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| 1 | A complete sequence and comparative analysis of a SARS-associated virus(Isolate BJ01)显示文摘The genome sequence of the Severe Acute Respiratory Syndrome (SARS)-associated virus provides essential information for the identification of pathogen(s), exploration of etiology and evolution, interpretation of transmission and pathogenesis, development of diagnostics, prevention by future vaccination, and treatment by developing new drugs. We report the complete genome sequence and comparative analysis of an isolate (BJ01) of the coronavirus that has been recognized as a pathogen for SARS. The genome is 29725 nt in size and has 11 ORFs (Open Reading Frames). It is composed of a stable region encoding an RNA-dependent RNA polymerase (composed of 2 ORFs) and a variable region representing 4 CDSs (coding sequences) for viral structural genes (the S, E, M, N proteins) and 5 PUPs (putative uncharacterized proteins). Its gene order is identical to that of other known coronaviruses. The sequence alignment with all known RNA viruses places this virus as a member in the family of Coronaviridae. Thirty putative substitutions have been identified by comparative analysis of the 5 SARS- associated virus genome sequences in GenBank. Fifteen of them lead to possible amino acid changes (non-synonymous mutations) in the proteins. Three amino acid changes, with predicted alteration of physical and chemical features, have been detected in the S protein that is postulated to beinvolved in the immunoreactions between the virus and its host. Two amino acid changes have been detected in the Mprotein, which could be related to viral envelope formation. Phylogenetic analysis suggests the possibility of non-human origin of the SARS-associated viruses but provides noevidence that they are man-made. Further efforts should focus on identifying the etiology of the SARS-associated virus and ruling out conclusively the existence of otherpossible SARS-related pathogen(s). | QIN E'de ZHU Qingyu YU Man FAN Baochang CHANG Guohui SI Bingyin YANG Bao PENG Wenming JIANG Tao LIU Bohua DENG Yongqiang LIU Hong ZHANG Yu WANG Cui LI Yuquan GAN Yonghua LI Xiaoyu L Fushuang TAN Gang CAO Wuchun, YANG Ruifu Institute of Microbiology and Epidemiology, Chinese Academy of Military Medical Sciences, Beijing 100071, China WANG Jian, LI Wei, XU Zuyuan, LI Yan, WU Qingfa, LIN Wei, CHEN Weijun, TANG Lin, DENG Yajun, HAN Yujun, LI Changfeng, LEI Meng, LI Guoqing, LI Wenjie, L Hong, SHI Jianping, TONG Zongzhong, ZHANG Feng, LI Songgang, LIU Bin, LIU Siqi, DONG Wei, WANG Jun, Gane K-S Wong, YU Jun & YANG Huanming* Beijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300 National Center for Genome Information, Beijing 101300, China | 2003 | Chinese Science Bulletin2003，48，10： | 121 |
| 2 | Change of Cultivated Land and Its Implications on Food Security in China显示文摘The population growth and demand for high living standard not only increase food demand but also cause more loss of the limited cultivated land resources.Cultivated land loss caused by disasters and the implementation of the “Conversion of Cropland to Forest or Grassland” project make this situation even worse in China.Thus,there is a problem to be solved imminently that to what extent the cultivated land can guarantee food security of China.Based on time-series data on food production and cultivated land area from 1989 to 2003 and other research results,this paper constructs quality index of cultivated land according to different land quality.Regression models are adopted to predicate changes of main factors from 2004 to 2030,which have great effect on cultivated land area or grain productivity,and verify accuracy with coefficient of determination(R2).Nine results were got according to three scenarios of decreasing rate of population growth rate and three cases of urban and rural built-up area per capita.There results show that China’s food supply can only be maintained at a low to middle level of 370-410kg per capita,that is,China has enough land productivity to meet primary demand of food independently.However,it cannot reach the safe target of 500kg per capita if there is no breakthrough in breeding or no remarkable improvement of irrigation works,when the grain self-sufficiency maintains no less than 80%.To breed productive crops and to improve land productivity by meliorating low quality cultivated land are appropriate measures to shrink the gap between food demand and supply.The results may offer helpful information for the formulation of policies on population growth,land use,protection of cultivated land. | YU Bohua LU Changhe | 2006 | Chinese Geographical Science2006，16，4： | 19 |
