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| 1 | Glucosylated caffeoylquinic acid derivatives from the flower buds of Lonicera japonica显示文摘Three new glucosylated caffeoylquinic acid isomers(1–3),along with six known compounds,have been isolated from an aqueous extract of the flower buds of Lonicera japonica.Structures of the new compounds were determined by spectroscopic and chemical methods as()-4-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(1),()-3-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(2),and()-5-O-(4-O-β-D-glucopyranosylcaffeoyl)quinic acid(3),respectively.In the preliminary in vitro assays,two known compounds methyl caffeate and 2?-O-methyladenosine showed inhibitory activity against Coxsackie virus B3 with IC50 values of 3.70 μmol/L and 6.41 μmol/L and SI values of 7.8 and 12.1,respectively. | Yang Yu Zhibo Jiang Weixia Song Yongchun Yang Yuhuan Li Jiandong Jiang Jiangong Shi | 2015 | Acta Pharmaceutica Sinica B2015，5，3： | 23 |
| 2 | Sulfur-enriched alkaloids from the root of Isatis indigotica显示文摘Five new sulfur-enriched alkaloids isatithioetherins A–E(1–5), and two pairs of scalemic enantiomers(t)-and( à)-isatithiopyrin B(6 a and 6 b) and isoepigoitrin and isogoitrin(7 a and 7 b), along with the known scalemic enantiomers epigoitrin and goitrin(8 a and 8 b), were isolated and characterized from an aqueous extract of the Isatis indigotica roots. Their structures were determined by extensive spectroscopic data analysis, including 2 D NMR and theoretical calculations of electronic circular dichroism(ECD) spectra based on the quantum-mechanical time-dependent density functional theory(TDDFT). Compounds 1–5 represent a novel group of sulfur-enriched alkaloids, biogenetically originating from stereoselective assemblies of epigoitrin-derived units. Isolation and structure characterization of 6 a and 6 b support the postulated biosynthetic pathways for the diastereomers 9 a and 9 b via a rare thio-Diels–Alder reaction. Compounds 2 and 4 showed antiviral activity against the influenza virus A/Hanfang/359/95(H3 N2, IC500.60 and 1.92 μmol/L) and the herpes simplex virus 1(HSV-1, IC503.70 and 2.87 μmol/L), and 2 also inhibited Coxsackie virus B3(IC500.71 μmol/L).& 2018 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V. This is an open access article under the CC BY-NC-ND license(http://gffzzeb6f7f563f66445dhnv5wcncppw6c6o5k.ffgz.tsg.suse.edu.cn/licenses/by-nc-nd/4.0/). | Qinglan Guo Chengbo Xu Minghua Chen Sheng Lin Yuhuan Li Chenggen Zhu JiANDong Jiang Yongchun Yang Jiangong Shi | 2018 | Acta Pharmaceutica Sinica B2018，8，6： | 8 |
| 3 | Incidence and clinical characteristics of inflammatory bowel disease in a developed region of G uangdong P rovince, C hina: A prospective population‐based study显示文摘 | Zhirong Zeng Zhenhua Zhu Yuyu Yang Weishan Ruan Xiabiao Peng Yuhuan Su Lin Peng Jinquan Chen Quan Yin Chao Zhao Haihua Zhou Shuai Yuan Yuantao Hao Jiaming Qian Siew Chien Ng Minhu Chen Pinjin Hu | 2013 | J Gastroenterol Hepatol2013，，7： | 5 |
| 4 | Comparative study on virus shedding patterns in nasopharyngeal and fecal specimens of COVID-19 patients显示文摘Dear Editor,An acute viral pneumonia(COVID-19),caused by the novel coronavirus known as SARS-CoV-2,was first identified during December 2019 in China(Zhu et al.,2020).SARSCoV-2 was found to be highly transmissible in humans(Wang et al.,2020)and is now a pandemic spreading to over 140 countries and causing over 150,000 infections and 6,000 deaths as of March 15,2020.Diagnosis is critical for confirmation and treatment of COVID-19.Currently the primary criterion for diagnosis of COVID-19 is viral RNA detection for respiratory samples.Recently,two studies on virus loads in clinical samples reported that viral loads in nasal and throat swabs and sputum specimens peaked at 3–7 days after illness onset(d.a.o.)and virtually disappeared before 15 d.a.o.