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| 1 | Artificial intelligence in gastrointestinal endoscopy:The future is almost here显示文摘Artificial intelligence(AI) enables machines to provide unparalleled value in a myriad of industries and applications. In recent years, researchers have harnessed artificial intelligence to analyze large-volume, unstructured medical data and perform clinical tasks, such as the identification of diabetic retinopathy or the diagnosis of cutaneous malignancies. Applications of artificial intelligence techniques, specifically machine learning and more recently deep learning, are beginning to emerge in gastrointestinal endoscopy. The most promising of these efforts have been in computeraided detection and computer-aided diagnosis of colorectal polyps, with recent systems demonstrating high sensitivity and accuracy even when compared to expert human endoscopists. AI has also been utilized to identify gastrointestinal bleeding, to detect areas of inflammation, and even to diagnose certain gastrointestinal infections. Future work in the field should concentrate on creating seamless integration of AI systems with current endoscopy platforms and electronic medical records, developing training modules to teach clinicians how to use AI tools, and determining the best means for regulation and approval of new AI technology. | Muthuraman Alagappan Jeremy R Glissen Brown Yuichi Mori Tyler M Berzin | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，10： | 14 |
| 2 | Hepatocellular carcinoma in extremely elderly patients:An analysis of clinical characteristics,prognosis and patient survival显示文摘瞄准:80 年或更多与肝细胞癌(HCC ) 识别病人的临床、预示的特征。方法:有 HCC 的 1310 个病人的一个总数在这研究被包括。80 年或更多的 91 个病人在 HCC 的诊断的时候被定义为极其老的组。>
或 = 的 234 个病人 50 年但是不到 60 年被认为是非老的组。结果:两性比率(到女性的男性) 比在非老的组在极其老的组(0.90:1 ) 是显著地更低的(3.9:1, P <
0.001 ) 。为 HBsAg 的积极的率在极其老的组和为显然在极其老的组增加的 HBsAg 和 HCVAb 否定的病人的比例是显著地更低的(P <
0.001 ) 。在下列参数没有有效差量:肿瘤,分级的孩子呸,肿瘤阶段,门静脉血栓形成或腹水的存在,和为 HCVAb 的积极的率的直径和数字。极其老的病人经常没收到外科疗法(P <
0.001 ) 并且他们是更可能的收到保守疗法(P <
0.01 ) 。基于与在二个组之间的全面病人比较的 Kaplan-Meier 方法在幸存曲线没有有效差量。然而,幸存曲线在有阶段 I/II 的极其老的病人是显著地更坏的,上演 I/II,孩子呸分级与非老的组比较的肝硬化。死亡的原因没在病人之中不同,并且大多数盒子甚至在极其老的病人死于肝相关的疾病。结论:在有好肝功能和好表演地位的病人,为 HCC 的好攻击的治疗可能改进幸存率,甚至在极其老的病人。 | Gengo Tsukioka Satoru Kakizaki Naondo Sohara Ken Sato Hitoshi Takagi Hirotaka Arai Takehiko Abe Mitsuo Toyoda Kenji Katakai Akira Kojima Yuichi Yamazaki Toshiyuki Otsuka Yutaka Matsuzaki Fujio Makita Daisuke Kanda Katsuhiko Horiuchi Tetsuya Hamada Mieko Kaneko Hideyuki Suzuki Masatomo Mori | 2006 | World Journal of Gastroenterology2006，12，1： | 7 |
| 3 | Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis显示文摘AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral center.We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013.ECNBI was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or Dilated.Obscure was indicative of inactive disease,while Visible and Dilated were indicative of acute inflammation.This study received Institutional Review Board approval.The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity.The conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active disease.RESULTS:Fifty-two patients were enrolled.There was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,respectively.Compared with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC. | Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada Masashi Misawa Akihiro Yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 4 | MK-0626,a selective DPP-4 inhibitor,attenuates hepatic steatosis in ob/ob mice显示文摘AIM:To investigate the mechanism and in vivo effects of MK-0626,a dipeptidyl peptidase-4 inhibitor,on hepatic steatosis using ob/ob mice.METHODS:We analyzed obese(ob/ob)8-wk-old male mice that had been randomly divided into two groups of ob/ob mice(n=16 each)and were treated with1.5 or 3 mg/kg MK-0626 and two control groups of untreated ob/ob mice and lean littermates(n=16 each).All mice were fed a normal chow diet with or without MK-0626 for either four or eight weeks.Blood samples were collected,and total hepatectomy was