| 3 | A finite element modeling of posterior atlantoaxial fixation and biomechanical analysis of C2 intralaminar screw fixation显示文摘 | Ma Xuexiao Peng Xianbo Xiang Hongfei Zhang Yan Zhang Guoqing Chen Bohua | 2014 | Chinese Medical Journal2014，，7： | 15 |
| 4 | Production potential and yield gaps of summer maize in the Beijing-Tianjin-Hebei Region显示文摘庄稼潜力生产率是科学地估价庄稼生产的一个关键索引并且打支持人口的能力。这研究第一与 40 年的气象学的数据用 WOFOST 模型在 Beijing-Tianjin-Hebei (BTH ) 区域模仿了潜力和夏天玉米的 waterlimited 产量,然后在县水平基于统计数据分析了在实际、潜在的收益之间的收益差距。潜力和在 BTH 区域的夏天玉米的水有限产量是 68548789 kg/hm2 和 64348741 kg/hm2,并且为整个区域的加权的一般水准分别地是 7861 kg/hm2 和 7185 kg/hm2。模仿的收益逐渐地特别地处于气候的条件与变化从东北减少到西南温度和降水。潜在的产量的年度变化比东北部分在中央、南部的部分是更高的。把产量比作潜力,水有限收益有变化(CV ) 的更高的系数,因为降水效果。夏天玉米的实际收益是 25378730 kg/hm2,地区性在 5582 点平均 kg/hm2,大约 70% 潜力让步,暗示这个区域有空间由改进庄稼管理和灌溉系统增加收益。 | WANG Tao LU Changhe YU Bohua | 2011 | Journal of Geographical Sciences2011，21，4： | 13 |
| 5 | Environmental impact and health risk assessment of volatile organic compound emissions during different seasons in Beijing显示文摘Volatile organic compounds(VOCs)are major contributors to air pollution.Based on the emission characteristics of 99 VOCs that daily measured at 10 am in winter from 15 December 2015 to 17 January 2016 and in summer from 21 July to 25 August 2016 in Beijing,the environmental impact and health risk of VOC were assessed.In the winter polluted days,the secondary organic aerosol formation potential(SOAP)of VOC(199.70±15.05 mg/m^3)was significantly higher than that on other days.And aromatics were the primary contributor(98.03%)to the SOAP during the observation period.Additionally,the result of the ozone formation potential(OFP)showed that ethylene contributed the most to OFP in winter(26.00%and 27.64%on the normal and polluted days).In summer,however,acetaldehyde was the primary contributor to OFP(22.00%and 21.61%on the normal and polluted days).Simultaneously,study showed that hazard ratios and lifetime cancer risk values of acrolein,chloroform,benzene,1,2-dichloroethane,acetaldehyde and 1,3-butadiene exceeded the thresholds established by USEPA,thereby presenting a health risk to the residents.Besides,the ratio of toluene-to-benzene indicated that vehicle exhausts were the main source of VOC pollution in Beijing.The ratio of m-/p-xylene-toethylbenzene demonstrated that there were more prominent atmospheric photochemical reactions in summer than that in winter.Finally,according to the potential source contribution function(PSCF)results,compared with local pollution sources,the spread of pollution from long-distance VOCs had a greater impact on Beijing. | Chuanqi Li Qianqian Li Dongge Tong Qingliang Wang Mingge Wu Bohua Sun Guijin Su Li Tan | 2020 | Journal of Environmental Sciences2020，32，7： | 10 |
| 6 | Powder injection molding of pure titanium显示文摘An improved wax-based binder was developed for powder injection molding of pure titanium. A critical powder loading of 69 vol.% and a pseudo-plastic flow behavior were obtained by the feedstock based on the binder. The injection molding, debinding, and sintering process were studied. An ideal control of carbon and oxygen contents was achieved by thermal debinding in vacuum atmosphere (10-3 Pa). The mechanical properties of as-sintered specimens were less than those of titanium made by the conventional press-sintering process. Good shape retention and ±0.04 mm dimension deviation were achieved. | GUO Shibo DUAN Bohua HE Xinb QU Xuanhui | 2009 | Rare Metals2009，28，3： | 9 |
