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| 1 | Endocytoscopic narrow-band imaging efficiency for evaluation of inflammatory activity in ulcerative colitis显示文摘AIM:To assess the efficacy of endocytoscopic narrowband imaging(EC-NBI)for evaluating the severity of inflammation in ulcerative colitis(UC).METHODS:This retrospective study was conducted at a single tertiary care referral center.We included UC patients who underwent colonoscopy with endocytoscopy from July 2010 to December 2013.ECNBI was performed,and the images were evaluated by assessing visibility,increased vascularization,and the increased calibers of capillaries and were classified as Obscure,Visible or Dilated.Obscure was indicative of inactive disease,while Visible and Dilated were indicative of acute inflammation.This study received Institutional Review Board approval.The primary outcome measures included the diagnostic ability of EC-NBI to distinguish between active and inactive UC on the basis of histological activity.The conventional endoscopic images were classified according to the Mayo endoscopic score.A score of 0 or 1 indicated inactive disease,whereas a score of 2 indicated active disease.RESULTS:Fifty-two patients were enrolled.There was a strong correlation between the EC-NBI findings and the histological assessment(r=0.871,P<0.01).The sensitivity,specificity,positive predictive value,negative predictive value,and accuracy of EC-NBI for diagnosing acute inflammation were 84.0%,100%,87.1%,100%,and 92.3%,respectively,while those for the Mayo endoscopic score were 100%,40.7%,100%,61.0%,and 69.2%,respectively.Compared with conventional endoscopy,EC-NBI was superior in diagnostic specificity,negative predictive value,and accuracy(P<0.001,P=0.001 and P=0.047,respectively).CONCLUSION:The EC-NBI finding of capillaries in the rectal mucosa was strongly correlated with histological inflammation and aided in the differential diagnosis between active and inactive UC. | Yasuharu Maeda Kazuo Ohtsuka Shin-ei Kudo Kunihiko Wakamura Yuichi Mori Noriyuki Ogata Yoshiki Wada Masashi Misawa Akihiro Yamauchi Seiko Hayashi Toyoki Kudo Takemasa Hayashi Hideyuki Miyachi Fuyuhiko Yamamura Fumio Ishida Haruhiro Inoue Shigeharu Hamatani | 2015 | World Journal of Gastroenterology2015，21，7： | 4 |
| 2 | Efficiency of endocytoscopy in differentiating types of serrated polyps显示文摘 | Makoto Kutsukawa Shin-ei Kudo Nobunao Ikehara Yushi Ogawa Kunihiko Wakamura Yuichi Mori Katsuro Ichimasa Masashi Misawa Toyoki Kudo Yoshiki Wada Takemasa Hayashi Hideyuki Miyachi Haruhiro Inoue Shigeharu Hamatani | 2014 | Gastrointestinal Endoscopy2014，，4： | 3 |
| 3 | Prognosis in patients with hepatocellular carcinoma correlates to mutations of p53 and/or hMSH2 genes 显示文摘 | YANO M HAMATANI K EGUCHI H | 2007 | Eur J Cancer2007，43，6： | 1 |
| 4 | RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose显示文摘 | Hamatani K Eguchi H Ito R | 2008 | Cancer Res2008，68，17： | 1 |
| 5 | Lobularendocervical- glandularhyperplasia might become a precursor of adeno- carcinoma with pylorie gland features 显示文摘 | Ohta Y Suzuki T Hamatani S | 2008 | Pathol Res Pract2008，204，9： | 1 |
| 6 | Cloning and chromosomal mapping of the mouse DNA-dependent protein kinase gene显示文摘 | Hamatani K Matsuda Y Araki R | 1996 | Immunogenetics1996，45，1： | 1 |
| 7 | Optimization of an electron beam remelting of HVOF sprayed alloys and carbides 显示文摘 | Hideki Hamatani Yasunobu Miyazaki | 2002 | Surface and Coatings Technology2002，154，23： | 1 |
| 8 | RET/PTC rearrangements preferentially occurred in papillary thyroid cancer among atomic bomb survivors exposed to high radiation dose显示文摘 | Hamatani K Eguchi H Ito R | 2008 | Cancer Res2008，68，17： | 1 |
| 9 | Appropriate administrationschedule of D - penicillammine for pediatric Wilsonps disease patients based on urinary copper excretion 显示文摘 | Fukuoka N Morita S Hamatani S | 2002 | Yakugaku Zasshi2002，122，8： | 1 |
| 10 | Comprehensive diagnostic ability of endocytoscopy compared with biopsy for colorectal neoplasms: a prospective randomized noninferiority trial显示文摘 | Y. Mori S. Kudo N. Ikehara K. Wakamura Y. Wada M. Kutsukawa M. Misawa T. Kudo Y. Kobayashi H. Miyachi F. Yamamura K. Ohtsuka H. Inoue S. Hamatani | 2013 | Endoscopy2013，，02： | 1 |
| 11 | Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation显示文摘 | Hamatani T Daikoku T Wang H | 2004 | 101(28):10326- 103312004，101，10： | 1 |
| 12 | Age-associ- ated alteration of gene expression patterns in mouse oocytes 显示文摘 | HAMATANI T FALCO G CARTER M G | 2004 | Human Molecular Genetics2004，13，19： | 1 |
| 13 | Role of β1 intergrins in human endornetrium and decid-ua during implantation显示文摘 | Yoshimura Y Miyakoshi K Hamatani T | 1998 | Horm Res1998，50，2： | 1 |
| 14 | Diagnosis of colorectal lesions with a novel endocytoscopic classification – a pilot study显示文摘 | S-E Kudo K. Wakamura N. Ikehara Y. Mori H. Inoue S. Hamatani | 2011 | Endoscopy2011，，10： | 1 |
| 15 | Age -associated alteration of gene expression patterns in mouse oocytes 显示文摘 | Hamatani T Falco G Carter MG | 2004 | Hum Mol Genet2004，13，： | 1 |
| 16 | Optimization of an electron beam remelting of HVOF sprayed alloys and carbides 显示文摘 | HIDEKI HAMATANI YASUNOBU MIYAZAKI | 2002 | Surface and Coatings Technology2002，154，： | 1 |
| 17 | Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation显示文摘 | Hamatani T Daikoku T Wang H | 2004 | Acad Sc12004，101，10： | 1 |
| 18 | Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immune deficiency mice显示文摘 | Araki R Fujimori A Hamatani K | 1997 | Proc Natl Acad Sci USA1997，94，6： | 1 |
| 19 | Dynamics of global gene expression changes during mouse preimplantation development显示文摘 | HAMATANI T GARTER M G SHAROV A A | 2004 | Development of Cell2004，6，1： | 1 |
| 20 | Nonsense mutation at Tyr-4046 in the DNA-dependent protein kinase catalytic subunit of severe combined immunodeficiency mice显示文摘 | Araki R Fujimori A Hamatani K Mita K Saito T Mori M | 1997 | Proc Natl Acad Sci USA1997，94，6： | 1 |
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