performed.RESULTS:The administration of dietary MK-0626 ameliorated the hepatic lipid accumulation in ob/ob micetreated with 3 mg/kg MK-0626(3 MK),P<0.05,vs untreated ob/ob mice(ob/ob).The MK-0626 treatment reduced the serum alanine aminotransferase levels(both treatment groups,P<0.05 vs ob/ob)and glucoses/insulin levels/calculated HOMA scores(1.5 MK,P<0.05vs ob/ob;3 MK,P<0.01 vs ob/ob)and increased the serum adiponectin levels(3 MK,P<0.05 vs ob/ob)in a dose-dependent manner.The MK-0626 treatment increased the m RNA expression of peroxisome proliferator-activated receptorα/microsomal triglyceride transfer protein(1.5 MK,P<0.05 vs ob/ob;3 MK,P<0.01vs ob/ob)but reduced the sterol regulatory element binding transcription factor-1c/fatty acid synthase/stearoyl-Co A desaturase-1(both treatment groups,P<0.01 vs ob/ob).The MK-0626 treatment increased the activity of AMP-activated protein kinase(AMPK)(both treatment groups,P<0.01 vs ob/ob).CONCLUSION:MK-0626 could attenuate hepatic steatosis through enhancing AMPK activity,inhibiting hepatic lipogenic gene expression,enhancing triglyceride secretion from liver and increasing serum adiponectin levels. | Tatsuya Ohyama Ken Sato Yuichi Yamazaki Hiroaki Hashizume Norio Horiguchi Satoru Kakizaki Masatomo Mori Motoyasu Kusano Masanobu Yamada | 2014 | World Journal of Gastroenterology2014，20，43： | 4 |
| 5 | Efficiency of endocytoscopy in differentiating types of serrated polyps显示文摘 | Makoto Kutsukawa Shin-ei Kudo Nobunao Ikehara Yushi Ogawa Kunihiko Wakamura Yuichi Mori Katsuro Ichimasa Masashi Misawa Toyoki Kudo Yoshiki Wada Takemasa Hayashi Hideyuki Miyachi Haruhiro Inoue Shigeharu Hamatani | 2014 | Gastrointestinal Endoscopy2014，，4： | 3 |
| 6 | Artificial intelligence-assisted colonoscopy:A review of current state of practice and research显示文摘Colonoscopy is an effective screening procedure in colorectal cancer prevention programs;however,colonoscopy practice can vary in terms of lesion detection,classification,and removal.Artificial intelligence(AI)-assisted decision support systems for endoscopy is an area of rapid research and development.The systems promise improved detection,classification,screening,and surveillance for colorectal polyps and cancer.Several recently developed applications for AIassisted colonoscopy have shown promising results for the detection and classification of colorectal polyps and adenomas.However,their value for real-time application in clinical practice has yet to be determined owing to limitations in the design,validation,and testing of AI models under real-life clinical conditions.Despite these current limitations,ambitious attempts to expand the technology further by developing more complex systems capable of assisting and supporting the endoscopist throughout the entire colonoscopy examination,including polypectomy procedures,are at the concept stage.However,further work is required to address the barriers and challenges of AI integration into broader colonoscopy practice,to navigate the approval process from regulatory organizations and societies,and to support physicians and patients on their journey to accepting the technology by providing strong evidence of its accuracy and safety.This article takes a closer look at the current state of AI integration into the field of colonoscopy and offers suggestions for future research. | Mahsa Taghiakbari Yuichi Mori Daniel von Renteln | 2021 | World Journal of Gastroenterology2021，27，47： | 2 |
| 7 | Overexpression of NK2 inhibits liver regeneration after partial hepatectomy in mice显示文摘AIM: To investigate the in vivo effects of NK2 on liver regeneration after partial hepatectomy (PH). METHODS: Survival after PH was observed with 21 NK2 transgenic mice and 23 wild-type (WT) mice over 10 d. Liver regeneration was analyzed using histology and immunohistochemistry. Expressions of genes were analyzed using Northern blot analysis, immunoprecipitation and immunoblotting, and reverse transcriptase polymerase chain reaction assay. KaplanMeier method and the log-rank test were used for ahalyzing the survival after PH. Differences in