| 7 | Spatial Distribution of Traditional Villages and Influence Factors in Hunan Province显示文摘To develop and protect traditional villages reasonably, this paper applied Arc GIS Spatial Analyst Tools to analyze spatial distribution and infl uence factors of 101 traditional villages in Hunan Province. The research showed the agglomerate distribution of traditional villages in Hunan; from the city scale, distribution of traditional villages was concentrated mainly in West Hunan Tujia Nationality Autonomous Prefecture, Chenzhou, Yongzhou, Huaihua and Shaoyang; concentrated distribution of traditional villages in the fi ve major geographic regions showed poor equilibrium, West Hunan had the most concentrated traditional villages, and South Hunan has the second most; relatively closed regional environment, perilous hills, inconvenient transportation, and underdeveloped social economy contributed to the protection of traditional villages, and they were all signifi cant infl uence factors for the distribution of traditional villages in Hunan. | LI Bohua YIN Sha LIU Peilin DOU Yindi | 2016 | Journal of Landscape Research2016，8，2： | 4 |
| 8 | Impacts of Sloping Land Conversion Program on the vegetation in loess hilly and gully area of northern Shaanxi显示文摘Aiming at alleviating the serious soil erosion, the Chinese government initiated the Sloping Land Conversion Program (SLCP) in 1999. Now, after 8 years of project implementation, the ecological recovery effects of the SLCP have become the hot issue of academic circle. This paper, taking the loess hill and gully area of northern Shaanxi as an example, presents a methodology for assessing the vegetation restoration effect of SLCP with normalized difference vegetation index (NDVI). The key components include calculation of the Growing Season NDVI (GSNDVI), and estimation of the NVDI change induced by climate and SLCP, respectively. Based on the method, the NDVI change between 2000 and 2006 was obtained using the GSNDVI that excluded the noise from snow and ice. After the part of total NDVI change caused by climate variation was estimated using empiric formulae, we obtained the part induced by human factors, i.e. the SLCP. The human induced part of NDVI change was considered as an approximation indicating the effect of the SLCP on the vegetation. Finally, we analyzed the NDVI change characters of the whole study area, different slope lands and different land use types by spatial statistics method. Results show that the vegetation condition is significantly improved by the SLCP, particularly land types that directly involved in the SLCP, such as steeply slope farmlands, degraded grasslands, etc. | Ma Junfei Lu Changhe Yu Bohua | 2009 | Ecological Economy2009，5，2： | 3 |
| 9 | Interdecadal Variations of ENSO around 1999/2000显示文摘This paper discusses the interdecadal changes of the climate in the tropical Pacific with a focus on the corresponding changes in the characteristics of the El Ni?o–Southern Oscillation(ENSO). Compared with 1979–1999, the whole tropical Pacific climate system, including both the ocean and atmosphere, shifted to a lower variability regime after 1999/2000. Meanwhile, the frequency of ENSO became less regular and was closer to a white noise process.The lead time of the equatorial Pacific's subsurface ocean heat content in preceding ENSO decreased remarkably, in addition to a reduction in the maximum correlation between them. The weakening of the correlation and the shortening of the lead time pose more challenges for ENSO prediction, and is the likely reason behind the decrease in skill with respect to ENSO prediction after 2000. Coincident with the changes in tropical Pacific climate variability, the mean states of the atmospheric and oceanic components also experienced physically coherent changes. The warm anomaly of SST in the western Pacific and cold anomaly in the eastern Pacific resulted in an increased zonal SST gradient, linked to an enhancement in surface wind stress and strengthening of the Walker circulation, as well as an increase in the slope of the thermocline. These changes were consistent with an increase(a decrease) in precipitation and an enhancement(a suppression) of the deep convection in the western(eastern) equatorial Pacific. Possible connections between the mean state and ENSO variability and frequency changes in the tropical Pacific are also discussed. | Zeng-Zhen HU Arun KUMAR Bohua HUANG Jieshun ZHU Hong-Li REN | 2017 | Journal of Meteorological Research2017，31，1： | 3 |
| 10 | Cell junction proteins within the cochlea: A review of recent research显示文摘Cell-cell junctions in the cochlea are highly complex and well organized. The role of these junctions is to maintain structural and functional integrity of the cochlea. In this review, we describe classification of cell junction-associated proteins identified within the cochlea and provide a brief overview of the function of these proteins in adherent junctions, gap junctions and tight junctions. | Bo Wang Bohua Hu Shiming Yang | 2015 | Journal of Otology2015，10，4： | 2 |
