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| 1 | ABNORMAL FLOWER AND GRAIN 1 encodes OsMADS6 and determines palea identity and affects rice grain yield and quality显示文摘The palea and lemma are floral organ structures unique to grasses;these structures form the hull and directly affect grain size and quality. However, the molecular mechanisms controlling the development of the hull are not well understood. In this study, we characterized the rice(Oryza sativa) abnormal flower and grain1(afg1) mutant, a new allele of OsMADS6. Similar to previously characterized osmads6 alleles, in the afg1 floret, the palea lost its marginal region and acquired the lemma identity. However, in contrast to other osmads6 alleles, the afg1 mutant showed altered grain size and grain quality, with decreased total starch and amylose contents, and increased protein and soluble sugar contents. The analysis of transcriptional activity suggested that AFG1 is a transcriptional activator and may affect grain size by regulating the expression levels of several genes related to cell expansion and proliferation in the afg1 mutant. These results revealed that AFG1 plays an important role in determining palea identity and affecting grain yield and quality in rice. | Xiaoqi Yu Saisai Xia Qiankun Xu Yuanjiang Cui Ming Gong Dali Zeng Qiang Zhang Lan Shen Guiai Jiao Zhenyu Gao Jiang Hu Guangheng Zhang Li Zhu Longbiao Guo Deyong Ren Qian Qian | 2020 | Science China(Life Sciences)2020，63，2： | 10 |
| 2 | Detection of serum IgM and IgG for COVID-19 diagnosis显示文摘Dear Editor,Infection with the novel coronavirus(SARS-CoV-2,which is the virus responsible for the coronavirus disease 2019(COVID-19))was first reported in Wuhan,China on December 31,2019.The outbreak of COVID-19 remains ongoing and was linked to more than 80,000 infected patients and more than 3,000 deaths in China as of March 7,2020(Holshue et al.,2020). | Ling Zhong Junlan Chuan Bo Gong Ping Shuai Yu Zhou Yi Zhang Zhilin Jiang Dingding Zhang Xiaoqi Liu Shi Ma Yi Huang He Lin Qingwei Wang Lulin Huang Dan Jiang Fang Hao Juan Tang Chunqi Zheng Hua Yu Zhibin Wang Qi Jiang Tao Zeng Mei Luo Fanwei Zeng Fanxin Zeng Jianghai Liu Junxi Tian Yu Xu Tengxiang Long Kaiju Xu Xingxiang Yang Yuping Liu Yi Shi Li Jiang Zhenglin Yang | 2020 | Science China(Life Sciences)2020，63，5： | 8 |
| 3 | Numerical Investigation of Pressure Distribution in a Low Specific Speed Centrifugal Pump显示文摘To study the pressure distribution of the volute casing, front casing and back casing in a prototype centrifugal pump, the pressure experiments and numerical simulations are carried out at six working conditions in this paper. The experimental results shows that the asymmetry of static pressure distribution on volute casing and front cavity is caused by the tongue of the volute and it may result in high radial and axial resultant force which can cause vibration and noise in the centrifugal pump. With the increasing of flow rate, the asymmetry of static pressure distribution and the magnitude of static pressure values reduce. The numerical results indicate that the pressure fluctuation near the tongue is strongest and it becomes slighter at point away from the tongue. With the increasing of flow rate, the local high-pressure region in impeller passage reduces and the flow becomes smoother accordingly, whereas the fluid speed becomes much higher which may cause further flow losses. The results predicted by numerical simulation are in coincident with the experimental ones. It shows that the turbulence model for simulating the flow field in centrifugal pumps is feasible. | JIA Xiaoqi CUI Baoling ZHU Zuchao YU Xiaoli | 2018 | Journal of Thermal Science2018，27，1： | 7 |
| 4 | Effects of blocking Le^Y oligosaccharide on cell surface to MMPs secreted by blastocysts and epithelial cells in mouse in vitro显示文摘In order to understand the role of Le+Y oligosaccharide antigen (Le+Y) during implantation, the relationship of Le+Y on the cell surface with matrix metalloproteinase (MMPs) secreted by blastocysts and monolayer epithelial cells during implantation in the mouse %in vitro% was studied by monoclonal antibody (mAb) AH-6, directed to Le+Y[Fuc α1-2 Gal β1-4 (Fuc α1-3) GlcNAc-], and gelatin zymography. The results showed that MMPs secretion was reduced after Le+Y on the cell surface of either epithelial cells or trophoblasts was blocked. It indicated that MMPs expression which played an important function during the process of implantation were regulated by Le+Y. Therefore, it was considered that Le+Y could regulate embryos invasion by some mechanism. | Xiaoqi Wang Yu Liu Enkui Duan Guoqing Zeng Zhengmei Zhu | 1998 | Chinese Science Bulletin1998，43，17： | 6 |