(Pan et al.,2020;Zou et al.,2020).Another study showed that the median duration of virus shedding in throat swabs was 20 d.a.o.in survivors and was detectable until death in non-survivors(Zhou et al.,2020).Additionally,live viruses have been isolated in the feces and urine samples of COVID-19 patients.However,the viral dynamics in these types of specimens has not yet been clearly elucidated,as well as comparative studies on virus shedding in the upper respiratory,intestinal,and urinary tracts. | Ning Zhang Yuhuan Gong Fanping Meng Yi Shi Jun Wang Panyong Mao Xia Chuai Yuhai Bi Penghui Yang Fusheng Wang | 2021 | Science China(Life Sciences)2021，64，3： | 5 |
| 5 | Catalytic microwave assisted pyrolysis of aspen显示文摘The effect of catalysts on the microwave pyrolysis of aspen pellets was studied.A range of chlorides,nitrates and metal-oxides were added at 2%of the aspen mass(air dry aspen pellet weight basis).Chlorides in particular were found to favor liquid yield,especially the yield of water phase residue.Average liquid yield with added chlorides was 41%mass of the total biomass input,compared to 35%mass without catalyst.Metal-oxides were found to favor pyrolysis heavy oil,and thus total oil yield,since the yield of light oils seemed to be fairly constant.Nitrates were found to favor pyrolysis gas production.Pure light oils and light oils blended with diesel were found to be a potential diesel fuel substitute. | Johannes Moen Changyan Yang Bo Zhang Hanwu Lei Kevin Hennessy Yiqin Wan Zhiping Le Yuhuan Liu Paul Chen Roger Ruan | 2009 | International Journal of Agricultural and Biological Engineering2009，2，4： | 5 |
| 6 | Accuracy Improvement of GTEM Cells for EMI Noise Measurement显示文摘针对吉赫兹横电磁波fgigahertz transverse electromagnetic,GTEMl小室用于辐射电磁干扰(electromagnetic interference,EMI)测量精度不高的问题,提出一种GTEM小室测量EMI噪声的的校准方法,采用多项式模型提取辐射噪声,利用方差对该模型的计算误差进行补偿,并基于高阶矩分析校准后的GTEM小室和3m电波暗室测量辐射电场值分布的相似性。实验结果表明,采用该文所提方法可显著提高GTEM小室的测量精度,验证了方法的有效性。 | ZHAO Yang RONG Rong ZHANG Yuhuan YAN Wei ZHAO Bo WANG Enrong QIU Xiaohui | 2012 | 中国电机工程学报2012，32，27： | 5 |
| 7 | Aircraft Measurements of Cloud–Aerosol Interaction over East Inner Mongolia显示文摘To investigate the potential effects of aerosols on the microphysical properties of warm clouds, airborne observational data collected from 2009 to 2011 in Tongliao, Inner Mongolia, China, were statistically analyzed in this study. The results demonstrated that the vertical distribution of the aerosol number concentration(N_a) was similar to that of the clean rural continent. The average aerosol effective diameter(D_e) was maintained at approximately 0.4 μm at all levels. The data obtained during cloud penetrations showed that there was a progressive increase in the cloud droplet concentration(N_c) and liquid water content(LWC) from outside to inside the clouds, while the Nawas negatively related to the Ncand LWC at the same height. The fluctuation of the N_a, Ncand LWC during cloud penetration was more obvious under polluted conditions(Type 1) than under clean conditions(Type 2). Moreover, the wet scavenging of cloud droplets had a significant impact on the accumulation mode of aerosols, especially on particles with diameters less than 0.4 μm. The minimum wet scavenging coefficient within the cloud was close to 0.02 under Type 1 conditions, while it increased to 0.1 under Type 2 conditions,which proved that the cloud wet scavenging effect under Type 1 conditions was stronger than that under Type 2 conditions.Additionally, cloud droplet spectra under Type 1 conditions were narrower, and their horizontal distributions were more homogeneous than those under Type 2 conditions. | Yuhuan Lü Hengchi LEI Jiefan YANG | 2017 | Advances in Atmospheric Sciences2017，34，8： | 4 |
