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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Facile synthesis and characterization of hydrophobic vaterite CaCO 3 with novel spike-like morphology via a solution route显示文摘 | Yinxia Chen Xianbing Ji Xiaobo Wang | 2010 | Materials Letters2010，，20： | 1 |
| 3 | An analyzing on material removal mechanism in Cu chemical mechanical polishing显示文摘 | Su Jianxiu Zhang Yinxia Chen Xiqu | 2009 | Key Engineering Material2009，416，： | 1 |
| 4 | Facile preparation of cubic calcium carbonate nanoparticles with hydrophobic properties via a car- bonation route显示文摘 | Chen Yinxia Ji Xianbing Zhao Gaiqing | 2010 | Powder Technology2010，200，3： | 1 |
| 5 | Synthesis of graphite nanosheets/AgCl/polypyrrole composites via two-step inverse microemulsion method显示文摘 | Zunli Mo Dandan Zuo Hong Chen Yinxia Sun Ping Zhang | 2006 | European Polymer Journal2006，，2： | 1 |
| 6 | Synthesis of PMA/Eu_2O_3 porous-layered nanocomposite by in situ polymerization and its morphology显示文摘PMA/Eu_2O_3 多孔、分层的 nanocomposite 被准备由在 situpolymerization 并且借助于 X 光检查衍射(XRD ) 描绘了,传播电子显微镜学(TEM ) ,扫描电子显微镜(SEM ) ,和红外线的光线(红外) 。nanocomposite 的 Microscopicinvestigation 被原子力量显微镜学(AFM ) 执行。结果证明形状合成分层、多孔。Eu_2O_3 是 grafted 什么时候 methylacrylate (麻省) polymerized;因此, Eu_2O_3 粒子出现在压克力吃了的聚合甲基(PMA ) 的链的双方上。 | MO Zunli LIU Yanzhi WANG Kunjie LI Hejun CHEN Hong SUN Yinxia | 2006 | Rare Metals2006，25，1： | 0 |
| 7 | Waste-to-wealth:Functional biomass carbon dots based on bee pollen waste and application显示文摘Waste utilization is not only the protection of the environment and the practice of green chemistry,but also one of the ways to develop new materials.Herein,we report two biomass carbon dots which prepared from bee pollen waste by one-step hydrothermal method.The new two carbon dots were used in sensing,cell imaging and plant growth regulation.The differences in the structure and properties of the two carbon dots were evaluated by TEM,XPS,TG and various spectroscopic methods.Both two carbon dots contain abundant functional groups,polyatomic doping,excellent water solubility and stable photoluminescence.Due to these good properties,we have demonstrated its versatile applications in Fe3+sensing,cell imaging and plant growth regulation.It shows sensitive and specific Fe^(3+) responsiveness and good biocompatibility.This research provides a green and simple method for the recycling and reuse of bee pollen waste,and also provides a reference for the application of biomass carbon dots. | Feishi Shan Lijuan Fu Xiangyu Chen Xiangyan Xie Chengshuang Liao Yinxia Zhu Haoyu Xia Jing Zhang Li Yan Zhouyu Wang Xiaoqi Yu | 2022 | Chinese Chemical Letters2022，33，6： | 0 |
| 8 | Molecular Dynamics and Preparation of HO-PAMAM-2.5G Protected Lanthanum Cluster显示文摘HO-PAMAM-2.5 G-protected lanthanum cluster was studied by Virtual Molecule(VM) software. Molecular dynamics (MD) simulation of the nanocomposite system was performed from the view-points of molecular structure and energy′s fluctuation in NVT system. The motivation of this work was to understand the stability and mechanism of the nanocomposite in different proportion. The molecular dynamics simulation results reveal that when the quantity of La in per HO-PAMAM-2.5G amounted to 0~60, the radius of gyration of HO-PAMAM-2.5/La nanocomposite is obviously decreased. The potential energy (PE) that determines the stability of nanocomposite is different according to the quantity of La. The energy of the nanocomposite fluctuated clearly within the range of 0~50 La atoms and this fluctuation gradually tends to flatness in 50~80. While the quantity of La reaches 60, the energy of the nanocomposite drops to the lowest point, the system is steady relatively. Whereafter, according to the simulation results, HO-PAMAM-2.5 G-protected lanthanum clusters were prepared and characterized by transmission electron microscopy (TEM). The result is consistent with MD simulation. | Mo Zunli Liu Yanzhi Chen Hong Sun Yaling Sun Wanhong Sun Yinxia Li Hejun | 2006 | Journal of Rare Earths2006，24，1： | 0 |
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