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| 1 | Cationic nanocarriers induce cell necrosis through impairment of Na^+/K^+-ATPase and cause subsequent inflammatory response显示文摘有积极表面费用的 Nanocarriers 以他们限制了他们的临床的应用的毒性著名。位于他们的毒性下面的机制例如煽动性的反应的正式就职,仍然保持大部分未知。在我们发现了 cationic nanocarriers 的那注射的现在的学习,包括 cationic liposomes, PEI,和 chitosan,导致了坏死的房间的快速的外观。cationic nanocarriers 导致的房间坏死依赖于他们的积极表面费用,但是不要求 RIP1 和 Mlkl。相反,细胞内部的 Na + 超载被发现伴随房间死亡。在文化媒介或有 Na +/K+-ATPase 阳离子绑定地点禁止者 ouabain 的房间的预告的处理的 Na + 的弄空,从房间坏死的保护的房间。而且,有 cationic nanocarriers 的处理在 vitro 并且在 vivo 禁止了 Na +/K+-ATPase 活动。计算模拟证明 cationic 搬运人能与 Na +/K+-ATPase 的阳离子绑定地点交往。有 ouabain 的小剂量的老鼠 pretreated 在 cationic nanocarriers 的致命的剂量的注射以后显示出改进幸存。进一步的分析建议 cationic nanocarriers 和 mitochondrial DNA 的产生的漏导致的那房间坏死能在 vivo 触发严重发炎,它被包含 TLR9 并且 MyD88 发信号的一条小径调停。一起拿,我们的结果揭示由此的新奇机制 cationic nanocarriers 通过和 mitochondrial 的随后的暴露的和 Na +/K+-ATPase, 的相互作用导致尖锐房间坏死是的联系损坏的分子的模式调停的一个关键事件煽动性的回答。我们的学习为评估 nanocarriers 的 biocompatibility 并且为药交货设计更好、更安全的有重要含意。 | Xiawei Wei Bin Shao Zhiyao He Tinghong Ye Min Luo Yaxiong Sang Xiao Liang Wei Wang Shuntao Luo Shengyong Yang Shuang Zhang Changyang Gong Maling Gou Hongxing Deng Yinglan Zhao Hanshuo Yang Senyi Deng Chengjian Zhao Li Yang Zhiyong Qian Jiong Li Xun Sun Jiahuai Han Chengyu Jiang Min Wu Zhirong Zhang | 2015 | Cell Research2015，25，2： | 21 |
| 2 | Epigenetic regulation in B-cell maturation and its dysregulation in autoimmunity显示文摘B cells have a critical role in the initiation and acceleration of autoimmune diseases, especially those mediated byautoantibodies. In the peripheral lymphoid system, mature B cells are activated by self or/and foreign antigens andsignals from helper T cells for differentiating into either memory B cells or antibody-producing plasma cells.Accumulating evidence has shown that epigenetic regulations modulate somatic hypermutation and class switchDNA recombination during B-cell activation and differentiation. Any abnormalities in these complex regulatoryprocesses may contribute to aberrant antibody production, resulting in autoimmune pathogenesis such as systemiclupus erythematosus. Newly generated knowledge from advanced modern technologies such as next-generationsequencing, single-cell sequencing and DNA methylation sequencing has enabled us to better understand B-cellbiology and its role in autoimmune development. Thus this review aims to summarize current research progress inepigenetic modifications contributing to B-cell activation and differentiation, especially under autoimmuneconditions such as lupus, rheumatoid arthritis and type 1 diabetes. | Haijing Wu Yaxiong Deng Yu Feng Di Long Kongyang Ma Xiaohui Wang Ming Zhao Liwei Lu Qianjin Lu | 2018 | Cellular & Molecular Immunology2018，15，7： | 10 |
| 3 | Identification and location of grapevine sucker based on information fusion of 2D laser scanner and machine vision显示文摘Chemical sucker control has been proven to be a more efficient method than manual and mechanical removals.The quick and effective identification and location of suckers are key technologies for targeted spray that can reduce chemical applications and alleviate potential problems.The goal of this research was to improve the accuracy of identification and location algorithm of grapevine suckers for real-time mobile targeted spray based on information fusion of two dimensional(2D)laser scanner and camera machine vision.A triangle white calibration board was used to determine the invisible laser scanning line.The positions of the terminated points of the scanning line on the calibration board in the laser scanner’s coordinates were calculated.Suckers size and center location were obtained by ExGExR segmentation,then the relative position between the suckers and triangle calibration board was determined in the image coordinates.Eventually,the actual size and relative position between the identified suckers and the platform were calculated by integrating the laser line and image information.The results of the field trials showed that the consumed time of the developed algorithm was 0.787 s,the width recognition rate 91.8%,height recognition rate 88.2%,and the relative position accuracies 92.0%,87.3%,which could meet the requirement of grapevine sucker precision targeted spray. | Wang Yaxiong Xu Shasha Li Wenbin Kang Feng Zheng Yongjun | 2017 | International Journal of Agricultural and Biological Engineering2017，10，2： | 4 |