| 8 | Investigation and Reduction on Conducted Electromagnetic Interference Noise Mechanism for Complex Power Electronics Systems显示文摘针对复杂电子系统产生的传导EMI噪声,该文分别利用电偶极子模型、电路分析方法和散射参数方法提出了3种传导EMI噪声理论模型及其等效电路,包括因串扰引起的传导噪声模型,因接地不良引起的传导噪声模型,以及因PCB线缆阻抗失配引起的传导噪声模型。同时,还设计了一种串扰扼流圈以有效抑制因串扰引起的传导EMI噪声。实验结果表明,采用文中方法,某型商用车载导航和刷卡器能够通过GB 9254标准测试,噪声抑制效果分别可达44.8和29.28 dB V,从而验证了方法的有效性。 | YAN Wei ZHAO Yang WANG Ertrong ZHANG Yuhuan QIU Xiaohui SUN Hongyan CHEN Xueli | 2012 | 中国电机工程学报2012，32，30： | 4 |
| 9 | Fractionation and characterization of bio-oil from microwave-assisted pyrolysis of corn stover显示文摘Bio-oil from thermochemical conversion of biomass is a complex mixture of polar and non-polar compounds,and cannot be used directly as a combustion engine fuel due to its low heating value,high viscosity,chemical instability,and incomplete volatility.Mixed-solvent extraction was developed to fractionate bio-oils from microwave-assisted pyrolysis of corn stover to produce light oil(a mixture of light and inflammable fuel oil components from bio-oil)with low viscosity and low combustion residue,and high value chemicals.Different fractions from bio-oil were characterized using GC/MS and TG,and a major chemical(hydroxy-butanedioic acid diethyl ester)was separated. | Changyan Yang Bo Zhang Johannes Moen Kevin Hennessy Yuhuan Liu Xiangyang Lin Yiqin Wan Hanwu Lei Paul Chen Roger Ruan | 2010 | International Journal of Agricultural and Biological Engineering2010，3，3： | 4 |
| 10 | Microwave-assisted pyrolysis of vegetable oil soapstock:Comparative study of rapeseed,sunflower,corn,soybean,rice,and peanut oil soapstock显示文摘In this study,the effects of catalytic temperature and the type of soapstock on products from microwave-assisted pyrolysis were investigated.HZSM-5 was used as the catalyst to study the pyrolysis of six different soapstocks at 200℃,300℃,and 400℃ catalytic temperature.Results showed that the bio-oil yields initially increased and then decreased with the increase in catalytic temperature.When the catalytic temperature was 300℃,the bio-oil reached up to the maximum value(65.8 wt.%).Findings indicated that the composition of bio-oil was related to the degree of unsaturation of fatty acids sodium in the soapstocks.In the case of saturated fatty acid sodium,a series of alkanes was formed,whereas the pyrolysis of monounsaturated fatty acid sodium resulted mainly in cycloalkanes,the cycloalkenes obtained from bio-oil was produced by polyunsaturated fatty acid sodium. | Yunpu Wang Shumei Zhang Qiuhao Wu Dengle Duan Yuhuan Liu Roger Ruan Guiming Fu Leilei Dai Lin Jiang Zhenting Yu Zihong Zeng Xiaojie Tian Xiuhua Yang | 2019 | International Journal of Agricultural and Biological Engineering2019，12，6： | 3 |
| 11 | Airborne Observations of Cloud Condensation Nuclei Spectra and Aerosols over East Inner Mongolia显示文摘A set of vertical profiles of aerosol number concentrations, size distributions and cloud condensation nuclei(CCN)spectra was observed using a passive cloud and aerosol spectrometer(PCASP) and cloud condensation nuclei counter, over the Tongliao area, East Inner Mongolia, China. The results showed that the average aerosol number concentration in this region was much lower than that in heavily polluted areas. Monthly average aerosol number concentrations within the boundary layer reached a maximum in May and a minimum in September, and the variations in CCN number concentrations at different supersaturations showed the same trend. The parameters c and k of the empirical function N = c S^kwere 539 and1.477 under clean conditions, and their counterparts under polluted conditions were 1615 and 1.42. Measurements from the airborne probe mounted on a Yun-12(Y12) aircraft, together with Hybrid Single-Particle Lagrangian Integrated Trajectory model backward trajectories indicated that the air mass from the south of Tongliao contained a high concentration of aerosol particles(1000–2500 cm^(-3)) in the middle and lower parts of the troposphere. Moreover, detailed intercomparison of data obtained on two days in 2010 indicated that the activation efficiency in terms of the ratio of NCCNto N_a(aerosols measured from PCASP) was 0.74(0.4 supersaturations) when the air mass mainly came from south of Tongliao, and this value increased to 0.83 on the relatively cleaner day. Thus, long-range transport of anthropogenic pollutants from heavily polluted mega cities,such as Beijing and Tianjin, may result in slightly decreasing activation efficiencies. | Jiefan YANG Hengchi LEI Yuhuan Lü | 2017 | Advances in Atmospheric Sciences2017，34，8： | 3 |
