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| 1 | Tuning of band gaps for a two-dimensional piezoelectric phononic crystal with a rectangular lattice显示文摘In this paper,the elastic wave propagation in atwo-dimensional piezoelectric phononic crystal is studiedby considering the mechanic-electric coupling.The gener-alized eigenvalue equation is obtained by the relation of themechanic and electric fields as well as the Bloch-Floquet the-orem.The band structures of both the in-plane and anti-planemodes are calculated for a rectangular lattice by the plane-wave expansion method.The effects of the lattice constantratio and the piezoelectricity with different filling fractionsare analyzed.The results show that the largest gap width isnot always obtained for a square lattice.In some situations,a rectangular lattice may generate larger gaps.The band gapcharacteristics are influenced obviously by the piezoelectric-ity with the larger lattice constant ratios and the filling frac-tions. | Yize Wang Fengming Li Yuesheng Wang Kikuo Kishimoto Wenhu Huang | 2009 | Acta Mechanica Sinica2009，25，1： | 8 |
| 2 | WAVE LOCALIZATION IN RANDOMLY DISORDERED PERIODIC PIEZOELECTRIC RODS WITH INITIAL STRESS显示文摘在有起始的应力的混乱的周期的压电的杆的有弹性的波浪本地化用转移矩阵和 Lyapunov 代表方法被学习。电场作为伪静电干扰被接近。乐队差距特征上的起始的压力的效果被调查。本地化因素和本地化长度的数字计算被执行。它能从结果被观察乐队结构能被施加合适的起始的压力调节。为压电的杆长度和有弹性的常数的不同价值,乐队结构和本地化现象是很不同的。更大的混乱度能导致更多的明显的本地化现象。 | Yize Wang Fengming Li Kikuo Kishimoto Yuesheng Wang Wenhu Huang | 2008 | Acta Mechanica Solida Sinica2008，21，6： | 5 |
| 3 | GNSS clock corrections densification at SHAO:from 5 min to 30 s显示文摘High frequency multi-GNSS zero-difference applications like Precise Orbit Determination(POD)for Low Earth Orbiters(LEO)and high frequency kinematic positioning require corresponding high-rate GNSS clock corrections.The determination of the GNSS clocks in the orbit determination process is time consuming,especially in the combined GPS/GLONASS processing.At present,a large number of IGS Analysis Centers(AC)provide clock corrections in 5-min sampling and only a few ACs provide clocks in 30-s sampling for both GPS and GLONASS.In this paper,an efficient epoch-difference GNSS clock determination algorithm is adopted based on the algorithm used by the Center for Orbit Determination in Europe(CODE).The clock determination procedure of the GNSS Analysis Center at Shanghai Astronomical Observatory(SHAO)and the algorithm is described in detail.It is shown that the approach greatly speeds up the processing,and the densified 30-s clocks have the same quality as the 5-min clocks estimated based on a zero-difference solution.Comparing the densified 30-s GNSS clocks provided by SHAO with that of IGS and its ACs,results show that our 30-s GNSS clocks are of the same quality as that of IGS.Allan deviation also gives the same conclusion.Further validation of the SHAO 30-s clock product is performed in kinematic PPP and LEO POD.Results indicate that the positions have the same accuracy when using SHAO 30-s GNSS clocks or IGS(and its AC)finals.The robustness of the algorithm and processing approach ensure its extension to provide clocks in 5-s or even higher frequencies.The implementation of the new approach is simple and it could be delivered as a black-box to the current scientific software packages. | CHEN JunPing ZHANG YiZe ZHOU XuHua PEI Xiao WANG JieXian WU Bin | 2014 | Science China(Physics,Mechanics & Astronomy)2014，57，1： | 4 |
| 4 | Elastic wave propagation and localization in band gap materials:a review显示文摘Band gap materials(i.e.phononic crystals) are the artificially periodic structures,which have the stop band characteristic for elastic waves.The elastic waves will be localized in phononic crystals with defects,which results in the energy being accumulated around the defects.As a result,it is important to analyze the wave propagation and localization in band gap materials,especially for the structures consisting of smart materials.For example,with the mechanical-electro and mechanical-electro-magneto coupling,the phononic crystals consisting of piezoelectric and magnetoelectroelastic materials can be applied widely.This sets the theoretical basis for the design of band gap materials with multi fields coupling.This paper reviews the recent development of the elastic wave propagation and localization in both ordered and disordered band gap materials.The discussion focuses on the stop band and localization characteristics of elastic waves.Analytical methods and important results are also presented.Finally,some problems for further studies are discussed.This work aims to present the basic properties of wave band gaps in phononic crystals and wave localization in disordered periodic structures(e.g.phononic crystals with definite and random defects and phononic quasicrystals). | LI FengMing WANG YiZe | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，10： | 4 |
