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| 1 | Effect of pore size on CH4/N2 separation using activated carbon显示文摘In this paper,a model of activated carbon was established by molecular simulation and the separation performance of N2 and CH4 on activated carbon was studied.In order to evaluate the adsorption selectivity and diffusion selectivity of N2 and CH4,Grand Canonical Monte Carlo and molecular dynamic methods were used to obtain equilibrium adsorption isotherms and mean square displacements of N2 and CH4 on activated carbon with different pore sizes.Research results showed that the difference in adsorption isosteric heat of N2 and CH4 at the pore size of 0.46 nm is the largest,which is 5.759 and 7.03 kcal·mol^-1(1 cal=4.184 J),respectively.Activated carbon with pore size of 0.46 nm has the best N2 and CH4 adsorption selectivity,while its diffusion selectivity is not obvious. | Gaofei Chen Yaxiong An Yuanhui Shen Yayan Wang Zhongli Tang Bo Lu Donghui Zhang | 2020 | Chinese Journal of Chemical Engineering2020，28，4： | 2 |
| 2 | MKP-1 reduces Aβ generation and alleviates cognitive impairments in Alzheimer’s disease models显示文摘Mitogen-activated protein kinase(MAPK)phosphatase 1(MKP-1)is an essential negative regulator of MAPKs by dephosphorylating MAPKs at both tyrosine and threonine residues.Dysregulation of the MAPK signaling pathway has been associated with Alzheimer’s disease(AD).However,the role of MKP-1 in AD pathogenesis remains elusive.Here,we report that MKP-1 levels were decreased in the brain tissues of patients with AD and an AD mouse model.The reduction in MKP-1 gene expression appeared to be a result of transcriptional inhibition via transcription factor specificity protein 1(Sp1)cis-acting binding elements in the MKP-1 gene promoter.Amyloid-β(Aβ)-induced Sp1 activation decreased MKP-1 expression.However,upregulation of MKP-1 inhibited the expression of both Aβprecursor protein(APP)andβ-site APP-cleaving enzyme 1 by inactivating the extracellular signal-regulated kinase 1/2(ERK)/MAPK signaling pathway.Furthermore,upregulation of MKP-1 reduced Aβproduction and plaque formation and improved hippocampal long-term potentiation(LTP)and cognitive deficits in APP/PS1 transgenic mice.Our results demonstrate that MKP-1 impairment facilitates the pathogenesis of AD,whereas upregulation of MKP-1 plays a neuroprotective role to reduce Alzheimer-related phenotypes.Thus,this study suggests that MKP-1 is a novel molecule for AD treatment. | Yehong Du Yexiang Du Yun Zhang Zhilin Huang Min Fu Junjie Li Yayan Pang Peng Lei Yu Tian Wang Weihong Song Guiqiong He Zhifang Dong | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 2 |
| 3 | Two-Hop Gaussian Relay Channel with Linear Relaying: Achievable Rate and Optimization Design显示文摘The relay node with linear relaying transmits the linear combination of its past received signals.The optimization of two-hop relay channel with linear relaying is discussed in this paper.The capacity for the two-hop Gaussian relay channel with linear relaying is derived,which can be formulated as an optimization problem over the relaying matrix and the covariance matrix of the signals transmitted at the source.It is proved that the solution to this optimization problem is equivalent to a 'single-letter' optimization problem.We also show that the solution to this 'single-letter' optimization problem has the same form as the expression of the rate achieved by Time-Sharing Amplify and Forward(TSAF).In order to solve this equivalent problem,we proposed an iterative algorithm.Simulation results show that if channel gain of one hop is relatively smaller,the achievable rate with TSAF is closer to the max-flow min-cut capacity bound,but at a lower complexity. | Deng Zhixiang Wang Baoyun Lang Fei Ma Yayan Liu Chen | 2012 | China Communications2012，9，2： | 1 |
| 4 | Valuation of shrimp ecosystem services--A case study of Leizhou City, China 显示文摘 | Liu Yayan Wang Weina | 2010 | Internation- al Journal of Sustainable Development & World Ecology2010，17，3： | 1 |
| 5 | Coenzyme Q10 Inhibits the Aging of Mesenchymal Stem Cells Induced by D-Galactose through Akt/mTOR Signaling显示文摘 | Dayong Zhang Bingxi Yan Shanshan Yu Chong Zhang Baoming Wang Yayan Wang Junbo Wang Zhanggen Yuan Lihuang Zhang Jianping Pan Sidhartha D. Ray | 2015 | Oxidative Medicine and Cellular Longevity2015，，： | 1 |