| 12 | Epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing,China显示文摘Importance:Within the coronavirus disease 2019(COVID-19)global pandemic,more attention is warranted for whether this new infectious disease has unique manifestations in children.Objective:To retrospectively determine the epidemiological and clinical characteristics of 35 children with COVID-19 in Beijing,China.Methods:We collected data for 35 children diagnosed with COVID-19 who were admitted to Beijing Ditan Hospital from January 2020 to June 2020,and analyzed their epidemiological characteristics,clinical manifestations,laboratory examinations,chest imaging findings,treatments,and outcomes.Results:The children comprised 18 boys(51.4%)and 17 girls(48.6%)aged 6 months to 15 years.All patients had clear epidemiological history,with family clusters accounting for 28 cases(80.0%)and clear tracing of exposure to high epidemic areas in the remaining 7 cases(20.0%).Four(11.4%)patients were classified as asymptomatic,17(48.6%)as acute upper respiratory infection,and 14(40.0%)as mild pneumonia,with no severe or critical cases.Clinical manifestations were mild,including fever in 18(51.4%),cough in 14(40.0%),and nausea and diarrhea in 7(20.0%)patients.White blood cell count was mostly normal(26 cases,74.3%)or decreased(7 cases,20.0%);lymphocyte percentage was increased in 24(68.7%);neutrophil percentage was decreased in 25(71.4%);alanine aminotransferase was increased in 3(8.6%);and serum potassium was decreased in 4(11.4%).Time to negative viral nucleic acid testing was 2-42 days(mean:14.0±9.4 days).Chest imaging examination revealed that 20 patients(57.1%)had different forms of lung inflammation.Treatment was mainly isolation and nutritional support.Eleven patients were treated with interferon atomization inhalation.No patients required oxygen therapy.All 35 children were cured and discharged.Length of hospital stay was 9-54 days(mean:25.4±13.8 days).During regular follow-up after discharge,5 children showed positivity again in the viral nucleic acid test and were re-hospitalized for observation and treatment.The mean length of re-hospitalization stay was 10.8 days.Interpretation:Children with COVID-19 mainly become infected within their family,and children of all ages are generally susceptible.The disease in children is mostly mild and the prognosis is good.Nucleic acid tests in some patients become positive again after discharge,suggesting that it is of great significance to carry out centralized isolation medical observations and active nucleic acid tests in close contacts for early detection of patients and routine epidemic prevention and control. | Ming He Caiying Wang Lin Xu Huimin Zhang Yuhuan Liu Yang Zhao Shuxin He Yanlan Zhang Hongling Yang Yang Liu Min Miao Zhihai Chen Lin Pang | 2020 | Pediatric Investigation2020，4，4： | 3 |