| 5 | An Improved Method for the Fitting and Prediction of the Number of COVID-19 Confirmed Cases Based on LSTM显示文摘New coronavirus disease(COVID-19)has constituted a global pandemic and has spread to most countries and regions in the world.Through understanding the development trend of confirmed cases in a region,the government can control the pandemic by using the corresponding policies.However,the common traditional mathematical differential equations and population prediction models have limitations for time series population prediction,and even have large estimation errors.To address this issue,we propose an improved method for predicting confirmed cases based on LSTM(Long-Short Term Memory)neural network.This work compares the deviation between the experimental results of the improved LSTM prediction model and the digital prediction models(such as Logistic and Hill equations)with the real data as reference.Furthermore,this work uses the goodness of fitting to evaluate the fitting effect of the improvement.Experiments show that the proposed approach has a smaller prediction deviation and a better fitting effect.Compared with the previous forecasting methods,the contributions of our proposed improvement methods are mainly in the following aspects:1)we have fully considered the spatiotemporal characteristics of the data,rather than single standardized data.2)the improved parameter settings and evaluation indicators are more accurate for fitting and forecasting.3)we consider the impact of the epidemic stage and conduct reasonable data processing for different stage. | Bingjie Yan Jun Wang Zhen Zhang Xiangyan Tang Yize Zhou Guopeng Zheng Qi Zou Yao Lu Boyi Liu Wenxuan Tu Neal Xiong | 2020 | Computers, Materials & Continua2020，，9： | 2 |
| 6 | Dynamical properties of nanotubes with nonlocal continuum theory: A review显示文摘As the typical systems of nano structures, nanotubes can be widely applied in mechanical electronics, mechanical manufacture and other fields at nano scales. The superior dynamical properties of nanotubes have become a hot topic. Furthermore, there are always complicated conditions for practical engineering (e.g. initial stress/strain, temperature change for external environment and the interaction between the structure and elastic matrix). Then, it is important to establish the proper model and apply the effective analysis method. By using the nonlocal continuum method, this paper reviews the recent progress of dynamical properties of micro structures at nano scales. The discussion is focused on dynamical behaviors of nanotubes, including vibration, wave propagation and fluid-structure interaction, etc. At last, conclusions and prospects in future studies are discussed. | WANG YiZe LI FengMing | 2012 | Science China(Physics,Mechanics & Astronomy)2012，55，7： | 2 |
| 7 | Insight into multiple-triggering effect in DTSCRs for ESD protection显示文摘The diode-triggered silicon-controlled rectifier(DTSCR) is widely used for electrostatic discharge(ESD) protection in advanced CMOS process owing to its advantages, such as design simplification, adjustable trigger/holding voltage, low parasitic capacitance. However, the multiple-triggering effect in the typical DTSCR device may cause undesirable larger overall trigger voltage, which results in a reduced ESD safe margin. In previous research, the major cause is attributed to the higher current level required in the intrinsic SCR. The related discussions indicate that it seems to result from the current division rule between the intrinsic and parasitic SCR formed in the triggering process. In this letter, inserting a large space into the trigger diodes