| 5 | Near-infrared light-activated cancer cell targeting and drug delivery with aptamer-modified nanostructures显示文摘为肿瘤的高度精确的治疗的激活刺激的指向的交货系统在最近的年里收到了可观的注意。此处,我们揭示使用一个互补 DNA 序列到 hybridize 和结合到象金 nanorods 或围单人赛的碳 nanotubes (SWNT ) 那样的 photothermal 代理人上的面具 sgc8 aptamers 的光能被活化的指向癌症的策略。在暴露到之上在红外线附近(NIR ) 激光,局部性的 photothermal 在双 stranded DNA 的 dehybridization 加热那些 nano 代理人结果的表面并且 aptamer 顺序放允许指向的特定的癌症房间。作为一个模型系统利用装载 doxorubicin 的 SWNT,到 NIR 光激活的癌症房间的指向的药交货被完成。这个工作与有约束力的可控制的癌症房间表明 NIR 能被活化的指向肿瘤的交货系统的概念潜在地启用高度特定、有效的癌症治疗。 | Yu Yang Jingjing Liu Xiaoqi Sun Liangzhu Feng Wenwen Zhu Zhuang Liu Meiwan Chen | 2016 | Nano Research2016，0，1： | 4 |
| 6 | A digital energy spectroscopy based on FIR filter显示文摘We designed a universal digital energy spectroscopy based on online digital signal processing. A prototype system was built and tested. Signals from radiation detectors were processed via a digital filter whose coefficients could be modified without changing the hardware. The paper introduces the hardware design of the digital energy spectroscopy system as well as the full set of software consisting of the selection of the coefficients of the finite impulse response (FIR) filter and the coding in the field-programmable gate array (FPGA). The system was tested with the high purity germanium (HPGe) detector. The results showed that this prototype can achieve an energy resolution close to that of a traditional multi-channel analyzer (MCA) with a much higher counting rate. | XIE ShuXin LIANG Hao SUN Jian YU XiaoQi | 2011 | Science China(Technological Sciences)2011，54，1： | 4 |
| 7 | Novel cyclen-based linear polymer as a high-affinity binding material for DNA condensation显示文摘A novel cyclen-based linear polyamine (POGEC) was designed and synthesized from the reaction between 1,3-propanediol diglycidyl ether and 1,7-bis(diethoxyphosphory)-1,4,7,10-tetraazacyclod-odecane. High-affinity binding between POGEC and DNA was demonstrated by agarose gel electrophoresis and scanning electron microscopy (SEM). Moreover,the formed POGEC/DNA complex (termed polyplex) could be disassociated to release the free DNA through addition of the physiological concentration of NaCl solution. Fluorescence spectrum was used to measure the high-affinity binding and DNA condensation capability of POGEC. Circular dichroism (CD) spectrum indicates that the DNA conformation did not change after binding to POEGC. | XIANG YongZhe WANG Na ZHANG Ji LI Kun ZHANG ZhongWei LIN HongHui YU XiaoQi | 2009 | Science China Chemistry2009，52，4： | 3 |
| 8 | Novel strategy of constructing fluorescent probe for MAO-B via cascade reaction and its application in imaging MAO-B in human astrocyte显示文摘To detect monoamine oxidase B(MAO-B), the level of which is one of the most important indicators of neurodegenerative diseases such as Parkinson's disease, a new type of cascade reaction based on the formation of coumarin was applied in this research. After the reaction with MAO-B, the protecting group of hydroxyl group in probes(DEAN-MA and DEAB-MA) was removed, and the fluorescence intensity significantly increased(l_(em) 456 nm) as the structure of coumarin was formed subsequently. The probes showed excellent sensitivity and selectivity to MAO-B. The detection limit of DEAN-MA and DEAB-MA were 0.6ng/mL and 0.2 ng/mL, respectively. We succeeded in detecting MAO-B in vitro and imaging it in human astrocyte(U87). | Huihuan Qin Lingling Li Kun Li Xiaoqi Yu | 2019 | Chinese Chemical Letters2019，30，1： | 2 |
