|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Protein-Protein Interactions in the Regulation of WRKY Transcription Factors显示文摘自从一个 WRKY 抄写因素的第一份报告,现在是几乎 20 年, SPF1,从香甜的土豆。大进步从那以后在在植物生长,开发,和对关於生命、不能生活的应力的回答建立 WRKY 抄写因素的多样的生物角色被取得了。尽管有功能的差异,几乎所有分析 WRKY 蛋白质认出 TTGACC/T W 盒子序列并且,因此除核心 W 盒子倡导者元素的仅仅的识别以外的机制是必要的完成 WRKY 抄写因素的规章的特性。在过去的几年的研究表明了 WRKY 抄写因素身体上在发信号,抄写,并且染色质改变与角色与大量蛋白质交往。交往 WRKY 蛋白质的研究提供了重要卓见进抄写因素的重要家庭的成员的行动的规定和模式。稍微改变的 WRKY 领域和在每七个 WRKY 亚科以内保存的另外的蛋白质主题参予 proteinprotein 相互作用并且调停,这也出现了在 WRKY 蛋白质之间并且在在重要生物过程的调整的 WRKY 和另外的规章的蛋白质之间的复杂功能的相互作用。在这评论,我们为 WRKY 抄写因素总结 proteinprotein 相互作用的研究并且讨论交往的搭挡怎么作出贡献,到 WRKY 抄写因素的复杂规章、功能的网络的建立,在不同层次。 | Yingjun Chi Yan Yang Yuan Zhou Jie Zhou Baofang Fan Jing-Quan Yu Zhixiang Chen | 2013 | Molecular Plant2013，6，2： | 39 |
| 2 | Neuroinflammation in Parkinson’s disease and its potential as therapeutic target显示文摘Parkinson’s disease(PD),the second most common age-associated neurodegenerative disorder,is characterized by the loss of dopaminergic(DA)neurons and the presence ofα-synuclein-containing aggregates in the substantia nigra pars compacta(SNpc).Chronic neuroinflammation is one of the hallmarks of PD pathophysiology.Postmortem analyses of human PD patients and experimental animal studies indicate that activation of glial cells and increases in pro-inflammatory factor levels are common features of the PD brain.Chronic release of proinflammatory cytokines by activated astrocytes and microglia leads to the exacerbation of DA neuron degeneration in the SNpc.Besides,peripheral immune system is also implicated in the pathogenesis of PD.Infiltration and accumulation of immune cells from the periphery are detected in and around the affected brain regions of PD patients.Moreover,inflammatory processes have been suggested as promising interventional targets for PD and even other neurodegenerative diseases.A better understanding of the role of inflammation in PD will provide new insights into the pathological processes and help to establish effective therapeutic strategies.In this review,we will summarize recent progresses in the neuroimmune aspects of PD and highlight the potential therapeutic interventions targeting neuroinflammation. | Qinqin Wang Yingjun Liu Jiawei Zhou | 2015 | Translational Neurodegeneration2015，4，1： | 25 |
| 3 | Common-anode LED on a Si substrate for beyond 15 Gbit/s underwater visible light communication显示文摘Visible light communication based on light-emitting diodes(LEDs) has become a promising candidate by providing high data rates, low latency, and secure communication for underwater environments. In this paper,a self-designed common-anode GaN-based five-primary-color LED(RGBYC LED) on a Si substrate is proposed and fabricated. The design of a common anode is used to mitigate the saturation effect for a low-frequency component. Additionally, compared with commercially available LEDs that suffer from nonlinearity distortion,applying the designed LED can provide much better and broader linearity according to the measurement results.Therefore, the modulation depth and system performance can be further improved to implement a high-speed underwater visible light communication(UVLC) system. There is no nonlinearity compensation algorithm applied due to the good linearity of the proposed LED;thus, the offline digital signal processing is simplified. We experimentally demonstrate 14.81 Gbit/s 64 quadrature amplitude modulation(QAM)-discrete multitone(DMT)and 15.17 Gbit/s bit-loading-DMT transmissions through a 1.2-m-long underwater channel based on the proposed RGBYC LED with an intrasymbol frequency-domain averaging channel estimation and zero-forcing equalization.As far as we know, this is the highest data rate for an LED-based UVLC system. | YINGJUN ZHOU XIN ZHU FANGCHEN HU JIANYANG SHI FUMIN WANG PENG ZOU JUNLIN LIU FENGYI JIANG NAN CHI | 2019 | Photonics Research2019，7，9： | 7 |