the resultsof immunohistochemistry and percentage of liver regeneration was determined by the Student's t-test. RESULTS: More than half of NK2 transgenic mice died within 48 h after PH. After PH, increased deposition of small lipid droplets in hepatocytes was evident and hepatic proliferation was inhibited in NK2 transgenic mice. The hepatic expression and kinase activity of HGF receptor, c-Met, were unchanged among WT mice and NK2 transgenic mice after PH. The expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) in liver tissues were prolonged in NK2 transgenic mice that died after PH.CONCLUSION: Our findings indicate that overexpression of NK2 inhibits liver regeneration after PH. | Toshiyuki Otsuka Norio Horiguchi Daisuke Kanda Takashi Kosone Yuichi Yamazaki Kazuhisa Yuasa Naondo Sohara Satoru Kakizaki Ken Sato Hitoshi Takagi Glenn Merlino Masatomo Mori | 2005 | World Journal of Gastroenterology2005，11，47： | 2 |
| 8 | Clinicopathological features of small T1 colorectal cancers显示文摘BACKGROUND Although small colorectal neoplasms(<10 mm)are often easily resected endoscopically and are considered to have less malignant potential compared with large neoplasms(≥10 mm),some are invasive to the submucosa.AIM To clarify the clinicopathological features of small T1 colorectal cancers.METHODS Of 32025 colorectal lesions between April 2001 and March 2018,a total of 1152 T1 colorectal cancers resected endoscopically or surgically were included in this study and were divided into two groups by tumor size:a small group(<10 mm)and a large group(≥10 mm).We compared clinicopathological factors including lymph node metastasis(LNM)between the two groups.RESULTS The incidence of small T1 cancers was 10.1%(116/1152).The percentage of initial endoscopic treatment in small group was significantly higher than in large group(<10 mm 74.1%vs≥10 mm 60.2%,P<0.01).In the surgical resection cohort(n=798),the rate of LNM did not significantly differ between the two groups(small 12.3%vs large 10.9%,P=0.70).In addition,there were also no significant differences between the two groups in pathological factors such as histological grade,vascular invasion,or lymphatic invasion.CONCLUSION Because there was no significant difference in the rate of LNM between small and large T1 colorectal cancers,the requirement for additional surgical resection should be determined according to pathological findings,regardless of tumor size. | Yuki Takashina Shin-Ei Kudo Katsuro Ichimasa Yuta Kouyama Kenichi Mochizuki Yoshika Akimoto Yasuharu Maeda Yuichi Mori Masashi Misawa Noriyuki Ogata Toyoki Kudo Tomokazu Hisayuki Takemasa Hayashi Kunihiko Wakamura Naruhiko Sawada Toshiyuki Baba Fumio Ishida Kazunori Yokoyama Mitsuru Daita Tetsuo Nemoto Hideyuki Miyachi | 2021 | World Journal of Clinical Cases2021，9，33： | 1 |
| 9 | Status of occupational health elements in occupational safety and health management systems in Japan显示文摘 | Koji Mori Takashi Kameda Yuichi Kobayashi | 2006 | International Congress Series2006，1294，： | 1 |
| 10 | A novel noninvasive diagnostic method for nonalcoholic steatohepatitis using two glycobiomarkers显示文摘 | Yoshihiro Kamada Masafumi Ono Hideyuki Hyogo Hideki Fujii Yoshio Sumida Kojiroh Mori Saiyu Tanaka Makoto Yamada Maaya Akita Kayo Mizutani Hironobu Fujii Akiko Yamamoto Shinji Takamatsu Yuichi Yoshida Yoshito Itoh Norifumi Kawada Kazuaki Chayama Toshiji Sa | 2015 | Hepatology2015，，5： | 1 |
| 11 | Frequent inactivation of RASSF1A , BLU , and SEMA3B on 3p21.3 by promoter hypermethylation and allele loss in non-small cell lung cancer显示文摘 | Masao Ito Genshi Ito Masashi Kondo Mika Uchiyama Takayuki Fukui Shoichi Mori Hiromu Yoshioka Yuichi Ueda Kaoru Shimokata Yoshitaka Sekido | 2004 | Cancer Letters2004，，： | 1 |
