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| 1 | The kinase AKT1 potentiates the suppressive functions of myeloid-derived suppressor cells in inflammation and cancer显示文摘Myeloid-derived suppressor cells(MDSCs)are a group of heterogeneous cells1 that play crucial negative regulatory roles in immune-associated diseases,including infections,2 cancer,3 transplantation4,and autoimmunity.5 We and others have shown that mTOR signaling and its downstream metabolic pathways regulate MDSC recruitment and function in inflammation and autoimmunity. | Anna Jia Yuexin Wang Yufei Wang Yan Li Qiuli Yang Yejin Cao Ying He Lin Dong Yingjie Dong Yueru Hou Ruoning Wang Yujing Bi Guangwei Liu | 2021 | Cellular & Molecular Immunology2021，18，4： | 7 |
| 2 | Glucocorticoid receptor promotes the function of myeloid-derived suppressor cells by suppressing HIF1α-dependent glycolysis显示文摘Immunomodulatory signaling imposes tight regulations on metabolic programs within immune cells and consequentially determines immune response outcomes.Although the glucocorticoid receptor(GR)has been recently implicated in regulating the function of myeloid-derived suppressor cells(MDSCs),whether the dysregulation of GR in MDSCs is involved in immune-mediated hepatic diseases and how GR regulates the function of MDSCs in such a context remains unknown.Here,we revealed the dysregulation of GR expression in MDSCs during innate immunological hepatic injury(IMH)and found that GR regulates the function of MDSCs through modulating HIF1α-dependent glycolysis.Pharmacological modulation of GR by its agonist(dexamethasone,Dex)protects IMH mice against inflammatory injury.Mechanistically,GR signaling suppresses HIF1αand HIF1α-dependent glycolysis in MDSCs and thus promotes the immune suppressive activity of MDSCs.Our studies reveal a role of GR-HIF1αin regulating the metabolism and function of MDSCs and further implicate MDSC GR signaling as a potential therapeutic target in hepatic diseases that are driven by innate immune cell-mediated systemic inflammation. | Yun Lu Huanrong Liu Yujing Bi Hui Yang Yan Li Jian Wang Zhengguo Zhang Yu Wang Chunxiao Li Anna Jia Linian Han Ying Hu Yong Zhao Ruoning Wang Guangwei Liu | 2018 | Cellular & Molecular Immunology2018，15，6： | 4 |
| 3 | Gather wisdom to overcome barriers:Well-designed nano-drug delivery systems for treating gliomas显示文摘Due to the special physiological and pathological characteristics of gliomas,most therapeutic drugs are prevented from entering the brain.To improve the poor prognosis of existing therapies,researchers have been continuously developing non-invasive methods to overcome barriers to gliomas therapy.Although these strategies can be used clinically to overcome the blood-brain barrier(BBB),the accurate delivery of drugs to the glioma lesions cannot be ensured.Nano-drug delivery systems(NDDS)have been widely used for precise drug delivery.In recent years,researchers have gathered their wisdom to overcome barriers,so many well-designed NDDS have performed prominently in preclinical studies.These meticulous designs mainly include cascade passing through BBB and targeting to glioma lesions,drug release in response to the glioma microenvironment,biomimetic delivery systems based on endogenous cells/extracellular vesicles/protein,and carriers created according to the active ingredients of traditional Chinese medicines.We reviewed these well-designed NDDS in detail.Furthermore,we discussed the current ongoing and completed clinical trials of NDDS for gliomas therapy,and analyzed the challenges and trends faced by clinical translation of these well-designed NDDS. | Jiwei Cui Yuanxin Xu Haiyan Tu Huacong Zhao Honglan Wang Liuqing Di Ruoning Wang | 2022 | Acta Pharmaceutica Sinica B2022，12，3： | 2 |
| 4 | c-Myc Is a Universal Amplifier of Expressed Genes in Lymphocytes and Embryonic Stem Cells显示文摘 | Zuqin Nie Gangqing Hu Gang Wei Kairong Cui Arito Yamane Wolfgang Resch Ruoning Wang Douglas R. Green Lino Tessarollo Rafael Casellas Keji Zhao David Levens | 2012 | Cell2012，，1： | 1 |
| 5 | Identification of a novel astrovirus(astrovirus VA1)associated with an outbreak of acute gastroenteritis显示文摘 | Finkbeiner S R Li Y Ruone S Conrardy C Gregoricus N Toney D Virgin H W Anderson L J VinjéJ Wang D Tong S | 2009 | J Virol2009，83，10： | 1 |
