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| 1 | Efficacy and safety of metformin and sitagliptin based triple antihyperglycemic therapy(STRATEGY):a multicenter,randomized,controlled,non-inferiority clinical trial显示文摘Despite the current guideline's recommendation of a timely stepwise intensification therapy,the 'clinical inertia',termed as the delayed treatment intensification,commonly exists in the real world,which may be partly due to the relatively little substantial evidence and no clear consensus regarding the efficacy and safety of triple oral agents in patients inadequately controlled with dual therapy.In this clinical trial performed in 237 centers in China,5,535 type 2 diabetic patients inadequately controlled by previous therapies were treated with a stable metformin/sitagliptin dual therapy for 20 weeks.The patients who did not reach the glycated hemoglobin A1c(HbA1c) goal were then further randomized into glimepiride,gliclazide,repaglinide,or acarbose group for an additional 24-week triple therapy.A mean HbAlc reduction of 0.85%was observed when sitagliptin was added to the patients inadequately controlled with metformin in 16 weeks.Further HbAlc reductions in the 24-week triple therapy stage were 0.65%in glimepiride group,0.70%in gliclazide group,0.61%in repaglinide group,and 0.45%in acarbose group.The non-inferiority criterion for primary hypotheses was met for gliclazide and repaglinide,but not for acarbose,compared with glimepiride,when added to metformin/sitagliptin dual therapy.The incidences of adverse events(AEs) were 29.2%in the dual therapy stage and30.3%in the triple therapy stage.Metformin/sitagliptin as baseline therapy,with the addition of a third oral antihyperglycemic agent,including glimepiride,gliclazide,repaglinide,or acarbose,was effective,safe and well-tolerated for achieving an HbAlc<7.0%goal in type 2 diabetic patients inadequately controlled with previous therapies.The timely augmentation of up to three oral antihyperglycemic agents is valid and of important clinical benefit to prevent patients from exposure to unnecessarily prolonged hyperglycemia. | Wen Xu Yiming Mu Jiajun Zhao Dalong Zhu Qiuhe Ji Zhiguang Zhou Bin Yao Anhua Mao Samuel S.Engel Bin Zhao Yan Bi Longyi Zeng Xingwu Ran Juming Lu Linong Ji Wenying Yang Weiping Jia Jianping Weng | 2017 | Science China(Life Sciences)2017，60，3： | 19 |
| 2 | Global overview of research progress and development of precision maize planters显示文摘Maize is the most important crop for food and widely used for industrial materials,leading to its increasing demand all over the world.Precision planting is the effective method to increase maize yield.To meet the agronomic requirement of precision planting,different kinds of precision maize planters were developed.However,because of the difference of geographical environment,cropping system,farm scale and economic status among different countries,types of maize planters are various and the technologies involved are at different levels.This paper summarizes the precision maize planters currently available in the world and classifies them into four types:precision planters for tilled-land,minimum/no tilled-land,hilly&small land,and cold&arid land.Detailed characteristics have been provided for some typical precision planters and comparisons were made as to their suitability under particular working conditions.High-efficiency and high-accuracy are the main features of precision planters for tilled-land,while the ability to clean residue from seed rows and prevent planters to be blocked are the important function of precision planters for minimum/no tilled-land.To fit for hilly&small land,planters should be light-weighted and small-sized,and to warm up soil and keep moisture,planters for cold&arid land should be equipped with plastic-film mulching mechanism.Finally,developing trend of precision planting technology was analyzed and suggestions,including policy support and technical improvement,were made for developing countries to make suitable precision maize planters according to the local geographical conditions and cropping systems. | Yang Li Yan Bingxin Cui Tao Yu Yiming He Xiantao Liu Quanwei Liang Zhijie Yin Xiaowei Zhang Dongxing | 2016 | International Journal of Agricultural and Biological Engineering2016，9，1： | 17 |
