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| 1 | A Study on Tribological Properties of Polypropylene Nanocomposites Reinforced with Pretreated HNTs显示文摘The polypropylene(PP) nanocomposites filled with pretreated halloysite nanotubes(HNTs) were prepared by the melt-blending method. Before filling, the as-received HNTs powder was at first purified and then modified. The characterization tests showed that the purified HNTs had less impurity and more uniform pore size distribution and the surface hydrophobicity of the modified HNTs was obviously improved. The mechanical and tribological properties of the PP/HNTs nanocomposites were extensively investigated. The results showed that the tensile, bending and notched impact strength of the PP/HNTs nanocomposites was somewhat improved, but the wear resistance of the PP/HNTs nanocomposites was obviously enhanced. | Liu Zan Li Yanxiang Ma Lu Qin Dunzhong Cheng Zhilin | 2017 | China Petroleum Processing & Petrochemical Technology2017，19，3： | 2 |
| 2 | The role of a drug-loaded poly(lactic co-glycolic acid)(PLGA) copolymer stent in the treatment of ovarian cancer显示文摘Objectives:Cisplatin(CDDP)is a widely used and effective basic chemotherapeutic drug for the treatment of a variety of tumors,including ovarian cancer.However,adverse side effects and acquired drug resistance are observed in the clinical application of CDDP.Identifying a mode of administration that can alleviate side effects and reduce drug resistance has become a promising strategy to solve this problem.Methods:In this study,3 D printing technology was used to prepare a CDDP-poly(lactic-co-glycolic acid)(CDDP-PLGA)polymer compound stent,and its physicochemical properties and cytotoxicity were evaluated both in vitro and in vivo.Results:The CDDP-PLGA stent had a significant effect on cell proliferation and apoptosis and clearly decreased the size of subcutaneous tumors in nude mice,whereas the systemic side effects were mild compared with those of intraperitoneal CDDP injection.Compared with the control group,CDDP-PLGA significantly increased the mRNA and protein levels of p-glycoprotein(P<0.01;P<0.01)and decreased vascular endothelial growth factor mRNA(P<0.05)and protein levels(P<0.01),however,CDDP-PLGA significantly decreased the mR NA and protein levels of p-glycoprotein(P<0.01;P<0.01)and vascular endothelial growth factor(P<0.01;P<0.01),which are associated with chemoresistance,in subcutaneous tumor tissue.Immunohistochemistry assay results revealed that,in the CDDP-PLGA group,the staining of the proliferation-related genes Ki67 and PCNA were lightly,and the apoptosis-related gene caspase-3 stained deeply.Conclusions:PLGA biomaterials loaded with CDDP,as compared with the same amount of free CDDP,showed good efficacy in terms of cytotoxicity,as evidenced by changes in apoptosis.Continuous local CDDP release can decrease the systemic side effects of this drug and the occurrence of drug resistance and angiogenesis,and improve the therapeutic effect.This new approach may be an effective strategy for the local treatment of epithelial ovarian cancer. | Yanqing Wang Xiaoyin Qiao Xiao Yang Mengqin Yuan Shu Xian Li Zhang Dongyong Yang Shiyi Liu Fangfang Dai Zhikai Tan Yanxiang Cheng | 2020 | Cancer Biology & Medicine2020，17，1： | 2 |
| 3 | RNA干扰技术裸鼠体内沉默缺氧诱导因子1α的表达对宫颈癌的抑瘤效应(英文)显示文摘Objective: The aim of our study was to observe the anti-tumor effect of silencing the expression of HIF-1α on cervical cancer in nude mice and to explore its mechanism of action. Methods: Human cervical cancer cell line Siha cells were divided into 3 groups: mock control group, control group transfected with scrambled sequence plasmid, and experimental group transfected with pU-HIF-1a-shRNA eukaryotic expression plasmid. Cultured cells of the three groups were inoculated in nude mice to establish cervical cancer-bearing nude mice. HIF-1α RNAi assay was performed to evaluate the tumor-suppressive effect of HIF-1α silencing on cervical cancer-bearing nude mice. Immunohistochemistry and Western