| 13 | Geochemical characteristics of hadal sediment in the northern Yap Trench显示文摘Two sediment cores were retrieved in the hadal zone of the Yap Trench,and their concentrations of six major elements Mg,Al,Ca,Ti,Mn and Fe and nine trace elements Sr,Ba,Pb,V,Cr,Co,Ni,Cu and Zn were determined in inductively coupled plasma atomic emission spectrometry(ICP-AES).According to the vertical distribution profiles of the 15 elements,the correlation of their concentrations,the ratios of Ni/Co,V/Cr,Fe/Al,and Ti/Al,and morphological characteristics of the sediment samples,the implications of the depositional environment and the sediment provenance were analyzed.The results show that the ratio of Ni/Co in all depths of the two sediment cores were below 5,and the ratio of V/Cr were lower than 2,indicating that the depositional environment of the hadal zone in the trench was oxidative and might have inflow of the Antarctic bottom oxygen-rich water.The sediment samples on the eastern side of the trench were siliceous mud mainly composed of diatoms,radiolarian,and sponge needles from surface to deep layer.The vertical profile of the elements,the concentration of TOC and the fossil record indicated that the sediment sample from station Dive113 was well mixed from surface to bottom layer.Based on the correlation of concentrations of the elements,the morphological characteristics of the sediment,and the ratios of Fe/Al and Ti/Al,we inferred that the sediment in the hadal zone of the trench had terrestrial,volcanic,biological,and authigenic sources.Major source of the sediment in the eastern side of the trench were terrestrial;whereas the sediment in the western side of the trench received more volcaniclastic input. | HUANG Yuhuan SUN Chengjun YANG Guipeng YUE Xin’an JIANG Fenghua CAO Wei YIN Xiaofei GUO Chaonan NIU Jiaohong DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 3 |
| 14 | Distribution characteristics of lipids in hadal sediment in the Yap Trench显示文摘In this study,cored sediment samples collected by the Jiaolong Submersible at 6779 m depth from the hadal zone of the Yap Trench in May 2016 were sliced in 1-cm interval from top to bottom,and lipids in each sediment layer were quantitatively and qualitatively analyzed.The vertical distribution profiles of the lipids in the sediment sample,their main existing forms,and their possible sources were investigated.The results show that the concentration of lipid in the surface sediment was the highest with the carbon number from 12 to 27,dominated by medium and short-chain lipids.The total concentration of fatty acids in surface sediment was much higher than those in the offshore and deep-sea areas,being up to 325.77μg/g due to the funnel effect caused by the“V”terrain of the trench.Fatty acid 18:0 was the most abundant lipids in the sediment sample.Abnormal high concentrations of fatty acid 18:1ω7 and alkanes indicated the existence of hydrothermal fluids in the study area.In addition,saturated fatty acids and monounsaturated fatty acids existed mainly in free form,and polyunsaturated fatty acids existed mainly in bound form.Most of the alkanes were in bound form,and their major source was autochthounous input.The carbon number of alcohols in the sediment sample ranged from 12 to 20,mainly existed in bound form.The source of fatty acids was mainly autochthonous input,and the neutral lipids had both marine and terrestrial origin.This is the first study of lipids in hadal sediment of the Yap Trench.The results will promote deeper understanding of organic carbon cycle in marine environment. | YAN Yixin SUN Chengjun HUANG Yuhuan CAO Wei JIANG Fenghua YANG Guipeng DING Haibing | 2020 | Journal of Oceanology and Limnology2020，38，3： | 2 |
| 15 | C60intercalating Ti_(3)C_(2)T_(x) MXenes assisted by γ-cyclodextrin for electromagnetic interference shielding films with high stability显示文摘Ti_(3)C_(2)T_(x)MXenes with excellent metallic conductivity and flexibility have shown a promising prospect as electromagnetic interference(EMI) shielding materials. Ultrathin, hierarchical hybrid films were fabricated by using C60intercalating Ti_(3)C_(2)T_(x)MXenes with the assistance of water-soluble γ-cyclodextrin(CD). The C_(60)/CD complex was obtained by high-speed vibration milling using hydrophilic CD as dispersing agent. After thermal annealing treatment, the obtained hybrid film exhibited excellent EMI shielding(53.52±0.43 dB), hydrophobicity(water contact angle: 93.7°) and mechanical stability(over 0.9 million bending times). Taking advantage of the antioxidant of C_(60), the chemical durability of Ti_(3)C_(2)T_(x) MXenes based hybrid films was also improved as expected. These results indicate that the well-designed hierarchical hybrid films with the intercalation of C_(60) have promising potential for high-performance EMI shielding applications. | Kunpeng Qian Shuang Li Jianhui Fang Yuhuan Yang Shaomei Cao Miao Miao Xin Feng | 2022 | Journal of Materials Science & Technology2022，，32： | 2 |