| 4 | A graphene rheostat for highly durable and stretchable strain sensor显示文摘Strain sensors for human health monitoring are of paramount importance in wearable medical diagnostics and personal health monitoring.Despite extensive studies,strain sensors with both high durability and stretchability are still desired,particularly with the stability for different environmental conditions.Here,we report a series of strain sensors possessing the graphene network with a high density of intermittent physical interconnections,which produces the relative resistance change by varying the overlap area between the neighboring graphene sheets under stretching and releasing,analogous to the slide rheostat working in electronics.Our in-situ transmission electron microscope observation reveals the full recoverability of the structure from large deformation upon unloading for ensuring the exceptional cycle stability of our material on monitoring full-range body movements.The stable response is also demonstrated over wide temperature range and frequency range,because the peculiar dynamic structure can be maintained through the self-adjustment to the thermal expansion of the bulk material.Based on the working mechanism of graphene“slide rheostat,”the sensing properties of the strain sensor are tailored by tuning the graphene network structure with different mass densities using different concentrations of graphene oxide dispersion,while the stretchability and sensitivity can be separately optimized for different application requirements. | Jing Ren Wenjun Zhang Yubo Wang Yaxiong Wang Jun Zhou Liming Dai Ming Xu | 2019 | InfoMat2019，1，3： | 4 |
| 5 | Finite Element Analysis of the Pelvis after Customized Prosthesis Reconstruction显示文摘 | Enchun Dong Ling Wang Taimoor Iqbal Dichen Li Yaxiong Liu Jiankang He Binghui Zhao Yuan Li | 2018 | Journal of Bionic Engineering2018，15，3： | 2 |
| 6 | Transferrin plays a central role in coagulation balance by interacting with clotting factors显示文摘Coagulation balance is maintained through fine-tuned interactions among clotting factors,whose physiological concentrations vary substantially.In particular,the concentrations of coagulation proteases(pM to nM)are much lower than their natural inactivator antithrombin(AT,〜3μM),suggesting the existence of other coordinators.In the current study,we found that transferrin(norm plasma concentration〜40 μM)interacts with fibrinogen,thrombin,factor Xlla(FXlla),and AT with different affinity to maintain coagulation balance.Normally,transferrin is sequestered by binding with fibrinogen(normal plasma concentration〜10 μM)at a molar ratio of 4:1.In atherosclerosis,abnormally up-regulated transferrin interacts with and potentiates thrombin/FXlla and blocks ATs inactivation effect on coagulation proteases by binding to AT,thus inducing hypercoagulability.In the mouse model,transferrin overexpression aggravated atherosclerosis,whereas transferrin inhibition via shRNA knockdown or treatment with antitransferrin antibody or designed peptides interfering with transferrin-thrombin/FXlla interactions alleviated atherosclerosis.Collectively,these findings identify that transferrin is an important clotting regulator and an adjuster in the maintenance of coagulation balance and modifies the coagulation cascade. | Xiaopeng Tang Zhiye Zhang Mingqian Fang Yajun Han Gan Wang Sheng Wang Min Xue Yaxiong Li Li Zhang Jian Wu Biqing Yang James Mwangi Qiumin Lu Xiaoping Du Ren Lai | 2020 | Cell Research2020，30，2： | 2 |
| 7 | Novel human H7N9 influenza virus in China显示文摘Outbreaks of H7N9 avian influenza in humans in 5 provinces and 2 municipalities of China have reawakened concern that avian influenza viruses may again cross species barriers to infect the human population and thereby initiate a new influenza pandemic.Evolutionary analysis shows that human H7N9 influenza viruses originated from the H9N2,H7N3 and H11N9 avian viruses,and that it is as a novel reassortment influenza virus.This article reviews current knowledge on 11 subtypes of influenza A virus from human which can cause human infections. | Chengmin WANG Jing LUO Jing WANG Wen SU Shanshan GAO Min ZHANG Li XIE Hua DING Shelan LIU Xiaodong LIU Yu CHEN Yaxiong JIA Hongxuan HE | 2014 | Integrative Zoology2014，9，3： | 2 |
