases had tumor and matched adjacent non-cancer tissues and were subjected to both RT-PCR and quantitative real-time PCR.OY-TES-1 protein was subsequently observed on a panel of tissue microarrays.Sera from patients were tested for OY-TES-1 antibody by ELISA.To identify OY-TES-1 capable of inducing cellular immune response,OY-TES-1 protein was used to sensitize dentritic cells and the cytotoxicity effect was measured in vitro.The results showed that OY-TES-1 mRNA was highly expressed in 41 of the 56(73.21%)HCC tissues,whereas none in 5 normal liver tissues.OY-TES-1 mRNA was frequently expressed not only in HCC tissues(72.97%,27/37),but also in paired adjacent non-cancer tissues(64.86%,24/37).But the mean expression level of OY-TES-1 mRNA in HCC tissues was significantly higher than that in adjacent non-cancer tissues(0.76854 vs.0.09834,P=0.021).Immunohistochemistry showed that OY-TES-1 protein expression was detected in 6 of the 49 cases of HCC tissues,and absent in 9 cases of normal liver and 6 cases of cirrhosis tissues.Seropositivity was detected in 10 of the 45 HCC patients,but not detected in 17 cirrhosis patients and 76 healthy donors.The specific cytotoxic T cells elicited by OY-TES-1 could kill HLA-A2^+HCC cell line which expressed OY-TES-1.The target lysis was mainly HLA class I-dependent and could be blocked by antibodies against monomorphic HLA class I but not HLA class II molecule.In summary,OY-TES-1 expression is upregulated in HCC tissues and can be recognized by humoral and cellular responses,which suggests that OY-TES-1 is an attractive target for tumor immunotherapy in HCC. | Bin LUO Xiang YUN Jing LI Rong FAN Wen-wen GUO Chang LIU Yong-da LIN Ying-ying GE Xia ZENG Shui-qing BI Wei-xia NONG Qing-mei ZHANG Xiao-xun XIE | 2020 | Current Medical Science2020，40，4： | 2 |
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