| 11 | Effect of Traditional Chinese Medicine plus narrow-band medium-wave ultraviolet B radiation on moderate-to-severe psoriasis vulgaris in a case series显示文摘OBJECTIVE: To investigate the efficacy and safety of Traditional Chinese Medicine (TCM) therapy combined with ultraviolet B light therapy in the treatment of moderate-to-severe psoriasis. METHODS: Patients with moderate-to-severe psoriasis (skin lesion area > 10% of the body surface area) for 2 consecutive years were treated with TCM (oral and external use of herbal medicines, acupuncture, and herbal bathing) and narrow-band medium-wave ultraviolet B light treatment for 12 weeks. The treatment effect was evaluated based on the Psoriasis Area Severity Index (PASI), the achievement of a 50% reduction in the PASI (PASI50), the achievement of a 75% reduction in the PASI (PASI75), pruritus score, Dermatology Life Quality Index, and safety. RESULTS: A total of 95 outpatients were enrolled, and 92 subjects (96.8%) completed the 12-week treatment course. At baseline, the average proportion of the body surface area covered by skin lesions was 12.4%, and the average PASI was 17.7. All patients had previously been treated with conventional medicine (89.1% of patients received ultraviolet light treatment, 50.0% received glucocorticoids, and 21.7% received acitretin). After the 12-week treatment course, 22 patients (23.9%) achieved PASI75, and 43 (46.7%) achieved PASI50. The post-treatment pruritus score and Dermatology Life Quality Index of all treated patients were significantly lower than the respective baseline values (P < 0.0001). No adverse effects were detected by the monitoring of blood, urine, stools, liver and kidney function, and echocardiography.CONCLUSION: Comprehensive therapy comprising TCM therapy combined with ultraviolet B light therapy achieved good outcomes for patients with moderate-to-severe psoriasis. | Li Tiantian Zhou Dongmei Xu Xuying Qu Jianhua Jiang Chunyan Lan Haibing Lou Weihai Chen Weiwen Jin Li Liu Rongqi Liu Zhiyong Zhang Cang Duan Lanhua Bohua Li Xu Jingna Zhou Tao Jiang Xi Cao Wei Zhang Guangzhong Liu Jianping Sun Liyun Wang Ping | 2019 | Journal of Traditional Chinese Medicine2019，39，5： | 2 |
| 12 | Kepler's third law of n-body periodic orbits in a Newtonian gravitation field显示文摘One of the central and most vivid problems of celestial mechanics in the 18th and 19th centuries was the motion description of the Sun-Earth-Moon system under the Newtonian gravitation field(Figure 1(a)).Notable work was done by Euler(1760),Lagrange(1776),Laplace(1799),Hamilton(1834),Liouville(1836),Jacobi(1843),and Poincar′e(1889)[1]and Xia(1992)[2].The study of the motion between | BoHua Sun | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，5： | 2 |
| 13 | Powder injection molding of Fe-Ni soft magnetic alloys显示文摘With miniaturization and complication of the shape of electronic devices in recent years, powder injection molding (PIM) seems to be a suitable process for fabricating the higher performance soft magnetic components. In this paper, high quality Fe-50Ni soft magnetic alloy was fabricated by PIM with carbonyl iron and nickel, and the effect of sintering process on its microstructure and magnetic properties were investigated. The mechanical and magnetic properties can be obviously improved by increasing the sintering temperature or using the hydrogen atmosphere instead of high vacuum, which causes by the increase of grain size and the densification. At the optimum sintering conditions, the PIM Fe-50Ni soft magnetic alloy with high properties are obtained, whose relative density, tensile strength, Bm, Hc, μm are 97%, 465 MPa, 1.52 T, 16.62 A·m-1, 42.5 mH·m-1, respectively. | DUAN Bohua QU Xuanhui QIN Mingli GUO Shibo | 2006 | Rare Metals2006，25，z1： | 2 |