| 8 | Effect of pore size on CH4/N2 separation using activated carbon显示文摘In this paper,a model of activated carbon was established by molecular simulation and the separation performance of N2 and CH4 on activated carbon was studied.In order to evaluate the adsorption selectivity and diffusion selectivity of N2 and CH4,Grand Canonical Monte Carlo and molecular dynamic methods were used to obtain equilibrium adsorption isotherms and mean square displacements of N2 and CH4 on activated carbon with different pore sizes.Research results showed that the difference in adsorption isosteric heat of N2 and CH4 at the pore size of 0.46 nm is the largest,which is 5.759 and 7.03 kcal·mol^-1(1 cal=4.184 J),respectively.Activated carbon with pore size of 0.46 nm has the best N2 and CH4 adsorption selectivity,while its diffusion selectivity is not obvious. | Gaofei Chen Yaxiong An Yuanhui Shen Yayan Wang Zhongli Tang Bo Lu Donghui Zhang | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 2 |
| 9 | Utilization of Bayer Red Mud Derived from Bauxite for Belite-Ferroaluminate Cement Production显示文摘Bayer red mud(BRM)is a kind of industrial solid waste characterized by huge volume and high alkalinity.Its disposal generates serious environmental pollution and occupies a large number of farmland.The utilization and recycling of BRM is currently a crucial issue and needs to be addressed as soon as possible.The chemical composition of BRM is similar to cement clinker.In this study,the feasibility of preparing Belite-ferroaluminate clinker(BFAC)with different BRM was explored.The physical properties,mechanics performance,radioactivity levels and trace harmful metals leaching were measured.XRD,BEI and EDS were used to characterize the mineral formation,and SEM is used to reveal the solidified mechanism of trace harmful metal.The results show that the preparation of BFAC using a certain amount of BRM was feasible.The formed phases in clinkers mainly included C_(4)A_(3)Š,C_(2)S and C_(4)AF.The flexural strength and compressive strength of BFAC at 3 days increased whereas 28 and 90 days decreased with the increase of BRM due to the formation of higher C_(4)AF and lower C_(2)S.The formation of large amounts of Al_(2)O_(3)·3H_(2)O gel and Fe_(2)O_(3)·3H_(2)O gel in hydration products enhanced the adsorption capability to heavy metals and other ions.The trace harmful metal concentration in the leaching solution was much less than the upper limits.The radioactivity level of leaching solution was close to natural radioactive background.BRM is safe as raw material of BFAC. | Yanrong Zhao Ping Chen Shifeng Wang Yaxiong Ji Yuanhao Wang Bolin Wu Rongjin Liu | 2020 | Journal of Renewable Materials2020，8，11： | 2 |
| 10 | Layer-by-layer micromolding of natural biopolymer scaffolds with intrinsic microfluidic networks显示文摘 | HE Jiankang WANG Ye LIU Yaxiong | 2013 | Biofabrication2013，5，02： | 1 |
| 11 | Investigation of a Novel Flat Heat Pipe 显示文摘 | Yaxiong Wang Petersonl G P | 2005 | Journal of Heat Transfer2005，，： | 1 |
| 12 | SJES14110700479122显示文摘 | Song Wang Tingting Zheng Ming Xie Yaxiong Wang Jiming Zhang | 2014 | Rare Metal Materials and Engineering2014，，4： | 1 |
| 13 | Evaporation/Boiling in Thin Capillary Wicks (1) Wick Thickness Effects 显示文摘 | LI Chen Peterson G P WANG Yaxiong | 2006 | Journal of Heat Transfer2006，128，： | 1 |
| 14 | 3-77 Radiation Induces Premature Chromatid Separation by MiR-142-3p/Bod1 Pathway in Carcinoma Cells显示文摘Radiation-induced genomic instability plays a vital role in carcinogenesis[1]. Bod1 is required for proper chro- mosome biorientation, and Bod1 depletion increases premature chromatid separation[2]. miR-142-3p inuences cell cycle progression and inhibits proliferation and invasion in cervical carcinoma cells[3]. | Pan Dong Du Yarong Ren Zhenxin Chen Yaxiong Li Xiaoman Wang Jufang Hu Burong | 2015 | IMP & HIRFL Annual Report2015，，1： | 0 |