blot were used to observe the distribution and protein expression of HIF-1α and GLUT1, while RT-PCR was adopted to detect the gene expression of HIF-1α, GLUTl and HK II. The product of glycolysis (lactic acid) and apoptosis in tumor cells were detected by colorimetry and semi-quantitative TUNEL staining, respectively. Results: The tumor growth in experimental group was significantly slower than that in the two control groups (P < 0.05). In the 50th day after transplantation, the tumor weight in the experimental group was (1.90 ± 0.28) g, significantly lower than (2.95 ± 0.77) g in the control group and (2.54 ± 0.56) g in the mock group (P < 0.01). In the experimental group, the gene and protein levels of HIF-1α were 0.45 ± 0.04 and 1.25 ± 0.92, and the levels of GLUT1 were 0.32 ± 0.02 and 1.25 ± 0.48, respectively. Both indicators in HIF-1α and GLUT1 were lower than that in the two control groups (P < 0.05). The expression levels of HK II gene and lactic acid in the experimental group were lower than that in the two control groups (P < 0.05), but the apoptotic cells were much more numerous in the experimental group than that in matched control groups (P < 0.01). Conclusion: The gene therapy by siRNA targeted silencing of HIF-1α may down-regulate its downstream genes GLUT1 and HK II expression, therefore, to reduce the tumor glycolysis activity and promote tumor cell apoptosis, and exert a tumor-suppressing effect in vivo. | Yanxiang Cheng Wen Fan Bingshu Li Qin Wang Min Hu Li Hong | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，7： | 1 |
| 4 | Solution proeessible rediridium dendrimers based on oligocarbazole host dendrons : synthesis, properties and their applications in organ- ic light-emitting diodes 显示文摘 | Junqiao Ding Jianhong Lu Yanxiang Cheng | 2008 | Adv Funet Mater2008，，18： | 1 |
| 5 | Starburst substituted hexaazatriphenylene compounds: synthesis, photophysical and electrochemical properties显示文摘 | Baoxiang Gao Yueling Liu Yanhou Geng Yanxiang Cheng Lixiang Wang Xiabin Jing Fosong Wang | 2009 | Tetrahedron Letters2009，，14： | 1 |
| 6 | Pream-ble design and synchronization algorithm for cooperativerelay systems 显示文摘 | YuSi Cheng YanXiang Jiang and XiaoHu You | 2009 | IEEE Transactions on Vehicular Tech-nology2009，，： | 1 |
| 7 | Highly efficient green emitting phosphorescent iridium dendrimers based on carbazoledendrons显示文摘 | Ding J unqiao Gao Jia Cheng Yanxiang | 2006 | Adv Funct Mater2006，16，4： | 1 |
| 8 | RNA干扰HIF-1α的表达能抑制宫颈癌血管生成和糖代谢(英文)显示文摘Objective:Cervical cancer has become a major public health problem.The development of effective,systemic therapies for cervical cancer is highly desired.We show here that hypoxia inducible factor-1α(HIF-1α) was indicated as an attractive therapeutic molecular target for cervical cancer.Methods:Firstly,we observed the expressional level of HIF-1α in cervical cancer and Hela and Siha cell lines.Secondly,by constructuring HIF-1α shRNA targeting human HIF-1α mRNA common sequence and transfecting it with plasmid to cervical cell,we detected the changes of HIF-1α and its downstream genes levels VEGF.Then we injected selected stably transfected cell line into athymic nude mice to estimate its' antitumor effects.Results:We observed that HIF-1α inhibition was related to down-regulated VEGF resulting in prevention of angiogenesis,then leading to slower-growing tumors.Conclusion:The underlying concept of transfecting a HIF-1α shRNA expression vector to block the HIF-1α holds promise as the clinical potential of gene therapy for cervical cancer. | Yanxiang Cheng Li Hong Xuexian Xu Wen Fan | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，5： | 0 |
