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| 1 | Neutrophil elastase:From mechanisms to therapeutic potential显示文摘Neutrophil elastase(NE),a major protease in the primary granules of neutrophils,is involved in microbicidal activity.NE is an important factor promoting inflammation,has bactericidal effects,and shortens the inflammatory process.NE also regulates tumor growth by promoting metastasis and tumor microenvironment remodeling.However,NE plays a role in killing tumors under certain conditions and promotes other diseases such as pulmonary ventilation dysfunction.Additionally,it plays a complex role in various physiological processes and mediates several diseases.Sivelestat,a specific NE inhibitor,has strong potential for clinical application,particularly in the treatment of coronavirus disease 2019(COVID-19).This review discusses the pathophysiological processes associated with NE and the potential clinical applications of sivelestat. | Weilin Zeng Yingqiu Song Runze Wang Rong He Tianlu Wang | 2023 | Journal of Pharmaceutical Analysis2023，13，4： | 4 |
| 2 | Browning of chitooligomers and their optimum preservation显示文摘 | ZENG Lintao QIN Caiqin CHI Weilin | 2007 | Carbohydrate Polymers2007，67，419： | 1 |
| 3 | Economic analysis of defaulted tuition by university students显示文摘 | Zeng Weilin Wan Yiping | 2009 | Journal of Nanchang Institute of Technology2009，，2： | 1 |
| 4 | Ambient Temperature and Years of Life Lost:A National Study in China显示文摘Although numerous studies have investigated premature deaths attributable to temperature,effects of temperature on years of life lost(YLL)remain unclear.We estimated the relationship between temperatures and YLL,and quantified the YLL per death caused by temperature in China.We collected daily meteorological and mortality data,and calculated the daily YLL values for 364 locations(2013–2017 in Yunnan,Guangdong,Hunan,Zhejiang,and Jilin provinces,and 2006–2011 in other locations)in China.A time-series design with a distributed lag nonlinear model was first employed to estimate the location-specific associations between temperature and YLL rates(YLL/100,000 population),and a multivariate meta-analysis model was used to pool location-specific associations.Then,YLL per death caused by temperatures was calculated.The temperature and YLL rates consistently showed U-shaped associations.A mean of 1.02(95%confidence interval:0.67,1.37)YLL per death was attributable to temperature.Cold temperature caused 0.98 YLL per death with most from moderate cold(0.84).The mean YLL per death was higher in those with cardiovascular diseases(1.14),males(1.15),younger age categories(1.31 in people aged 65–74 years),and in central China(1.34)than in those with respiratory diseases(0.47),females(0.87),older people(0.85 in people R75 years old),and northern China(0.64)or southern China(1.19).The mortality burden was modified by annual temperature and temperature variability,relative humidity,latitude,longitude,altitude,education attainment,and central heating use.Temperatures caused substantial YLL per death in China,which was modified by demographic and regional characteristics. | Tao Liu Chunliang Zhou Haoming Zhang Biao Huang Yanjun Xu Lifeng Lin Lijun Wang Ruying Hu Zhulin Hou Yize Xiao Junhua Li Xiaojun Xu Donghui Jin Mingfang Qin Qinglong Zhao Weiwei Gong Peng Yin Yiqing Xu Jianxiong Hu Jianpeng Xiao Weilin Zeng Xing Li Siqi Chen Lingchuan Guo Zuhua Rong Yonghui Zhang Cunrui Huang Yaodong Du Yuming Guo Shannon Rutherford Min Yu Maigeng Zhou Wenjun Ma | 2021 | The Innovation2021，2，1： | 1 |
| 5 | When and How to Adjust Non-Pharmacological Interventions Concurrent with Booster Vaccinations Against COVID-19—Guangdong,China,2022显示文摘Introduction:With the large-scale roll-out of the coronavirus disease 2019(COVID-19)booster vaccination effort(a vaccine dose given 6 months after completing primary vaccination)in China,we explore when and how China could lift non-pharmacological interventions(NPIs)against COVID-19 in 2022.Methods:Using a modified susceptible-infectiousrecovered(SIR)mathematical model,we projected the COVID-19 epidemic situation and required medical resources in Guangdong Province,China.Results:If the number of people entering from overseas recovers to 20%of the number in 2019,the epidemic in 2022 could be controlled at a low level by a containment(215 local cases)or