| 15 | Nanoparticle-strengthened Ni_(2)CoCrNb_(0.2)medium-entropy alloy with an ultrastrong cryogenic yield strength fabricated by additive manufacturing显示文摘To improve the yield strength of metallic materials at low temperatures,a strategy of combining the calculation of phase diagrams(CALPHAD)technique with the overall valence electron concentration(OVEC)principle is applied,and a Ni_(2)CoCrNb_(0.2)medium-entropy alloy(MEA)with D022 superlattice(noted as theγ″phase)is designed.Bulk MEA samples without defects were successfully fabricated using laser additive manufacturing(AM),followed by solution treatment at 1200℃for 1 h and then aging at 650℃for 120 h.The nanoscaleγ″phase precipitated.The tensile results indicated that the MEA had superior yield strengths of∼1180 MPa and∼1320 MPa and tensile strengths of∼1335 MPa and∼1552 MPa at 293 K and 77 K,respectively.The yield strength obtained was superior to that of currently reported medium/high-entropy alloys and typical advanced cryogenic steel.The mechanical properties of the Ni_(2)CoCrNb_(0.2)MEA demonstrated a strong temperature dependence,and the increased yield strength was mainly attributed to the increase in lattice friction stress at low temperatures.This research provides a new strategy for producing materials with ultrastrong cryogenic yield strengths by AM. | Fangping Wang Yaxiong Guo Qibin Liu Xiaojuan Shanga | 2023 | Journal of Materials Science & Technology2023，，32： | 0 |
| 16 | Design of multi-section luffing apple pruning equipment and cutting test of the key components显示文摘In order to reduce the labor intensity and improve the efficiency of pruning,this study designed a multi-section luffing apple pruning equipment suitable for apple orchards in hilly and mountainous areas of China.In the essay,the structure and working principle of the equipment are expounded,the cutter was analyzed,and the parameters were determined.Using the self-made test bench to simulate the field experiment,this study selected the ratio of cutting speed to feeding speed and feeding speed as the influencing factors and took the cut-off rate,cutting efficiency and cutting power as the objectives to carry out single factor experiment and quadratic regression orthogonal experiment.The test results show that the cutting power increases with the increase of ratio of cutting speed to feeding speed,and the cut-off rate and cutting efficiency first increase and then decrease.As the feeding speed increases,the cutting efficiency and power increase,and the cut-off rate decreases.When the cutoff rate was greater than 80%,the optimal combination of operating parameters was the feeding speed of 0.55 m/s and ratio of cutting speed to feeding speed of 1.29.Under this combination,the cut-off rate was 84.9%,the cutting efficiency was 13.1,and the cutting power was 175.7 W.The error between the predicted target value of the model and the average measured target value was less than 7%,so the test results are reliable.According to the obtained optimal operating parameters,the actual cutting experiment of the pruning equipment in the field was carried out,and the cutting rate was 96.3%,which meet the design requirements.This study can also meet the needs of mechanized pruning of fruit trees with different crown shapes,improve the applicability of pruning equipment,and provide support for the development of mechanized pruning equipment in China. | Siyuan Tong Wenbin Li Yaxiong Wang Lei Zhang Feng Kang | 2024 | International Journal of Agricultural and Biological Engineering2024，17，1： | 0 |
| 17 | Deposition law of flat fan nozzle for pesticide application in horticultural plants显示文摘Pesticide spraying is to protect the plants with adequate target coverage and a minimum of off-target drift.Understanding the spatial distribution characteristics of spray droplets is essential for regulating pesticide deposition,in order to investigate the relationship between the two at the mechanistic level and provide an accurate basis for nozzle selection,this study compared the characteristics of the atomization field under different pressures,angles,and flow rate types by phase Doppler particle analyzer(PDPA),the unit spatial density of droplet was used as a link to explore the internal mechanism that affects the deposition efficiency by constructing a transport model and conducting actual spraying experiments.The results showed that the cumulative distribution of droplet diameter could be perfectly fitted by the Rosin-Rammler correlation,and the deposition efficiency had a strong correlation with the peak particle size range.For strawberry and chrysanthemum plants,the optimal droplet deposition particle size ranges were 250-270μm and 240-260μm,respectively.This article explained the deposition efficiency from a single droplet dynamics mechanism and deposition of droplet cloud,which provided a new research idea for the study of precision plant protection. | Xiaoyi Wu Yalan Jia Bo Luo Chongchong Chen Yaxiong Wang Feng Kang Jiale Li | 2022 | International Journal of Agricultural and Biological Engineering2022，15，4： | 0 |