| 3 | The microphysics of ice accretion on wires:Observations and simulations显示文摘The weather system, meteorological conditions, and microphysics of cloud, fog, and rain droplets are studied during the formation, growth, maintenance, and shedding periods of ice accretion on wires in Enshi, Hubei Province in China using 2008/2009 and 2009/2010 winter observations. The comprehensive observations include data of visibility, microphysics of fog and rain droplets, and ice thickness, as well as data from an automated weather station and other routinely recorded meteorological data. The results show that icing occurred during the passage of a cold front, with a high-pressure system and a cold temperature trough at 850 hPa, and a southeasterly at 500 hPa that provided abundant moisture. Ice formation usually started in the evening or early morning, and ice shed around noon the following day when the temperature was-1°C to 0°C. The averaged liquid water content of the fog droplet was distinctly greater during the growth period than during the other three periods, and there was precipitation during the growth period in each case of ice accretion. The growth rate of the ice thickness was clearly correlated with the liquid water content, with a correlation coefficient of 0.62. Simulations using empirical equations were carried out, and the simulated ice thickness agreed with observations fairly well. | NIU ShengJie ZHOU Yue JIA Ran YANG Jun LUE JingJing KE YiMing YANG ZhiBiao | 2012 | Science China Earth Sciences2012，55，3： | 12 |
| 4 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 5 | Electronic Skin from High-Throughput Fabrication of Intrinsically Stretchable Lead Zirconate Titanate Elastomer显示文摘Electronic skin made of thin,soft,stretchable devices that can mimic the human skin and reconstruct the tactile sensation and perception offers great opportunities for prosthesis sensing,robotics controlling,and human-machine interfaces.Advanced materials and mechanics engineering of thin film devices has proven to be an efficient route to enable and enhance flexibility and stretchability of various electronic skins;however,the density of devices is still low owing to the limitation in existing fabrication techniques.Here,we report a high-throughput one-step process to fabricate large tactile sensing arrays with a sensor density of 25 sensors/cm^(2) for electronic skin,where the sensors are based on intrinsically stretchable piezoelectric lead zirconate titanate(PZT)elastomer.The PZT elastomer sensor arrays with great uniformity and passive-driven manner enable highresolution tactile sensing,simplify the data acquisition process,and lower the manufacturing cost.The high-throughput fabrication process provides a general platform for integrating intrinsically stretchable materials into large area,high device density soft electronics for the next-generation electronic skin. | Yiming Liu Huanxi Zheng Ling Zhao Shiyuan Liu Kuanming Yao Dengfeng Li Chunki Yiu Shenghan Gao Raudel Avila Pakpong Chirarattananon Lingqian Chang Zuankai Wang Xian Huang Zhaoqian Xie Zhengbao Yang Xinge Yu | 2020 | Research2020，，1： | 11 |
| 6 | Geomicrobial functional groups:A window on the interaction between life and environments显示文摘Microbes are well-known for their great diversity and abundance in modern natural environments.They also are believed to pro-vide critical links among higher organisms and their associated environments.However,the low diversity of morphological fea-tures and structures of ancient microbes preserved in sediments and rocks make them difficult to identify and classify.This diffi-culty greatly hinders the investigation of geomicrobes throughout Earth history.Thus,most previous paleontological studies have focused on faunal and floral fossils.Here,geomicrobial functional groups(GFGs),or a collection of microbes featured in specific ecological,physiological or biogeochemical functions,are suggested to provide a way to overcome the difficulties of ancient mi-crobe investigations.GFGs are known for their great diversity in ecological,physiological and biogeochemical functions.In addi-tion,GFGs may be preserved as the biogeochemical,mineralogical and sedimentological records in sediments and rocks.We reviewed the functions,origins and identification diagnostics of some important GFGs involved in the elemental cycles of carbon,sulfur,nitrogen and iron.GFGs were further discussed with respect to their significant impacts on paleoclimate,sulfur chemistry of ancient seawater,nutritional status of geological environments,and the deposition of Precambrian banded iron formations. | XIE ShuCheng YANG Huan LUO GenMing HUANG XianYu LIU Deng WANG YongBiao GONG YiMing XU Rana | 2012 | Chinese Science Bulletin2012，57，1： | 11 |