is proposed to get a deeper insight into this issue. The triggering current is observed to be regularly reduced along with the increased space, which confirms that the current division is determined by the parasitic resistance distributed between the intrinsic and parasitic SCR paths. The theoretical analysis is well confirmed by device simulation and transmission line pulse(TLP) test results. The reduced overall trigger voltage is achieved in the modified DTSCR structures due to the comprehensive result of the parasitic resistance vs triggering current, which indicates a minimized multipletriggering effect. | Lizhong Zhang Yuan Wang Yize Wang Yandong He | 2017 | Journal of Semiconductors2017，38，7： | 2 |
| 8 | A Role for Transmembrane Protein 16C/Slack Impairment in Excitatory Nociceptive Synaptic Plasticity in the Pathogenesis of Remifentanil-induced Hyperalgesia in Rats显示文摘Remifentanil is widely used to control intraoperative pain. However, its analgesic effect is limited by the generation of postoperative hyperalgesia. In this study, we investigated whether the impairment of transmembrane protein 16C(TMEM16C)/Slack is required for a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic receptor(AMPAR) activation in remifentanil-induced postoperative hyperalgesia. Remifentanil anesthesia reduced the paw withdrawal threshold from 2 h to 48 h postoperatively,with a decrease in the expression of TMEM16C and Slack in the dorsal root ganglia(DRG) and spinal cord.Knockdown of TMEM16C in the DRG reduced the expression of Slack and elevated the basal peripheral sensitivity and AMPAR expression and function. Overexpression of TMEM16C in the DRG impaired remifentanilinduced ERK1/2 phosphorylation and behavioral hyperalgesia. AMPAR-mediated current and neuronal excitability were downregulated by TMEM16C overexpression in the spinal cord. Taken together, these findings suggest that TMEM16C/Slack regulation of excitatory synaptic plasticity via GluA1-containing AMPARs is critical in the pathogenesis of remifentanil-induced postoperative hyperalgesia in rats. | Yize Li Linlin Zhang Jing Li Chunyan Wang Yi Chen Yuan Yuan Keliang Xie Guolin Wang Yonghao Yu | 2021 | Neuroscience Bulletin2021，37，5： | 2 |
| 9 | SLC1A1-mediated cellular and mitochondrial influx of R-2-hydroxyglutarate in vascular endothelial cells promotes tumor angiogenesis in IDH1-mutant solid tumors显示文摘Muta nt isocitrate dehydrog en ase 1(mlDH1)drives tumorigenesis via produci ng on cometabolite R-2-hydroxyglutarate(R-2-HG)across various tumor types.However,mlDHl in hibitors appear only effective in hematological tumors.The therapeutic ben efit in solid tumors remains elusive,likely due to the complex tumor microenvironment.In this study,we discover that R-2-HG produced by IDH1-mutant tumor cells is preferentially imported into vascular endothelial cells and remodels mitochondrial respiration to promote tumor angiogenesis,conferring a therapeutic vulnerability in IDH1-mutant solid tumors.Mechanistically,SLC1 Alz a Na'-depe ndent glutamate tran sporter that is prefere ntially expressed in en dothelial cells,facilitates the in flux of R-2-HG from the tumor microenvironment into the endothelial cells as well as the intracellular trafficking of R-2-HG from cytoplasm to mitochondria.R-2-HG hijacks SLC1A1 to promote mitochondrial Na^(+)/Ca^(2+)exchange,which activates the mitochondrial respiratory chain and fuels vascular en dothelial cell migratio n in tumor an giogenesis.SLC1A1 deficiency in mice abolishes mlDHl-promoted tumor an giogenesis as well as the therapeutic benefit of mlDHl in hibitor in solid tumors.Moreover,we report that HH2301,a newly discovered mlDHl inhibitor,shows promising efficacy in treating IDH1-mutant cholangiocarcinoma in preclinical models.Together,we identify a new role of SLC1A1 as a gatekeeper of R-2-HG-mediated crosstalk between IDH1-mutant tumor cells and vascular en dothelial cells,and dem on strate the therapeutic potential of mlDHl in hibitors in treating IDH1-muta nt solid tumors via disrupting R-2-HG-promoted tumor angiogenesis. | Xiaomin Wang Ziqi Chen Jun Xu Shuai Tang Nan An Lei Jiang Yixiang Zhang Shaoying Zhang Qingli Zhang Yanyan Shen Shijie Chen Xiaojing Lan Ting Wang Linhui Zhai Siyuwei Cao Siqi Guo Yingluo Liu Aiwei Bi Yuehong Chen Xiameng Gai Yichen Duan Ying Zheng Yixian Fu Yize Li Liang Yuan Linjiang Tong Kun Mo Mingcheng Wang Shu-Hai Lin Minjia Tan Cheng Luo Yi Chen Jia Liu Qiansen Zhang Leping Li Min Huang | 2022 | Cell Research2022，32，7： | 2 |