| 9 | Clinical significance of survivin in the diagnosis and prognosis of endometrial carcinoma显示文摘Objective:To investigate the clinical significance of survivin in endometrial carcinoma and to investigate the relationship between the expression of survivin and Ki-67.Methods:Immunohistochemical S-P(streptavidin-biotin-peroxidase complex)method was performed to detect the expression of survivin and Ki-67 antigen in 15 cases of normal endometrium,21 cases of endometrial simple and complex hyperplasia,22 cases of endometrial atypical hyperplasia,and 61 cases of endometrial carcinoma.Results:Survivin was hardly detected in some normal endometrium in the proliferative phase and in the secretory phase.However,the level of survivin expression in atypical hyperplasia endometrium(72.73%)was higher than that in normal endometrium(7.14%)(P < 0.05),including simple and complex hyperplasia(42.38%)(P < 0.01),and was lower than that in endometrial carcinoma(90.17%)(P < 0.05).Moreover,significant correlation was present between the expression of survivin and the characteristics of endometrial carcinoma,including clinical stage,histological grade and the presence of invasion to myometrium(P < 0.05).In addition,Ki-67 antigen expression was positively correlated with survivin expression in all specimen.Ki-67 labeled indexes(LIs)in hyperplasia endometrium were significantly lower than those in atypical hyperplasia endometrium and endometrial carcinoma(P < 0.01),while there was no significant difference in Ki-67 LIs between atypical hyperplasia endometrium and endometrial carcinoma(P > 0.05).There was no significant relationship between Ki-67 LIs and the characteristics of endometrial carcinoma,including histological grade,clinical stage or the invasion to myometrium(P > 0.05).Conclusion:Survivin may participate in the onset and progression of endometrial carcinoma through inhibiting apoptosis and promoting proliferation.Survivin expression is correlated with the malignant degree and prognosis of tumor.Ki-67 is also associated with carcinogenesis and progression of endometrial carcinoma.The results suggest that survivin could be a diagnostic and prognostic marker for endometrial carcinoma and might provide pathways to treat the patients with recurrent or refractory or rudimental endometrial carcinoma. | Yanxiang Cheng Gantao Chen Yanjun Cheng Demin Pu | 2006 | Journal of Nanjing Medical University2006，20，4： | 0 |
| 10 | Carbazole ring: A delicate rack for constructing thermally activated delayed fluorescent compounds with through-space charge transfer显示文摘Three carbazole derivatives, Ac PTC, Px PTC and Pt PTC, consisting of two 9,9-dimethyl-9,10-dihydroacridine,phenoxazine or phenothiazine donor groups and one diphenyltriazine acceptor group fixed at 1,8,9-positions of a single carbazole ring via phenylene, are designed and synthesized. X-ray diffraction analysis of Ac PTC reveals that there exist multiple π-π interactions between the donor and acceptor groups to form a sandwich-like structural unit with edge-to-face interaction model. The compounds thus show obvious thermally activated delayed fluorescence with through-space charge transfer character and possess considerable photoluminescence quantum yields of up to 73% in doped films with sky-blue to yellow emissions. The solution-processed electroluminescent devices achieve the highest maximum external quantum efficiencies of 10.0%, 11% and 5.6% for Ac PTC, Px PTC and Pt PTC, respectively, with small efficiency roll-offs. | Kuofei Li Tao Wang Bing Yao Yuannan Chen Hao Deng Hongmei Zhan Zhiyuan Xie Yanxiang Cheng | 2021 | Chinese Chemical Letters2021，32，12： | 0 |
| 11 | The role of TLRs in cervical cancer with HPV infection:a review显示文摘The main cause of cervical cancer is persistent infection with high-risk human papilloma virus(HR-HPV),but not all human papilloma virus(HPV)infections lead to cervical cancer.The key factors that determine the outcome of HPV infection remain poorly understood,and how the host immune system protects against HPV infection is unclear.Toll-like receptors(TLRs)are a group of pattern recognition receptors present in the cytoplasm and cell membrane,and can specifically recognize pathogen-associated molecular patterns.As the key molecules of innate and acquired immunity,TLRs not only play important roles in the immune defense against infectious diseases,but also are involved in the occurrence and development of a variety of malignant tumors.In cervical cancer caused by HR-HPV infection,TLRs have been found to regulate the local immune microenvironment.The role of TLRs in HR-HPV infection and HPV-induced cervical cancer and its relationship with HPV vaccine are reviewed in this article. | Xiao Yang Yanxiang Cheng Chunsheng Li | 2017 | Signal Transduction and Targeted Therapy2017，2，1： | 0 |