| 6 | 显示文摘 | Liu Yayan Yu Jiayan Wang Xiuyan | 2002 | Ferroelectrics2002，273，1： | 1 |
| 7 | Simulation and experiment of six-bed PSA process for air separation with rotating distribution valve显示文摘In this work,a six-bed pressure swing adsorption(PSA)process was investigated to produce medical oxygen from air,which uses the combination of six-way rotating distribution valve and PSA and has the main advantage of effectively saving space compared to the traditional two-bed or four-bed PSA process and can obtain greater productivity.The mathematical model of adsorption beds was developed based on the separation mechanism and the interaction among different equipment.Moreover,a pilot-scale device has been constructed to verify the accuracy of mathematical model by experiment.The oxygen product conformed to the medical standard(>93%(vol))with a recovery of over 57%.Some related parameters were also discussed in detail,such as step time,ratio of length to the diameter,flow rate of product. | Tao Tian Yayan Wang Bing Liu Zhaoyang Ding Xinxi Xu Meisheng Shi Jun Ma Yanjun Zhang Donghui Zhang | 2022 | Chinese Journal of Chemical Engineering2022，35，2： | 1 |
| 8 | Research on Nanometer Technique and Low-Work-Loss Sensor显示文摘The preparation process of the CO gas sensor used at normal temperature is presented.The electric conductance of this type of sensor evolved oscillation from regularly when the sensor is exposed to low level CO gas.The gas sensing mechanism was investigated by its crystalline structure.The mechanism of information sensing,which was the concurrence of the grain boundary barrier control and the crystal surface control,is discussed. | Lan Wang Yayan Liu Yifei Yang Jingwen He1 | 2006 | 稀有金属材料与工程2006，35，A03： | 0 |
| 9 | miR-429-3p mediates memory decline by targeting MKP-1 to reduce surface GluA1- containing AMPA receptors in a mouse model of Alzheimer’s disease显示文摘Alzheimer ’s disease(AD) is a leading cause of dementia in the elderly.Mitogen-activated protein kinase phosphatase 1(MKP-1) plays a neuroprotective role in AD.However,the molecular mechanisms underlying the effects of MKP-1 on AD have not been extensively studied.MicroRNAs(miRNAs) regulate gene expression at the post-transcriptional level,thereby repressing mRNA translation.Here,we reported that the microRNA-429-3p(miR-429-3p) was significantly increased in the brain of APP23/PS45 AD model mice and N2AAPPAD model cells.We further found that miR-429-3p could downregulate MKP-1 expression by directly binding to its 3’-untranslated region(3’ UTR).Inhibition of miR-429-3p by its antagomir(A-miR-429) restored the expression of MKP-1 to a control level and consequently reduced the amyloidogenic processing of APP and Aβ accumulation.More importantly,intranasal administration of A-miR-429 successfully ameliorated the deficits of hippocampal CA1 long-term potentiation and spatial learning and memory in AD model mice by suppressing extracellular signal-regulated kinase(ERK1/2)-mediated GluAl hyperphosphorylation at Ser831 site,thereby increasing the surface expression of GluAl-containing α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors(AMPARs).Together,these results demonstrate that inhibiting miR-429-3p to upregulate MKP-1 effectively improves cognitive and synaptic functions in AD model mice,suggesting that miR-429/MKP-1 pathway may be a novel therapeutic target for AD treatment. | Man Luo Yayan Pang Junjie Li Lilin Yi Bin Wu Qiuyun Tian Yan He Maoju Wang Lei Xia Guiqiong He Weihong Song Yehong Du Zhifang Dong | 2024 | Acta Pharmaceutica Sinica B2024，14，2： | 0 |
| 10 | Expert consensus on irrigation and intracanal medication in root canal therapy显示文摘Chemical cleaning and disinfection are crucial steps for eliminating infection in root canal treatment. However, irrigant selection or irrigation procedures are far from clear. The vapor lock effect in the apical region has yet to be solved, impeding irrigation efficacy and resulting in residual infections and compromised treatment outcomes. | Xiaoying Zou Xin Zheng Yuhong Liang Chengfei Zhang Bing Fan Jingping Liang Junqi Ling Zhuan Bian Qing Yu Benxiang Hou Zhi Chen Xi Wei Lihong Qiu Wenxia Chen Wenxi He Xin Xu Liuyan Meng Chen Zhang Liming Chen Shuli Deng Yayan Lei Xiaoli Xie Xiaoyan Wang Jinhua Yu Jin Zhao Song Shen Xuedong Zhou Lin Yue | 2024 | International Journal of Oral Science2024，16，1： | 0 |
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