suppression strategy(1,397 local cases).A mitigation strategy would lead to 21,722 local cases.A coexistence strategy would lead to a large epidemic with 6,850,083 local cases that would overwhelm Guangdong’s medical system.With 50%or 100%recovery of the 2019 level of travelers from overseas,the epidemic could also be controlled with containment or suppression,but enormous resources,including more hotel rooms for border quarantine,will be required.However,coexistence would lead to an uncontrollable epidemic with 12,922,032 local cases.Discussion:With booster vaccinations,the number of travelers from overseas could increase slightly in 2022,but a suppression strategy would need to be maintained to ensure a controllable epidemic. | Guanhao He Fangfang Zeng Jianpeng Xiao Jianguo Zhao Tao Liu Jianxiong Hu Sicong Zhang Ziqiang Lin Huaiping Zhu Dan Liu Min Kang Haojie Zhong Yan Li Limei Sun Yuwei Yang Zhixing Li Zuhua Rong Weilin Zeng Xing Li Zhihua Zhu Xiaofeng Liang Wenjun Ma | 2022 | China CDC weekly2022，4，10： | 0 |
| 6 | Design of imaging system for CSNS near-target beam diagnostics显示文摘Introduction China Spallation Neutron Source(CSNS)is an accelerator-based pulsed neutron source which produces neutron with spallation reaction induced by proton bombarding tungsten target.With increasing beam powers and influences on target,near-target monitoring becomes extreme necessary.In this situation,an optical imaging system for proton beam diagnostics and monitoring near the target is being developed at CSNS,which can provide real-time images of the beam on target and beam distribution information.Target imaging system design and development In the design of CSNS target imaging system,coating of Cr^(3+):Al_(2)O_(3) is used to convert particle radiation into emission light.According to the geometry limits of CSNS target station,a special optical system was designed and fabricated to collect the emission light.When the proton beams strike on the target,the coating on the target will be excited,emitting luminescence at the same time.The mirrors and lenses of the optical system image the distribution of emission light into a radiation-hard imaging fiber,which transmits the images to the GigE camera located at low-dose area outside of the target station.Software was written on the LabView platform to control the camera and analyze the images on line.Mock-up of the imaging system was manufactured to test and evaluate the performances of the system.Some important characteristics of the system were obtained and studied.Conclusion Tests on the mock-up of the system present reliably expectation for beam diagnostics.The imaging system has been installed at CSNS recently.More work will be continued to improve the properties of the system. | Zhirong Zeng Shanhua Zhang Weilin Cheng Quanzhi Yu Shaohong Wei Bin Zhou Donghui Zhu Quan Ji Aijun Zeng Tianjiao Liang Yuanbo Chen | 2018 | Radiation Detection Technology and Methods2018，2，2： | 0 |
| 7 | Recent progress on fluorescent probes for viruses显示文摘Viruses are ubiquitous in human life. Some viruses can be used as vectors of genetic engineering and specific pesticides. Other viruses trigger a variety of diseases in humans, animals and plants, resulting in high infection rates and mortality. Therefore, convenient, accurate and rapid detection of viruses is of great significance for the diagnosis and treatment of subsequent diseases. In contrast to traditional methods of detection, which rely on time-consuming and complex techniques such as polymerase chain reaction (PCR), fluorescent probes and imaging methods generate real-time results, with high specificity, and have been widely used in viral detection. In this review, the application of viral fluorescent probes in analyzing the molecular structure, detection and biological imaging is discussed. In particular, we categorized the probes based on their specificity for human and plant viruses, reviewing the latest findings and analyzing their limitations. The potential of fluorescent molecular probes in the treatment of viral disease and environmental analysis, and their possible combinations with protein and immune technology are discussed. | Siyang Shen Weilin Xu Jianxiang Lu Shuhui Wang Yurou Huang Xiaoyan Zeng Weimin Xiao Jun Yin | 2024 | Chinese Chemical Letters2024，35，1： | 0 |
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