| 7 | Methane emissions from rice fields under continuous straw return in the middle-lower reaches of the Yangtze River显示文摘A three-year experiment was conducted in the middle-lower reaches of the Yangtze River in China to study the influence of continuous wheat straw return during the rice season and continuous rice straw return in wheat on methane (CH 4 ) emissions from rice fields in which, the rice-wheat rotation system is the most dominant planting pattern. The field experiment was initiated in October 2009 and has continued since the wheat-growing season of that year. The analyses for the present study were conducted in the second (2011) and third (2012) rice growing seasons. Four treatments, namely, the continuous return of wheat straw and rice straw in every season (WR), of rice straw but no wheat straw return (R), of wheat straw but no rice straw return (W) and a control with no straw return (CK), were laid out in a randomized split-plot design. The total seasonal CH 4 emissions ranged from 107.4 to 491.7 kg/ha (2011) and 160.3 to 909.6 kg/ha (2012). The increase in CH 4 emissions for treatments WR and W were 289% and 230% in the second year and 185% and 225% in the third year, respectively, in relation to CK. We observed less methane emissions in the treatment R than in CK by 14%-43%, but not statistically significant. Treatment R could increase rice productivity while no more CH 4 emission occurs. The difference in the total CH 4 emissions mainly related to a difference in the methane flux rate during the first 30-35 days after transplant in the rice growing season, which was caused by the amount of dissolved oxygen in paddy water and the amount of reducible soil materials. | Pengfu Hou Ganghua Li Shaohua Wang Xin Jin Yiming Yang Xiaoting Chen Chengqiang Ding Zhenghui Liu Yanfeng Ding | 2013 | Journal of Environmental Sciences2013，25，9： | 10 |
| 8 | Glycine attenuates myocardial ischemia-reperfusion injury by inhibiting myocardial apoptosis in rats显示文摘Glycine is a well-documented cytoprotective agent.However,whether it has a protective effect against myocar-dial ischemia-reperfusion injury in vivo is still unknown.By using an open-chest anesthetized rat model,we found that glycine reduced the infarct size by 21% in ischemia-reperfusion injury rats compared with that in the vehicle-treated MI/R rats.The left ventricular ejection fraction and fractional shortening were increased by 19.11% and 30.98%,respectively,in glycine-treated rats.The plasma creatine kinase levels in ischemia-reperfusion injury rats decreased following glycine treatment.Importantly,administration of glycine significantly inhibited apoptosis in post-ischemia-reperfusion myocardium,which was accompanied by suppression of phosphorylated p38 mitogen-activated protein kinase and c-Jun NH2-terminal kinase,as well as the Fas ligand.These results suggest that gly-cine attenuates myocardial ischemia-reperfusion injury in vivo by inhibiting cardiomyocytes apoptosis. | Xiaozheng Zhong Xiaoyu Li Lingling Qiana Yiming Xu Yan Lu Jing Zhang Nan Li Xudong Zhu Jingjing Ben Qing Yang Qi Chen | 2012 | The Journal of Biomedical Research2012，26，5： | 10 |
| 9 | Bioaccumulation and translocation of cadmium in cole (Brassica campestris L.) and celery (Apium graveolens) grown in the polluted oasis soil,Northwest of China显示文摘A pot experiment was conducted to study the bioaccumulation and translocation of cadmium (Cd) in cole (Brassica campestris L.) and celery (Apium graveolens) grown in the Cd-polluted oasis soil,Northwest of China.The results showed that Cd in the unpolluted oasis soil was mainly bound to carbonate fraction (F2) and Fe-Mn oxide fraction (F3).However,marked change of Cd fractions was observed with increasing soil Cd concentrations,in which the concentration of Cd in F1 (exchangeable fraction),F2 and F3 increased significantly (p<0.001 for F1,F2 and F3).The growth of cole and celery could be facilitated by low concentrations of Cd,but inhibited by high concentrations.The correlation analysis between the fraction distribution coefficient of Cd in the soil and Cd concentration accumulated in the two vegetables showed that Cd in F1 in the soil made the greatest contribution on the accumulation of Cd in the two vegetables.The high bio-concentration factor and the translocation factor of Cd in both cole and celery were observed,and Cd had higher accumulation in the edible parts of the two vegetables.Therefore,both cole and celery grown in Cd-polluted oasis soil have higher risk to human health.And the two vegetables are not suitable to be cultivated as vegetables consumed by human in the Cd-polluted oasis soil. | Yiming Yang Zhongren Nan Zhuanjun Zhao Zhaowei Wang Shengli Wang Xia Wang Wangqiang Jin Cuicui Zhao | 2011 | Journal of Environmental Sciences2011，23，8： | 8 |
