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| 1 | Precision surgical approach with lymph-node dissection in early gastric cancer显示文摘The gravest prognostic factor in early gastric cancer is lymph-node metastasis,with an incidence of about 10% overall. About two-thirds of early gastric cancer patients can be diagnosed as node-negative prior to treatment based on clinicpathological data. Thus, the tumor can be resected by endoscopic submucosal dissection. In the remaining third, surgical resection is necessary because of the possibility of nodal metastasis. Nevertheless, almost all patients can be cured by gastrectomy with D1+ lymph-node dissection. Laparoscopic or robotic gastrectomy has become widespread in East Asia because perioperative and oncological safety are similar to open surgery. However, after D1+ gastrectomy,functional symptoms may still result. Physicians must strive to minimize postgastrectomy symptoms and optimize long-term quality of life after this operation.Depending on the location and size of the primary lesion, preservation of the pylorus or cardia should be considered. In addition, the extent of lymph-node dissection can be individualized, and significant gastric-volume preservation can be achieved if sentinel node biopsy is used to distinguish node-negative patients.Though the surgical treatment for early gastric cancer may be less radical than in the past, the operative method itself seems to be still in transition. | Shinichi Kinami Naohiko Nakamura Yasuto Tomita Takashi Miyata Hideto Fujita Nobuhiko Ueda Takeo Kosaka | 2019 | World Journal of Gastroenterology2019，25，14： | 21 |
| 2 | Impact of diabetes on long term follow-up of elderly patients with chronic total occlusion post percutaneous coronary intervention显示文摘Ba ckground The prognosis of elderly patients with chronic total occlusion (CTO) and diabetes mellitus (DM) treated with percutaneous coronary intervention (PCI) is not known. Objective To investigate the effect of diabetes on long-term follow-up of CTO after PCI in elderly patients.Methods A total of 153 elderly patients (age > 65 years old) with CTO lesions which were successfully treated with PCI were enrolled. Fifty one patients with diabetes and 102 without diabetes were compared for long-term outcomes (mean follow up: 36 ±12 months). Major adverse cardiac events (MACE) which include death, myocardial infarction or target lesion revascularization (TLR) were considered as a combined endpoint. Results The combined endpoint occurred in 29.4% of diabetes patients, and 11.3% of the patients without diabetes (P < 0.05). The Cox proportional hazards model identified: drug eluting stent (DES) or bare metal stent (BMS) (HR: 0.13, 95% confidence interval (95%CI): 0.03–0.62, P = 0.004), DM(HR: 6.69, 95% CI: 1.62–15.81, P = 0.01) and final minimal lumen diameter (MLD) (HR: 0.37, 95% CI: 0.13–0.90, P = 0.03 ) as independent predictors of MACE, DM with renal impairment (HR: 6.64, 95% CI: 1.32–33.36, P = 0.02), HBA1C on admission (HR: 1.79, 95% CI: 1.09–2.94, P = 0.02), as independent predictors of MACE at long term follow-up. Conclusions The study demonstrates that DMis a predictive factor for MACE in elderly CTOpatients treatedwith PCI, type of stent, final minimal lumen diameter and DMwith renal impairment, and HBA1C level on admission are predictors of MACE. | Wei Liu Kenji Wagatsuma Hideo Nii Mikihito Toda Hideo Amano Yasuto Uchida | 2013 | Journal of Geriatric Cardiology2013，10，1： | 3 |