| 12 | The 3rd Global Summit of Research Institutes for Disaster Risk Reduction:Expanding the Platform for Bridging Science and Policy Making显示文摘The Global Alliance of Disaster Research Institutes held its 3rd Global Summit of Research Institutes for Disaster Risk Reduction at the Disaster Prevention Research Institute,Kyoto University,Japan,19–21 March,2017.The Global Alliance seeks to contribute to enhancing disaster risk reduction(DRR) and disaster resilience through the collaboration of research organizations around the world.The summit aim was to expand the platform for bridging science and policy making by evaluating the evidence base needed to meet the expected outcomes and actions of the Sendai Framework for Disaster RiskReduction 2015–2030 and its Science and Technology Roadmap.The summit reflected the international nature of collaborative research and action.A pre-conference questionnaire filled out by Global Alliance members identified323 research projects that are indicative of current research.These were categorized to support seven parallel discussion sessions related to the Sendai Framework priorities for action.Four discussion sessions focused on research that aims to deepen the understanding of disaster risks.Three cross-cutting sessions focused on research that is aimed at the priorities for action on governance,resilience,and recovery.Discussion summaries were presentedin plenary sessions in support of outcomes for widely enhancing the science and policy of DRR. | Andrew Collins Hirokazu Tatano Wilma James Chadia Wannous Kaoru Takara Virginia Murray Charles Scawthorn Jim Mori Sarah Aziz Khalid M.Mosalam Stefan Hochrainer-Stigler Irasema Alcántara-Ayala Elisabeth Krausmann Wei-Sen Li Ana Maria Cruz Subhajyoti Samaddar Tom De Groeve Yuichi Ono Kelvin Berryman Koji Suzuki Mark Ashley Parry Peter McGowran John G.Rees | 2017 | International Journal of Disaster Risk Science2017，8，2： | 1 |
| 13 | Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: A n in vivo prospective pilot study显示文摘 | Katsuro Ichimasa Shin‐ei Kudo Yuichi Mori Kunihiko Wakamura Nobunao Ikehara Makoto Kutsukawa Kenichi Takeda Masashi Misawa Toyoki Kudo Hideyuki Miyachi Fuyuhiko Yamamura Shogo Ohkoshi Shigeharu Hamatani Haruhiro Inoue | 2014 | Digestive Endoscopy2014，，3： | 1 |
| 14 | On-orbit verification of fuel-free attitude control system for spinning solar sail utilizing solar radiation pressure显示文摘 | Ryu Funase Yoji Shirasawa Yuya Mimasu Osamu Mori Yuichi Tsuda Takanao Saiki Jun’ichiro Kawaguchi | 2011 | Advances in Space Research2011，，11： | 1 |
| 15 | Role of nuclear receptor CAR in carbon tetrachloride-induced hepatotoxicity显示文摘AIM: To investigate the precise roles of CAR in CCl4-induced acute hepatotoxicity.METHODS: To prepare an acute liver injury model, CCl4 was intraperitoneally injected in CAR+/+ and CAR-/- mice.RESULTS: Elevation of serum alanine aminotransferase and extension of centrilobular necrosis were slightly inhibited in CAR-/- mice compared to CAR+/+ mice without PB. Administration of a CAR inducer, PB, revealed that CCl4-induced liver toxicity was partially inhibited in CAR-/- mice compared with CAR+/+ mice. On the other hand,androstanol, an inverse agonist ligand, inhibited hepatotoxicity in CAR+/+ but not in CAR-/- mice. Thus, CAR activation caused CCl4 hepatotoxicity while CAR inhibition resulted in partial protection against CCl4-induced hepatotoxicity.There were no differences in the expression of CYP2E1, the main metabolizing enzyme for CCl4, between CAR+/+ and CAR-/- mice. However, the expression of other CCl4-metabolizing enzymes, such as CYP2B10 and 3A11, was induced by PB in CAR+/+ but not in CAR-/- mice. Although the main pathway of CCl4-induced acute liver injury is mediated by CYP2E1, CAR modulates its pathway via induction of CYP2B10 and 3A11 in the presence of activator or inhibitor.CONCLUSION: The nuclear receptor CAR modulates CCl4-induced liver injury via induction of CCl4-metabolizing enzymes in the presence of an activator. Our results suggest that drugs interacting with nuclear receptors such as PB might play critical roles in drug-induced liver injury or drugdrug interaction even though such drugs themselves are not hepatotoxic. | Yuichi Yamazaki Satoru Kakizaki Norio Horiguchi Hitoshi Takagi Masatomo Mori Masahiko Negishi | 2005 | World Journal of Gastroenterology2005，11，38： | 1 |