| 4 | Response of Pinus taiwanensis growth to climate changes at its southern limit of Daiyun Mountain, China's Mainland Fujian Province显示文摘The Pinus taiwanensis trees of a Chinese endemic species form pure forests at infertile sites in humid subtropical China, which can aid soil reservation and ecological resiliency at such sites. Herein, we used dendrochronological methods to investigate the growth patterns and their relationship with climate by analyzing 158 cores of 79 P. taiwanensis trees at 4 sites in their southernmost distribution in China's Mainland at Daiyun Mountain in Fujian Province. Tree growths at sites with favorable conditions generally showed an age-related growth trend, which decreased from approximately 5 mm to 0.5 mm in about a century. Trees in moderately stressed environments established high growth in their juvenile periods but were highly susceptible to environmental stresses such as a sharp growth decline in the 1990 s. The temperature in February and the moisture in July are the major limiting factors for most of the tree growths, except for a few extremely stressed P. taiwanensis trees. The growth of the dwarf P. taiwanensis trees, with all ring diameters of the first 20 years less than 4 mm, is mainly limited by the dry climate in May. Under the potential future warming trend, drought stress can be particularly threatening to these dwarf P. taiwanensis trees, which are likely to be the germplasm resources for this species in this region. | CHEN Dan FANG KeYan LI YingJun DONG ZhiPeng ZHANG Yu ZHOU FeiFei | 2016 | Science China Earth Sciences2016，59，2： | 6 |
| 5 | Historical trends in the anthropogenic heavy metal levels in the tidal flat sediments of Lianyungang, China显示文摘The sedimentation of metals can preserve the historical record of contaminant input from local and regional sources and provide information on the historical changes in regionalwater and sediment quality. We report the 210Pb activities and the heavy metal (Cd, Cr, Cu, Mn, Pb and Zn)depth profiles from sediment cores retrieved in 2010. The mean sedimentation rates of 0.85-1.5 cm/yr aredetermined by 210 Pbdating. The sediments in the tidal flat have recorded heavy metaldeposition and thus allow the establishment of a connection between the temporal evolution of the heavy metal pollution and the historical changes in the economicdevelopment of Lianyungang. The enrichment factors (EF) are calculated to estimate the level of contamination stored in these sediments. The results show that in the studied sites, Cr and Cudisplay low EF values and are mainly from lithogenic origin. For the other studied trace metals, a great variability in the sedimentary record is observed. Significant anthropogenic enrichment over the last 50 years is revealed at the tidal flat that receives fluvial inputs. Zinc is the elementwith the highest EF values, followed by the order of Pb > Cd > Mn > Cu and Cr. The temporal variations of the heavy metals peakduring the late 1980s to the early2000s and show adecreasing trend afterward. The pollution intensity of the tidal flat isdetermined by using EF and thegeo-accumulation index (Igeo ),which show that, based on the Igeo scale, the tidal flat of Haizhou Bay is unpolluted to moderately polluted. | Rui Zhang Fan Zhang Yingjun Ding Jinrong Gao Jing Chen Li Zhou | 2013 | Journal of Environmental Sciences2013，25，7： | 5 |
| 6 | A wave of Foxp3^(+) regulatory T cell accumulation in the neonatal liver plays unique roles in maintaining self-tolerance显示文摘Newborn animals require tightly regulated local and systemic immune environments to govern the development and maturation of multiple organs/tissues even though the immune system itself is far from mature during the neonatal period.Regulatory T cells(Tregs)are essential for maintaining immune tolerance/homeostasis and modulating inflammatory responses.The features of Tregs in the neonatal liver under steady-state conditions are not well understood.The present study