| 10 | Prognostic implications of epidermal growth factor receptor variant Ⅲ expression and nuclear translocation in Chinese human gliomas显示文摘Objective: To determine the prognostic implications and clinical significance of epidermal growth factor receptor variant Ⅲ(EGFRvⅢ) expression and EGFRvⅢ nuclear translocation in Chinese human gliomas.Methods: We retrospectively examined EGFRvⅢ expression and EGFRvⅢ nuclear translocation using immunohistochemistry in specimens of 240 Chinese patients with glioma, including 84 World Health Organization(WHO) II gliomas, 84 WHO Ⅲ gliomas and 72 glioblastomas(WHO IV). Factors that correlated with EGFRvⅢ and EGFRvⅢ nuclear translocation expression were analyzed by the Chi-square test. Kaplan-Meier methodology and Cox regression were used for the survival analysis.Results: Log-rank tests showed that patient age, Karnofsky performance scale(KPS) score, tumor grade,EGFRvⅢ expression, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, isocitrate dehydrogenase(IDH)mutation, Ki-67 labeling index and O6-methylguanine-DNA methyltransferase(MGMT) status(P<0.05) were significantly correlated with overall survival(OS) time. Multivariate Cox regression analysis revealed that patient age, tumor grade, EGFRvⅢ nuclear translocation, 1 p/19 q codeletion, and IDH mutation(P<0.05) were significantly correlated with OS. Patients with a high level of EGFRvⅢ nuclear translocation(≥7%) had both significantly shorter OS [hazard ratio(HR): 1.920, 95% confidence interval(95% CI): 1.228-3.003, P=0.004] and progression-free survival(PFS) times(HR: 1.661, 95% CI: 1.116-2.471, P=0.012) than those with a low level of EGFRvⅢ nuclear translocation(<7%).Conclusions: A high level of EGFRvⅢ nuclear translocation in glioma is an independent factor indicating a poor prognosis, but EGFRvⅢ expression is not an independent clinical prognostic factor. The level of EGFRvⅢ nuclear translocation maybe a novel and crucial prognostic biomarker in glioma. | Kaiyuan Yang Xiaohui Ren Liyuan Tao Peipei Wang Haihui Jiang Li Shen Yiming Zhao Yong Cui Mingxiao Li Song Lin | 2019 | Chinese Journal of Cancer Research2019，31，1： | 8 |
| 11 | Recyclable adsorbent of BiFeO_3/Carbon for purifying industrial dye wastewater via photocatalytic reproducible显示文摘It is essential to prepare highly-efficiency reproducible adsorbent for purifying industrial dye wastewater. In this work, biscuit with a layered porous structure as a template is applied to prepare a photocatalytic recyclable adsorbent of BiFeO3/Carbon nanocomposites for purifying simulative industrial dye wastewater. It is found that the structure of the prepared BiFeO3/Carbon nanocomposite is related to the natural structure of the biscuit, annealing temperatures and immersing times, demonstrated by XRD, TEM, UV-Vis and adsorptive activities. Kinetics data shows that the adsorption rate of the adsorbent to the dye is rapid and fitted well with the pseudo-second-order model, that more than 80% of dyes can be removed in the beginning 30 min. The adsorption isotherm can be perfectly described by the Langmuir model as well. It can be seen from the adsorption data that the adsorption performance can reach over 90% at pH ? 2–12, which can imply its universal utilization. The prepared BiFeO_3/Carbon nanocomposites have also displayed excellent capacities(over 90% within 30 min) for adsorption of seven different dyes and their mixed one. According to the five times photocatalytic reproducible experiments, it is proved that BiFeO_3/Carbon nanocomposites show the excellent stability and reproduction for purifying simulative industrial dyes, even the sample have been placed for one year. These research results indicate that the adsorbent BiFeO_3/Carbon can be a suitable material used in treating industrial dye wastewater potentially. | Shuang Jiao Yiming Zhao Chensha Li Binsong Wang Yang Qu | 2019 | Green Energy & Environment2019，4，1： | 8 |