| 10 | Wave localization in randomly disordered layered three-component phononic crystals with thermal effects 显示文摘 | WANG Yize LI Fengming KISHIMOTO K | 2010 | Archive of Applied Mechanics2010，80，6： | 1 |
| 11 | Improving BDS broadcast ephemeris accuracy using ground-satellite-link observations显示文摘The BeiDou Navigation Satellite System(BDS)employs a hybrid constellation including GEO(Geosynchronous Earth Orbit),IGSO(Inclined Geosynchronous Orbit),and MEO(Medium Earth Orbit)satellites,where the GEO and IGSO satellites are critical to providing continuous and reliable Positioning,Navigation,and Timing(PNT)services in the Asia–Pacifc region.To handle the inconsistency between the satellite orbits and clocks in the broadcast ephemeris,which are determined by the Orbit Determination and Time Synchronization(ODTS)and the Two-way Satellite Time Frequency Transfer(TWSTFT)technique,respectively,we present the strategies using ground-satellite-link observations to improve the accuracy of broadcast ephemeris.The clock diferences between the ODTS and TWSTFT techniques are used for correcting the radial orbit component to derive the refned orbits,which are used to generate the refned broadcast ephemeris.The test results show the precision of the refned orbits is improved by 50–60%in the 3-h to 12-h predicted arcs for the GEO satellites,and by 40–50%for the IGSO satellites.Moreover,the validation using satellite laser ranging observations shows the mean precision of the refned broadcast ephemeris is improved by 27%compared to the original one.Applying the proposed strategies in the BDS Operational Control Segment(OCS),the time evolution of BDS Single Point Positioning(SPP)in the period from Jan.2016 to April 2021 is evaluated.The SPP accuracy is improved from 1.94,2.06 and 3.29 m to 1.39,1.85,and 2.39 m in the north,east,and up components,respectively.Further update with the inclusion of BDS-3 satellites improve the corresponding SPP precision to 0.68,0.70 and 1.91 m. | Junping Chen Jungang Wang Chao Yu Yize Zhang Bin Wang | 2022 | Satellite Navigation2022，3，1： | 1 |
| 12 | Improved turn-on behavior in a diode-triggered silicon-controlled rectifier for high-speed electrostatic discharge protection显示文摘A conventional diode-triggered silicon-controlled rectifier(DTSCR) structure with a layout strategy for electrostatic discharge(ESD) protection is presented and confirmed in a 65-nm CMOS technology.The modified device is featured by a scaled-down trigger-diode string, which shortens its turn-on time using a variable scaling factor. To confirm the parasitic resistance adjustments of the modified DTSCR, transmission line pulsing(TLP)/very fast transmission line pulsing(VF-TLP) tests and simulations are performed on the device. Compared to a conventional DTSCR, this structure exhibits an improved turn-on speed and robustness, which are suitable for I/O protection of ESD events in the nanosecond range, particularly the charged-device model(CDM) event. | Lizhong ZHANG Yuan WANG Yize WANG Xing ZHANG YANDong HE | 2019 | Science China(Information Sciences)2019，62，6： | 1 |
| 13 | Inhibition of Glycogen Synthase Kinase- 313 Prevents Remifentanil-Indueed Hy- peralgesia via Regulating the Expression and Function of Spinal N-Methyl-D-As- partate Receptors In Vivo and Vitro 显示文摘 | Yize Li Haiyun Wang Keliang Xie | 2013 | Plos One2013，8，10： | 1 |
| 14 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 15 | Tunable three-dimensional nonreciprocal transmission in a layered nonlinear elastic wave metamaterial by initial stresses显示文摘In this work,the three-dimensional(3 D)propagation behaviors in the nonlinear phononic crystal and elastic wave metamaterial with initial stresses are investigated.The analytical solutions of the fundamental wave and second harmonic with the quasilongitudinal(qP)and quasi-shear(qS_(1) and qS_(2))modes are derived.Based on the transfer and stiffness matrices,band gaps with initial stresses are obtained by the Bloch theorem.The transmission coefficients are calculated to support the band gap property,and the tunability of the nonreciprocal transmission by the initial stress is discussed.This work is expected to provide a way to tune the nonreciprocal transmission with vector characteristics. | Zhenni LI Yize WANG Yuesheng WANG | 2022 | Applied Mathematics and Mechanics(English Edition)2022，43，2： | 0 |