aimed to investigate the phenotype,functions,and significance of neonatal Tregs in the liver.We found a wave of thymus-derived Treg influx into the liver during 1–2 weeks of age.Depletion of these Tregs between days 7 and 11 after birth rapidly resulted in Th1-type liver inflammation and metabolic disorder.More Tregs in the neonatal liver than in the spleen underwent MHC II-dependent activation and proliferation,and the liver Tregs acquired stronger suppressive functions.The transcriptomic profile of these neonatal liver Tregs showed elevated expression of PPARγand T-bet and features of Tregs that utilize lipid metabolic machinery and are capable of regulating Th1 responses.The accumulation of Tregs with unique features in the neonatal liver is critical to ensure self-tolerance and liver maturation. | Mingyang Li Weijia Zhao Yifan Wang Lixue Jin Gaowen Jin Xiuyuan Sun Wei Wang Ke Wang Xi Xu Jie Hao Rong Jin Wenxian Fu Ying Sun Yingjun Chang Xiaojun Huang Xuyu Zhou Hounan Wu Kunshan Zhang Qing Ge | 2020 | Cellular & Molecular Immunology2020，17，5： | 4 |
| 7 | Progress of Geological Survey Using Airborne Hyperspectral Remote Sensing Data in the Gansu and Qinghai Regions显示文摘Hyperspectral remote sensing is now a frontier of the remote sensing technology.Airborne hyperspectral remote sensing data have hundreds of narrow bands to obtain complete and continuous ground-object spectra.Therefore,they can be effectively used to identify | ZHAO Yingjun QIN Kai SUN Yu LIU Dechang TIAN Feng PEI Chengkai YANG Yanjie YANG Guofang ZHOU Jiajing | 2015 | Acta Geologica Sinica(English Edition)2015，89，5： | 2 |
| 8 | Effect of microbial transglutaminase on NMR relaxometry and microstructure of pork myofibrillar protein gel显示文摘 | Minyi Han Yingjun Zhang Ying Fei Xinglian Xu Guanghong Zhou | 2009 | European Food Research and Technology2009，，4： | 2 |
| 9 | Oligodendrocytes in neurodegenerative diseases显示文摘Oligodendrocyte 是一个高度专业化的 glial 房间录入中央神经系统,它由生产包邻近的轴突的髓磷脂鞘保证行动潜力的长途的传播脊椎动物。破坏髓磷脂和 oligodendrocytes 是某破坏的特点神经病学的疾病例如多重硬化,尽管他们对在给定的疾病的 neurodegeneration 的贡献仍然是争论的。然而,从临床的研究和基因动物模型积累证据含有是的 oligodendrocyte 机能障碍在开始的过程和 neurodegeneration 的前进的主要事件之一。在这篇文章,我们将在在 neuronal 支持和到 neurodegeneration 的髓磷脂鞘和它的可能的贡献的保护独立人士理解 oligodendrocytes 的非传统的功能考察最近的进步。Oligodendrocytes 玩在特殊强调在之中被给多重系统萎缩的 neurodegenerative 疾病和在这评论的 Alzheimers 疾病的一个枢轴的角色。 | Yingjun LIU Jiawei ZHOU | 2013 | Frontiers in Biology2013，8，2： | 1 |
| 10 | SNX14 deficiency-induced defective axonal mitochondrial transport in Purkinje cells underlies cerebellar ataxia and can be reversed by valproate显示文摘Loss-of-function mutations in sorting nexin 14(SNX14)cause autosomal recessive spinocerebellar ataxia 20,which is a form of early-onset cerebellar ataxia that lacks molecular mechanisms and mouse models.We generated Snx14-deficient mouse models and observed severe motor deficits and cell-autonomous Purkinje cell degeneration.SNX14 deficiency disrupted microtubule organization and mitochondrial transport in axons by destabilizing the microtubule-severing enzyme spastin,which is implicated in dominant hereditary spastic paraplegia with cerebellar ataxia,and compromised axonal integrity and mitochondrial function.Axonal transport disruption and mitochondrial dysfunction further led to degeneration of high-energy-demanding Purkinje cells,which resulted in the pathogenesis of cerebellar ataxia.The antiepileptic drug valproate ameliorated motor deficits and cerebellar degeneration in Snx14-deficient mice via the restoration of mitochondrial transport and function in Purkinje cells.Our study revealed an unprecedented role for SNX14-dependent axonal transport in cerebellar ataxia,demonstrated the convergence of SNX14 and spastin in mitochondrial dysfunction,and suggested valproate as a potential therapeutic agent. | Hongfeng Zhang Yujuan Hong Weijie Yang Ruimin Wang Ting Yao Jian Wang Ke Liu Huilong Yuan Chaoqun Xu Yuanyuan Zhou Guanxian Li Lishan Zhang Hong Luo Xian Zhang Dan Du Hao Sun Qiuyang Zheng Yun-Wu Zhang Yingjun Zhao Ying Zhou Huaxi Xu Xin Wang | 2021 | National Science Review2021，8，7： | 1 |