| 3 | Impact of Natural Forest Protection Program policies on forests in northeastern China显示文摘This study analyzes the effects of the Natural Forest Protection Program (NFPP) on the restoration of forest resources in the northeastern forest region of China, an important region because of its ecological and geographical location and timber supply in China, by using panel data sets of 35 forest farms of state-owned forest enterprises. Panel data analysis results show that related policies under the NFPP have had positive effects on forest resources. Planting activity had a statistically significant effect on forest growth and could be reinforced continually by planting tree species suitable for a warming climate in temperate forests. Forest management and protection played a powerful role in increasing the growing stock of the forests. In NFPP areas timber harvests, after implementation of the NFPP, were a positive factor in increasing forest resources if the harvests combined effective tending and thinning under a carefully guided management plan. | ZHANG Kun Yasuto HORI ZHOU Shao-zhou Tetsuya MICHINAKA Yuichiro HIRANO Satoshi TACHIBANA | 2011 | Forestry Studies in China2011，13，3： | 3 |
| 4 | Alpha-fetoprotein before and after pegylated interferon therapy for predicting hepatocellular carcinoma development显示文摘AIM: To investigate factors that accurately predict hepatocellular carcinoma(HCC) development after antiviral therapy in chronic hepatitis C(CHC) patients. METHODS: CHC patients who received pegylated interferon and ribavirin were enrolled in this cohort study that investigated the ability of alpha-fetoprotein(AFP) to predict HCC development after interferon(IFN) therapy. RESULTS: Of 1255 patients enrolled, 665 developed sustained virological response(SVR) during mean follow-up period of 5.4 years. HCC was occurred in 89 patients, and 20 SVR patients were included. Proportional hazard models showed that HCC occurred in SVR patients showing AFP ≥ 5 ng/m L before therapy and in non-SVR patients showing AFP ≥ 5 ng/m L before and 1 year after therapy besides older age, and low platelet counts. SVR patients showing AFP ≥ 5 ng/m L before therapy and no decrease in AFP to < 5 ng/m L 1 year after therapy had significantly higher HCC incidence than non-SVR patients showing AFP ≥ 5 ng/m L before therapy and decreased AFP(P = 0.043). AFP ≥ 5 ng/m L before therapy was significantly associated with low platelet counts and high values of alanine aminotransferase(ALT) in stepwise logistic regression analysis. After age, gender, platelet count, and ALT was matched by propensity score, significantly lower HCC incidence was shown in SVR patients showing AFP < 5 ng/m L before therapy than in those showing AFP ≥ 5 ng/m L.CONCLUSION: The criteria of AFP < 5 ng/m L before and 1 year after IFN therapy is a benefical predictor for HCC development in CHC patients. | Yasuto Takeuchi Fusao Ikeda Toshiya Osawa Yasuyuki Araki Kouichi Takaguchi Youichi Morimoto Noriaki Hashimoto Kousaku Sakaguchi Tatsuro Sakata Masaharu Ando Yasuhiro Makino Shuji Matsumura Hiroki Takayama Hiroyuki Seki Shintarou Nanba Yuki Moritou Tetsuya Yasunaka Hideki Ohnishi Akinobu Takaki Kazuhiro Nouso Yoshiaki Iwasaki Kazuhide Yamamoto | 2015 | World Journal of Hepatology2015，7，19： | 3 |
| 5 | Expression of vascular endothelial growth factor?C and vascular endothelialgrowth factor receptor?3 in esophageal squamous cell carcinoma显示文摘 | Itaru Omoto Masataka Matsumoto Hiroshi Okumura Yasuto Uchikado Tetsuro Setoyama Yoshiaki Kita Tetsuhiro Owaki Yuko Kijima Hiroyuki Shinchi Sumiya Ishigami Shinichi Ueno Shoji Natsugoe | 2014 | Oncology Letters2014，，4： | 3 |
| 6 | Risk factors for recurrence after transarterial chemoembolization for early-stage hepatocellular carcinoma显示文摘 | Hideaki Kinugasa Kazuhiro Nouso Yasuto Takeuchi Tetsuya Yasunaka Hideki Onishi Shin-ichiro Nakamura Hidenori Shiraha Kenji Kuwaki Hiroaki Hagihara Fusao Ikeda Yasuhiro Miyake Akinobu Takaki Kazuhide Yamamoto | 2012 | Journal of Gastroenterology2012，，4： | 2 |