| 9 | LRG1 maintains sterile lemma identity by regulating OsMADS6 expression in rice显示文摘Dear Editor,Spikelet is the unique structural unit of grass panicles with florets and diverse glume-like organs.In rice,a normal spikelet usually has two pairs of glume-like organs,including a pair of sterile lemmas and a pair of rudimentary glumes.Generally,the sterile lemma is considered to be the severely degenerated bract,but its origin is still controversial. | Qiankun Xu Xiaoqi Yu Yuanjiang Cui Saisai Xia Dali Zeng Qian Qian Deyong Ren | 2021 | Science China(Life Sciences)2021，64，7： | 2 |
| 10 | α-Lipoic Acid Exerts Its Antiviral Effect against Viral Hemorrhagic Septicemia Virus(VHSV) by Promoting Upregulation of Antiviral Genes and Suppressing VHSV-Induced Oxidative Stress显示文摘Viral hemorrhagic septicemia virus(VHSV), belonging to the genus Novirhabdovirus, Rhabdoviridae family, is a causative agent of high mortality in fish and has caused significant losses to the aquaculture industry. Currently, no effective vaccines, Food and Drug Administration-approved inhibitors, or other therapeutic intervention options are available against VHSV. α-Lipoic Acid(LA), a potent antioxidant, has been proposed to have antiviral effects against different viruses. In this study, LA(CC_(50)= 472.6 lmol/L) was repurposed to exhibit antiviral activity against VHSV. In fathead minnow cells,LA significantly increased the cell viability post-VHSV infection(EC_(50)= 42.7 lmol/L), and exerted a dose-dependent inhibitory effect on VHSV induced-plaque, cytopathic effects, and VHSV glycoprotein expression. The time-of-addition assay suggested that the antiviral activity of LA occurred at viral replication stage. Survival assay revealed that LA could significantly upregulated the survival rate of VHSV-infected largemouth bass in both co-injection(38.095% vs. 1.887%,P < 0.01) and post-injection manner(38.813% vs. 8.696%, P < 0.01) compared with the control group. Additional comparative transcriptome and q RT-PCR analysis revealed LA treatment upregulated the expression of several antiviral genes, such as IRF7, Viperin, and ISG15. Moreover, LA treatment reduced VHSV-induced reactive oxygen species production in addition to Nrf2 and SOD1 expression. Taken together, these data demonstrated that LA suppressed VHSV replication by inducing antiviral genes expression and reducing VHSV-induced oxidative stress. These results suggest a new direction in the development of potential antiviral candidate drugs against VHSV infection. | Wanwan Zhang Xiaoqi Chen Fangzhao Yu Fengquan Li Wangdong Li Meisheng Yi Kuntong Jia | 2021 | Virologica Sinica2021，36，6： | 2 |
| 11 | Dual-site fluorescent probe for highly selective and sensitive detection of sulfite and biothiols显示文摘A dual-site fluorescent probe with double bond and aldehyde as reactive sites, was designed for the selective detection of sulfite and biothiols. Sulfite reacts with conjugate bond selectively, while Cys responses with aldehyde and GSH occurs substitution reaction. Different interactions cause different absorption and fluorescence responses. Moreover, it could be further applied in imaging in living cells. | Mengyang Li Pengcheng Cui Kun Li Jiahui Feng Mingming Zou Xiaoqi Yu | 2018 | Chinese Chemical Letters2018，29，6： | 1 |
| 12 | Structural study of fucoidan from sea cucumber Acaudina molpadioides : A fucoidan containing novel tetrafucose repeating unit显示文摘 | Long Yu Lei Ge Changhu Xue Yaoguang Chang Cuiyu Zhang Xiaoqi Xu Yanchao Wang | 2013 | Food Chemistry2013，，： | 1 |
| 13 | Thermodynamic Analysis for Carbothermal Reduction and Nitridation of TiO_2显示文摘The diagrams of stability relations(namely,Predominance area phase diagram,PAPD)of nitride,carbide and oxides in Ti-C-N-O system were plotted by thermodynamic calculation.The optimum conditions and main influence factors for the synthesis of titanium nitride and titanium carbide by carbothermal reduction in nitrogen atmosphere were discussed. | YU Renhong JIANG Mingxue SHI Xiaoqi | 2007 | China's Refractories2007，16，1： | 1 |
| 14 | Synthesis of novel chiral lipophilic pyridyl - containing α - amino alcohol ligands and enantioselective hydrolysis of α -amino acid esters by ehiral metallomicelles 显示文摘 | J'INGSONG YOU XIAOQI YU KE LIU | 1999 | Tetrahedron: Asymmetry1999，10，： | 1 |
| 15 | Simultaneous determination of chloramphenicol, florfenicol and florfenicol amine in ham sausage with a hybrid chemiluminescent immunoassay显示文摘 | Xiaoqi Tao Haiyang Jiang Xuezhi Yu Jinghui Zhu Xia Wang Zhanhui Wang Lanlan Niu Xiaoping Wu Jianzhong Shen | 2013 | Food Additives & Contaminants: Part A2013，，5： | 1 |