| 16 | In vivo assessment of a carcinoid tumor using endocytoscopy显示文摘 | Yasuharu Maeda Shin‐ei Kudo Yuichi Mori | 2013 | Digestive Endoscopy2013，，4： | 1 |
| 17 | Magnifying narrow-band imaging of surface patterns for diagnosing colorectalcancer显示文摘 | Masashi Misawa Shin-Ei Kudo Yoshiki Wada Hiroki Nakamura Naoya Toyoshima Seiko Hayashi Yuichi Mori Toyoki Kudo Takemasa Hayashi Kunihiko Wakamura Hideyuki Miyachi Fuyuhiko Yamamura Shigeharu Hamatani | 2013 | Oncology Reports2013，，1： | 1 |
| 18 | Acceleration of the alternating least squares algorithm for principal components analysis显示文摘 | Masahiro Kuroda Yuichi Mori Masaya Iizuka Michio Sakakihara | 2010 | Computational Statistics and Data Analysis2010，，1： | 1 |
| 19 | Extended therapy duration for therapy-refractory hepatitis C patients with genotype 2显示文摘We devised an extended 72-wk peginterferon--2a/ribavirin therapy regimen for the retreatment of highly intractable cases,i.e.,48-wk peginterferon--2b/ribavirin therapy-intractable cases.Although 2 cases achieved a rapid virological response to 72-wk peginterferon--2a/ribavirin therapy,1 case failed to achieve a sustained virological response.Although the reason for this difference in the effectiveness of 72-wk peginterferon--2a/ribavirin therapy between the cases was unclear,the rebound phenomenon of serum transaminase after48-wk peginterferon--2b/ribavirin therapy and the resultant lower viral load compared to that before 48-wk peginterferon--2b/ribavirin therapy might have influenced the treatment outcome.Thus,it may be beneficial to consider the rebound phenomenon of serum transaminase and the changes in viral load resulting from previous interferon-based therapy and then cau-tiously determine the indication and the timing of the administration of 72-wk peginterferon--2a/ribavirin in highly intractable cases.Further studies should be performed to confirm this strategy. | Ken Sato Masatoshi Yanagisawa Hiroaki Hashizume Yuichi Yamazaki Norio Horiguchi Satoru Kakizaki Masatomo Mori | 2013 | World Journal of Gastroenterology2013，19，34： | 0 |
| 20 | Fulminant amebic colitis in a patient with concomitant cytomegalovirus infection after systemic steroid therapy:A case report显示文摘BACKGROUND Amebic colitis is an infection caused by Entamoeba histolytica and most commonly observed in regions with poor sanitation.It is also seen as a sexually transmitted disease in developed countries.While amebic colitis usually has a chronic course with repeated exacerbations and remissions,it may also manifest as a fulminant form that rapidly progresses and leads to severe,life-threatening complications,such as intestinal perforation,peritonitis,and sepsis,that have a high mortality rate.CASE SUMMARY A 68-year-old man was admitted to our hospital with chest pain and acute dyspnea.He was diagnosed with acute coronary syndrome,acute heart failure,and bacterial pneumonia.His respiratory condition worsened despite receiving intensive care and intravenous antibiotics.On the fifth day of hospitalization,he was diagnosed with acute respiratory distress syndrome and was started on steroid therapy.He subsequently developed bloody stools and was diagnosed with cytomegalovirus(CMV)enterocolitis based on biopsy results and a peripheral blood CMV pp65 antigenemia test result.Although we started antiviral therapy with ganciclovir,which was successful in reducing his antigen titers,he continued to have bloody diarrhea.Three weeks after initiation of ganciclovir therapy and six weeks after his admission,the patient died from intestinal perforation.We only posthumously diagnosed him with amebic colitis and CMV enterocolitis based on autopsy findings of transmural necrosis of the entire colon with massive ameba infiltration.CONCLUSION We urge clinicians to consider Entamoeba histolytica infection if severe colitis progresses after steroid therapy.Preemptive treatment is recommended then. | Naoki Shijubou Toshiyuki Sumi Koki Kamada Takeyuki Sawai Yuichi Yamada Tatsuru Ikeda HisashiNakata Yuji Mori Hirofumi Chiba | 2021 | World Journal of Clinical Cases2021，9，15： | 0 |
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