| 16 | An evaluation of safety and survival for patients with locally advanced pancreatic cancer treated with irreversible electroporation combined with chemotherapy:a retrospectively observational study显示文摘Objective:lreversible electroporation(IRE)is emerging as a new therapy for locally advanced pancreatic cancer(LAPC).We aimed to conduct survival and safety analyses in L APC patients after treatment with IRE combined with chemotherapy.Methods:A total of 64 patients with LAPC who had received IRE and chemotherapy were retrospectively collected from August 2015 to March 2019 at Sun Yat-sen University Cancer Center.Overall survival(OS)and progression-free survival(PFS)were evaluated using Kaplan-Meier method and compared by the log-rank test.A multivariate Cox regression model was used to determine the prognostic factors of survival.The perioperative complications of IRE were also evaluated.The study was approved by the Institutional Review Board of Sun Yat-sen University Cancer Center(approval No.C2021-003).Results:The median survival of all included patients were 24.63(95%confidence interval:21.78-27.49)for overall survival and 13.00(95%confidence inteval:8.81-17.19)months for progression-free survival,with 96.8%,51.9%,18.3%;and 52.3%,21.5%,7.9%as the 1-,2-and 3-year OS and PFS rates,respectively.Tumor size[OS,hazard ratio(HR)=1.768,P=0.048;PFS,HR=0.304,P=0.010],neoadjuvant chemotherapy(OS,HR=0338,P=0.030;PFS,HR=0.358,P=0.034),carbohydrate antigen 19-9 variation after IRE(OS,HR=19.320,P=0.003;PFS,HR=14.591,P=0.021)and tumor response after neoadjuvant chemotherapy(OS,HR-8.779,P=0.033;PFS,HR-5.562,P=0.008)were predictive factors of survival in patients with LAPC after IRE.Complications were observed in 20.3%of patients.Grade B pancreatic fistula was the most common complication.The complication rates of the late treatment group(6.1%)were significantly lower than those of the first 15 patients after IRE treatment(66.7%).The median length of hospital stay of late treatment group was 8.6days,which was also shorter than that of the early treatment group(10.0days).Conclusions:IRE combined with chemotherapy could improve survival of LAPC patients with acceptable complication rates.Therefore,it may be a suitable method for LAPC but should be validated in prospective randomized trials. | Chaobin He Jun Wang Yize Mao Xiangming Lao Shengping Li | 2022 | Journal of Pancreatology2022，5，1： | 0 |
| 17 | Cationized Melamine-formaldehyde Resin for Improving the Wet Strength of Paper显示文摘In this work, melamine-formaldehyde resin was cationized by adding modifiers so that the fibers closely bonded to improve their usability and the wet strength of paper was greatly improved. Triethanolamine and dimethylamine were added to modify the melamine-formaldehyde resin,respectively.The mechanism of the cationized resin was explored and the possible chemical reactions were deduced. It was concluded that,with the use of triethanolamine,the most optimum product was obtained by hydroxymethylation for 30 min with a temperature of 85℃ and p H of 9. 0 where n( melamine) ∶ n( formaldehyde) ∶ n( methanol) ∶ n( triethanolamine) was 100 ∶ 330 ∶ 450 ∶ 15. With the combined use of dimethylamine and methanol,the optimal product was acquired by condensation for 30 min at a temperature of 50℃ and p H of 2. 0 at melamine, formaldehyde, methanol, and dimethylamine molar ratio of100∶ 330∶ 350∶ 20. With the only use of dimethylamine,the optimal product was obtained by condensation at melamine,formaldehyde,dimethylamine molar ratio of 100∶ 330∶ 10. The wet tensile strength of fruit-bagging paper was improved by adding cationized melamine-formaldehyde resin. The zeta potential,charge density,and conductivity of the melamine-formaldehyde resin were also studied. | HuaShan Wang LuMing Yang YuFang Liu KaiWen Mou YiZe Li RuiTao Cha | 2016 | Paper And Biomaterials2016，1，1： | 0 |