| 11 | Grassland management practices in Chinese steppes impact productivity, diversity and the relationship显示文摘Grasslands are crucial parts of the terrestrial ecosystem, with an extremely high differentiation of productivity and diversity across spatial scales and land use patterns. The practices employed to manage grassland,such as grazing, haymaking, fertilization or reseeding, can improve the grassland condition. This study focuses on the changes in productivity and diversity and the relationship between them as affected by management practices.Productivity and diversity have unequivocally been altered in response to different management practices. When grazing intensity of a typical steppe increased from 1.5 to 9 sheep per hectare, both productivity and diversity declined.Higher grazing intensity(6 to 9 sheep per hectare)accelerated loss of diversity because of lower productivity.Productivity was significantly improved but diversity was lost by fertilizing. N fertilization also reduced the sensitivity of diversity to productivity. A similar response was found in mown grassland with increased productivity and diversity but their relationship was negatively affected.Mowing also slowed down the decline in diversity as productivity increased. Reseeding purple-flowered alfalfa led to an increased diversity, while yellow-flowered alfalfa increased productivity significantly. The negative productivity-diversity relationship was transformed to a positive one by reseeding alfalfa. These results enhance understanding of how productivity, diversity and their relationships change in response to altered grassland management practices, and support an integrated approach for improving both productivity and diversity. | Yingjun ZHANG Wenjie LU Hao ZHANG Jiqiong ZHOU Yue SHEN | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 1 |
| 12 | Vitexins, nature-derived lignan compounds, induce apoptosis and suppress tumor growth显示文摘 | Zhou YingJun Liu Y E Cao JianGuo | 2009 | Clin Cancer Res2009，15，16： | 1 |
| 13 | Optimal Option of Distributed Generation Technologies for Various Commercial Buildings 显示文摘 | Yingjun Ruan Qingrong Liu Weiguo Zhou | 2009 | Applied Energy2009，86，9： | 1 |
| 14 | Knockdown of RNA N6-methyladenosine methyltransferase METTL3 represses Warburg effect in colorectal cancer via regulating HIF-1a显示文摘Dear Editor,Colorectal cancer(CRC)is an important digestive tract tumor with high malignancy.Nearly one million people suffer from CRC every year with a mortality rate of 33%.Therefore,it is urgent to determine the mechanism for the development of CRC,in order to find more effective diagnosis markers and therapeutic targets.Various RNA modifications have been identified in both mRNA and non-coding RNAs,with RNA methylation being the most common mRNA modification in eukaryotes. | Zhou Yang Yingjun Quan Yusheng Chen Yijun Huang Renhong Huang Weiping Yu Dejun Wu Min Ye Zhijun Min Bo Yu | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 1 |
| 15 | Effect of thermal pretreatment on the physical and chemical properties of municipal biomass waste显示文摘 | Xiao Liu Wei Wang Xingbao Gao Yingjun Zhou Renjie Shen | 2011 | Waste Management2011，，2： | 1 |
| 16 | In vitro generation of osteochondral differentiation of human marrow mesenchymal stem cells in novel collagen–hydroxyapatite layered scaffolds显示文摘 | Jiaan Zhou Caixia Xu Gang Wu Xiaodong Cao Liangming Zhang Zhichen Zhai Zhiwen Zheng Xiaofeng Chen Yingjun Wang | 2011 | Acta Biomaterialia2011，，11： | 1 |