| 6 | Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders显示文摘Despite noteworthy technological progress and promising preclinical trials,brain disorders are still the leading causes of death globally.Extracellular vesicles(EVs),nano-/micro-sized membrane vesicles carrying bioactive molecules,are involved in cellular communication.Based on their unique properties,including superior biocompatibility,non-immunogenicity,and blood-brain barrier(BBB)penetration,EVs can shield their cargos from immune clearance and transport them to specific site,which have attracted increasing interests as novel nanocarriers for brain disorders.However,considering the limitations of native EVs,such as poor encapsulation efficiency,inadequate targeting capability,uncontrolled drug release,and limited production,researchers bioengineer EVs to fully exploit the clinical potential.Herein,this review initially describes the basic properties,biogenesis,and uptake process of EVs from different subtypes.Then,we highlight the application of EVs derived from different sources for personalized therapy and novel strategies to construct bioengineered EVs for enhanced diagnosis and treatment of brain disorders.Besides,it also presents a systematic comparison between EVs and other brain-targeted nanocarriers.Finally,existing challenges and future perspectives of EVs have been discussed,hoping to bolster the research from benchtop to bedside. | Jie Wu Lei Ma Danni Sun Xinru Zhang Jiwei Cui Yingjiang Du Yumiao Guo Xue Wang Liuqing Di Ruoning Wang | 2023 | Nano Research2023，16，2： | 1 |
| 7 | Sierpiński triangles formed by molecules with linear backbones on Au(111)显示文摘Fractals play an important role in mathematics, aesthetic, science, and engineering. The representative Sierpinski-triangle fractals have been successfully constructed by V-shape molecules in experiments. The molecular Sierpinski triangles formed by molecules with linear backbones have been theoretically predicted but not experimentally discovered. To achieve this goal in the experiment, we used[1,1';4',1'';4'',1''']-quaterphenyl-3,40 0-dicarbonitrile molecules as building blocks and employed cobalt atoms as cements, then successfully obtained metal-organic Sierpinski triangles with an order up to 2 on the Au(111) surface. There are twenty-four types of three-fold coordination nodes formed between the metal atom and organic ligands via coordinate interactions. The coexistence of various nodes is responsible for that the highest order of Sierpinski triangles is limited to 2. | Xue Zhang Ruoning Li Na Li Gaochen Gu Yajie Zhang Shimin Hou Yongfeng Wang | 2018 | Chinese Chemical Letters2018，29，6： | 0 |
| 8 | Self-assembly of L-tryptophan on Cu(111) studied by low-temperature scanning tunneling microscopy显示文摘The self-assembly of L-tryptophan on Cu(111) is investigated by an ultrahigh vacuum scanning tunneling microscope(STM) at 4.4 K.When deposited onto the substrate at around 120 K with a coverage of 0.1 monolayer,molecular trimers,tetramers,hexamers,and chains coexist on Cu(111).Then almost all molecules self-assemble into chiral hexamers after being annealed at room temperature.When increasing molecular coverage to the full layer,a new type of chain is observed on the surface.Based on the high-resolution STM images at sub-molecular level,we suggest that the L-tryptophan molecules are present in neutral,zwitterionic or anionic states in these structures. | Qiang Xue Yajie Zhang Ruoning Li Chao Li Na Li Chenyang Yuan Shimin Hou Yongfeng Wang | 2019 | Chinese Chemical Letters2019，30，12： | 0 |
| 9 | Structure transformation from Sierpiński triangles to chains assisted by gas molecules显示文摘Reversible transformations between fractals and perio dic structures are of fundamental importance for understanding the formation mechanism of fractals.Currently,it is still a challenge to controllably achieve such a transformation.We investigate the effect of CO and CO_(2)molecules on Sierpiński triangles(STs)assembled from Fe atoms and 4,4″-dicyano-1,1′:3′,1″-terphenyl(C3PC)molecules on Au surfaces.Using scanning tunneling microscopy,we discover that the gas molecules induce a transition from STs into 1D chains.Based on density functional theory modeling,we propose that the atomistic mechanism involves the transformation of a stable 3-fold coordination Fe(C3PC)_(3)motif to Fe(C3PC)_(4)with an axially bonded CO molecule.CO_(2)causes the structural transformation through a molecular catassembly process. | Chao Li Zhen Xu Yajie Zhang Jie Li Na Xue Ruoning Li Mingjun Zhong Tianhao Wu Yifan Wang Na Li Ziyong Shen Shimin Hou Richard Berndt Yongfeng Wang Song Gao | 2023 | National Science Review2023，10，7： | 0 |