| 16 | Inhibitory effect on protein kinase Cθ by Crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes显示文摘 | Lina Yang Zhiyu Qian Hui Ji Ruhui Yang Yuhuan Wang Liang Xi Liang Sheng Bohua Zhao Xiaoming Zhang | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 17 | CpG or IFN-α are more potent adjuvants than GM-CSF to promote anti-tumor immunity following idiotype vaccine in multiple myeloma显示文摘 | Sungyoul Hong Jianfei Qian Haiyan Li Jing Yang Yong Lu Yuhuan Zheng Qing Yi | 2012 | Cancer Immunology, Immunotherapy2012，，： | 1 |
| 18 | Effectiveness and safety of Pingxiao capsule(平消胶囊)as adjuvant therapy in treatment of breast cancer:a systematic review and Meta-analysis显示文摘OBJECTIVE:To systematically review the effectiveness and safety of Pingxiao capsule(平消胶囊)adjuvant chemotherapy in the treatment of breast cancer.METHODS:A total of 8 databases including the Cochrane Library,PubMed,EMBASE,Engineering Index,Chinese Biomedical Literature Database,Wanfang database,China National Knowledge Infrastructure Database,and China Science and Technology Journal Database were searched for the Randomized Controlled Trials(RCTs)of Pingxiao capsule combined with chemotherapy in the treatment of breast cancer published before June 2022.Two researchers independently screened the literature,extracted data,and evaluated the risk of bias.R language was used for estimating risks of bias of included studies,data analysis,and plotting.RESULTS:A total of 15 RCTs involving 1272 patients were included in this study.Meta-analysis results indicated that compared with chemotherapy alone,Pingxiao capsule combined with chemotherapy could significantly improve breast cancer patients'objective response rate of breast cancer patients[rate ratio(RR)=1.35,95%confidence interval(CI)(1.12,1.63),P=0.0017],the disease control rate[RR=1.16,95%CI(1.08,1.25),P<0.0001],the quality of life[RR=1.42,95%CI(1.16,1.74),P=0.007],and the level of the immune cells[CD3+:standardized mean difference(SMD)=1.42,95%CI(0.76,2.09),P<0.001;CD4+:SMD=1.18,95%CI(0.70,1.66),P<0.001].In addition,Pingxiao capsule combined with chemotherapy can also significantly reduce CD8+level(P<0.0001)and reduce the symptoms of decreased white blood cell count[SMD=0.62,95%CI(0.39,0.85),P<0.0001],and the occurrence of adverse reactions such as gastrointestinal adverse reactions and limb pain(P<0.05).CONCLUSIONS:Pingxiao capsule can significantly improve the efficacy of chemotherapy,the quality of life and immune function of patients,and reduce the clinical side effects caused by chemotherapy.However,highquality randomized clinical trials with large samples are required for further verification of these results. | YANG Yuqing CHEN Yuhuan LI Chunxiao LING Xiao WANG Panpan GUO Jing ZHANG Yingying | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 1 |
| 19 | Microwave-assisted pyrolysis of biomass: Catalysts to improve product selectivity显示文摘 | Yiqin Wan Paul Chen Bo Zhang Changyang Yang Yuhuan Liu Xiangyang Lin Roger Ruan | 2009 | Journal of Analytical and Applied Pyrolysis2009，，1： | 1 |
| 20 | Th9 cells promote antitumor immune responses in vivo显示文摘 | Lu Yong Hong Sungyoul Li Haiyan Park Jungsun Hong Bangxing Wang Lijuan Zheng Yuhuan Liu Zhiqiang Xu Jingda He Jin Yang Jing Qian Jianfei Yi Qing | 2012 | EN2012，，11： | 1 |
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