| 7 | 利用小震震源机制解研究汶川地震后龙门山断裂带中段应力场时空演化显示文摘利用川西流动地震台阵观测资料,求解汶川地震后发生在龙门山断裂带中段地区的余震震源机制解,反演了相应的应力场,得到了应力场的时空演化特征。结果显示,小震震源机制以逆冲为主并含有一定数量的走滑和正断型地震,逆冲型地震的比重随时间明显增加。震源机制类型的空间分布与断层深部展布及区域速度结构具有相关性。应力张量反演结果显示早期余震各分区水平最大主压应力S_H方位主要分布在近EW—NWW范围内,沿小鱼洞—理县方向余震分支地壳浅部主压应力则沿NE-SW向,表明震后早期应力场主要受主震破裂传播引起的动态应力影响,S_H方位与破裂面特征密切相关。应力张量随时间的变化显示深部应力结构由逆冲、走滑混合向纯逆冲转变,表明深部区域通过走滑型地震来平衡初期应力释放造成的局部库仑应力,并逐渐恢复到接近背景应力场,浅部应力变化追随深部变化特征,显示出在时间上的滞后。 | 江敏 陈九辉 Yasuto Kuwahara Reiken Matsushita | 2018 | 地震地质2018，40，2： | 2 |
| 8 | Dendritic cell-based vaccination in metastatic melanoma patients: PhaseII clinical trial显示文摘 | Chie Oshita Masako Takikawa Akiko Kume Haruo Miyata Tadashi Ashizawa Akira Iizuka Yoshio Kiyohara Shusuke Yoshikawa Ryuji Tanosaki Naoya Yamazaki Akifumi Yamamoto Kazutoh Takesako Ken Yamaguchi Yasuto Akiyama | 2012 | Oncology Reports2012，，4： | 2 |
| 9 | Microsatellite polymorphism in the human heme oxygenase-1 gene promoter and its application in association studies with Alzheimer and Parkinson disease显示文摘 | Teiko Kimpara A. Takeda Koichi Watanabe Yasuto Itoyama Shuntaro Ikawa Minro Watanabe Hiroyuki Arai Hidetada Sasaki Susumu Higuchi Naoshi Okita Sadao Takase Hiroshi Saito Kazuhiro Takahashi Shigeki Shibahara | 1997 | Human Genetics1997，，1： | 1 |
| 10 | Functional Clarification of MCT1-mediated Transport of Monocarboxylic Acids at the Blood-brain Barrier Using in vitro Cultured Cells and in vivo BUI Studies显示文摘 | Yasuto K IkumiT Akira T | 2000 | Pharm Research2000，1，： | 1 |
| 11 | Snail plays a key role in E-cadherin-preserved esophageal squamous cellcarcinoma显示文摘 | Shoji Natsugoe Yasuto Uchikado Hiroshi Okumura Masataka Matsumoto Tetsuro Setoyama Kiyokazu Tamotsu Yoshiaki Kita Akihiko Sakamoto Testuhiro Owaki Sumiya Ishigami Takashi Aikou | 2007 | Oncology Reports2007，，3： | 1 |
| 12 | Estimating the permeability of the nojima fault zone by a hydrophone: vertical seismic profiling experiment显示文摘 | Tsutomu Kiguchi Hisaso Ito Yasuto Kuwahara | 2001 | The island arc2001，10，： | 1 |
| 13 | Utility of ovomucoidspecific IgE concentrations in predicting symptomatic egg allergy显示文摘 | HITOSHI A ROBERT M YASUTO K | 2008 | J Allergy Clin Immunol2008，122，3： | 1 |
| 14 | Visible light-induced desulfurization technique for light oil显示文摘 | YASUHIRO S YASUTO T TAKAYUKI H ISAO K | 1998 | Chem Commun1998，，23： | 1 |
| 15 | Slug expression in the E - cadherin preserved tumors is re- lated to prognosis in patients with esophageal squamous cell carcinoma显示文摘 | Yasuto Uehikado Shoji Natsugoe Hiroshi Okumura | 2005 | Cli Cancer Res2005，11，： | 1 |
| 16 | Ductile regime nanomachining of single-crystal silicon carbide显示文摘 | PATTEN J GAO W YASUTO K | 2005 | Journal of Manufacturing Science and Engineering2005，127，3： | 1 |
| 17 | Overexpression of vascular endothelial growth factor-C correlates with lymph node micrometastasis in submucosal esophageal cancer显示文摘 | Masataka Matsumoto M.D. Ph.D. Shoji Natsugoe M.D. Ph.D. Hiroshi Okumura M.D. Ph.D. Hideo Arima M.D. Shigehiro Yanagita M.D. Yasuto Uchikado M.D. Ph.D. Naoya Yokomakura M.D. Tetsuro Setoyama M.D. Sumiya Ishigami M.D. Ph.D. Sonshin Takao M.D. Ph.D. Ta | 2006 | Journal of Gastrointestinal Surgery2006，，7： | 1 |
| 18 | Visible light-induced deep desulfurization process for light oils by photochemical electron-transfer oxidation in an organic twophase extraction system显示文摘 | YASUHIRO S YASUTO T TAKAYUKI H | 1999 | Ind Eng Chem Res1999，38，： | 1 |
| 19 | Effects of Aeration on Suction Pressure in a Submerged Membrane Bioreactur显示文摘 | Tatsuki Ueda Kenji Jata Yasuto Kikuoka | 1997 | Wat Res1997，31，3： | 1 |
| 20 | An Algorithm for Disjioint Paths in Bubble-sort Graphs显示文摘 | Yasuto Suzuchi Keiichi kaneko | 2006 | Systems and Computer in Japan2006，37，： | 1 |
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