| 18 | Progress and challenges in multi-stack fuel cell system for high power applications:Architecture and energy management显示文摘With the development of fuel cells,multi-stack fuel cell system(MFCS)for high power application has shown tremendous development potential owing to their obvious advantages including high efficiency,durability,reliability,and pollution-free.Accordingly,the state-of-the-art of MFCS is summarized and analyzed to advance its research.Firstly,the MFCS applications are presented in high-power scenarios,especially in transportation applications.Then,to further investigate the MFCS,MFCS including hydrogen and air subsystem,thermal and water subsystem,multi-stack architecture,and prognostics and health monitoring are reviewed.It is noted that prognostics and health monitoring are investigated rarely in MFCS compared with previous research.In addition,the efficiency and durability of MFCS are not only related to the application field and design principle but also the energy management strategy(EMS).The reason is that the EMS is crucial for lifespan,cost,and efficiency in the multi-stack fuel cell system.Finally,the challenge and development potential of MFCS is proposed to provide insights and guidelines for future research. | Yuqi Qiu Tao Zeng Caizhi Zhang Gucheng Wang Yaxiong Wang Zhiguang Hu Meng Yan Zhongbao Wei | 2023 | Green Energy and Intelligent Transportation2023，2，2： | 0 |
| 19 | Modeling and Decentralized Predictive Control of Ejector Circulation‑Based PEM Fuel Cell Anode System for Vehicular Application显示文摘The dynamic response of fuel cell vehicle is greatly affected by the pressure of reactants.Besides,the pressure difference between anode and cathode will also cause mechanical damage to proton exchange membrane.For maintaining the relative stability of anode pressure,this study proposes a decentralized model predictive controller(DMPC)to control the anodic supply system composed of a feeding and returning ejector assembly.Considering the important influence of load current on the system,the piecewise linearization approach and state space with current-induced disturbance compensation are com-paratively analyzed.Then,an innovative switching strategy is proposed to prevent frequent switching of the sub-model-based controllers and to ensure the most appropriate predictive model is applied.Finally,simulation results demonstrate the better stability and robustness of the proposed control schemes compared with the traditional proportion integration differentia-tion controller under the step load current,variable target and purge disturbance conditions.In particular,in the case of the DC bus load current of a fuel cell hybrid vehicle,the DMPC controller with current-induced disturbance compensation has better stability and target tracking performance with an average error of 0.15 kPa and root mean square error of 1.07 kPa. | Bo Zhang Dong Hao Jinrui Chen Caizhi Zhang Bin Chen Zhongbao Wei Yaxiong Wang | 2022 | Automotive Innovation2022，5，3： | 0 |
| 20 | Porous bio-high entropy alloy scaffolds fabricated by direct ink writing显示文摘Porous tantalum-titanium-niobium-zirconium(Ta-Ti-Nb-Zr)bio-high entropy alloy(bioHEA)scaffolds are fabricated using direct ink writing 3D printing technology in this study.A composite ink is prepared using four metal powders as raw materials:Ta,Ti,Nb and Zr.Ink extrusion is used to build 3D scaf-folds with interconnected porous structures at room temperature,which are then sintered in a vacuum environment.The interdiffusion of metal elements yields porous bioHEA scaffolds with a body-centered cubic(BCC)structure.The fabricated scaffolds have uniform compositions with a significant alloying ef-fect and good biocompatibility.The scaffolds have a compressive strength of 70.08-149.95 MPa and an elastic modulus of 0.18-0.64 GPa,indicating that the mechanical properties can be controlled over a wide range.The scaffolds have a compressive strength close to that of human cortical bone and thus meet the requirements for porous structure characteristics and biological and mechanical properties of orthopedic implants. | Guangbin Zhao Xiaoxi Shao Qingxian Zhang Yanlong Wu Yaning Wang Xu Chen Hang Tian Yaxiong Liu Yanpu Liu Bingheng Lu | 2023 | Journal of Materials Science & Technology2023，，26： | 0 |
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