| 14 | Bismuth oxide nanoflake@carbon film: A free-standing battery-type electrode for aqueous sodium ion hybrid supercapacitors显示文摘Aqueous hybrid supercapacitors are promising due to their low cost and high safety. Herein, a freestanding battery-type electrode of Bi_2O_3 nanoflake@C on carbon cloth is designed for aqueous sodium ion hybrid supercapacitors. Due to the integration of nanoarray architecture and the conductive carbon,the Bi_2O_3@C electrode exhibits a high specific capacity of 207 mAh/g at 2 A/g(6C), good rate capability and cycling stability(133 m Ah/g after 1000 cycles). With the activated carbon as the capacitive electrode and neutral sodium salts as the electrolyte, a 1.9 V hybrid supercapacitor is assembled,delivering a high energy density of 18.94 Wh/kg. The device can still maintain 72.3% of initial capacity after 650 cycles. The present work holds great promise for developing next-generation hybrid supercapacitors. | Zhenshuai Zhao Yihua Ye Weihua Zhu Liang Xiao Bohua Deng Jinping Liu | 2018 | Chinese Chemical Letters2018，29，4： | 2 |
| 15 | Hierarchical Area Partitioning Method of Urban Road Networks Matching显示文摘In view of the “Node-Arc” data model of road network in the aspect of structured expressing the deficiencies, the hierarchical area partitioning of road network based on the principle of stroke, which made road network space structure characteristics of the expression with the hierarchical feature was designed. Based on road hierarchy and connected relationship with the area domain boundaries, the road in the area was hierarchically divided. A hierarchical model was established based on “whole-part-object” data model. Finally, the model of urban road network matching is proposed, which used consistency evaluation model selected matching objects from high-grade road to the low-level road. The experiment results indicated that the method was suitable to solve the road matching problem with typical urban features. | Bohua HUANG Wei ZHONG Renjian ZHAI Qing ZHOU | 2019 | Journal of Geodesy and Geoinformation Science2019，2，3： | 1 |
| 16 | It 'needs level theory' and does a good job of the psychology to attend to to comprehend Maslow显示文摘 | Nie XiaoDong Hu BoHua | 2005 | The vocational education of hygiene2005，23，15： | 1 |
| 17 | Suppression of NF-κB pathway by crocetin contributes to attenuation of lipopolysaccharide-induced acute lung injury in mice显示文摘 | Ruhui Yang Lina Yang Xiangchun Shen Wenyuan Cheng Bohua Zhao Kazi Hamid Ali Zhiyu Qian Hui Ji | 2011 | European Journal of Pharmacology2011，，2： | 1 |
| 18 | 螺旋CT胰胆管三维成像对梗阻性黄疸的诊断价值(英文)显示文摘Objective: Computerized tomography (CT) plays an important role in the diagnosis of diseases of biliary tract. Recently, three dimensions (3D) spiral CT imaging has been used in surgical diseases gradually. This study was designed to evaluate the diagnostic value of 3D spiral CT imaging of cholangiopancreatic ducts on obstructive jaundice. Methods: Thirty patients with obstructive jaundice had received B-mode ultrasonography, CT, percutaneous transhepatic cholangiography (PTC) or endoscopic retrograde cholangiopancreatography (ERCP), and 3D spiral CT imaging of cholangiopancreatic ducts preoperatively. Then the diagnose accordance rate of these examinational methods were compared after operations. Results: The diagnose accordance rate of 3D spiral CT imaging of cholangiopancreatic ducts was higher than those of B-mode ultrasonography, CT, or single PTC or ERCP, which showed clear images of bile duct tree and pathological changes. As to malignant obstructive jaundice, this examinational technique could clearly display the adjacent relationship between tumor and liver tissue, biliary ducts, blood vessels, and intrahepatic metastases. Conclusion: 3D spiral CT imaging of cholangiopancreatic ducts has significant value for obstructive diseases of biliary ducts, which provides effective evidence for the feasibility of tumor-resection and surgical options. | Linquan Wu Xiangbao Yin Qingshan Wang Bohua Wu Xiao Li Huaqun Fu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，11： | 1 |
| 19 | Inhibitory effect on protein kinase Cθ by Crocetin attenuates palmitate-induced insulin insensitivity in 3T3-L1 adipocytes显示文摘 | Lina Yang Zhiyu Qian Hui Ji Ruhui Yang Yuhuan Wang Liang Xi Liang Sheng Bohua Zhao Xiaoming Zhang | 2010 | European Journal of Pharmacology2010，，1： | 1 |
| 20 | EFFECT OF CROCETIN ON BLOOD PRESSURE RESTORATION AND SYNTHESIS OF INFLAMMATORY MEDIATORS IN HEART AFTER HEMORRHAGIC SHOCK IN ANESTHETIZED RATS显示文摘 | Junling Yan Zhiyu Qian Liang Sheng Bohua Zhao Lina Yang Hui Ji Xiaoyuan Han Rong Zhang | 2010 | Shock2010，，1： | 1 |
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