| 12 | Identification of novel cis-elements bound by BplMYB46 involved in abiotic stress responses and secondary wall deposition显示文摘Transcription factors(TFs)play vital roles in various biological processes by binding to cis-acting elements to control expressions of their target genes.The MYB TF BplMYB46,from Betula platyphylla,is involved in abiotic stress responses and secondary wall deposition.In the present study,we used a TF-centered yeast onehybrid technology(TF-centered Y1H)to identify the cisacting elements bound by BplMYB46.We screened a shortinsert random library and identified three cis-elements bound by BplMYB46:an E-box(CA(A/T/C)(A/G/C)TG)and two novel motifs,a TC-box(T(G/A)TCG(C/G))and a GT-box(A(G/T)T(A/C)GT(T/G)C).Chromatin immunoprecipitation(ChIP)and effector-reporter coexpression assays in Nicotiana tabacum confirmed binding of BplMYB46 to the TC-box,GT-box,and E-box motifs in the promoters of the phenylalanine ammonia lyase(PAL),peroxidase(POD),and superoxide dismutase(SOD)genes,which function in abiotic stress tolerance and secondary wall biosynthesis.This finding improves our understanding of potential regulatory mechanisms in the response to abiotic stress and secondary wall deposition of BplMYB46 in B.platyphylla. | Huiyan Guo Liuqiang Wang Chuanping Yang Yiming Zhang Chunrui Zhang Chao Wang | 2018 | Journal of Integrative Plant Biology2018，60，10： | 7 |
| 13 | Devonian Frasnian-Famennian transitional event deposits of Guangxi, South China and their possible tsunami origin显示文摘A suite of event deposits, isochronous and interrelated in origin, occurs widely near the Frasnian- Famennian boundary in Guangxi, South China. It is mainly distributed in the facies areas of the platform-margin slope and inter-platform rift-trough. The rudstone or calcirudite occur in the Liujing section of Hengxian and Luoxiu and Baqi sections of Xiangzhou in the facies area of platform-margin slope. The turbidites are observed in the sections of Yangdi and Baisha of Guilin, Du'an of Debao, Nandong and Sanli of Wuxuan, Xiangtian, Ma'anshan of Xiangzhou, Nayi of Chongzuo, Yunpan of Shanglin in the facies area of inter-platform rift-trough. The massive homogenites occur in sections of Mangchang, Luofu and Road from Nandan to Tian'e and Ma'anshan etc in the facies area of inter-platform rift-trough. Herein event deposits can be correlated in stratohorizon to the turbidite in the bottom of the Lower triangularis Zone in Hony railroad cut of Belgium, Devils Gate of Nevada, USA, Atrous of Morocco, South Urals and Fore-Kolyma of northeastern Siberia of Russia, and erosional discontinuities and brecciation in the Frasnian-Famennian boundary in South Polish-Moravian shelf. The event deposits could be caused by a violent tsunami related to bolide impacts into ocean. | DU YuanSheng GONG YiMing ZENG XiongWei HUANG HongWei YANG JiangHai ZHANG Zhe HUANG ZhiQiang | 2008 | Science China Earth Sciences2008，51，11： | 6 |
| 14 | Synthesis of low-cost porous ceramic microspheres from waste gangue for dye adsorption显示文摘Low-cost porous ceramic microspheres from waste gangue were prepared by simple spray drying and subsequent calcination. Effects of calcination temperature on phase and microstructure evolution, specific surface area, pore structure, and dye adsorption mechanism of the microspheres were investigated systematically. Results showed that the microspheres were spherical, with some mesopores both on the surface and inside the spheres. The phase kept kaolinite after calcined at 800 and 900 ℃ and transformed into mullite at 1000 ℃. The microspheres calcined at 800 ℃ showed larger adsorption capacity and removal efficiency than those calcined at higher temperatures. Methylene blue(MB) and basic fuchsin(BF) removal efficiency reached 100% and 99.9% with the microsphere dosage of 20 g/L, respectively, which was comparable to that of other low-cost waste adsorbents used to remove dyes in the literature. Adsorption kinetics data followed the pseudosecond-order kinetic model, and the isotherm data fit the Langmuir isotherm model. The adsorption process was attributed to multiple adsorption mechanisms including physical adsorption, hydrogen bonding, and electrostatic interactions between dyes and gangue microspheres. The low-cost porous microspheres with excellent cyclic regeneration properties are promising absorbent for dyes in wastewater filtration and adsorption treatment. | Shu YAN Yiming PAN Lu WANG Jingjing LIU Zaijuan ZHANG Wenlong HUO Jinlong YANG Yong HUANG | 2018 | Journal of Advanced Ceramics2018，7，1： | 6 |