| 12 | An integrative review on the applications of 3D printing in the field of in vitro diagnostics显示文摘Biomedicine is one of the fastest growing areas of additive manufacturing.Especially,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concept designing ranging from materials,devices to system integration;ii)conceptual design simpli-fication and improved practicality of IVD products;iii)shifting the IVD applications from centralized labs to point-of-care testing(POCT).In this review,the latest developments of 3D printing and its advantages in IVD applications are summarized.A series of 3D-printed objects for IVD applications,including single-function modules,multi-function devices which integrate several single-function modules for specific an-alytical applications such as sample pre-treatment and chemo-/bio-sensing,and all-in-one systems which integrate multi-function devices and the instrument operating them,are analyzed from the perspective of functional integration.The current and potential commercial applications of 3D-printed objects in the IVD field are highlighted.The features of 3D printing,especially rapid prototyping and low start-up,en-able the easy fabrication of bespoke modules,devices and systems for a range of analytical applications,and broadens the commercial IVD prospects. | Jian Yang Yanxiang Cheng Xia Gong Shengzhu Yi Cheuk-Wing Li Lelun Jiang Changqing Yi | 2022 | Chinese Chemical Letters2022，33，5： | 0 |
| 13 | Hyperbolic metamaterial using chiral molecules显示文摘We theoretically investigate the intra-band transitions in Mobius molecules.Due to the weak magnetic response,the relative permittivity is significantly modified by the presence of the medium while the relative permeability is not.We show that there is hyperbolic dispersion relation induced by the intra-band transitions because one of the eigen-values of permittivity possesses a different sign from the other two,while all three eigen-values of permeability are positive.We further demonstrate that the bandwidth of negative refraction is 0.165 eV for the H-polarized incident light,which is broader than the ones for inter-band transitions by 3 orders of magnitude.Moreover,the frequency domain has been shifted from ultra-violet to visible domain.Although there is negative refraction for the E-polarized incident light,the bandwidth is much narrower and depends on the incident angle. | JieXing Zhao JingJing Cheng YingQi Chu YanXiang Wang FuGuo Deng Qing Ai | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，6： | 0 |
| 14 | Touchable cell biophysics property recognition platforms enable multifunctional blood smart health care显示文摘As a crucial biophysical property,red blood cell(RBC)deformability is pathologically altered in numerous disease states,and biochemical and structural changes occur over time in stored samples of otherwise normal RBCs.However,there is still a gap in applying it further to point-of-care blood devices due to the large external equipment(high-resolution microscope and microfluidic pump),associated operational difficulties,and professional analysis.Herein,we revolutionarily propose a smart optofluidic system to provide a differential diagnosis for blood testing via precise cell biophysics property recognition both mechanically and morphologically.Deformation of the RBC population is caused by pressing the hydrogel via an integrated mechanical transfer device.The biophysical properties of the cell population are obtained by the designed smartphone algorithm.Artificial intelligence-based modeling of cell biophysics properties related to blood diseases and quality was