| 17 | Controlling the strontium-doping in calcium phosphate microcapsules through yeastregulated biomimetic mineralization显示文摘Yeast cells have controllable biosorption on metallic ions during metabolism.However,few studies were dedicated to using yeast-regulated biomimetic mineralization process to control the strontium-doped positions in calcium phosphate microcapsules.In this study,the yeast cells were allowed to pre-adsorb strontium ions metabolically and then served as sacrificing template for the precipitation and calcination of mineral shell.The pre-adsorption enabled the microorganism to enrich of strontium ions into the inner part of the microcapsules,which ensured a slow-release profile of the trace element from the microcapsule.The co-culture with human marrow stromal cells showed that gene expressions of alkaline phosphatase and Collagen-I were promoted.The promotion of osteogenic differentiation was further confirmed in the 3D culture of cell-material complexes.The strategy using living microorganism as‘smart doping apparatus’to control incorporation of trace element into calcium phosphate paved a pathway to new functional materials for hard tissue regeneration. | Miaojun Huang Tianjie Li Ting Pan Naru Zhao Yongchang Yao Zhichen Zhai Jiaan Zhou Chang Du Yingjun Wang | 2016 | Regenerative Biomaterials2016，3，5： | 1 |
| 18 | Imitated Ecological Cultivation Technology of Dendrobium offcinale: A Case Study of Longshitou Village,Longmen County显示文摘In order to optimize the planting structure of Longshitou Village in Longmen County and promote the efficient cultivation of Dendrobium offcinale industry,the imitate ecological cultivation technology of D.offcinale is studied from the aspects of site selection,seedling domestication,seedling colonization,and disease and pest control after colonization according to the natural environmental conditions of Longshitou Village. | Xiulian Lin Yingjun Zhou Junhong Zhong Jinhe Zhu Xiaoru Chen Yonggeng Lin Minchun Huang Lihua Yang Zhi Zhang | 2021 | Plant Diseases and Pests2021，12，2： | 1 |
| 19 | Opposite Regulation of Chondrogenesis and Angiogenesis in Cartilage Repair ECM Materials under Hypoxia显示文摘Although cartilage tissue engineering has been developed for decades, it is still unclear whether angiogenesis was the accompaniment of chondrogenesis in cartilage regeneration. This study aimed to explore the process of anti-angiogenesis during cartilage regenerative progress in cartilage repair extracellular matrix(ECM) materials under Hypoxia. C3H10T1/2 cell line, seeded as pellet or in ECM materials, was added with chondrogenic medium or DMEM medium for 21 days under hypoxia or normoxia environment. Genes and mi RNAs related with chondrogenesis and angiogenesis were detected by RT-q PCR technique on Days 7, 14, and 21. Dual-luciferase report system was used to explore the regulating roles of mi RNAs on angiogenesis. Results showed that the chondrogenic medium promotes chondrogenesis both in pellet and ECM materials culture. HIF1α was up-regulated under hypoxia compared with normoxia(P < 0.05). Meanwhile, hypoxia enhanced chondrogenesis. miR-140-5p exhibited higher expression while miR-146 b exhibited lower expression. The chondrogenic phenotype was more stabilized in the ECM materials in chondrogenic medium than DMEM medium, with lower VEGFα expression even under hypoxia.Dual-luciferase report assays demonstrated that mi R-140-5p directly targets VEGFα by binding its 3′-UTR. Taken together, chondrogenic cytokines, ECM materials and hypoxia synergistically promoted chondrogenesis and inhibited angiogenesis. mi R-140-5p played an important role in this process. | Shaoming Chen Manman Gao Zhiyu Zhou Jiabi Liang Ming Gong Xuejun Dai Tangzhao Liang Jiacheng Ye Gang Wu Lijin Zou Yingjun Wang Xuenong Zou | 2016 | Journal of Materials Science & Technology2016，32，9： | 1 |
| 20 | MicroRNA-26a acts as a tumor suppressor inhibiting gallbladder cancercell proliferation by directly targeting HMGA2显示文摘 | Huading Zhou Weijie Guo Yingjun Zhao Yifei Wang Ruopeng Zha Jie Ding Linhui Liang Jun Hu Hao Shen Zongyou Chen Baobing Yin Baojin Ma | 2014 | International Journal of Oncology2014，，6： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员