| 15 | Zircon SHRIMP U–Pb age of Late Jurassic OIB-type volcanic rocks from the Tethyan Himalaya: constraints on the initial activity time of the Kerguelen mantle plume显示文摘This work presents zircon U–Pb age and wholerock geochemical data for the volcanic rocks from the Lakang Formation in the southeastern Tethyan Himalaya and represents the initial activity of the Kerguelen mantle plume. SHRIMP U–Pb dating of zircons from the volcanic rocks yielded a ^(206) Pb/^(238) U age of 147 ± 2 Ma that reflects the time of Late Jurassic magmatism. Whole rock analyses of major and trace elements show that the volcanic rocks are characterized by high content of Ti O_2(2.62 wt%–4.25 wt%) and P_2O_5(0.38 wt%–0.68 wt%), highly fractionated in LREE/HREE [(La/Yb)N= 5.35–8.31] with no obvious anomaly of Eu, and HFSE enrichment with no obvious anomaly of Nb and Ta, which are similar to those of ocean island basalts and tholeiitic basaltic andesites indicating a mantle plume origin. The Kerguelen mantle plume produced a massive amount of magmatic rocks from Early Cretaceous to the present, which widely dispersed from their original localities of emplacement due to the changing motions of the Antarctic, Australian, and Indian plates. However, our new geochronological and geochemical results indicate that the Kerguelen mantle plume started from the Late Jurassic. Furthermore, we suggest that the Kerguelen mantle plume may played a significant role in the breakup of eastern Gondwanaland according to the available geochronological, geochemical and paleomagnetic data. | Yuruo Shi Chenyang Hou J. Lawford Anderson Tianshui Yang Yiming Ma Weiwei Bian Jingjie Jin | 2018 | Acta Geochimica2018，37，3： | 6 |
| 16 | Scalable microfabrication of three-dimensional porous interconnected graphene scaffolds with carbon spheres for high-performance all carbon-based micro-supercapacitors显示文摘As one of the most important micro energy storage devices(MESDs),graphene-based micro-supercapacitors(G-MSCs)possess the advantages of excellent flexibility,long cycle life,affordability and high reliability.In most cases,constructing three-dimensional(3D)graphene networks is widely utilized to promote the permeation of electrolyte and enhance the utilization of active materials.In this work,conventional freeze-drying process is utilized in the fabrication of G-MSCs to constitute 3D interconnected networks micro-electrodes,and further by regulating the composition of inks,carbon spheres(CSs)at different mass loadings are introduced into the graphene scaffolds to further increase the active sites of the micro-electrodes.The fabricated all carbon-based MSC with the optimal mass loading of CSs(0.406 mg cm^(-2))exhibits a high specific areal capacitance of 17.01mF cm^(-2)at the scan rate of 10mV s^(-1)and a capacitance retention of 93.14%after 10000 cycles at the scan rate of 500 mV s^(-1).The proposed microfabrication process is facile and fully compatible with modern microtechnologies and will be highly suitable for large-scale production and integration. | Yiming Chen Minghao Guo Liang He Wei Yang Lin Xu Jiashen Meng Xiaocong Tian Xinyu Ma Qiang Yu Kaichun Yang Xufeng Hong Liqiang Mai | 2019 | Journal of Materiomics2019，5，2： | 6 |
| 17 | The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation显示文摘Interleukin(IL)17-producing T helper(Th17)cells play critical roles in the clearance of extracellular bacteria and fungi as well as the pathogenesis of various autoimmune diseases,such as multiple sclerosis,psoriasis,and ulcerative colitis.Although a global transcriptional regulatory network of Th17 cell differentiation has been mapped recently,the participation of epigenetic modifications in the differentiation process has yet to be elucidated.We demonstrated here that histone H3 lysine-27(H3K27)demethylation,predominantly mediated by the H3K27 demethylase Jmjd3,crucially regulated Th17 cell differentiation.Activation of naı¨ve CD41 T cells immediately induced high expression of Jmjd3.Genetic depletion of Jmjd3 in CD41 T cells specifically impaired Th17 cell differentiation both in vitro and in vivo.Ectopic expression of Jmjd3 largely rescued the impaired differentiation of Th17 cells in vitro in Jmjd3-deficientCD41 T cells.Importantly,Jmjd3-deficient mice were resistant to the induction of experimental autoimmune encephalomyelitis(EAE).Furthermore,inhibition of the H3K27 demethylase activity with the specific inhibitor GSK-J4 dramatically suppressed Th17 cell differentiation in vitro.At the molecular level,Jmjd3 directly bound to and reduced the level of H3K27 trimethylation(me3)at the genomic sites ofRorc,which encodes the masterTh17 transcription factorRorgt,and Th17 cytokine genes such as Il17,Il17f,and Il22.Therefore,our studies established acritical role of Jmjd3-mediatedH3K27demethylation inTh17 cell differentiation andsuggest that Jmjd3 can be a novel therapeutic target for suppressing autoimmune responses. | Zhi Liu Wei Cao Longxia Xu Xi Chen Yu Zhan Qian Yang Sanhong Liu Pengfei Chen Yuhang Jiang Xiaohua Sun Yu Tao Yiming Hu Cuifeng Li Qi Wang Ying Wang Charlie Degui Chen Yufang Shi Xiaoren Zhang | 2015 | Journal of Molecular Cell Biology2015，7，6： | 6 |