| 16 | A BINOL Based Fluorescence Sensor for Distinction of D-Glucose显示文摘A saccharide fluorescent receptor based on 1,1'-binaphthol was developed.The boronic acids groups are di-rectly attached to the 3,3'-positions of BINOL which acted as probes to saccharides.The methyl protected receptor R1 showed better response to D-fructose compared to other saccharides in the fluorescence quenching experiment.To improve the selectivity of D-glucose,the triethylene glycol protected receptor R2 was developed.Receptor R2 has a better water-solubility than R1 that can be applied in completely aqueous environment.With receptor R2,D-glucose has a different response to other saccharides that can be useful for the distinction of D-glucose. | Bangyu Xu Jiting Hou Kun Li Zhengwei Lu Xiaoqi Yu | 2015 | Chinese Journal of Chemistry2015，33，1： | 1 |
| 17 | Experimental and numerical study on the dynamic shear banding mechanism of HfNbZrTi high entropy alloy显示文摘High-entropy alloys(HEAs) have attracted considerable attention in recent years because of their unique mechanical properties.In this work, the mechanism of dynamic shear banding(also called adiabatic shear bands, ASBs) in a BCC HEA HfNbZrTi was investigated combining dynamic experiments and numerical simulations. The temperature evolution during dynamic shear banding, which has been believed to play a dominant role during ASB formation in the literature, was measured using high-speed infrared thermal detectors synchronized with a split Hopkinson pressure bar system. The dynamic mechanical behavior of the BCC HEA was described using the Johnson-Cook model accompanied by damage accumulation. The process of ASB formation,considering potential contributions from thermal softening and damage softening, was numerically investigated by controlling the activation of each softening mechanism separately. Based on the results of experimental observation and numerical analysis,dynamic shear banding in this BCC HEA is proposed to be dominated by damage softening, and thermal softening only plays a secondary role, which differs from the thermal-softening-dominated ASB formation in typical FCC HEAs such as the Cantor alloy. | SONG Wei-Li MA Quan ZENG QingLei ZHU ShengXin SUI MingBin CAO TangQing QI Wei CHEN YinQiang YU XiaoQi XUE YunFei CHEN Hao-Sen | 2022 | Science China(Technological Sciences)2022，65，8： | 1 |
| 18 | An engineering-purpose preparation strategy for ammonium-type ionic liquid with high purity显示文摘 | SUN Xiaoqi JI Yang LIU Yu | 2010 | AIChE Journal2010，56，4： | 1 |
| 19 | A multiplexed circulating tumor DNA detection platform engineered from 3D-coded interlocked DNA rings显示文摘Circulating tumor DNA(ctDNA)is a critical biomarker not only important for the early detection of tumors but also invaluable for personalized treatments.Currently ctDNA detection relies on sequencing.Here,a platform termed three-dimensional-coded interlocked DNA rings(3D-coded ID rings)was created for multiplexed ctDNA identification.The ID rings provide a ctDNA recognition ring that is physically interlocked with a reporter ring.The specific binding of ctDNA to the recognition ring initiates target-responsive cutting via a restriction endonuclease;the cutting then triggers rolling circle amplification on the reporter ring.The signals are further integrated with internal 3D codes for multiplexed readouts.ctDNAs from non-invasive clinical specimens including plasma,feces,and urine were detected and validated at a sensitivity much higher than those obtained through sequencing.This 3D-coded ID ring platform can detect any multiple DNA fragments simultaneously without sequencing.We envision that our platform will facilitate the implementation of future personalized/precision medicine. | Sha Yang Xinyu Zhan Xiaoqi Tang Shuang Zhao Lianyu Yu Mingxuan Gao Dan Luo Yunxia Wang Kai Chang Ming Chen | 2022 | Bioactive Materials2022，7，4： | 1 |
| 20 | Iron Encapsulated Within Pod-Like Carbon Nanotubes for Oxygen ReductionReaction显示文摘 | Deng Dehui Yu Liang Chen Xiaoqi | 2013 | Angew Chem Int Ed2013，52，1： | 1 |
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