| 18 | Tailoring light on three-dimensional photonic chips: a platform for versatile OAM mode optical interconnects显示文摘Explosive growth in demand for data traffic has prompted exploration of the spatial dimension of lightwaves, which provides a degree of freedom to expand data transmission capacity. Various techniques basedon bulky optical devices have been proposed to tailor light waves in the spatial dimension. However, theirinherent large size, extra loss, and precise alignment requirements make these techniques relativelydifficult to implement in a compact and flexible way. In contrast, three-dimensional (3D) photonic chips withcompact size and low loss provide a promising miniaturized candidate for tailoring light in the spatialdimension. Significantly, they are attractive for chip-assisted short-distance spatial mode optical interconnectsthat are challenging to bulky optics. Here, we propose and fabricate femtosecond laser-inscribed 3D photonicchips to tailor orbital angular momentum (OAM) modes in the spatial dimension. Various functions on theplatform of 3D photonic chips are experimentally demonstrated, including the generation, (de)multiplexing,and exchange of OAM modes. Moreover, chip-chip and chip–fiber–chip short-distance optical interconnectsusing OAM modes are demonstrated in the experiment with favorable performance. This work paves the wayto flexibly tailor light waves on 3D photonic chips and offers a compact solution for versatile opticalinterconnects and other emerging applications with spatial modes. | Jue Wang Chengkun Cai Feng Cui Min Yang Yize Liang Jian Wang | 2023 | Advanced Photonics2023，5，3： | 0 |
| 19 | Amorphous calcium magnesium phosphate nanocomposites with superior osteogenic activity for bone regeneration显示文摘The seek of bioactive materials for promoting bone regeneration is a challenging and longterm task.Functionalization with inorganic metal ions or drug molecules is considered effective strategies to improve the bioactivity of various existing biomaterials.Herein,amorphous calcium magnesium phosphate(ACMP)nanoparticles and simvastatin(SIM)-loaded ACMP(ACMP/SIM)nanocomposites were developed via a simple co-precipitation strategy.The physiochemical property of ACMP/SIM was explored using transmission electron microscope(TEM),Fourier transform infrared spectroscopy(FTIR),powder X-ray diffraction(XRD)and highperformance liquid chromatograph(HPLC),and the role of Mg^(2+) in the formation of ACMP/SIM was revealed using X-ray absorption near-edge structure(XANES).After that,the transformation process of ACMP/SIM in simulated body fluid(SBF)was also tracked to simulate and explore the in vivo mineralization performance of materials.We find that ACMP/SIM releases ions of Ca^(2+),Mg^(2+)and PO_(4)^(3),when it is immersed in SBF at 37℃,and a phase transformation occurred during which the initially amorphous ACMP turns into self-assembled hydroxyapatite(HAP).Furthermore,ACMP/SIM displays high cytocompatibility and promotes the proliferation and osteogenic differentiation of MC3T3-E1 cells.For the in vivo studies,lamellar ACMP/SIM/Collagen scaffolds with aligned pore structures were prepared and used to repair a rat defect model in calvaria.ACMP/SIM/Collagen scaffolds show a positive effect in promoting the regeneration of calvaria defect after 12weeks.The bioactive ACMP/SIM nanocomposites are promising as bone repair materials.Considering the facile preparation process and superior in vitro/vivo bioactivity,the as-prepared ACMP/SIM would be a potential candidate for bone related biomedical applications. | Yingying Jiang Shuo Tan Jianping Hu Xin Chen Feng Chen Qianting Yao Zhi Zhou Xiansong Wang Zifei Zhou Yunshan Fan Junjian Liu Yize Lin Lijia Liu Shisheng He | 2021 | Regenerative Biomaterials2021，8，6： | 0 |
| 20 | 乙肝病毒相关肝细胞癌的整合蛋白基因组学特征性研究显示文摘文章简介研究团队利用159例患者手术切除的肿瘤组织和临近的正常组织,首次进行了乙肝病毒相关肝细胞癌的蛋白基因组学特征性研究。通过蛋白基因组学整合分析,我们揭示了乙肝病毒相关肝细胞癌在多组学,关键信号通路激活状态,以及肝脏特异性代谢重编程等方面的诸多一致性和不一致性。 | Qing Gao Hongwen Zhu Liangqing Dong Weiwei Shi Ran Chen Zhijian Song Chen Huang Junqiang Li Xiaowei Dong Yanting Zhou Qian Liu Lijie Ma Xiaoying Wang Jian Zhou Yansheng Liu 8 Emily Boja Ana I.Robles Weiping Ma Pei Wang Yize Li Li Ding Bo Wen Bing Zhang Henry Rodriguez 高大明 周虎 樊嘉 | 2020 | 科学新闻2020，，2： | 0 |
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