| 18 | Tomography-like flow visualization of a hypersonic inward-turning inlet显示文摘The flow field in a typical inward-turning inlet was visualized using the Planar Laser Scattering(PLS)method in a shock tunnel with a nominal Mach number of 6.The opaque inlet,which is truncated at a series of sections,and the following transparent isolator,are combined to enable the optical access at different streamwise locations.The sequential PLS images provide a tomography-like flow visualization,which confirm the existence of streamwise Counter-rotating Vortex Pairs(CVPs)in both external and internal flow field of the inlet.Generation mechanisms of these CVPs are unraveled with the help of a numerical simulation,among which the cowl notch plays an important role in the generation of surface trailing CVPs along the centerline of the cowl.Moreover,the cowl shock sweeps the internal boundary layer towards the body side,which ultimately accumulates low-momentum flow on the body side in forms of a large CVP propagating downstream through the isolator.The CVPs formed in the shape-transition are responsible for the nonuniform flow field of the inward-turning inlet.This study indicates that the V-shaped cowl notch affects the downstream flow significantly and,therefore,should be examined thoroughly in practical applications. | Yiming LI Zhufei LI Jiming YANG | 2021 | Chinese Journal of Aeronautics2021，34，1： | 6 |
| 19 | Monitoring somatosensory evoked potentials in spinal cord ischemia-reperfusion injury显示文摘It remains unclear whether spinal cord ischemia-reperfusion injury caused by ischemia and other non-mechanical factors can be monitored by somatosensory evoked potentials.Therefore,we monitored spinal cord ischemia-reperfusion injury in rabbits using somatosensory evoked potential detection technology.The results showed that the somatosensory evoked potential latency was significantly prolonged and the amplitude significantly reduced until it disappeared during the period of spinal cord ischemia.After reperfusion for 30–180 minutes,the amplitude and latency began to gradually recover;at 360 minutes of reperfusion,the latency showed no significant difference compared with the pre-ischemic value,while the somatosensory evoked potential amplitude increased,and severe hindlimb motor dysfunctions were detected.Experimental findings suggest that changes in somatosensory evoked potential latency can reflect the degree of spinal cord ischemic injury,while the amplitude variations are indicators of the late spinal cord reperfusion injury,which provide evidence for the assessment of limb motor function and avoid iatrogenic spinal cord injury. | Yiming Ji Bin Meng Chenxi Yuan Huilin Yang Jun Zou | 2013 | Neural Regeneration Research2013，8，33： | 5 |
| 20 | Optimization on Production Key Factors of Microbial Fermented Feed and Analysis on Composition Variation During Fermentation显示文摘[Objective] In order to study the production key factors of microbial fermented feed and the composition variation during fermentation. [Methods]Water,temperature,energy and protein were selected to study the effects on microbial fermented feed. And the fermentation conditions were optimized. Changes on nutrient composition during fermentation were determined and analyzed. [Result] Test results showed that feed formula with high sugar content,low protein,34%-36% water content,high fermentation temperature was more conducive to the production and actual production needs of fermentation strains. During the fermentation,strains showed interactions,test tended to be completed at the 144^(th)h after the fermentation,and number of lactic acid bacteria reached the peak of 1. 86 × 10~9 strain/g,contents of lactic acid could even reach 0. 89%. As time prolonged,contents of total energy,fiber and isothiocyanate gradually reduced,while contents of water and protein increased slightly. Contents of vitamin were stable,which in an order of V_B> V_E> V_K> V_A> V_D. Composition of amino acids showed an better change,contents of glutamic acid and proline decreased slowly,while contents of glycine and phenylalanine increased slowly. [Conclusion]High quality microbial fermentation feed could improve the palatability and safety of feed and keep the intestinal balance of livestock and poultry,which had broad application prospect. | Lin Biaosheng Luo Jian Li Yiming He Yuqin Luo Maochun Yang Xiaoyan | 2017 | Animal Husbandry and Feed Science2017，9，3： | 4 |
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