| 10 | Antimicrobial activities and analysis of the crude extract,fractions and compounds from the Lomatogonium rotatum显示文摘This study was evaluated the antimicrobial activities of the crude extract,different fractions,and compounds from the plant of Lomatogonium carinthiacum.The fractions of chloroform and compounds 5,2 and 6 exhibited stronger antimicrobial activities.Compound 5 was the most active while Staphylococcus aureus and Candida albicans were sensitive to all the tested compounds.The existence of a relationship between the xanthone structures and inhibition of microorganism activity.The antimicrobial activity of this plant was reported here firstly.The results provided evidence that the studied plant extract,fractions as well as some of the isolated compounds might be potential sources of new antimicrobial drug. | Ruoning Wang Qin He Qingdi Mu Mengyuan Tan Jing Wang Chongning Lv Hang He Jincai Lu Lingyun Jia | 2020 | Asian Journal of Traditional Medicines2020，15，4： | 0 |
| 11 | Lipoprotein-biomimetic nanostructure enables tumor-targeted penetration delivery for enhanced photo-gene therapy towards glioma显示文摘Glioma is one of the most malignant primary tumors affecting the brain.The efficacy of therapeutics for glioma is seriously compromised by the restriction of blood-brain barrier(BBB),interstitial tumor pressure of resistance to chemotherapy/radiation,and the inevitable damage to normal brain tissues.Inspired by the natural structure and properties of high-density lipoprotein(HDL),a tumor-penetrating lipoprotein was prepared by the fusion tLyP-1 to apolipoprotein A-I-mimicking peptides(D4F),together with indocyanine green(ICG)incorporation and lipophilic small interfering RNA targeted HIF-1α(siHIF)surface anchor for site-specific photo-gene therapy.tLyP-1 peptide is fused to HDL-surface to facilitate BBB permeability,tumor-homing capacity and-site accumulation of photosensitizer and siRNA.Upon NIR light irradiation,ICG not only served as real-time targeted imaging agent,but also provided toxic reactive oxygen species and local hyperthermia for glioma phototherapy.The HIF-1αsiRNA in this nanoplatform downregulated the hypoxia-induced HIF-1αlevel in tumor microenvironment and enhanced the photodynamic therapy against glioma.These studies demonstrated that the nanoparticles could not only efficiently across BBB and carry the payloads to orthotopic glioma,but also modulate tumor microenvironment,thereby inhibiting tumor growth with biosafety.Overall,this study develops a new multifunctional drug delivery system for glioma theranostic,providing deeper insights into orthotopic brain tumor imaging and treatment. | Ruoning Wang Xiaohong Wang Junsong Li Liuqing Di Jianping Zhou Yang Ding | 2022 | Bioactive Materials2022，7，7： | 0 |
| 12 | Activity of xanthones isolated from Lomatogonium rotatum显示文摘Thirteen xanthones were isolated from L.rotatum,which were established as l,8-dihydroxy-3,4,5-trimethoxyxanthone(1);l-hydroxy-3异,8-trimethoxyxanthone(2);8-hydroxy-l,3?5-trimethoxyxaiithone(3);l-hydroxy-3,4,5-trimethoxyxanthone(4);l-hydroxy-3,5,8-trimethoxyxanthone(5);l,4,8-trihydroxy-5,6-dimethoxyxanthone(6);l,3,8-trihydroxy-4,7-dimethoxyxanthone(;7)l,8-dihydroxy-3,7-dimethoxyxanthone(8);l-hydroxy-3,5-dimethoxyxanthone(9);l-hydroxy-2,3,4,5-tetramethoxyxanthone(;10)l-hydroxy-2,3,4,7-tetramethoxyxanthone(11);l,7-dihydroxy-3,8-dimethoxyxanthone(12);rel-l,3,5,8-tetrahydroxy-2,4,6,7-tetrahydroxanthen-9-one(13).Compounds 4,6,7,9,10,11,12 and 13 are reported for the first time from Lomatogonium.Furthermore,the activity of xanthones was assessed. | Qingdi Mu Qin He Mengyuan Tan Ruoning Wang Jing Wang Chongning Lv Hang He Jincai Lu Lingyun Jia | 2020 | Asian Journal of Traditional Medicines2020，15，3： | 0 |
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