developed for online testing.We currently achieve 100%diagnostic accuracy for five typical clinical blood diseases(90 megaloblastic anemia,78 myelofibrosis,84 iron deficiency anemia,48 thrombotic thrombocytopenic purpura,and 48 thalassemias)via real-world prospective implementation;furthermore,personalized blood quality(for transfusion in cardiac surgery)monitoring is achieved with an accuracy of 96.9%.This work suggests a potential basis for next-generation blood smart health care devices. | Longfei Chen Yantong Liu Hongshan Xu Linlu Ma Yifan Wang Le Yu Fang Wang Jiaomeng Zhu Xuejia Hu Kezhen Yi Yi Yang Hui Shen Fuling Zhou Xiaoqi Gao Yanxiang Cheng Long Bai Yongwei Duan Fubing Wang Yimin Zhu | 2021 | Microsystems & Nanoengineering2021，7，6： | 0 |
| 15 | Challenges and improvement in management of neonates born to mothers with COVID-19 in China显示文摘Objective:China was the first country suffering from the SARS-CoV-2 pandemic and one of the countries with stringent mother-neonate isolation measure implemented.Now increasing evidence suggests that coronavirus disease 2019(COVID-19)should not be taken as an indication for formula feeding or isolation of the infant from the mother.Methods:We conducted a retrospective cohort study in 44 hospitals from 14 provinces in China to investigate the management of neonates whose mothers have confirmed or suspected COVID-19.In addition,65 members of Chinese Neonatologist Association(CNA)were invited to give their comments and suggestions on the clinical management guidelines for high-risk neonates.Results:There were 121 neonates born to 118 mothers suspected with COVID-19 including 42 mothers with SARS-CoV-2 positive results and 76 mothers with SARS-CoV-2 negative results.All neonates were born by caesarean section,isolated from their mothers immediately after birth and were formula-fed.Five neonates were positive for SARSCoV-2 at initial testing between 36 and 46 h after birth.Regarding the confusion on the clinical management guidelines,58.78%of the newborns were put into isolation,32.22%were subject to PCR tests,and 5.16%and 2.75%received breastfeeding and vaccination,respectively.Conclusion:The clinical symptoms of neonates born to mothers with confirmed SARS-CoV-2 were mild,though five neonates might have been infected in utero or during delivery.Given the favorable outcomes of neonates born to COVID-confirmed mothers,full isolation may not be warranted.Rather,separation of the mother and her newborn should be assessed on a case-by-case basis,considering local facilities and risk factors for adverse outcomes,such as prematurity and fetal distress. | Jie Yang Zhuxiao Ren Lingkong Zeng Shiwen Xia Lin Wang Jiayu Miao Zhe Zhao Chuanzhong Yang Xiuyong Cheng Huayan Zhang Yuanfang Zhu Li Liu Xirong Gao Bin Yi Zhenlang Lin Wei Liu Xiaoyu Zhou Benqing Wu Ling Chen Zhankui Li Xuefeng Zhang Wei Lu Lianhong Zhang Xiao Chen Xiaoyun Zhong Falin Xu Jinhui Wu Yong Ji Jiahua Pan Yanxiang Chen Carine Ronsmans Zhichun Feng | 2022 | Frigid Zone Medicine2022，2，2： | 0 |
| 16 | Synthesis,characterization and photoluminescence of aluminum N-aryloxo functionalized β-ketoiminate complexes显示文摘The synthesis,characterization and luminescent properties of aluminum complexes containing a dianionic N-aryloxo functionalized β-ketoiminate ligand are presented.4-(2-Hydroxy-5-R-phenyl)imino-2-pentanone (R=Me,L 1 H 2;R=tert-butyl,L 2 H 2) ligands reacted with AlEt 3 in tetrahydrofuran to give the aluminum complexes (L 1 AlEt) 2 (1) and (L 2 AlEt) 2 (2) in reasonable isolated yields.X-ray diffraction revealed that complexes 1 and 2 have solvent-free centrosymmetric dimeric structures,and each aluminum center has distorted trigonal bipyramidal geometry.At room temperature,complexes 1 and 2 exhibit blue photoluminescence in acetonitrile with maximum emission wavelengths of 419 and 413 nm,respectively. | FENG Tao PENG HongMei YAO YingMing ZHANG Yong SHEN Qi CHENG YanXiang | 2011 | Chinese Science Bulletin2011，56，14： | 0 |
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